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Protein

Thioredoxin reductase

Gene

trxB

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandFADUniRule annotation, Flavoprotein, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductaseUniRule annotation (EC:1.8.1.9UniRule annotation)
Gene namesi
Name:trxBImported
Synonyms:trxB_1Imported, trxB_2Imported
ORF Names:AYM22_04140Imported, AYM23_04140Imported, AYM24_04140Imported, AYM25_04140Imported, AYM26_04130Imported, AYM27_04140Imported, AYM28_04140Imported, AYM29_04140Imported, AYM30_04140Imported, AYM31_04140Imported, AYM32_04140Imported, AYM33_04110Imported, AYM34_04130Imported, AYM35_04105Imported, AYM36_04105Imported, AYM37_04140Imported, BN1321_180007Imported, BO217_1188Imported, BZP34_06515Imported, ERS072738_00208Imported, ERS073071_00665Imported, ERS073147_00364Imported, ERS073583_00469Imported, ERS074020_00203Imported, HMPREF3211_01109Imported, SAMEA3448837_01130Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000039437 Componenti: Unassembled WGS sequence
  • UP000188477 Componenti: Chromosome
  • UP000184359 Componenti: Unassembled WGS sequence
  • UP000189251 Componenti: Chromosome
  • UP000188815 Componenti: Chromosome
  • UP000189233 Componenti: Chromosome
  • UP000187916 Componenti: Chromosome
  • UP000189011 Componenti: Chromosome
  • UP000188936 Componenti: Chromosome
  • UP000189120 Componenti: Chromosome
  • UP000070177 Componenti: Unassembled WGS sequence
  • UP000187274 Componenti: Unassembled WGS sequence
  • UP000072664 Componenti: Unassembled WGS sequence
  • UP000188954 Componenti: Chromosome
  • UP000188899 Componenti: Chromosome
  • UP000074953 Componenti: Unassembled WGS sequence
  • UP000187819 Componenti: Unassembled WGS sequence
  • UP000188908 Componenti: Chromosome
  • UP000189034 Componenti: Chromosome
  • UP000189407 Componenti: Chromosome
  • UP000187748 Componenti: Unassembled WGS sequence
  • UP000188557 Componenti: Chromosome
  • UP000188645 Componenti: Chromosome
  • UP000071995 Componenti: Unassembled WGS sequence
  • UP000189117 Componenti: Chromosome
  • UP000188986 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL0829.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 293FAD/NAD-binding_domInterPro annotationAdd BLAST288

Sequence similaritiesi

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
KOiK00384.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
PfamiView protein in Pfam
PF07992. Pyr_redox_2. 1 hit.
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiView protein in PROSITE
PS00573. PYRIDINE_REDOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O54079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEIDFDIAI IGAGPAGMTA AVYASRANLK TVMIERGIPG GQMANTEEVE
60 70 80 90 100
NFPGFEMITG PDLSTKMFEH AKKFGAVYQY GDIKSVEDKG EYKVINFGNK
110 120 130 140 150
ELTAKAVIIA TGAEYKKIGV PGEQELGGRG VSYCAVCDGA FFKNKRLFVI
160 170 180 190 200
GGGDSAVEEG TFLTKFADKV TIVHRRDELR AQRILQDRAF KNDKIDFIWS
210 220 230 240 250
HTLKSINEKD GKVGSVTLTS TKDGSEETHE ADGVFIYIGM KPLTAPFKDL
260 270 280 290 300
GITNDVGYIV TKDDMTTSVP GIFAAGDVRD KGLRQIVTAT GDGSIAAQSA
310
AEYIEHLNDQ A
Length:311
Mass (Da):33,616
Last modified:October 1, 2003 - v4
Checksum:i1A337DE3736C9265
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei311Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP019563 Genomic DNA. Translation: AQD18940.1.
CP014392 Genomic DNA. Translation: AQR06909.1.
CP014397 Genomic DNA. Translation: AQR09848.1.
CP014402 Genomic DNA. Translation: AQR12787.1.
CP014407 Genomic DNA. Translation: AQR15728.1.
CP014409 Genomic DNA. Translation: AQR18602.1.
CP014412 Genomic DNA. Translation: AQR21545.1.
CP014415 Genomic DNA. Translation: AQR24490.1.
CP014420 Genomic DNA. Translation: AQR27475.1.
CP014423 Genomic DNA. Translation: AQR30420.1.
CP014426 Genomic DNA. Translation: AQR33367.1.
CP014429 Genomic DNA. Translation: AQR36314.1.
CP014432 Genomic DNA. Translation: AQR39252.1.
CP014435 Genomic DNA. Translation: AQR42191.1.
CP014438 Genomic DNA. Translation: AQR45130.1.
CP014441 Genomic DNA. Translation: AQR48066.1.
CP014444 Genomic DNA. Translation: AQR51009.1.
AJ223781 Genomic DNA. Translation: CAA11546.2.
Y18636 Genomic DNA. Translation: CAB60740.1.
CVOQ01000010 Genomic DNA. Translation: CRI08321.1.
FFPZ01000001 Genomic DNA. Translation: CXE21571.1.
FGBR01000001 Genomic DNA. Translation: CXL50386.1.
FGJX01000003 Genomic DNA. Translation: CXR51438.1.
FGLU01000002 Genomic DNA. Translation: CXS74939.1.
FGWW01000002 Genomic DNA. Translation: CYA17896.1.
LRQH01000096 Genomic DNA. Translation: KXA36788.1.
MPPH01000014 Genomic DNA. Translation: OMK04803.1.
FQTF01000001 Genomic DNA. Translation: SHD95176.1.
RefSeqiWP_000134963.1. NZ_MUEG01000007.1.

Genome annotation databases

EnsemblBacteriaiAIL57262; AIL57262; CH51_03985.
CEK43824; CEK43824; SASCBU26_00724.
CFO15309; CFO15309; ERS179246_00139.
COX89076; COX89076; ERS195423_00753.
CPB30318; CPB30318; ERS092844_00275.
CRI08321; CRI08321; BN1321_180007.
CUC38888; CUC38888; ERS365775_00559.
CUE06168; CUE06168; ERS410449_01569.
CUF01839; CUF01839; ERS411017_00589.
CUF06005; CUF06005; ERS411009_00588.
KLN12254; KLN12254; RL02_07750.
KQB70740; KQB70740; AL077_07065.
KEGGisaud:CH52_01945.
sauf:X998_0811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP019563 Genomic DNA. Translation: AQD18940.1.
CP014392 Genomic DNA. Translation: AQR06909.1.
CP014397 Genomic DNA. Translation: AQR09848.1.
CP014402 Genomic DNA. Translation: AQR12787.1.
CP014407 Genomic DNA. Translation: AQR15728.1.
CP014409 Genomic DNA. Translation: AQR18602.1.
CP014412 Genomic DNA. Translation: AQR21545.1.
CP014415 Genomic DNA. Translation: AQR24490.1.
CP014420 Genomic DNA. Translation: AQR27475.1.
CP014423 Genomic DNA. Translation: AQR30420.1.
CP014426 Genomic DNA. Translation: AQR33367.1.
CP014429 Genomic DNA. Translation: AQR36314.1.
CP014432 Genomic DNA. Translation: AQR39252.1.
CP014435 Genomic DNA. Translation: AQR42191.1.
CP014438 Genomic DNA. Translation: AQR45130.1.
CP014441 Genomic DNA. Translation: AQR48066.1.
CP014444 Genomic DNA. Translation: AQR51009.1.
AJ223781 Genomic DNA. Translation: CAA11546.2.
Y18636 Genomic DNA. Translation: CAB60740.1.
CVOQ01000010 Genomic DNA. Translation: CRI08321.1.
FFPZ01000001 Genomic DNA. Translation: CXE21571.1.
FGBR01000001 Genomic DNA. Translation: CXL50386.1.
FGJX01000003 Genomic DNA. Translation: CXR51438.1.
FGLU01000002 Genomic DNA. Translation: CXS74939.1.
FGWW01000002 Genomic DNA. Translation: CYA17896.1.
LRQH01000096 Genomic DNA. Translation: KXA36788.1.
MPPH01000014 Genomic DNA. Translation: OMK04803.1.
FQTF01000001 Genomic DNA. Translation: SHD95176.1.
RefSeqiWP_000134963.1. NZ_MUEG01000007.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL0829.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIL57262; AIL57262; CH51_03985.
CEK43824; CEK43824; SASCBU26_00724.
CFO15309; CFO15309; ERS179246_00139.
COX89076; COX89076; ERS195423_00753.
CPB30318; CPB30318; ERS092844_00275.
CRI08321; CRI08321; BN1321_180007.
CUC38888; CUC38888; ERS365775_00559.
CUE06168; CUE06168; ERS410449_01569.
CUF01839; CUF01839; ERS411017_00589.
CUF06005; CUF06005; ERS411009_00588.
KLN12254; KLN12254; RL02_07750.
KQB70740; KQB70740; AL077_07065.
KEGGisaud:CH52_01945.
sauf:X998_0811.

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
KOiK00384.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
PfamiView protein in Pfam
PF07992. Pyr_redox_2. 1 hit.
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiView protein in PROSITE
PS00573. PYRIDINE_REDOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO54079_STAAU
AccessioniPrimary (citable) accession number: O54079
Secondary accession number(s): Q9RL89
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: October 1, 2003
Last modified: May 10, 2017
This is version 106 of the entry and version 4 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.