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Protein

Thioredoxin reductase

Gene

trxB

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductaseUniRule annotation (EC:1.8.1.9UniRule annotation)
Gene namesi
Name:trxBImported
Synonyms:trxB_1Imported, trxB_3Imported
ORF Names:A4U86_00395Imported, A7J36_07115Imported, BN1321_180007Imported, ERS072738_00208Imported, ERS073147_00364Imported, ERS073767_00250Imported, ERS074020_00203Imported, ERS1058648_00332Imported, HMPREF3211_01109Imported, SAMEA2384487_01924Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000077578 Componenti: Unassembled WGS sequence
  • UP000071995 Componenti: Unassembled WGS sequence
  • UP000070177 Componenti: Unassembled WGS sequence
  • UP000072664 Componenti: Unassembled WGS sequence
  • UP000074953 Componenti: Unassembled WGS sequence
  • UP000039437 Componenti: Unassembled WGS sequence
  • UP000078523 Componenti: Unassembled WGS sequence
  • UP000073331 Componenti: Unassembled WGS sequence
  • UP000075156 Componenti: Unassembled WGS sequence
  • UP000078125 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL0829.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 293FAD/NAD-binding_domInterPro annotationAdd BLAST288

Sequence similaritiesi

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
KOiK00384.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEIDFDIAI IGAGPAGMTA AVYASRANLK TVMIERGIPG GQMANTEEVE
60 70 80 90 100
NFPGFEMITG PDLSTKMFEH AKKFGAVYQY GDIKSVEDKG EYKVINFGNK
110 120 130 140 150
ELTAKAVIIA TGAEYKKIGV PGEQELGGRG VSYCAVCDGA FFKNKRLFVI
160 170 180 190 200
GGGDSAVEEG TFLTKFADKV TIVHRRDELR AQRILQDRAF KNDKIDFIWS
210 220 230 240 250
HTLKSINEKD GKVGSVTLTS TKDGSEETHE ADGVFIYIGM KPLTAPFKDL
260 270 280 290 300
GITNDVGYIV TKDDMTTSVP GIFAAGDVRD KGLRQIVTAT GDGSIAAQSA
310
AEYIEHLNDQ A
Length:311
Mass (Da):33,616
Last modified:October 1, 2003 - v4
Checksum:i1A337DE3736C9265
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei311Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223781 Genomic DNA. Translation: CAA11546.2.
Y18636 Genomic DNA. Translation: CAB60740.1.
CVOQ01000010 Genomic DNA. Translation: CRI08321.1.
FFPZ01000001 Genomic DNA. Translation: CXE21571.1.
FGBR01000001 Genomic DNA. Translation: CXL50386.1.
FGLU01000002 Genomic DNA. Translation: CXS74939.1.
FHAW01000001 Genomic DNA. Translation: CYC84453.1.
FJMW01000001 Genomic DNA. Translation: CZQ26001.1.
LRQH01000096 Genomic DNA. Translation: KXA36788.1.
LXNN01000103 Genomic DNA. Translation: OAF73645.1.
LWAL01000011 Genomic DNA. Translation: OAP80329.1.
FKSA01000005 Genomic DNA. Translation: SBC39300.1.
RefSeqiWP_000134963.1. NZ_MCFM01000012.1.

Genome annotation databases

EnsemblBacteriaiAIL57262; AIL57262; CH51_03985.
CEK43824; CEK43824; SASCBU26_00724.
CFO15309; CFO15309; ERS179246_00139.
COX89076; COX89076; ERS195423_00753.
CPB30318; CPB30318; ERS092844_00275.
CRI08321; CRI08321; BN1321_180007.
CUC38888; CUC38888; ERS365775_00559.
CUE06168; CUE06168; ERS410449_01569.
CUF01839; CUF01839; ERS411017_00589.
CUF06005; CUF06005; ERS411009_00588.
KLN12254; KLN12254; RL02_07750.
KQB70740; KQB70740; AL077_07065.
GeneIDi28381674.
KEGGisaud:CH52_01945.
sauf:X998_0811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223781 Genomic DNA. Translation: CAA11546.2.
Y18636 Genomic DNA. Translation: CAB60740.1.
CVOQ01000010 Genomic DNA. Translation: CRI08321.1.
FFPZ01000001 Genomic DNA. Translation: CXE21571.1.
FGBR01000001 Genomic DNA. Translation: CXL50386.1.
FGLU01000002 Genomic DNA. Translation: CXS74939.1.
FHAW01000001 Genomic DNA. Translation: CYC84453.1.
FJMW01000001 Genomic DNA. Translation: CZQ26001.1.
LRQH01000096 Genomic DNA. Translation: KXA36788.1.
LXNN01000103 Genomic DNA. Translation: OAF73645.1.
LWAL01000011 Genomic DNA. Translation: OAP80329.1.
FKSA01000005 Genomic DNA. Translation: SBC39300.1.
RefSeqiWP_000134963.1. NZ_MCFM01000012.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL0829.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIL57262; AIL57262; CH51_03985.
CEK43824; CEK43824; SASCBU26_00724.
CFO15309; CFO15309; ERS179246_00139.
COX89076; COX89076; ERS195423_00753.
CPB30318; CPB30318; ERS092844_00275.
CRI08321; CRI08321; BN1321_180007.
CUC38888; CUC38888; ERS365775_00559.
CUE06168; CUE06168; ERS410449_01569.
CUF01839; CUF01839; ERS411017_00589.
CUF06005; CUF06005; ERS411009_00588.
KLN12254; KLN12254; RL02_07750.
KQB70740; KQB70740; AL077_07065.
GeneIDi28381674.
KEGGisaud:CH52_01945.
sauf:X998_0811.

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
KOiK00384.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO54079_STAAU
AccessioniPrimary (citable) accession number: O54079
Secondary accession number(s): Q9RL89
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 101 of the entry and version 4 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.