Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O54537 (G6PD_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Gene names
Name:zwf
Ordered Locus Names:SP_1243
OrganismStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]
Taxonomic identifier170187 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 495495Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966
PRO_0000068133

Regions

Nucleotide binding11 – 188NADP By similarity
Nucleotide binding84 – 852NADP By similarity

Sites

Active site2391Proton acceptor By similarity
Binding site451NADP By similarity
Binding site1471NADP By similarity
Binding site1771Substrate By similarity
Binding site1811Substrate By similarity
Binding site2151Substrate By similarity
Binding site2341Substrate By similarity
Binding site3391Substrate By similarity
Binding site3441Substrate By similarity

Experimental info

Sequence conflict3481V → I Ref.2
Sequence conflict3481V → I Ref.3

Sequences

Sequence LengthMass (Da)Tools
O54537 [UniParc].

Last modified September 26, 2001. Version 2.
Checksum: 99093E9C8929FFAF

FASTA49556,790
        10         20         30         40         50         60 
MSSKVIVTIF GASGDLAKRK LYPSLFRLYQ SGNLSKHFAV IGTARRPWSK EYFESVVVES 

        70         80         90        100        110        120 
ILDLADSTEQ AQEFASHFYY QSHDVNDSEH YIALRQLQAE LNEKYQAEHN KLFFLSMAPQ 

       130        140        150        160        170        180 
FFGTIAKHLK SENIVDGKGF ERLIVEKPFG TDYATASKLN DELLATFDEE QIFRIDHYLG 

       190        200        210        220        230        240 
KEMIQSIFAV RFANLIFENV WNKDFIDNVQ ITFAERLGVE ERGGYYDQSG ALRDMVQNHT 

       250        260        270        280        290        300 
LQLLSLLAMD KPASFTKDEI RAEKIKVFKN LYHPTDEELK EHFIRGQYRS GKIDGMKYIS 

       310        320        330        340        350        360 
YRSEPNVNPE STTETFTSGA FFVDSDRFRG VPFFFRTGKR LTEKGTHVNI VFKQMDSIFG 

       370        380        390        400        410        420 
EPLAPNILTI YIQPTEGFSL SLNGKQVGEE FNLAPNSLDY RTDATATGAS PEPYEKLIYD 

       430        440        450        460        470        480 
VLNNNSTNFS HWDEVCASWK LIDRIEKLWA ENGAPLHDYK AGSMGPQASF DLLEKFGAKW 

       490 
TWQPDITYRQ DGRLE 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae."
Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. expand/collapse author list , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M.
Science 293:498-506(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-334 / TIGR4.
[2]"Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae."
Coffey T.J., Enright M.C., Daniels M., Morona J.K., Morona R., Hryniewicz W., Paton J.C., Spratt B.G.
Mol. Microbiol. 27:73-83(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-433.
Strain: ATCC 6323.
[3]"Serotype 19A variants of the Spanish serotype 23F multiresistant clone of Streptococcus pneumoniae."
Coffey T.J., Enright M.C., Daniels M., Wilkinson P., Berron S., Fenoll A., Spratt B.G.
Microb. Drug Resist. 4:51-55(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-433.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005672 Genomic DNA. Translation: AAK75348.1.
Z99802 Genomic DNA. Translation: CAB16927.1.
Z99865 Genomic DNA. Translation: CAB16990.1.
PIRC95144.
RefSeqNP_345708.1. NC_003028.3.

3D structure databases

ProteinModelPortalO54537.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING170187.SP_1243.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK75348; AAK75348; SP_1243.
GeneID931756.
KEGGspn:SP_1243.
PATRIC19706879. VBIStrPne105772_1284.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0364.
HOGENOMHOG000046191.
KOK00036.
OMAHAFTESS.
OrthoDBEOG61308Z.

Enzyme and pathway databases

BioCycSPNE170187:GHGN-1247-MONOMER.
UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_STRPN
AccessionPrimary (citable) accession number: O54537
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 26, 2001
Last modified: June 11, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways