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Protein

Cold shock-like protein

Gene

csp

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock-like protein
Gene namesi
Name:csp
Ordered Locus Names:TM_1683
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi9 – 91D → N: Destabilization at high temperature. 1 Publication
Mutagenesisi61 – 611H → N: No effect on thermal stability. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Cold shock-like proteinPRO_0000100339Add
BLAST

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi243274.TM1683.

Structurei

Secondary structure

1
66
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97Combined sources
Turni10 – 134Combined sources
Beta strandi14 – 196Combined sources
Beta strandi29 – 324Combined sources
Beta strandi42 – 5110Combined sources
Beta strandi53 – 553Combined sources
Beta strandi58 – 658Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G6PNMR-A1-66[»]
ProteinModelPortaliO54310.
SMRiO54310. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO54310.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 6260CSDAdd
BLAST

Sequence similaritiesi

Contains 1 CSD (cold-shock) domain.Curated

Phylogenomic databases

eggNOGiENOG4105VEQ. Bacteria.
COG1278. LUCA.
InParanoidiO54310.
KOiK03704.
OMAiPQAENIQ.
OrthoDBiEOG618R0J.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR012156. Cold_shock_CspA.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
PIRSFiPIRSF002599. Cold_shock_A. 1 hit.
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGKVKWFDS KKGYGFITKD EGGDVFVHWS AIEMEGFKTL KEGQVVEFEI
60
QEGKKGPQAA HVKVVE
Length:66
Mass (Da):7,473
Last modified:June 1, 1998 - v1
Checksum:i851E3B79C6114E8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11219 mRNA. Translation: CAA72105.1.
AE000512 Genomic DNA. Translation: AAD36750.1.
PIRiE72222.
RefSeqiNP_229483.1. NC_000853.1.
WP_004082199.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36750; AAD36750; TM_1683.
GeneIDi897898.
KEGGitma:TM1683.
PATRICi23938340. VBITheMar51294_1700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11219 mRNA. Translation: CAA72105.1.
AE000512 Genomic DNA. Translation: AAD36750.1.
PIRiE72222.
RefSeqiNP_229483.1. NC_000853.1.
WP_004082199.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G6PNMR-A1-66[»]
ProteinModelPortaliO54310.
SMRiO54310. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36750; AAD36750; TM_1683.
GeneIDi897898.
KEGGitma:TM1683.
PATRICi23938340. VBITheMar51294_1700.

Phylogenomic databases

eggNOGiENOG4105VEQ. Bacteria.
COG1278. LUCA.
InParanoidiO54310.
KOiK03704.
OMAiPQAENIQ.
OrthoDBiEOG618R0J.

Miscellaneous databases

EvolutionaryTraceiO54310.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR012156. Cold_shock_CspA.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
PIRSFiPIRSF002599. Cold_shock_A. 1 hit.
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, overexpression, purification, and physicochemical characterization of a cold shock protein homolog from the hyperthermophilic bacterium Thermotoga maritima."
    Welker C., Bohm G., Schurig H., Jaenicke R.
    Protein Sci. 8:394-403(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  3. "Does the elimination of ion pairs affect the thermal stability of cold shock protein from the hyperthermophilic bacterium Thermotoga maritima?"
    Frankenberg N., Welker C., Jaenicke R.
    FEBS Lett. 454:299-302(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS.
  4. "Solution NMR structure of the cold-shock protein from the hyperthermophilic bacterium Thermotoga maritima."
    Kremer W., Schuler B., Harrieder S., Geyer M., Gronwald W., Welker C., Jaenicke R., Kalbitzer H.R.
    Eur. J. Biochem. 268:2527-2539(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiCSP_THEMA
AccessioniPrimary (citable) accession number: O54310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: April 13, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.