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Protein

UDP-glucose 6-dehydrogenase

Gene

rkpK

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.1 Publication

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.Curated
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase (rkpK)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Pathwayi: capsule polysaccharide biosynthesis

This protein is involved in the pathway capsule polysaccharide biosynthesis, which is part of Capsule biogenesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway capsule polysaccharide biosynthesis and in Capsule biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30NADBy similarity1
Binding sitei35NADBy similarity1
Binding sitei86NADBy similarity1
Binding sitei122NAD; via amide nitrogenBy similarity1
Binding sitei155NADBy similarity1
Active sitei265NucleophileBy similarity1
Binding sitei268NADBy similarity1
Binding sitei333NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi2 – 19NADBy similarityAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCapsule biogenesis/degradation
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00038; UER00491
UPA00934

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenaseCurated (EC:1.1.1.221 Publication)
Short name:
UDP-Glc dehydrogenaseCurated
Short name:
UDP-GlcDHCurated
Short name:
UDPGDHCurated
Gene namesi
Name:rkpK1 Publication
Ordered Locus Names:R01082
ORF Names:SMc02641
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740501 – 437UDP-glucose 6-dehydrogenaseAdd BLAST437

Proteomic databases

PRIDEiO54068

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc02641

Structurei

3D structure databases

ProteinModelPortaliO54068
SMRiO54068
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C6Y Bacteria
COG1004 LUCA
HOGENOMiHOG000153773
KOiK00012
OMAiLCTEWDE

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028357 UDPglc_DH_bac
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500134 UDPglc_DH_bac, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

O54068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITMIGAGY VGLVSGVCFA DFGHDVVCVD KDEGKISALK KGQIPIFEPG
60 70 80 90 100
LDHLVASNVA SGRLNFTDDL KTAVAASDVV FIAVGTPSRR GDGHADLSYV
110 120 130 140 150
YAAAREIAAN LQGFTVVVTK STVPVGTGDE VERIIRETNP AADVTVVSNP
160 170 180 190 200
EFLREGAAIE DFKRPDRIVI GVDGSDGRAR EVMTEVYRPL YLNQSPLVFT
210 220 230 240 250
TRRTSELIKY AGNAFLAMKI TFINEIADLC EKVGANVQDV ARGIGLDGRI
260 270 280 290 300
GSKFLHAGPG YGGSCFPKDT LALVKTAQDH DTPVRLVETT VAVNDNRKRA
310 320 330 340 350
MGRKVIAAAG GDIRGSKIAV LGLTFKPNTD DMRDSPAIAV VQALQDAGAR
360 370 380 390 400
VTGYDPEGME NARKLIEGLD CARDPYEAAA EADALVIITE WNEFRALDFD
410 420 430
RLKSTMKTPL LVDLRNIYRK DEVAKHGFRY ASIGRPD
Length:437
Mass (Da):47,122
Last modified:May 30, 2000 - v2
Checksum:i2D458D39A1D8EEC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109A → S in CAA10918 (PubMed:9765575).Curated1
Sequence conflicti142A → V in CAA10918 (PubMed:9765575).Curated1
Sequence conflicti318I → Y in CAA10918 (PubMed:9765575).Curated1
Sequence conflicti335S → T in CAA10918 (PubMed:9765575).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ222661 Genomic DNA Translation: CAA10918.1
AL591688 Genomic DNA Translation: CAC45661.1
PIRiT46573
RefSeqiNP_385188.1, NC_003047.1
WP_010969031.1, NC_003047.1

Genome annotation databases

EnsemblBacteriaiCAC45661; CAC45661; SMc02641
GeneIDi1232726
KEGGisme:SMc02641
PATRICifig|266834.11.peg.2490

Similar proteinsi

Entry informationi

Entry nameiUDG_RHIME
AccessioniPrimary (citable) accession number: O54068
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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