O54689 (CCR6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 6
Short name=C-C CKR-6
Short name=CC-CKR-6
Short name=CCR-6

Alternative name(s):
KY411
CD_antigen=CD196

Gene names

Name:	Ccr6
Synonyms:	Cmkbr6

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC chemotaxis Inferred from electronic annotation. Source: InterPro elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	C-C chemokine receptor type 6		PRO_0000069287
Regions
	Topological domain	1 – 39	39	Extracellular Potential
	Transmembrane	40 – 66	27	Helical; Name=1; Potential
	Topological domain	67 – 75	9	Cytoplasmic Potential
	Transmembrane	76 – 96	21	Helical; Name=2; Potential
	Topological domain	97 – 111	15	Extracellular Potential
	Transmembrane	112 – 133	22	Helical; Name=3; Potential
	Topological domain	134 – 151	18	Cytoplasmic Potential
	Transmembrane	152 – 172	21	Helical; Name=4; Potential
	Topological domain	173 – 203	31	Extracellular Potential
	Transmembrane	204 – 230	27	Helical; Name=5; Potential
	Topological domain	231 – 246	16	Cytoplasmic Potential
	Transmembrane	247 – 271	25	Helical; Name=6; Potential
	Topological domain	272 – 295	24	Extracellular Potential
	Transmembrane	296 – 313	18	Helical; Name=7; Potential
	Topological domain	314 – 367	54	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	2	1	N-linked (GlcNAc...) Potential
	Glycosylation	35	1	N-linked (GlcNAc...) Potential
	Disulfide bond	110 ↔ 189		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O54689 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 6A309AF833B1117E	FASTA	367	42,103
	10 20 30 40 50 60 MNSTESYFGT DDYDNTEYYS IPPDHGPCSL EEVRNFTKVF VPIAYSLICV FGLLGNIMVV 70 80 90 100 110 120 MTFAFYKKAR SMTDVYLLNM AITDILFVLT LPFWAVTHAT NTWVFSDALC KLMKGTYAVN 130 140 150 160 170 180 FNCGMLLLAC ISMDRYIAIV QATKSFRVRS RTLTHSKVIC VAVWFISIII SSPTFIFNKK 190 200 210 220 230 240 YELQDRDVCE PRYRSVSEPI TWKLLGMGLE LFFGFFTPLL FMVFCYLFII KTLVQAQNSK 250 260 270 280 290 300 RHRAIRVVIA VVLVFLACQI PHNMVLLVTA VNTGKVGRSC STEKVLAYTR NVAEVLAFLH 310 320 330 340 350 360 CCLNPVLYAF IGQKFRNYFM KIMKDVWCMR RKNKMPGFLC ARVYSESYIS RQTSETVEND NASSFTM

References

[1]	"Mouse G protein-coupled receptor KY411." Yanagihara S., Komura E., Yamaguchi Y. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha." Varona R., Zaballos A., Gutierrez J., Martin P., Roncal F., Albar J.P., Ardavin C., Marquez G. FEBS Lett. 440:188-194(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB009369 mRNA. Translation: BAA23776.1. AJ222714 Genomic DNA. Translation: CAA10956.1.
IPI	IPI00117033.
RefSeq	NP_001177262.1. NM_001190333.1. NP_001177263.1. NM_001190334.1. NP_001177264.1. NM_001190335.1. NP_001177265.1. NM_001190336.1. NP_001177266.1. NM_001190337.1. NP_033965.1. NM_009835.4.
UniGene	Mm.8007.
3D structure databases
ProteinModelPortal	O54689.
SMR	O54689. Positions 27-323.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O54689.
Proteomic databases
PRIDE	O54689.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000097418; ENSMUSP00000095029; ENSMUSG00000040899. ENSMUST00000164411; ENSMUSP00000131153; ENSMUSG00000040899. ENSMUST00000166348; ENSMUSP00000128559; ENSMUSG00000040899. ENSMUST00000167956; ENSMUSP00000128529; ENSMUSG00000040899. ENSMUST00000177568; ENSMUSP00000137249; ENSMUSG00000040899. ENSMUST00000180103; ENSMUSP00000135945; ENSMUSG00000040899.
GeneID	12458.
KEGG	mmu:12458.
Organism-specific databases
CTD	1235.
MGI	MGI:1333797. Ccr6.
Phylogenomic databases
eggNOG	NOG147813.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	O54689.
KO	K04181.
OMA	YFLKIMK.
OrthoDB	EOG4640CT.
Gene expression databases
ArrayExpress	O54689.
Bgee	O54689.
CleanEx	MM_CCR6.
Genevestigator	O54689.
GermOnline	ENSMUSG00000040899. Mus musculus.
Family and domain databases
InterPro	IPR004067. Chemokine_CCR6. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01529. CHEMOKINER6. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	281312.
SOURCE	Search...

Entry information

Entry name

CCR6_MOUSE

Accession

Primary (citable) accession number: O54689

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program