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O54689

- CCR6_MOUSE

UniProt

O54689 - CCR6_MOUSE

Protein

C-C chemokine receptor type 6

Gene

Ccr6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: InterPro
    2. protein binding Source: MGI

    GO - Biological processi

    1. chemotaxis Source: InterPro
    2. immune response Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_199048. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 6
    Short name:
    C-C CKR-6
    Short name:
    CC-CKR-6
    Short name:
    CCR-6
    Alternative name(s):
    KY411
    CD_antigen: CD196
    Gene namesi
    Name:Ccr6
    Synonyms:Cmkbr6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1333797. Ccr6.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367C-C chemokine receptor type 6PRO_0000069287Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi110 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO54689.

    PTM databases

    PhosphoSiteiO54689.

    Expressioni

    Gene expression databases

    ArrayExpressiO54689.
    BgeeiO54689.
    CleanExiMM_CCR6.
    GenevestigatoriO54689.

    Structurei

    3D structure databases

    ProteinModelPortaliO54689.
    SMRiO54689. Positions 27-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 759CytoplasmicSequence Analysis
    Topological domaini97 – 11115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15118CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini173 – 20331ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini231 – 24616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini272 – 29524ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini314 – 36754CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6627Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 23027Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei247 – 27125Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei296 – 31318Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147813.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiO54689.
    KOiK04181.
    OMAiVVTFAFY.
    OrthoDBiEOG7PP57J.
    PhylomeDBiO54689.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR004067. Chemokine_CCR6.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF24. PTHR24227:SF24. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01529. CHEMOKINER6.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54689-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSTESYFGT DDYDNTEYYS IPPDHGPCSL EEVRNFTKVF VPIAYSLICV    50
    FGLLGNIMVV MTFAFYKKAR SMTDVYLLNM AITDILFVLT LPFWAVTHAT 100
    NTWVFSDALC KLMKGTYAVN FNCGMLLLAC ISMDRYIAIV QATKSFRVRS 150
    RTLTHSKVIC VAVWFISIII SSPTFIFNKK YELQDRDVCE PRYRSVSEPI 200
    TWKLLGMGLE LFFGFFTPLL FMVFCYLFII KTLVQAQNSK RHRAIRVVIA 250
    VVLVFLACQI PHNMVLLVTA VNTGKVGRSC STEKVLAYTR NVAEVLAFLH 300
    CCLNPVLYAF IGQKFRNYFM KIMKDVWCMR RKNKMPGFLC ARVYSESYIS 350
    RQTSETVEND NASSFTM 367
    Length:367
    Mass (Da):42,103
    Last modified:June 1, 1998 - v1
    Checksum:i6A309AF833B1117E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009369 mRNA. Translation: BAA23776.1.
    AJ222714 Genomic DNA. Translation: CAA10956.1.
    CCDSiCCDS28381.1.
    RefSeqiNP_001177262.1. NM_001190333.1.
    NP_001177263.1. NM_001190334.1.
    NP_001177264.1. NM_001190335.1.
    NP_001177265.1. NM_001190336.1.
    NP_001177266.1. NM_001190337.1.
    NP_033965.1. NM_009835.4.
    XP_006523345.1. XM_006523282.1.
    XP_006523346.1. XM_006523283.1.
    XP_006523347.1. XM_006523284.1.
    XP_006523348.1. XM_006523285.1.
    XP_006523349.1. XM_006523286.1.
    XP_006523350.1. XM_006523287.1.
    XP_006523351.1. XM_006523288.1.
    XP_006523352.1. XM_006523289.1.
    XP_006523353.1. XM_006523290.1.
    XP_006523354.1. XM_006523291.1.
    XP_006523355.1. XM_006523292.1.
    UniGeneiMm.8007.

    Genome annotation databases

    EnsembliENSMUST00000097418; ENSMUSP00000095029; ENSMUSG00000040899.
    ENSMUST00000164411; ENSMUSP00000131153; ENSMUSG00000040899.
    ENSMUST00000166348; ENSMUSP00000128559; ENSMUSG00000040899.
    ENSMUST00000167956; ENSMUSP00000128529; ENSMUSG00000040899.
    ENSMUST00000177568; ENSMUSP00000137249; ENSMUSG00000040899.
    ENSMUST00000180103; ENSMUSP00000135945; ENSMUSG00000040899.
    GeneIDi12458.
    KEGGimmu:12458.
    UCSCiuc008ajd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009369 mRNA. Translation: BAA23776.1 .
    AJ222714 Genomic DNA. Translation: CAA10956.1 .
    CCDSi CCDS28381.1.
    RefSeqi NP_001177262.1. NM_001190333.1.
    NP_001177263.1. NM_001190334.1.
    NP_001177264.1. NM_001190335.1.
    NP_001177265.1. NM_001190336.1.
    NP_001177266.1. NM_001190337.1.
    NP_033965.1. NM_009835.4.
    XP_006523345.1. XM_006523282.1.
    XP_006523346.1. XM_006523283.1.
    XP_006523347.1. XM_006523284.1.
    XP_006523348.1. XM_006523285.1.
    XP_006523349.1. XM_006523286.1.
    XP_006523350.1. XM_006523287.1.
    XP_006523351.1. XM_006523288.1.
    XP_006523352.1. XM_006523289.1.
    XP_006523353.1. XM_006523290.1.
    XP_006523354.1. XM_006523291.1.
    XP_006523355.1. XM_006523292.1.
    UniGenei Mm.8007.

    3D structure databases

    ProteinModelPortali O54689.
    SMRi O54689. Positions 27-323.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 63.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O54689.

    Proteomic databases

    PRIDEi O54689.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000097418 ; ENSMUSP00000095029 ; ENSMUSG00000040899 .
    ENSMUST00000164411 ; ENSMUSP00000131153 ; ENSMUSG00000040899 .
    ENSMUST00000166348 ; ENSMUSP00000128559 ; ENSMUSG00000040899 .
    ENSMUST00000167956 ; ENSMUSP00000128529 ; ENSMUSG00000040899 .
    ENSMUST00000177568 ; ENSMUSP00000137249 ; ENSMUSG00000040899 .
    ENSMUST00000180103 ; ENSMUSP00000135945 ; ENSMUSG00000040899 .
    GeneIDi 12458.
    KEGGi mmu:12458.
    UCSCi uc008ajd.2. mouse.

    Organism-specific databases

    CTDi 1235.
    MGIi MGI:1333797. Ccr6.

    Phylogenomic databases

    eggNOGi NOG147813.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi O54689.
    KOi K04181.
    OMAi VVTFAFY.
    OrthoDBi EOG7PP57J.
    PhylomeDBi O54689.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_199048. Beta defensins.

    Miscellaneous databases

    NextBioi 281312.
    PROi O54689.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O54689.
    Bgeei O54689.
    CleanExi MM_CCR6.
    Genevestigatori O54689.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR004067. Chemokine_CCR6.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF24. PTHR24227:SF24. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01529. CHEMOKINER6.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse G protein-coupled receptor KY411."
      Yanagihara S., Komura E., Yamaguchi Y.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha."
      Varona R., Zaballos A., Gutierrez J., Martin P., Roncal F., Albar J.P., Ardavin C., Marquez G.
      FEBS Lett. 440:188-194(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCCR6_MOUSE
    AccessioniPrimary (citable) accession number: O54689
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3