Reviewed,
UniProtKB/Swiss-Prot O54459 (AROH_ENTAG)
Last modified
September 22, 2009.
Version 48.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive EC=2.5.1.54 Alternative name(s): Phospho-2-keto-3-deoxyheptonate aldolase 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase DAHP synthetase | ||
| Gene names |
| ||
| Organism | Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans) | ||
| Taxonomic identifier | 549 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pantoea |
Protein attributes
| Sequence length | 348 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). |
| Catalytic activity | Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. |
| Pathway | |
| Sequence similarities | Belongs to the class-I DAHP synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Aromatic amino acid biosynthesis |
| Molecular function | Transferase |
| Gene Ontology (GO) | |
| Biological process | aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 348 | 348 | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive | PRO_0000140843 | |||
Sequences
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References
| [1] | "Substrate ambiguity of 3-deoxy-D-manno-octulosonate 8-phosphate synthase from Neisseria gonorrhoeae in the context of its membership in a protein family containing a subset of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthases." Subramaniam P.S., Xie G., Xia T., Jensen R.A. J. Bacteriol. 180:119-127(1998) [PubMed: 9422601] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| U93355 Genomic DNA. Translation: AAB96400.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1N8F based on UniProtKB P00886. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 2.5.1.54. 3054. |
Family and domain databases | |
| InterPro | IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| PANTHER | PTHR21225. AroFGH. 1 hit. |
| Pfam | PF00793. DAHP_synth_1. 1 hit. [Graphical view] |
| PIRSF | PIRSF001361. DAHP_synthase. 1 hit. |
| TIGRFAMs | TIGR00034. aroFGH. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | AROH_ENTAG | ||||||||
| Accession | Primary (citable) accession number: O54459 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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