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O54537

- G6PD_STRPN

UniProt

O54537 - G6PD_STRPN

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451NADPUniRule annotation
Binding sitei147 – 1471NADPUniRule annotation
Binding sitei177 – 1771SubstrateUniRule annotation
Binding sitei181 – 1811SubstrateUniRule annotation
Binding sitei215 – 2151SubstrateUniRule annotation
Binding sitei234 – 2341SubstrateUniRule annotation
Active sitei239 – 2391Proton acceptorUniRule annotation
Binding sitei339 – 3391SubstrateUniRule annotation
Binding sitei344 – 3441SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188NADPUniRule annotation
Nucleotide bindingi84 – 852NADPUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-1247-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:SP_1243
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Glucose-6-phosphate 1-dehydrogenasePRO_0000068133Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_1243.

Structurei

3D structure databases

ProteinModelPortaliO54537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiHAFTESS.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54537-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSKVIVTIF GASGDLAKRK LYPSLFRLYQ SGNLSKHFAV IGTARRPWSK
60 70 80 90 100
EYFESVVVES ILDLADSTEQ AQEFASHFYY QSHDVNDSEH YIALRQLQAE
110 120 130 140 150
LNEKYQAEHN KLFFLSMAPQ FFGTIAKHLK SENIVDGKGF ERLIVEKPFG
160 170 180 190 200
TDYATASKLN DELLATFDEE QIFRIDHYLG KEMIQSIFAV RFANLIFENV
210 220 230 240 250
WNKDFIDNVQ ITFAERLGVE ERGGYYDQSG ALRDMVQNHT LQLLSLLAMD
260 270 280 290 300
KPASFTKDEI RAEKIKVFKN LYHPTDEELK EHFIRGQYRS GKIDGMKYIS
310 320 330 340 350
YRSEPNVNPE STTETFTSGA FFVDSDRFRG VPFFFRTGKR LTEKGTHVNI
360 370 380 390 400
VFKQMDSIFG EPLAPNILTI YIQPTEGFSL SLNGKQVGEE FNLAPNSLDY
410 420 430 440 450
RTDATATGAS PEPYEKLIYD VLNNNSTNFS HWDEVCASWK LIDRIEKLWA
460 470 480 490
ENGAPLHDYK AGSMGPQASF DLLEKFGAKW TWQPDITYRQ DGRLE
Length:495
Mass (Da):56,790
Last modified:September 26, 2001 - v2
Checksum:i99093E9C8929FFAF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti348 – 3481V → I(PubMed:9466257)Curated
Sequence conflicti348 – 3481V → I(PubMed:9533725)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75348.1.
Z99802 Genomic DNA. Translation: CAB16927.1.
Z99865 Genomic DNA. Translation: CAB16990.1.
PIRiC95144.
RefSeqiNP_345708.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK75348; AAK75348; SP_1243.
GeneIDi931756.
KEGGispn:SP_1243.
PATRICi19706879. VBIStrPne105772_1284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75348.1 .
Z99802 Genomic DNA. Translation: CAB16927.1 .
Z99865 Genomic DNA. Translation: CAB16990.1 .
PIRi C95144.
RefSeqi NP_345708.1. NC_003028.3.

3D structure databases

ProteinModelPortali O54537.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_1243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK75348 ; AAK75348 ; SP_1243 .
GeneIDi 931756.
KEGGi spn:SP_1243.
PATRICi 19706879. VBIStrPne105772_1284.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi HAFTESS.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci SPNE170187:GHGN-1247-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.
  2. "Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae."
    Coffey T.J., Enright M.C., Daniels M., Morona J.K., Morona R., Hryniewicz W., Paton J.C., Spratt B.G.
    Mol. Microbiol. 27:73-83(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-433.
    Strain: ATCC 6323.
  3. "Serotype 19A variants of the Spanish serotype 23F multiresistant clone of Streptococcus pneumoniae."
    Coffey T.J., Enright M.C., Daniels M., Wilkinson P., Berron S., Fenoll A., Spratt B.G.
    Microb. Drug Resist. 4:51-55(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-433.

Entry informationi

Entry nameiG6PD_STRPN
AccessioniPrimary (citable) accession number: O54537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 26, 2001
Last modified: October 1, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3