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O54069 (COX1_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene names
Name:ctaD
Synonyms:coxA
Ordered Locus Names:RP405
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length534 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 534534Probable cytochrome c oxidase subunit 1
PRO_0000183449

Regions

Transmembrane35 – 5521Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane202 – 22221Helical; Potential
Transmembrane254 – 27421Helical; Potential
Transmembrane286 – 30621Helical; Potential
Transmembrane320 – 34021Helical; Potential
Transmembrane357 – 37721Helical; Potential
Transmembrane396 – 41621Helical; Potential
Transmembrane433 – 45321Helical; Potential
Transmembrane475 – 49521Helical; Potential

Sites

Metal binding811Iron (heme A axial ligand) Probable
Metal binding2601Copper B Probable
Metal binding2641Copper B Probable
Metal binding3091Copper B Probable
Metal binding3101Copper B Probable
Metal binding3951Iron (heme A3 axial ligand) Probable
Metal binding3971Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link260 ↔ 2641'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
O54069 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 326E6B5753548C3E

FASTA53459,261
        10         20         30         40         50         60 
MNSLTNIEDL NCDNQHIPNG FRRWIFSTNH KDIGIMYIIF AIFAGVVGGL FSLLFRLELA 

        70         80         90        100        110        120 
MPGGTFLNHN FQLYNVLITV HAIIMVFFMI MPALFSGFGN YFVPLLIGAP DMAFPRLNNI 

       130        140        150        160        170        180 
SFWLLIPAFL LLISSTFIDG GPGTGWTLYP PLSNLNGHTG AAVDVAIFSL HLTGLSSILG 

       190        200        210        220        230        240 
SINLIVTIFN MRTPGMGLFK MPLFVWSILV TAFLIILAMP VLSGAITMLL TDRNFGTTFF 

       250        260        270        280        290        300 
KPDGGGDPLL FQHLFWFFGH PEVYIVILPG FGIVSQVIST FSRKPIFGYQ GMVGAMVIIG 

       310        320        330        340        350        360 
FVGFIVWAHH MFTVGLSYNA LIYFTAGTMI IAVPTGIKIF SWIATMWGGS ITFPTPMLFA 

       370        380        390        400        410        420 
IGFIILFTIG GVTGIILSNS ALDRVLHDTY YVVAHFHYTM SLGALFTAFA GFYYWFGKIS 

       430        440        450        460        470        480 
GKQYPEILGK IHFWITFIGV NLTFFPQHFL GLAGMPRRIP DYPEAFAGWN MVSSIGAGIS 

       490        500        510        520        530 
IFAAFYFVFI VFYTLKYGKN CTANPWGDGA DTLEWKLNSP PPFHTFETPP HIVE 

« Hide

References

« Hide 'large scale' references
[1]"The bacterial origin of mitochondria inferred from a phylogenetic analysis of the cytochrome b and cytochrome c oxidase I genes."
Sicheritz T., Kurland C.G., Andersson S.G.E.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Madrid E.
[2]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y13855 Genomic DNA. Translation: CAA74167.1.
AJ235271 Genomic DNA. Translation: CAA14862.1.
PIRD71698.
RefSeqNP_220786.1. NC_000963.1.

3D structure databases

ProteinModelPortalO54069.
SMRO54069. Positions 21-530.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP405.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14862; CAA14862; CAA14862.
GeneID883394.
KEGGrpr:RP405.
PATRIC17901591. VBIRicPro72556_0418.

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000085274.
KOK02274.
OMAMGMTRRV.
OrthoDBEOG6B35XR.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_RICPR
AccessionPrimary (citable) accession number: O54069
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: May 14, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways