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O54069

- COX1_RICPR

UniProt

O54069 - COX1_RICPR

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Protein

Probable cytochrome c oxidase subunit 1

Gene
ctaD, coxA, RP405
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi81 – 811Iron (heme A axial ligand) Inferred
Metal bindingi260 – 2601Copper B Inferred
Metal bindingi264 – 2641Copper B Inferred
Metal bindingi309 – 3091Copper B Inferred
Metal bindingi310 – 3101Copper B Inferred
Metal bindingi395 – 3951Iron (heme A3 axial ligand) Inferred
Metal bindingi397 – 3971Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Synonyms:coxA
Ordered Locus Names:RP405
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521Helical; Reviewed predictionAdd
BLAST
Transmembranei76 – 9621Helical; Reviewed predictionAdd
BLAST
Transmembranei97 – 11721Helical; Reviewed predictionAdd
BLAST
Transmembranei120 – 14021Helical; Reviewed predictionAdd
BLAST
Transmembranei165 – 18521Helical; Reviewed predictionAdd
BLAST
Transmembranei202 – 22221Helical; Reviewed predictionAdd
BLAST
Transmembranei254 – 27421Helical; Reviewed predictionAdd
BLAST
Transmembranei286 – 30621Helical; Reviewed predictionAdd
BLAST
Transmembranei320 – 34021Helical; Reviewed predictionAdd
BLAST
Transmembranei357 – 37721Helical; Reviewed predictionAdd
BLAST
Transmembranei396 – 41621Helical; Reviewed predictionAdd
BLAST
Transmembranei433 – 45321Helical; Reviewed predictionAdd
BLAST
Transmembranei475 – 49521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Probable cytochrome c oxidase subunit 1PRO_0000183449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki260 ↔ 2641'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Protein-protein interaction databases

STRINGi272947.RP405.

Structurei

3D structure databases

ProteinModelPortaliO54069.
SMRiO54069. Positions 21-530.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
KOiK02274.
OMAiMGMTRRV.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54069-1 [UniParc]FASTAAdd to Basket

« Hide

MNSLTNIEDL NCDNQHIPNG FRRWIFSTNH KDIGIMYIIF AIFAGVVGGL    50
FSLLFRLELA MPGGTFLNHN FQLYNVLITV HAIIMVFFMI MPALFSGFGN 100
YFVPLLIGAP DMAFPRLNNI SFWLLIPAFL LLISSTFIDG GPGTGWTLYP 150
PLSNLNGHTG AAVDVAIFSL HLTGLSSILG SINLIVTIFN MRTPGMGLFK 200
MPLFVWSILV TAFLIILAMP VLSGAITMLL TDRNFGTTFF KPDGGGDPLL 250
FQHLFWFFGH PEVYIVILPG FGIVSQVIST FSRKPIFGYQ GMVGAMVIIG 300
FVGFIVWAHH MFTVGLSYNA LIYFTAGTMI IAVPTGIKIF SWIATMWGGS 350
ITFPTPMLFA IGFIILFTIG GVTGIILSNS ALDRVLHDTY YVVAHFHYTM 400
SLGALFTAFA GFYYWFGKIS GKQYPEILGK IHFWITFIGV NLTFFPQHFL 450
GLAGMPRRIP DYPEAFAGWN MVSSIGAGIS IFAAFYFVFI VFYTLKYGKN 500
CTANPWGDGA DTLEWKLNSP PPFHTFETPP HIVE 534
Length:534
Mass (Da):59,261
Last modified:June 1, 1998 - v1
Checksum:i326E6B5753548C3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13855 Genomic DNA. Translation: CAA74167.1.
AJ235271 Genomic DNA. Translation: CAA14862.1.
PIRiD71698.
RefSeqiNP_220786.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14862; CAA14862; CAA14862.
GeneIDi883394.
KEGGirpr:RP405.
PATRICi17901591. VBIRicPro72556_0418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13855 Genomic DNA. Translation: CAA74167.1 .
AJ235271 Genomic DNA. Translation: CAA14862.1 .
PIRi D71698.
RefSeqi NP_220786.1. NC_000963.1.

3D structure databases

ProteinModelPortali O54069.
SMRi O54069. Positions 21-530.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP405.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14862 ; CAA14862 ; CAA14862 .
GeneIDi 883394.
KEGGi rpr:RP405.
PATRICi 17901591. VBIRicPro72556_0418.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
KOi K02274.
OMAi MGMTRRV.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The bacterial origin of mitochondria inferred from a phylogenetic analysis of the cytochrome b and cytochrome c oxidase I genes."
    Sicheritz T., Kurland C.G., Andersson S.G.E.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Madrid E.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiCOX1_RICPR
AccessioniPrimary (citable) accession number: O54069
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi