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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidC
Alternative name(s):
Foldase YidC
Membrane integrase YidC
Membrane protein YidC
Gene namesi
Name:yidC
Ordered Locus Names:SCO3883
ORF Names:STH24.05
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001247561 – 431Membrane protein insertase YidCAdd BLAST431

Proteomic databases

PRIDEiO54569

Interactioni

Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration (By similarity).By similarity

Protein-protein interaction databases

STRINGi100226.SCO3883

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHW Bacteria
COG0706 LUCA
HOGENOMiHOG000249071
InParanoidiO54569
KOiK03217
OMAiPVSWVIV
OrthoDBiPOG091H00BE
PhylomeDBiO54569

Family and domain databases

InterProiView protein in InterPro
IPR028055 Membr_insert_YidC/Oxa1_C
IPR001708 YidC/ALB3/OXA1/COX18
PANTHERiPTHR12428 PTHR12428, 2 hits
PfamiView protein in Pfam
PF02096 60KD_IMP, 1 hit
TIGRFAMsiTIGR03592 yidC_oxa1_cterm, 1 hit

Sequencei

Sequence statusi: Complete.

O54569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTIASLFSF ITWPVSWVIV QFHTVYGAIF GPDTGWAWGL SIVSLVILIR
60 70 80 90 100
ICLIPLFVKQ IKATRGMQTL QPEMKKIQER YKNDKQRQSE EMMKLYKETG
110 120 130 140 150
TNPLSSCLPI LAQSPFFFAL YHVLNGIASG DTIGKINQPL LESAQKAHIF
160 170 180 190 200
GAPLAAKFTD GASKVESLGA SLTDVRVITA VMIVLMSASQ FFTQRQLMTK
210 220 230 240 250
NVDTSVKTPF MQQQKMLMYV FPVMFAVFGI NFPVGVLVYW LTTNVWTMGQ
260 270 280 290 300
QMYVIRNNPT PGSKAQASYL ERLHKSVTEH GRTRRRGEKA IVKAIVAKGR
310 320 330 340 350
DRNEAERKFI NGLNKAGLAA QADGNVVKND AAVAVQSEDG STVTTTAQPK
360 370 380 390 400
RQQPKRQSKS QRQAKPAGET EPKTSLTKSD EPQDAEPAGK QDAKPAAGAK
410 420 430
KPAQKSGGGG RSKAQSGQRK GPQRPKSPSK K
Length:431
Mass (Da):47,373
Last modified:June 1, 1998 - v1
Checksum:i6E6D2E04D3EC4D65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187159 Genomic DNA Translation: AAF16008.1
AF031590 Genomic DNA Translation: AAC03487.1
AL939118 Genomic DNA Translation: CAB42700.1
PIRiT36570
RefSeqiNP_628069.1, NC_003888.3
WP_011029289.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB42700; CAB42700; CAB42700
GeneIDi1099319
KEGGisco:SCO3883
PATRICifig|100226.15.peg.3956

Similar proteinsi

Entry informationi

Entry nameiYIDC_STRCO
AccessioniPrimary (citable) accession number: O54569
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health