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O54689

- CCR6_MOUSE

UniProt

O54689 - CCR6_MOUSE

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Protein
C-C chemokine receptor type 6
Gene
Ccr6, Cmkbr6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: InterPro
  2. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. chemotaxis Source: InterPro
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_199048. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 6
Short name:
C-C CKR-6
Short name:
CC-CKR-6
Short name:
CCR-6
Alternative name(s):
KY411
CD_antigen: CD196
Gene namesi
Name:Ccr6
Synonyms:Cmkbr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1333797. Ccr6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939Extracellular Reviewed prediction
Add
BLAST
Transmembranei40 – 6627Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini67 – 759Cytoplasmic Reviewed prediction
Transmembranei76 – 9621Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini97 – 11115Extracellular Reviewed prediction
Add
BLAST
Transmembranei112 – 13322Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini134 – 15118Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei152 – 17221Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini173 – 20331Extracellular Reviewed prediction
Add
BLAST
Transmembranei204 – 23027Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini231 – 24616Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei247 – 27125Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini272 – 29524Extracellular Reviewed prediction
Add
BLAST
Transmembranei296 – 31318Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini314 – 36754Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367C-C chemokine receptor type 6
PRO_0000069287Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...) Reviewed prediction
Glycosylationi35 – 351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi110 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO54689.

PTM databases

PhosphoSiteiO54689.

Expressioni

Gene expression databases

ArrayExpressiO54689.
BgeeiO54689.
CleanExiMM_CCR6.
GenevestigatoriO54689.

Structurei

3D structure databases

ProteinModelPortaliO54689.
SMRiO54689. Positions 27-323.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147813.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO54689.
KOiK04181.
OMAiVVTFAFY.
OrthoDBiEOG7PP57J.
PhylomeDBiO54689.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR004067. Chemokine_CCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF24. PTHR24227:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01529. CHEMOKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54689-1 [UniParc]FASTAAdd to Basket

« Hide

MNSTESYFGT DDYDNTEYYS IPPDHGPCSL EEVRNFTKVF VPIAYSLICV    50
FGLLGNIMVV MTFAFYKKAR SMTDVYLLNM AITDILFVLT LPFWAVTHAT 100
NTWVFSDALC KLMKGTYAVN FNCGMLLLAC ISMDRYIAIV QATKSFRVRS 150
RTLTHSKVIC VAVWFISIII SSPTFIFNKK YELQDRDVCE PRYRSVSEPI 200
TWKLLGMGLE LFFGFFTPLL FMVFCYLFII KTLVQAQNSK RHRAIRVVIA 250
VVLVFLACQI PHNMVLLVTA VNTGKVGRSC STEKVLAYTR NVAEVLAFLH 300
CCLNPVLYAF IGQKFRNYFM KIMKDVWCMR RKNKMPGFLC ARVYSESYIS 350
RQTSETVEND NASSFTM 367
Length:367
Mass (Da):42,103
Last modified:June 1, 1998 - v1
Checksum:i6A309AF833B1117E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009369 mRNA. Translation: BAA23776.1.
AJ222714 Genomic DNA. Translation: CAA10956.1.
CCDSiCCDS28381.1.
RefSeqiNP_001177262.1. NM_001190333.1.
NP_001177263.1. NM_001190334.1.
NP_001177264.1. NM_001190335.1.
NP_001177265.1. NM_001190336.1.
NP_001177266.1. NM_001190337.1.
NP_033965.1. NM_009835.4.
XP_006523345.1. XM_006523282.1.
XP_006523346.1. XM_006523283.1.
XP_006523347.1. XM_006523284.1.
XP_006523348.1. XM_006523285.1.
XP_006523349.1. XM_006523286.1.
XP_006523350.1. XM_006523287.1.
XP_006523351.1. XM_006523288.1.
XP_006523352.1. XM_006523289.1.
XP_006523353.1. XM_006523290.1.
XP_006523354.1. XM_006523291.1.
XP_006523355.1. XM_006523292.1.
UniGeneiMm.8007.

Genome annotation databases

EnsembliENSMUST00000097418; ENSMUSP00000095029; ENSMUSG00000040899.
ENSMUST00000164411; ENSMUSP00000131153; ENSMUSG00000040899.
ENSMUST00000166348; ENSMUSP00000128559; ENSMUSG00000040899.
ENSMUST00000167956; ENSMUSP00000128529; ENSMUSG00000040899.
ENSMUST00000177568; ENSMUSP00000137249; ENSMUSG00000040899.
ENSMUST00000180103; ENSMUSP00000135945; ENSMUSG00000040899.
GeneIDi12458.
KEGGimmu:12458.
UCSCiuc008ajd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009369 mRNA. Translation: BAA23776.1 .
AJ222714 Genomic DNA. Translation: CAA10956.1 .
CCDSi CCDS28381.1.
RefSeqi NP_001177262.1. NM_001190333.1.
NP_001177263.1. NM_001190334.1.
NP_001177264.1. NM_001190335.1.
NP_001177265.1. NM_001190336.1.
NP_001177266.1. NM_001190337.1.
NP_033965.1. NM_009835.4.
XP_006523345.1. XM_006523282.1.
XP_006523346.1. XM_006523283.1.
XP_006523347.1. XM_006523284.1.
XP_006523348.1. XM_006523285.1.
XP_006523349.1. XM_006523286.1.
XP_006523350.1. XM_006523287.1.
XP_006523351.1. XM_006523288.1.
XP_006523352.1. XM_006523289.1.
XP_006523353.1. XM_006523290.1.
XP_006523354.1. XM_006523291.1.
XP_006523355.1. XM_006523292.1.
UniGenei Mm.8007.

3D structure databases

ProteinModelPortali O54689.
SMRi O54689. Positions 27-323.
ModBasei Search...

Chemistry

GuidetoPHARMACOLOGYi 63.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O54689.

Proteomic databases

PRIDEi O54689.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000097418 ; ENSMUSP00000095029 ; ENSMUSG00000040899 .
ENSMUST00000164411 ; ENSMUSP00000131153 ; ENSMUSG00000040899 .
ENSMUST00000166348 ; ENSMUSP00000128559 ; ENSMUSG00000040899 .
ENSMUST00000167956 ; ENSMUSP00000128529 ; ENSMUSG00000040899 .
ENSMUST00000177568 ; ENSMUSP00000137249 ; ENSMUSG00000040899 .
ENSMUST00000180103 ; ENSMUSP00000135945 ; ENSMUSG00000040899 .
GeneIDi 12458.
KEGGi mmu:12458.
UCSCi uc008ajd.2. mouse.

Organism-specific databases

CTDi 1235.
MGIi MGI:1333797. Ccr6.

Phylogenomic databases

eggNOGi NOG147813.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi O54689.
KOi K04181.
OMAi VVTFAFY.
OrthoDBi EOG7PP57J.
PhylomeDBi O54689.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_199048. Beta defensins.

Miscellaneous databases

NextBioi 281312.
PROi O54689.
SOURCEi Search...

Gene expression databases

ArrayExpressi O54689.
Bgeei O54689.
CleanExi MM_CCR6.
Genevestigatori O54689.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR004067. Chemokine_CCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF24. PTHR24227:SF24. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01529. CHEMOKINER6.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse G protein-coupled receptor KY411."
    Yanagihara S., Komura E., Yamaguchi Y.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha."
    Varona R., Zaballos A., Gutierrez J., Martin P., Roncal F., Albar J.P., Ardavin C., Marquez G.
    FEBS Lett. 440:188-194(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCCR6_MOUSE
AccessioniPrimary (citable) accession number: O54689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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