Reviewed,
UniProtKB/Swiss-Prot O54537 (G6PD_STRPN)
Last modified
November 25, 2008.
Version 61.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glucose-6-phosphate 1-dehydrogenase Short name=G6PD EC=1.1.1.49 | ||||
| Gene names |
| ||||
| Organism | Streptococcus pneumoniae [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1313 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus |
Protein attributes
| Sequence length | 495 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH. |
| Pathway | |
| Sequence similarities | Belongs to the glucose-6-phosphate dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism Glucose metabolism |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 495 | 495 | Glucose-6-phosphate 1-dehydrogenase | PRO_0000068133 | |||||
Sites | |||||||||
| Active site | 239 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 13 | 1 | NADP By similarity | ||||||
| Binding site | 45 | 1 | NADP By similarity | ||||||
| Binding site | 177 | 1 | Substrate By similarity | ||||||
| Binding site | 181 | 1 | Substrate By similarity | ||||||
| Binding site | 344 | 1 | Substrate By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 348 | 1 | V → I Ref.2 Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. Fraser C.M.Science 293:498-506(2001) [PubMed: 11463916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4. |
| [2] | "Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae." Coffey T.J., Enright M.C., Daniels M., Morona J.K., Morona R., Hryniewicz W., Paton J.C., Spratt B.G. Mol. Microbiol. 27:73-83(1998) [PubMed: 9466257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-433. Strain: ATCC 6323. |
| [3] | "Serotype 19A variants of the Spanish serotype 23F multiresistant clone of Streptococcus pneumoniae." Coffey T.J., Enright M.C., Daniels M., Wilkinson P., Berron S., Fenoll A., Spratt B.G. Microb. Drug Resist. 4:51-55(1998) [PubMed: 9533725] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-433. |
Cross-references
Sequence databases | |
|---|---|
| AE005672 Genomic DNA. Translation: AAK75348.1. Z99802 Genomic DNA. Translation: CAB16927.1. Z99865 Genomic DNA. Translation: CAB16990.1. | |
| PIR | C95144. |
| RefSeq | NP_345708.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1DPG based on UniProtKB P11411. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 931756. |
| GenomeReviews | Gene locus SP_1243 in contig AE005672_GR. |
| KEGG | spn:SP_1243. |
| TIGR | SP_1243. |
Phylogenomic databases | |
| HOGENOM | O54537. |
Family and domain databases | |
| InterPro | IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR23429. G6PDH. 1 hit. |
| Pfam | PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000110. G6PD. 1 hit. |
| PRINTS | PR00079. G6PDHDRGNASE. |
| ProDom | PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00871. zwf. 1 hit. |
| PROSITE | PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | G6PD_STRPN | ||||||||
| Accession | Primary (citable) accession number: O54537 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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