Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C chemokine receptor type 6

Gene

Ccr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25122636). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (By similarity). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation (PubMed:19050256). Required for the normal migration of Th17 cells in Peyers patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine (PubMed:19129757). Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors (PubMed:24638065). Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches (PubMed:27174992). Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (PubMed:25505290). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).1 PublicationBy similarity8 Publications

GO - Molecular functioni

  • C-C chemokine binding Source: UniProtKB
  • C-C chemokine receptor activity Source: UniProtKB

GO - Biological processi

  • calcium-mediated signaling Source: UniProtKB
  • cell chemotaxis Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • DN2 thymocyte differentiation Source: UniProtKB
  • DN3 thymocyte differentiation Source: UniProtKB
  • isotype switching to IgA isotypes Source: UniProtKB
  • leukocyte migration involved in inflammatory response Source: UniProtKB
  • lymphocyte migration Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • positive regulation of dendritic cell chemotaxis Source: Ensembl
  • positive regulation of epithelial cell migration Source: Ensembl
  • positive regulation of sperm motility involved in capacitation Source: UniProtKB
  • regulation of T cell migration Source: UniProtKB
  • T cell migration Source: UniProtKB
  • thymocyte migration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-1461957. Beta defensins.
R-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 6
Short name:
C-C CKR-6
Short name:
CC-CKR-6
Short name:
CCR-6
Alternative name(s):
KY411
CD_antigen: CD196
Gene namesi
Name:Ccr6
Synonyms:Cmkbr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1333797. Ccr6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence analysisAdd
BLAST
Transmembranei40 – 6627Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini67 – 759CytoplasmicSequence analysis
Transmembranei76 – 9621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini97 – 11115ExtracellularSequence analysisAdd
BLAST
Transmembranei112 – 13322Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini134 – 15118CytoplasmicSequence analysisAdd
BLAST
Transmembranei152 – 17221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini173 – 20331ExtracellularSequence analysisAdd
BLAST
Transmembranei204 – 23027Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini231 – 24616CytoplasmicSequence analysisAdd
BLAST
Transmembranei247 – 27125Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini272 – 29524ExtracellularSequence analysisAdd
BLAST
Transmembranei296 – 31318Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini314 – 36754CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: MGI
  • cytosol Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • sperm flagellum Source: UniProtKB
  • sperm plasma membrane Source: UniProtKB
  • sperm principal piece Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367C-C chemokine receptor type 6PRO_0000069287Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi110 ↔ 189PROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO54689.
PRIDEiO54689.

PTM databases

iPTMnetiO54689.
PhosphoSiteiO54689.

Expressioni

Tissue specificityi

Sperm. Mainly localized in the principal piece and neck region of the tail but is also found in the acrosomal region in a small percentage of sperm cells. Expressed in natural regulatory T cells (nTregs) and a subset of early thymocyte progenitor double-negative 1 (DN1) cells. Expresssed in memory B cells. Expressed by IL17 producing helper T-cells (Th17), type 1 effector cells (Th1), type 2 effector cells (Th2) and regulatory T-cells (Treg) (at protein level). Expressed by Th17 cells in spleen, Peyers patches, and lamina propria of small and large intestine. Highly expressed in testis, lung, colon, and dendritic cells.5 Publications

Inductioni

Up-regulated on pre-germinal center B-cells in a CD40-dependent manner. Up-regulated and down-regulated in Th17 cells by TGFB1 and IL2 respectively.3 Publications

Gene expression databases

BgeeiENSMUSG00000040899.
CleanExiMM_CCR6.
ExpressionAtlasiO54689. baseline and differential.
GenevisibleiO54689. MM.

Interactioni

GO - Molecular functioni

  • C-C chemokine binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095029.

Structurei

3D structure databases

ProteinModelPortaliO54689.
SMRiO54689. Positions 27-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKPR. Eukaryota.
ENOG410XSP7. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO54689.
KOiK04181.
OMAiCYMFIVK.
OrthoDBiEOG091G08B0.
PhylomeDBiO54689.
TreeFamiTF330966.

Family and domain databases

InterProiIPR004067. Chemokine_CCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01529. CHEMOKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTESYFGT DDYDNTEYYS IPPDHGPCSL EEVRNFTKVF VPIAYSLICV
60 70 80 90 100
FGLLGNIMVV MTFAFYKKAR SMTDVYLLNM AITDILFVLT LPFWAVTHAT
110 120 130 140 150
NTWVFSDALC KLMKGTYAVN FNCGMLLLAC ISMDRYIAIV QATKSFRVRS
160 170 180 190 200
RTLTHSKVIC VAVWFISIII SSPTFIFNKK YELQDRDVCE PRYRSVSEPI
210 220 230 240 250
TWKLLGMGLE LFFGFFTPLL FMVFCYLFII KTLVQAQNSK RHRAIRVVIA
260 270 280 290 300
VVLVFLACQI PHNMVLLVTA VNTGKVGRSC STEKVLAYTR NVAEVLAFLH
310 320 330 340 350
CCLNPVLYAF IGQKFRNYFM KIMKDVWCMR RKNKMPGFLC ARVYSESYIS
360
RQTSETVEND NASSFTM
Length:367
Mass (Da):42,103
Last modified:June 1, 1998 - v1
Checksum:i6A309AF833B1117E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009369 mRNA. Translation: BAA23776.1.
AJ222714 Genomic DNA. Translation: CAA10956.1.
CCDSiCCDS28381.1.
RefSeqiNP_001177262.1. NM_001190333.1.
NP_001177263.1. NM_001190334.1.
NP_001177264.1. NM_001190335.1.
NP_001177265.1. NM_001190336.1.
NP_001177266.1. NM_001190337.1.
NP_033965.1. NM_009835.4.
XP_006523345.1. XM_006523282.2.
XP_006523346.1. XM_006523283.2.
XP_006523347.1. XM_006523284.2.
XP_006523349.1. XM_006523286.2.
XP_006523351.1. XM_006523288.2.
XP_006523353.1. XM_006523290.2.
XP_006523354.1. XM_006523291.1.
XP_006523355.1. XM_006523292.2.
XP_011244488.1. XM_011246186.1.
XP_011244489.1. XM_011246187.1.
XP_011244490.1. XM_011246188.1.
XP_011244491.1. XM_011246189.1.
UniGeneiMm.8007.

Genome annotation databases

EnsembliENSMUST00000097418; ENSMUSP00000095029; ENSMUSG00000040899.
ENSMUST00000164411; ENSMUSP00000131153; ENSMUSG00000040899.
ENSMUST00000166348; ENSMUSP00000128559; ENSMUSG00000040899.
ENSMUST00000167956; ENSMUSP00000128529; ENSMUSG00000040899.
ENSMUST00000177568; ENSMUSP00000137249; ENSMUSG00000040899.
ENSMUST00000180103; ENSMUSP00000135945; ENSMUSG00000040899.
GeneIDi12458.
KEGGimmu:12458.
UCSCiuc008ajd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009369 mRNA. Translation: BAA23776.1.
AJ222714 Genomic DNA. Translation: CAA10956.1.
CCDSiCCDS28381.1.
RefSeqiNP_001177262.1. NM_001190333.1.
NP_001177263.1. NM_001190334.1.
NP_001177264.1. NM_001190335.1.
NP_001177265.1. NM_001190336.1.
NP_001177266.1. NM_001190337.1.
NP_033965.1. NM_009835.4.
XP_006523345.1. XM_006523282.2.
XP_006523346.1. XM_006523283.2.
XP_006523347.1. XM_006523284.2.
XP_006523349.1. XM_006523286.2.
XP_006523351.1. XM_006523288.2.
XP_006523353.1. XM_006523290.2.
XP_006523354.1. XM_006523291.1.
XP_006523355.1. XM_006523292.2.
XP_011244488.1. XM_011246186.1.
XP_011244489.1. XM_011246187.1.
XP_011244490.1. XM_011246188.1.
XP_011244491.1. XM_011246189.1.
UniGeneiMm.8007.

3D structure databases

ProteinModelPortaliO54689.
SMRiO54689. Positions 27-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095029.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO54689.
PhosphoSiteiO54689.

Proteomic databases

PaxDbiO54689.
PRIDEiO54689.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097418; ENSMUSP00000095029; ENSMUSG00000040899.
ENSMUST00000164411; ENSMUSP00000131153; ENSMUSG00000040899.
ENSMUST00000166348; ENSMUSP00000128559; ENSMUSG00000040899.
ENSMUST00000167956; ENSMUSP00000128529; ENSMUSG00000040899.
ENSMUST00000177568; ENSMUSP00000137249; ENSMUSG00000040899.
ENSMUST00000180103; ENSMUSP00000135945; ENSMUSG00000040899.
GeneIDi12458.
KEGGimmu:12458.
UCSCiuc008ajd.2. mouse.

Organism-specific databases

CTDi1235.
MGIiMGI:1333797. Ccr6.

Phylogenomic databases

eggNOGiENOG410IKPR. Eukaryota.
ENOG410XSP7. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO54689.
KOiK04181.
OMAiCYMFIVK.
OrthoDBiEOG091G08B0.
PhylomeDBiO54689.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-1461957. Beta defensins.
R-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiO54689.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040899.
CleanExiMM_CCR6.
ExpressionAtlasiO54689. baseline and differential.
GenevisibleiO54689. MM.

Family and domain databases

InterProiIPR004067. Chemokine_CCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01529. CHEMOKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR6_MOUSE
AccessioniPrimary (citable) accession number: O54689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.