Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O54689 (CCR6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 6

Short name=C-C CKR-6
Short name=CC-CKR-6
Short name=CCR-6
Alternative name(s):
KY411
CD_antigen=CD196
Gene names
Name:Ccr6
Synonyms:Cmkbr6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367C-C chemokine receptor type 6
PRO_0000069287

Regions

Topological domain1 – 3939Extracellular Potential
Transmembrane40 – 6627Helical; Name=1; Potential
Topological domain67 – 759Cytoplasmic Potential
Transmembrane76 – 9621Helical; Name=2; Potential
Topological domain97 – 11115Extracellular Potential
Transmembrane112 – 13322Helical; Name=3; Potential
Topological domain134 – 15118Cytoplasmic Potential
Transmembrane152 – 17221Helical; Name=4; Potential
Topological domain173 – 20331Extracellular Potential
Transmembrane204 – 23027Helical; Name=5; Potential
Topological domain231 – 24616Cytoplasmic Potential
Transmembrane247 – 27125Helical; Name=6; Potential
Topological domain272 – 29524Extracellular Potential
Transmembrane296 – 31318Helical; Name=7; Potential
Topological domain314 – 36754Cytoplasmic Potential

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation351N-linked (GlcNAc...) Potential
Disulfide bond110 ↔ 189 By similarity

Sequences

Sequence LengthMass (Da)Tools
O54689 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 6A309AF833B1117E

FASTA36742,103
        10         20         30         40         50         60 
MNSTESYFGT DDYDNTEYYS IPPDHGPCSL EEVRNFTKVF VPIAYSLICV FGLLGNIMVV 

        70         80         90        100        110        120 
MTFAFYKKAR SMTDVYLLNM AITDILFVLT LPFWAVTHAT NTWVFSDALC KLMKGTYAVN 

       130        140        150        160        170        180 
FNCGMLLLAC ISMDRYIAIV QATKSFRVRS RTLTHSKVIC VAVWFISIII SSPTFIFNKK 

       190        200        210        220        230        240 
YELQDRDVCE PRYRSVSEPI TWKLLGMGLE LFFGFFTPLL FMVFCYLFII KTLVQAQNSK 

       250        260        270        280        290        300 
RHRAIRVVIA VVLVFLACQI PHNMVLLVTA VNTGKVGRSC STEKVLAYTR NVAEVLAFLH 

       310        320        330        340        350        360 
CCLNPVLYAF IGQKFRNYFM KIMKDVWCMR RKNKMPGFLC ARVYSESYIS RQTSETVEND 


NASSFTM 

« Hide

References

[1]"Mouse G protein-coupled receptor KY411."
Yanagihara S., Komura E., Yamaguchi Y.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha."
Varona R., Zaballos A., Gutierrez J., Martin P., Roncal F., Albar J.P., Ardavin C., Marquez G.
FEBS Lett. 440:188-194(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB009369 mRNA. Translation: BAA23776.1.
AJ222714 Genomic DNA. Translation: CAA10956.1.
RefSeqNP_001177262.1. NM_001190333.1.
NP_001177263.1. NM_001190334.1.
NP_001177264.1. NM_001190335.1.
NP_001177265.1. NM_001190336.1.
NP_001177266.1. NM_001190337.1.
NP_033965.1. NM_009835.4.
XP_006523345.1. XM_006523282.1.
XP_006523346.1. XM_006523283.1.
XP_006523347.1. XM_006523284.1.
XP_006523348.1. XM_006523285.1.
XP_006523349.1. XM_006523286.1.
XP_006523350.1. XM_006523287.1.
XP_006523351.1. XM_006523288.1.
XP_006523352.1. XM_006523289.1.
XP_006523353.1. XM_006523290.1.
XP_006523354.1. XM_006523291.1.
XP_006523355.1. XM_006523292.1.
UniGeneMm.8007.

3D structure databases

ProteinModelPortalO54689.
SMRO54689. Positions 27-323.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY63.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO54689.

Proteomic databases

PRIDEO54689.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000097418; ENSMUSP00000095029; ENSMUSG00000040899.
ENSMUST00000164411; ENSMUSP00000131153; ENSMUSG00000040899.
ENSMUST00000166348; ENSMUSP00000128559; ENSMUSG00000040899.
ENSMUST00000167956; ENSMUSP00000128529; ENSMUSG00000040899.
ENSMUST00000177568; ENSMUSP00000137249; ENSMUSG00000040899.
ENSMUST00000180103; ENSMUSP00000135945; ENSMUSG00000040899.
GeneID12458.
KEGGmmu:12458.
UCSCuc008ajd.2. mouse.

Organism-specific databases

CTD1235.
MGIMGI:1333797. Ccr6.

Phylogenomic databases

eggNOGNOG147813.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidO54689.
KOK04181.
OMACYMFIVK.
OrthoDBEOG7PP57J.
PhylomeDBO54689.
TreeFamTF330966.

Gene expression databases

ArrayExpressO54689.
BgeeO54689.
CleanExMM_CCR6.
GenevestigatorO54689.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR004067. Chemokine_CCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF24. PTHR24227:SF24. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01529. CHEMOKINER6.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281312.
PROO54689.
SOURCESearch...

Entry information

Entry nameCCR6_MOUSE
AccessionPrimary (citable) accession number: O54689
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries