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Protein
Submitted name:

RifA

Gene

rifA

Organism
Amycolatopsis mediterranei (Nocardia mediterranei)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14097.

Names & Taxonomyi

Protein namesi
Submitted name:
RifAImported
Submitted name:
Rifamycin polyketide synthase, type 1Imported
Gene namesi
Name:rifAImported
OrganismiAmycolatopsis mediterranei (Nocardia mediterranei)Imported
Taxonomic identifieri33910 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeAmycolatopsis

Interactioni

Protein-protein interaction databases

STRINGi749927.AMED_0617.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini541 – 61171Acyl carrierInterPro annotationAdd
BLAST
Domaini2104 – 217471Acyl carrierInterPro annotationAdd
BLAST
Domaini3077 – 315175Acyl carrierInterPro annotationAdd
BLAST
Domaini4580 – 465071Acyl carrierInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4108E1I. Bacteria.
COG0318. LUCA.
COG3321. LUCA.

Family and domain databases

Gene3Di1.10.1200.10. 4 hits.
3.40.366.10. 6 hits.
3.40.47.10. 6 hits.
3.40.50.720. 3 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR032821. KAsynt_C_assoc.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 3 hits.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PF16197. KAsynt_C_assoc. 3 hits.
PF00109. ketoacyl-synt. 3 hits.
PF02801. Ketoacyl-synt_C. 3 hits.
PF08659. KR. 2 hits.
PF00550. PP-binding. 4 hits.
[Graphical view]
SMARTiSM00827. PKS_AT. 3 hits.
SM00826. PKS_DH. 1 hit.
SM00825. PKS_KS. 3 hits.
SM00823. PKS_PP. 4 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 4 hits.
SSF51735. SSF51735. 4 hits.
SSF52151. SSF52151. 6 hits.
SSF53901. SSF53901. 4 hits.
SSF55048. SSF55048. 3 hits.
PROSITEiPS50075. ACP_DOMAIN. 4 hits.
PS00455. AMP_BINDING. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 3 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTDLIKPLH VALLENATRF AGKPAFADDH RTVTYGDLEA RTRRLAGHLA
60 70 80 90 100
GLGVRHGDRV AICLGNRVST VESYFAILRA GAVGVPLNPG SATAELEHPL
110 120 130 140 150
TDSGATVVVT DAAQAARLRL APHVELLVTG DDVPEGAHSY DELALSEPAE
160 170 180 190 200
PAADDLELDE PAWMFYTSGT TGRPKGVVST QRNCLWSVAS CYVPFPGLSD
210 220 230 240 250
QDRVLWPLPL FHSLSHIACV LSATVVGASV RIADGSSADD VMRLIEAESS
260 270 280 290 300
TFLAGVPTTY HHLVRAARQR GFSAPSLRIG LAGGAVLGAG LRSEFEETFG
310 320 330 340 350
VPLIDAYGST ETCGAITMNP PDGARVEGSC GLAVPGVDVR VVDPDTGLDV
360 370 380 390 400
PAGEEGEVWV SGPNVMLGYH NSPEATAAAM RDGWFRTGDL ARRDDAGYFT
410 420 430 440 450
ICGRIKELII RGGANIHPGE VEAVLRTVDG VADAAVGGVP HDTLGEVPVA
460 470 480 490 500
YVIPGPTGFD PAALIEKCRE QLSAYKVPDR ILEVAHIPRT ASGKIRRGLL
510 520 530 540 550
TDEPAQLRYA ATEHEEQSRH ADESVAAALR ARLSGLDERA QCELLEDLVR
560 570 580 590 600
TQAADVLGQP VPDGRAFRDL GFTSLAIVEL RNRLTEHTGL WLPASAVFDH
610 620 630 640 650
PTPAALAARV RAELLGITQA VAEPVVAADP GEPIAIVGMA CRLPGGVASP
660 670 680 690 700
EDLWRLVAER VDAVSEFPGD RGWDLDSLID PDRERAGTSY VGQGGFLHDA
710 720 730 740 750
GEFDAGFFGI SPREAVAMDP QQRLLLETSW EALENAGVDP IALKGTDTGV
760 770 780 790 800
FSGLMGQGYG SGAVAPELEG FVTTGVASSV ASGRVSYVLG LEGPAVTVDT
810 820 830 840 850
ACSSSLVAMH LAAQALRQGE CSMALAGGVT VMATPGSFVE FSRQRALAPD
860 870 880 890 900
GRCKAFAAAA DGTGWSEGVG VVVLERLSVA RERGHRILAV LRGSAVNQDG
910 920 930 940 950
ASNGLTAPNG LSQQRVIRRA LAAAGLAPSD VDVVEAHGTG TTLGDPIEAQ
960 970 980 990 1000
ALLATYGQER KQPLWLGSLK SNIGHAQAAA GVAGVIKMVQ ALRHETLPPT
1010 1020 1030 1040 1050
LHVDKPTLEV DWSAGAIELL TEARAWPRNG RPRRAGVSSF GVSGTNAHLI
1060 1070 1080 1090 1100
LEEAPAEEPV AAPELPVVPL VVSARSTESL SGQAERLASL LEGDVSLTEV
1110 1120 1130 1140 1150
AGALVSRRAV LDERAVVVAG SREEAVTGLR ALNTAGSGTP GKVVWVFPGQ
1160 1170 1180 1190 1200
GTQWAGMGRE LLAESPVFAE RIAECAAALA PWIDWSLVDV LRGEGDLGRV
1210 1220 1230 1240 1250
DVLQPACFAV MVGLAAVWES VGVRPDAVVG HSQGEIAAAC VSGALSLEDA
1260 1270 1280 1290 1300
AKVVALRSQA IAAELSGRGG MASVALGEDD VVSRLVDGVE VAAVNGPSSV
1310 1320 1330 1340 1350
VIAGDAHALD ATLEILSGEG IRVRRVAVDY ASHTRHVEDI RDTLAETLAG
1360 1370 1380 1390 1400
ISAQAPAVPF YSTVTSEWVR DAGVLDGGYW YRNLRNQVRF GAAATALLEQ
1410 1420 1430 1440 1450
GHTVFVEVSA HPVTVQPLSE LTGDAIGTLR REDGGLRRLL ASMGELFVRG
1460 1470 1480 1490 1500
IDVDWTAMVP AAGWVDLPTY AFEHRHYWLE PAEPASAGDP LLGTVVSTPG
1510 1520 1530 1540 1550
SDRLTAVAQW SRRAQPWAVD GLVPNAALVE AAIRLGDLAG TPVVGELVVD
1560 1570 1580 1590 1600
APVVLPRRGS REVQLIVGEP GEQRRRPIEV FSREADEPWT RHAHGTLAPA
1610 1620 1630 1640 1650
AAAVPEPAAA GDATDVTVAG LRDADRYGIH PALLDAAVRT VVGDDLLPSV
1660 1670 1680 1690 1700
WTGVSLLASG ATAVTVTPTA TGLRLTDPAG QPVLTVESVR GTPFVAEQGT
1710 1720 1730 1740 1750
TDALFRVDWP EIPLPTAETA DFLPYEATSA EATLSALQAW LADPAETRLA
1760 1770 1780 1790 1800
VVTGDCTEPG AAAIWGLVRS AQSEHPGRIV LADLDDPAVL PAVVASGEPQ
1810 1820 1830 1840 1850
VRVRNGVASV PRLTRVTPRQ DARPLDPEGT VLITGGTGTL GALTARHLVT
1860 1870 1880 1890 1900
AHGVRHLVLV SRRGEAPELQ EELTALGASV AIAACDVADR AQLEAVLRAI
1910 1920 1930 1940 1950
PAEHPLTAVI HTAGVLDDGV VTELTPDRLA TVRRPKVDAA RLLDELTREA
1960 1970 1980 1990 2000
DLAAFVLFSS AAGVLGNPGQ AGYAAANAEL DALARQRNSL DLPAVSIAWG
2010 2020 2030 2040 2050
YWATVSGMTE HLGDADLRRN QRIGMSGLPA DEGMALLDAA IATGGTLVAA
2060 2070 2080 2090 2100
KFDVAALRAT AKAGGPVPPL LRGLAPLPRR AAAKTASLTE RLAGLAETEQ
2110 2120 2130 2140 2150
AAALLDLVRR HAAEVLGHSG AESVHSGRTF KDAGFDSLTA VELRNRLAAA
2160 2170 2180 2190 2200
TGLTLSPAMI FDYPKPPALA DHLRAKLFGS AANRPAEIGT AAAEEPIAIV
2210 2220 2230 2240 2250
AMACRFPGGV HSPEDLWRLV ADGADAVTEF PADRGWDTDR LYHEDPDHEG
2260 2270 2280 2290 2300
TTYVRHGAFL DDAAGFDAAF FGISPNEALA MDPQQRLLLE TSWELFERAA
2310 2320 2330 2340 2350
IDPTTLAGQD IGVFAGVNSH DYSMRMHRAA GVEGFRLTGG SASVLSGRVA
2360 2370 2380 2390 2400
YHFGVEGPAV TVDTACSSSL VALHMAVQAL QRGECSMALA GGVMVMGTVE
2410 2420 2430 2440 2450
TFVEFSRQRG LAPDGRCKAF ADGADGTGWS EGVGLLLVER LSEAQRRGHQ
2460 2470 2480 2490 2500
VLAVVRGSAV NSDGASNGLT APNGPSQQRV IRKALAAAGL STSDVDAVEA
2510 2520 2530 2540 2550
HGTGTTLGDP IEAEALLATY GQNRETPLWL GSVKSNLGHT QAAAGVAGVI
2560 2570 2580 2590 2600
KMVMAMRHGV LPRTLHVDRP SSYVDWSAGA VELLTEARDW VSNGHPRRAG
2610 2620 2630 2640 2650
VSSFGIGGTN AHVVLEEVAA PITTPQPEPA EFLVPVLVSA RTAAGLRGQA
2660 2670 2680 2690 2700
GRLAAFLGDR TDVRVPDAAY ALATTRAQLD HRAVVLASDR AQLCADLAAF
2710 2720 2730 2740 2750
GSGVVTGTPV DGKLAVLFTG QGSQWAGMGR ELAETFPVFR DAFEAACEAV
2760 2770 2780 2790 2800
DTHLRERPLR EVVFDDSALL DQTMYTQGAL FAVETALFRL FESWGVRPGL
2810 2820 2830 2840 2850
LAGHSIGELA AAHVSGVLDL ADAGELVAAR GRLMQALPAG GAMVAVQATE
2860 2870 2880 2890 2900
DEVAPLLDGT VCVAAVNGPD SVVLSGTEAA VLAVADELAG RGRKTRRLAV
2910 2920 2930 2940 2950
SHAFHSPLME PMLDDFRAVA ERLTYRAGSL PVVSTLTGEL AALDSPDYWV
2960 2970 2980 2990 3000
GQVRNAVRFS DAVTALGAQG ASTFLELGPG GALAAMALGT LGGPEQSCVA
3010 3020 3030 3040 3050
TLRKNGAEVP DVLTALAELH VRGVGVDWTT VLDEPATAVG TVLPTYAFQH
3060 3070 3080 3090 3100
QRFWVDVDET AAVSVTPPPA EPIVDRPVQD VLELVRESAA VVLGHRDAGS
3110 3120 3130 3140 3150
FDLDRSFKDH GFDSLSAVKL RNRLRDFTGV ELPSTLIFDY PNPAVLADHL
3160 3170 3180 3190 3200
RAELLGERPA APAPVTRDVS DEPIAIVGMS TRLPGGADSP EELWKLVAEG
3210 3220 3230 3240 3250
RDAVSGFPVD RGWDLDGLYH PDPAHAGTSY TRSGGFLHDA AQFDAGLFGI
3260 3270 3280 3290 3300
SPREALAMDP QQRLLLETSW EALERAGVDP LSARGSDVGV FTGIVHHDYV
3310 3320 3330 3340 3350
TRLREVPEDV QGYTMTGTAS SVASGRVAYV FGFEGPAVTV DTACSSSLVA
3360 3370 3380 3390 3400
MHLAAQALRQ GECSMALAGG ATVMASPDAF LEFSRQRGLS ADGRCKAYAE
3410 3420 3430 3440 3450
GADGTGWAEG VGVVVLERLS VARERGHRVL AVLRGSAVNQ DGASNGLTAP
3460 3470 3480 3490 3500
NGPSQQRVIR GALASAGLAP SDVDVVEGHG TGTALGDPIE VQALLATYGQ
3510 3520 3530 3540 3550
EREQPLWLGS LKSNLGHTQA AAGVVGVIKM IMAMRHGVMP ATLHVDERTS
3560 3570 3580 3590 3600
QVDWSAGAIE VLTEAREWPR TGRPRRAGVS SFGASGTNAH LIIEEGPAEE
3610 3620 3630 3640 3650
AVDEEVASVV PLVVSARSAG SLAGQAGRLA AVLENESLAG VAGALVSGRA
3660 3670 3680 3690 3700
TLNERAVVIA GSRDEAQDGL QALARGENAP GVVTGTAGKP GKVVWVFPGQ
3710 3720 3730 3740 3750
GSQWMGMGRD LLDSSPVFAA RIKECAAALE QWTDWSLLDV LRGDADLLDR
3760 3770 3780 3790 3800
VDVVQPASFA MMVGLAAVWT SLGVTPDAVL GHSQGEIAAA CVSGALSLDD
3810 3820 3830 3840 3850
AAKVVALRSQ AIAGELAGRG GMASVALSEE DAVARLTPWA NRVEVAAVNS
3860 3870 3880 3890 3900
PSSVVIAGDA QALDEALEAL AGDGVRVRRV AVDYASHTRH VEAIAETLAK
3910 3920 3930 3940 3950
TLAGIDARVP AIPFYSTVLG TWIEQAVVDA GYWYRNLRQQ VRFGPSVADL
3960 3970 3980 3990 4000
AGLGHTVFVE ISAHPVLVQP LSEISDDAVV TGSLRRDDGG LRRLLASAAE
4010 4020 4030 4040 4050
LYVRGVAVDW TAAVPAAGWV DLPTYAFDRR HFWLHEAETA EAAEGMDGEF
4060 4070 4080 4090 4100
WTAIEQSDVD SLAELLELVP EQRGALSTVV PVLAQWRDRR RERSTAEKLR
4110 4120 4130 4140 4150
YQVTWQPLER EAAGVPGGRW LAVVPAGTTD ALLKELTGQG LDIVRLEIEE
4160 4170 4180 4190 4200
ASRAQLAEQL RNVLAEHDLT GVLSLLALDG GPADAAEITA STLALVQALG
4210 4220 4230 4240 4250
DTTTSAPLWC LTSGAVNIGI QDAVTAPAQA AVWGLGRAVA LERLDRWGGL
4260 4270 4280 4290 4300
VDLPAAIDAR TAQALLGVLN GAAGEDQLAV RRSGVYRRRL VRKPVPESAT
4310 4320 4330 4340 4350
SRWEPRGTVL VTGGAEGLGR HASVWLAQSG AERLIVTGTD GVDELTAELA
4360 4370 4380 4390 4400
EFGTTVEFCA DTDRDAIAQL VADSEVTAVV HAADIAQTSS VDDTGVADLD
4410 4420 4430 4440 4450
EVFAAKVTTA VWLDQLFEDT PLDAFVVFSS IAGIWGGGGQ GPAGAANAVL
4460 4470 4480 4490 4500
DALVEWRRAR GLKATSIAWG ALDQIGIGMD EAALAQLRRR GVIPMAPPLA
4510 4520 4530 4540 4550
VTAMVQAVAG NEKAVAVADM DWAAFIPAFT SVRPSPLFAD LPEAKAILRA
4560 4570 4580 4590 4600
AQDDGEDGDT ASSLADSLRA VPDAEQNRIL LKLVRGHAST VLGHSGAEGI
4610 4620 4630 4640 4650
GPRQAFQEVG FDSLAAVNLR NSLHAATGLR LPATLIFDYP TPEALVGYLR
4660 4670 4680 4690 4700
VELLREADDG LDGREDDLRR VLAAVPFARF KEAGVLDTLL GLADTGTEPG
4710 4720 4730
TDAETTEAAP AADDAELIDA LDISGLVQRA LGQTS
Length:4,735
Mass (Da):495,219
Last modified:June 1, 1998 - v1
Checksum:i0B717178FB68C39C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040570 Genomic DNA. Translation: AAC01710.1.
AJ223012 Genomic DNA. Translation: CAA11035.1.
PIRiT17463.
RefSeqiWP_013222547.1. NZ_JMQJ01000045.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040570 Genomic DNA. Translation: AAC01710.1.
AJ223012 Genomic DNA. Translation: CAA11035.1.
PIRiT17463.
RefSeqiWP_013222547.1. NZ_JMQJ01000045.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi749927.AMED_0617.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108E1I. Bacteria.
COG0318. LUCA.
COG3321. LUCA.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14097.

Family and domain databases

Gene3Di1.10.1200.10. 4 hits.
3.40.366.10. 6 hits.
3.40.47.10. 6 hits.
3.40.50.720. 3 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR032821. KAsynt_C_assoc.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 3 hits.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PF16197. KAsynt_C_assoc. 3 hits.
PF00109. ketoacyl-synt. 3 hits.
PF02801. Ketoacyl-synt_C. 3 hits.
PF08659. KR. 2 hits.
PF00550. PP-binding. 4 hits.
[Graphical view]
SMARTiSM00827. PKS_AT. 3 hits.
SM00826. PKS_DH. 1 hit.
SM00825. PKS_KS. 3 hits.
SM00823. PKS_PP. 4 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 4 hits.
SSF51735. SSF51735. 4 hits.
SSF52151. SSF52151. 6 hits.
SSF53901. SSF53901. 4 hits.
SSF55048. SSF55048. 3 hits.
PROSITEiPS50075. ACP_DOMAIN. 4 hits.
PS00455. AMP_BINDING. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 3 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei."
    Schupp T., Toupet C., Engel N., Goff S.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LBG A3136Imported.
  2. "Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699."
    August P.R., Tang L., Yoon Y.J., Ning S., Mueller R., Yu T.W., Taylor M., Hoffmann D., Kim C.G., Zhang X., Hutchinson C.R., Floss H.G.
    Chem. Biol. 5:69-79(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S699Imported.
  3. "3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics."
    Kim C.G., Yu T.W., Fryhle C.B., Handa S., Floss H.G.
    J. Biol. Chem. 273:6030-6040(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S699Imported.
  4. "Rifamycin insusceptibility: exploring the rif gene cluster of Amycolatopsis mediterranei S699."
    Yu T.-W., Pogosova-Agadjanyan E.L., Kuan L.-Y., Bai L., Tin A.M., Adman E., Floss H.G.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S699Imported.
  5. "Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699."
    Yu T.W., Muller R., Muller M., Zhang X., Draeger G., Kim C.G., Leistner E., Floss H.G.
    J. Biol. Chem. 276:12546-12555(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S699Imported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S699Imported.

Entry informationi

Entry nameiO54666_AMYMD
AccessioniPrimary (citable) accession number: O54666
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.