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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37NADPBy similarity1
Binding sitei89NADP; via carbonyl oxygenBy similarity1
Binding sitei141SubstrateBy similarity1
Active sitei154Proton acceptorPROSITE-ProRule annotation1
Binding sitei187NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADPBy similarity4
Nucleotide bindingi62 – 63NADPBy similarity2
Nucleotide bindingi154 – 158NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-3019-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:PA2967
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA2967

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546781 – 2473-oxoacyl-[acyl-carrier-protein] reductase FabGAdd BLAST247

Proteomic databases

PaxDbiO54438
PRIDEiO54438

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi208964.PA2967

Structurei

Secondary structure

1247
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni2 – 5Combined sources4
Beta strandi7 – 12Combined sources6
Helixi16 – 27Combined sources12
Beta strandi31 – 38Combined sources8
Helixi39 – 50Combined sources12
Turni51 – 53Combined sources3
Beta strandi56 – 60Combined sources5
Helixi66 – 79Combined sources14
Beta strandi85 – 88Combined sources4
Helixi98 – 100Combined sources3
Helixi103 – 105Combined sources3
Helixi106 – 131Combined sources26
Beta strandi134 – 139Combined sources6
Helixi142 – 146Combined sources5
Helixi147 – 172Combined sources26
Helixi173 – 175Combined sources3
Beta strandi177 – 184Combined sources8
Beta strandi186 – 189Combined sources4
Turni190 – 194Combined sources5
Helixi197 – 205Combined sources9
Helixi215 – 226Combined sources12
Helixi228 – 230Combined sources3
Beta strandi237 – 241Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AFNX-ray2.30A/B/C/D1-247[»]
4AG3X-ray1.80A/B/C/D1-247[»]
4BNTX-ray2.30A/B/C/D1-247[»]
4BNUX-ray2.00A/B/C/D1-247[»]
4BNVX-ray2.50A/B/C/D1-247[»]
4BNWX-ray1.60A/B/C/D1-247[»]
4BNXX-ray2.30A/B/C/D1-247[»]
4BNYX-ray1.80A/B/C/D1-247[»]
4BNZX-ray2.50A/B/C/D1-247[»]
4BO0X-ray2.40A/B/C/D1-247[»]
4BO1X-ray2.20A/B/C/D1-247[»]
4BO2X-ray1.90A/B/C/D1-247[»]
4BO3X-ray2.50A/B/C/D1-247[»]
4BO4X-ray2.70A/B/C/D1-247[»]
4BO5X-ray2.60A/B/C/D1-247[»]
4BO6X-ray2.80A/B/C/D1-247[»]
4BO7X-ray2.60A/B/C/D1-247[»]
4BO8X-ray2.70A/B/C/D1-247[»]
4BO9X-ray2.90A/B/C/D1-247[»]
ProteinModelPortaliO54438
SMRiO54438
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHR Bacteria
ENOG410XNW1 LUCA
InParanoidiO54438
KOiK00059
OMAiGSRNIRC
PhylomeDBiO54438

Family and domain databases

InterProiView protein in InterPro
IPR011284 3oxo_ACP_reduc
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01830 3oxo_ACP_reduc, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

O54438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQGKVALV TGASRGIGQA IALELGRLGA VVIGTATSAS GAEKIAETLK
60 70 80 90 100
ANGVEGAGLV LDVSSDESVA ATLEHIQQHL GQPLIVVNNA GITRDNLLVR
110 120 130 140 150
MKDDEWFDVV NTNLNSLYRL SKAVLRGMTK ARWGRIINIG SVVGAMGNAG
160 170 180 190 200
QTNYAAAKAG LEGFTRALAR EVGSRAITVN AVAPGFIDTD MTRELPEAQR
210 220 230 240
EALLGQIPLG RLGQAEEIAK VVGFLASDGA AYVTGATVPV NGGMYMS
Length:247
Mass (Da):25,585
Last modified:June 1, 1998 - v1
Checksum:iAB83A2B95027445B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91631 Genomic DNA Translation: AAB94395.1
AE004091 Genomic DNA Translation: AAG06355.1
PIRiT12020
RefSeqiNP_251657.1, NC_002516.2
WP_003091137.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG06355; AAG06355; PA2967
GeneIDi880433
KEGGipae:PA2967
PATRICifig|208964.12.peg.3113

Similar proteinsi

Entry informationi

Entry nameiFABG_PSEAE
AccessioniPrimary (citable) accession number: O54438
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health