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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidC
Alternative name(s):
Foldase YidC
Membrane integrase YidC
Membrane protein YidC
Gene namesi
Name:yidC
Ordered Locus Names:SCO3883
ORF Names:STH24.05
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence analysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Membrane protein insertase YidCPRO_0000124756Add
BLAST

Proteomic databases

PRIDEiO54569.

Interactioni

Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration (By similarity).By similarity

Protein-protein interaction databases

STRINGi100226.SCO3883.

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
HOGENOMiHOG000249071.
InParanoidiO54569.
KOiK03217.
OMAiPVSWVIV.
OrthoDBiPOG091H00BE.
PhylomeDBiO54569.

Family and domain databases

InterProiIPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 2 hits.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

O54569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTIASLFSF ITWPVSWVIV QFHTVYGAIF GPDTGWAWGL SIVSLVILIR
60 70 80 90 100
ICLIPLFVKQ IKATRGMQTL QPEMKKIQER YKNDKQRQSE EMMKLYKETG
110 120 130 140 150
TNPLSSCLPI LAQSPFFFAL YHVLNGIASG DTIGKINQPL LESAQKAHIF
160 170 180 190 200
GAPLAAKFTD GASKVESLGA SLTDVRVITA VMIVLMSASQ FFTQRQLMTK
210 220 230 240 250
NVDTSVKTPF MQQQKMLMYV FPVMFAVFGI NFPVGVLVYW LTTNVWTMGQ
260 270 280 290 300
QMYVIRNNPT PGSKAQASYL ERLHKSVTEH GRTRRRGEKA IVKAIVAKGR
310 320 330 340 350
DRNEAERKFI NGLNKAGLAA QADGNVVKND AAVAVQSEDG STVTTTAQPK
360 370 380 390 400
RQQPKRQSKS QRQAKPAGET EPKTSLTKSD EPQDAEPAGK QDAKPAAGAK
410 420 430
KPAQKSGGGG RSKAQSGQRK GPQRPKSPSK K
Length:431
Mass (Da):47,373
Last modified:June 1, 1998 - v1
Checksum:i6E6D2E04D3EC4D65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187159 Genomic DNA. Translation: AAF16008.1.
AF031590 Genomic DNA. Translation: AAC03487.1.
AL939118 Genomic DNA. Translation: CAB42700.1.
PIRiT36570.
RefSeqiNP_628069.1. NC_003888.3.
WP_011029289.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB42700; CAB42700; CAB42700.
GeneIDi1099319.
KEGGisco:SCO3883.
PATRICi23737550. VBIStrCoe124346_3956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187159 Genomic DNA. Translation: AAF16008.1.
AF031590 Genomic DNA. Translation: AAC03487.1.
AL939118 Genomic DNA. Translation: CAB42700.1.
PIRiT36570.
RefSeqiNP_628069.1. NC_003888.3.
WP_011029289.1. NC_003888.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO3883.

Proteomic databases

PRIDEiO54569.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB42700; CAB42700; CAB42700.
GeneIDi1099319.
KEGGisco:SCO3883.
PATRICi23737550. VBIStrCoe124346_3956.

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
HOGENOMiHOG000249071.
InParanoidiO54569.
KOiK03217.
OMAiPVSWVIV.
OrthoDBiPOG091H00BE.
PhylomeDBiO54569.

Family and domain databases

InterProiIPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 2 hits.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYIDC_STRCO
AccessioniPrimary (citable) accession number: O54569
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.