ID   G6PD_STRPN              Reviewed;         495 AA.
AC   O54537;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2001, sequence version 2.
DT   16-JUN-2009, entry version 64.
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase;
DE            Short=G6PD;
DE            EC=1.1.1.49;
GN   Name=zwf; OrderedLocusNames=SP_1243;
OS   Streptococcus pneumoniae.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   MEDLINE=21357209; PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T.,
RA   Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C.,
RA   Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-433.
RC   STRAIN=ATCC 6323;
RX   MEDLINE=98125733; PubMed=9466257;
RX   DOI=10.1046/j.1365-2958.1998.00658.x;
RA   Coffey T.J., Enright M.C., Daniels M., Morona J.K., Morona R.,
RA   Hryniewicz W., Paton J.C., Spratt B.G.;
RT   "Recombinational exchanges at the capsular polysaccharide biosynthetic
RT   locus lead to frequent serotype changes among natural isolates of
RT   Streptococcus pneumoniae.";
RL   Mol. Microbiol. 27:73-83(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-433.
RX   MEDLINE=98192409; PubMed=9533725;
RA   Coffey T.J., Enright M.C., Daniels M., Wilkinson P., Berron S.,
RA   Fenoll A., Spratt B.G.;
RT   "Serotype 19A variants of the Spanish serotype 23F multiresistant
RT   clone of Streptococcus pneumoniae.";
RL   Microb. Drug Resist. 4:51-55(1998).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = D-glucono-
CC       1,5-lactone 6-phosphate + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family.
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DR   EMBL; AE005672; AAK75348.1; -; Genomic_DNA.
DR   EMBL; Z99802; CAB16927.1; -; Genomic_DNA.
DR   EMBL; Z99865; CAB16990.1; -; Genomic_DNA.
DR   PIR; C95144; C95144.
DR   RefSeq; NP_345708.1; -.
DR   HSSP; P11411; 1DPG.
DR   GeneID; 931756; -.
DR   GenomeReviews; AE005672_GR; SP_1243.
DR   KEGG; spn:SP_1243; -.
DR   TIGR; SP_1243; -.
DR   HOGENOM; O54537; -.
DR   OMA; O54537; QRADNIE.
DR   BRENDA; 1.1.1.49; 600.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:EC.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001282; Glc-6-P_DH.
DR   InterPro; IPR019796; Glc-6-P_DH_AS.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR23429; G6PDH; 1.
DR   Pfam; PF02781; G6PD_C; 1.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PIRSF; PIRSF000110; G6PD; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   ProDom; PD001129; G6PD; 1.
DR   TIGRFAMs; TIGR00871; zwf; 1.
DR   PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP;
KW   Oxidoreductase.
FT   CHAIN         1    495       Glucose-6-phosphate 1-dehydrogenase.
FT                                /FTId=PRO_0000068133.
FT   ACT_SITE    239    239       Proton acceptor (By similarity).
FT   BINDING      13     13       NADP (By similarity).
FT   BINDING      45     45       NADP (By similarity).
FT   BINDING     177    177       Substrate (By similarity).
FT   BINDING     181    181       Substrate (By similarity).
FT   BINDING     344    344       Substrate (By similarity).
FT   CONFLICT    348    348       V -> I (in Ref. 2 and 3).
SQ   SEQUENCE   495 AA;  56790 MW;  99093E9C8929FFAF CRC64;
     MSSKVIVTIF GASGDLAKRK LYPSLFRLYQ SGNLSKHFAV IGTARRPWSK EYFESVVVES
     ILDLADSTEQ AQEFASHFYY QSHDVNDSEH YIALRQLQAE LNEKYQAEHN KLFFLSMAPQ
     FFGTIAKHLK SENIVDGKGF ERLIVEKPFG TDYATASKLN DELLATFDEE QIFRIDHYLG
     KEMIQSIFAV RFANLIFENV WNKDFIDNVQ ITFAERLGVE ERGGYYDQSG ALRDMVQNHT
     LQLLSLLAMD KPASFTKDEI RAEKIKVFKN LYHPTDEELK EHFIRGQYRS GKIDGMKYIS
     YRSEPNVNPE STTETFTSGA FFVDSDRFRG VPFFFRTGKR LTEKGTHVNI VFKQMDSIFG
     EPLAPNILTI YIQPTEGFSL SLNGKQVGEE FNLAPNSLDY RTDATATGAS PEPYEKLIYD
     VLNNNSTNFS HWDEVCASWK LIDRIEKLWA ENGAPLHDYK AGSMGPQASF DLLEKFGAKW
     TWQPDITYRQ DGRLE
//