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O54537

- G6PD_STRPN

UniProt

O54537 - G6PD_STRPN

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
zwf, SP_1243
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451NADP By similarity
Binding sitei147 – 1471NADP By similarity
Binding sitei177 – 1771Substrate By similarity
Binding sitei181 – 1811Substrate By similarity
Binding sitei215 – 2151Substrate By similarity
Binding sitei234 – 2341Substrate By similarity
Active sitei239 – 2391Proton acceptor By similarity
Binding sitei339 – 3391Substrate By similarity
Binding sitei344 – 3441Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188NADP By similarity
Nucleotide bindingi84 – 852NADP By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-1247-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:SP_1243
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Glucose-6-phosphate 1-dehydrogenaseUniRule annotationPRO_0000068133Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_1243.

Structurei

3D structure databases

ProteinModelPortaliO54537.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiHAFTESS.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54537-1 [UniParc]FASTAAdd to Basket

« Hide

MSSKVIVTIF GASGDLAKRK LYPSLFRLYQ SGNLSKHFAV IGTARRPWSK    50
EYFESVVVES ILDLADSTEQ AQEFASHFYY QSHDVNDSEH YIALRQLQAE 100
LNEKYQAEHN KLFFLSMAPQ FFGTIAKHLK SENIVDGKGF ERLIVEKPFG 150
TDYATASKLN DELLATFDEE QIFRIDHYLG KEMIQSIFAV RFANLIFENV 200
WNKDFIDNVQ ITFAERLGVE ERGGYYDQSG ALRDMVQNHT LQLLSLLAMD 250
KPASFTKDEI RAEKIKVFKN LYHPTDEELK EHFIRGQYRS GKIDGMKYIS 300
YRSEPNVNPE STTETFTSGA FFVDSDRFRG VPFFFRTGKR LTEKGTHVNI 350
VFKQMDSIFG EPLAPNILTI YIQPTEGFSL SLNGKQVGEE FNLAPNSLDY 400
RTDATATGAS PEPYEKLIYD VLNNNSTNFS HWDEVCASWK LIDRIEKLWA 450
ENGAPLHDYK AGSMGPQASF DLLEKFGAKW TWQPDITYRQ DGRLE 495
Length:495
Mass (Da):56,790
Last modified:September 26, 2001 - v2
Checksum:i99093E9C8929FFAF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti348 – 3481V → I1 Publication
Sequence conflicti348 – 3481V → I1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75348.1.
Z99802 Genomic DNA. Translation: CAB16927.1.
Z99865 Genomic DNA. Translation: CAB16990.1.
PIRiC95144.
RefSeqiNP_345708.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK75348; AAK75348; SP_1243.
GeneIDi931756.
KEGGispn:SP_1243.
PATRICi19706879. VBIStrPne105772_1284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75348.1 .
Z99802 Genomic DNA. Translation: CAB16927.1 .
Z99865 Genomic DNA. Translation: CAB16990.1 .
PIRi C95144.
RefSeqi NP_345708.1. NC_003028.3.

3D structure databases

ProteinModelPortali O54537.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_1243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK75348 ; AAK75348 ; SP_1243 .
GeneIDi 931756.
KEGGi spn:SP_1243.
PATRICi 19706879. VBIStrPne105772_1284.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi HAFTESS.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci SPNE170187:GHGN-1247-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.
  2. "Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae."
    Coffey T.J., Enright M.C., Daniels M., Morona J.K., Morona R., Hryniewicz W., Paton J.C., Spratt B.G.
    Mol. Microbiol. 27:73-83(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-433.
    Strain: ATCC 6323.
  3. "Serotype 19A variants of the Spanish serotype 23F multiresistant clone of Streptococcus pneumoniae."
    Coffey T.J., Enright M.C., Daniels M., Wilkinson P., Berron S., Fenoll A., Spratt B.G.
    Microb. Drug Resist. 4:51-55(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-433.

Entry informationi

Entry nameiG6PD_STRPN
AccessioniPrimary (citable) accession number: O54537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 26, 2001
Last modified: June 11, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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