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O54689

- CCR6_MOUSE

UniProt

O54689 - CCR6_MOUSE

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Protein

C-C chemokine receptor type 6

Gene

Ccr6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: InterPro
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_199048. Beta defensins.
REACT_230248. Chemokine receptors bind chemokines.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 6
Short name:
C-C CKR-6
Short name:
CC-CKR-6
Short name:
CCR-6
Alternative name(s):
KY411
CD_antigen: CD196
Gene namesi
Name:Ccr6
Synonyms:Cmkbr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1333797. Ccr6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
BLAST
Transmembranei40 – 6627Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini67 – 759CytoplasmicSequence Analysis
Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini97 – 11115ExtracellularSequence AnalysisAdd
BLAST
Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini134 – 15118CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei152 – 17221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini173 – 20331ExtracellularSequence AnalysisAdd
BLAST
Transmembranei204 – 23027Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini231 – 24616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei247 – 27125Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini272 – 29524ExtracellularSequence AnalysisAdd
BLAST
Transmembranei296 – 31318Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini314 – 36754CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367C-C chemokine receptor type 6PRO_0000069287Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi110 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO54689.

PTM databases

PhosphoSiteiO54689.

Expressioni

Gene expression databases

BgeeiO54689.
CleanExiMM_CCR6.
ExpressionAtlasiO54689. baseline and differential.
GenevestigatoriO54689.

Structurei

3D structure databases

ProteinModelPortaliO54689.
SMRiO54689. Positions 27-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147813.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO54689.
KOiK04181.
OMAiVVTFAFY.
OrthoDBiEOG7PP57J.
PhylomeDBiO54689.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR004067. Chemokine_CCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF24. PTHR24227:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01529. CHEMOKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54689-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSTESYFGT DDYDNTEYYS IPPDHGPCSL EEVRNFTKVF VPIAYSLICV
60 70 80 90 100
FGLLGNIMVV MTFAFYKKAR SMTDVYLLNM AITDILFVLT LPFWAVTHAT
110 120 130 140 150
NTWVFSDALC KLMKGTYAVN FNCGMLLLAC ISMDRYIAIV QATKSFRVRS
160 170 180 190 200
RTLTHSKVIC VAVWFISIII SSPTFIFNKK YELQDRDVCE PRYRSVSEPI
210 220 230 240 250
TWKLLGMGLE LFFGFFTPLL FMVFCYLFII KTLVQAQNSK RHRAIRVVIA
260 270 280 290 300
VVLVFLACQI PHNMVLLVTA VNTGKVGRSC STEKVLAYTR NVAEVLAFLH
310 320 330 340 350
CCLNPVLYAF IGQKFRNYFM KIMKDVWCMR RKNKMPGFLC ARVYSESYIS
360
RQTSETVEND NASSFTM
Length:367
Mass (Da):42,103
Last modified:June 1, 1998 - v1
Checksum:i6A309AF833B1117E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009369 mRNA. Translation: BAA23776.1.
AJ222714 Genomic DNA. Translation: CAA10956.1.
CCDSiCCDS28381.1.
RefSeqiNP_001177262.1. NM_001190333.1.
NP_001177263.1. NM_001190334.1.
NP_001177264.1. NM_001190335.1.
NP_001177265.1. NM_001190336.1.
NP_001177266.1. NM_001190337.1.
NP_033965.1. NM_009835.4.
XP_006523345.1. XM_006523282.1.
XP_006523346.1. XM_006523283.1.
XP_006523347.1. XM_006523284.1.
XP_006523348.1. XM_006523285.1.
XP_006523349.1. XM_006523286.1.
XP_006523350.1. XM_006523287.1.
XP_006523351.1. XM_006523288.1.
XP_006523352.1. XM_006523289.1.
XP_006523353.1. XM_006523290.1.
XP_006523354.1. XM_006523291.1.
XP_006523355.1. XM_006523292.1.
UniGeneiMm.8007.

Genome annotation databases

EnsembliENSMUST00000097418; ENSMUSP00000095029; ENSMUSG00000040899.
ENSMUST00000164411; ENSMUSP00000131153; ENSMUSG00000040899.
ENSMUST00000166348; ENSMUSP00000128559; ENSMUSG00000040899.
ENSMUST00000167956; ENSMUSP00000128529; ENSMUSG00000040899.
ENSMUST00000177568; ENSMUSP00000137249; ENSMUSG00000040899.
ENSMUST00000180103; ENSMUSP00000135945; ENSMUSG00000040899.
GeneIDi12458.
KEGGimmu:12458.
UCSCiuc008ajd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009369 mRNA. Translation: BAA23776.1 .
AJ222714 Genomic DNA. Translation: CAA10956.1 .
CCDSi CCDS28381.1.
RefSeqi NP_001177262.1. NM_001190333.1.
NP_001177263.1. NM_001190334.1.
NP_001177264.1. NM_001190335.1.
NP_001177265.1. NM_001190336.1.
NP_001177266.1. NM_001190337.1.
NP_033965.1. NM_009835.4.
XP_006523345.1. XM_006523282.1.
XP_006523346.1. XM_006523283.1.
XP_006523347.1. XM_006523284.1.
XP_006523348.1. XM_006523285.1.
XP_006523349.1. XM_006523286.1.
XP_006523350.1. XM_006523287.1.
XP_006523351.1. XM_006523288.1.
XP_006523352.1. XM_006523289.1.
XP_006523353.1. XM_006523290.1.
XP_006523354.1. XM_006523291.1.
XP_006523355.1. XM_006523292.1.
UniGenei Mm.8007.

3D structure databases

ProteinModelPortali O54689.
SMRi O54689. Positions 27-323.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 63.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O54689.

Proteomic databases

PRIDEi O54689.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000097418 ; ENSMUSP00000095029 ; ENSMUSG00000040899 .
ENSMUST00000164411 ; ENSMUSP00000131153 ; ENSMUSG00000040899 .
ENSMUST00000166348 ; ENSMUSP00000128559 ; ENSMUSG00000040899 .
ENSMUST00000167956 ; ENSMUSP00000128529 ; ENSMUSG00000040899 .
ENSMUST00000177568 ; ENSMUSP00000137249 ; ENSMUSG00000040899 .
ENSMUST00000180103 ; ENSMUSP00000135945 ; ENSMUSG00000040899 .
GeneIDi 12458.
KEGGi mmu:12458.
UCSCi uc008ajd.2. mouse.

Organism-specific databases

CTDi 1235.
MGIi MGI:1333797. Ccr6.

Phylogenomic databases

eggNOGi NOG147813.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi O54689.
KOi K04181.
OMAi VVTFAFY.
OrthoDBi EOG7PP57J.
PhylomeDBi O54689.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_199048. Beta defensins.
REACT_230248. Chemokine receptors bind chemokines.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 281312.
PROi O54689.
SOURCEi Search...

Gene expression databases

Bgeei O54689.
CleanExi MM_CCR6.
ExpressionAtlasi O54689. baseline and differential.
Genevestigatori O54689.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR004067. Chemokine_CCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF24. PTHR24227:SF24. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01529. CHEMOKINER6.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse G protein-coupled receptor KY411."
    Yanagihara S., Komura E., Yamaguchi Y.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha."
    Varona R., Zaballos A., Gutierrez J., Martin P., Roncal F., Albar J.P., Ardavin C., Marquez G.
    FEBS Lett. 440:188-194(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCCR6_MOUSE
AccessioniPrimary (citable) accession number: O54689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3