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Protein

Nitrogen regulatory protein P-II

Gene

glnB

Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNitrogen fixation, Transcription, Transcription regulation
LigandNucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrogen regulatory protein P-II
Gene namesi
Name:glnB
Synonyms:glnK
Ordered Locus Names:RHE_CH03974
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000001936 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001397821 – 112Nitrogen regulatory protein P-IIAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51O-UMP-tyrosinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi347834.RHE_CH03974

Structurei

3D structure databases

ProteinModelPortaliO54053
SMRiO54053
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P(II) protein family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108YZA Bacteria
COG0347 LUCA
HOGENOMiHOG000017847
KOiK04752
OMAiAIIRMER

Family and domain databases

Gene3Di3.30.70.120, 1 hit
InterProiView protein in InterPro
IPR002187 N-reg_PII
IPR011322 N-reg_PII-like_a/b
IPR015867 N-reg_PII/ATP_PRibTrfase_C
IPR017918 N-reg_PII_CS
PANTHERiPTHR30115 PTHR30115, 1 hit
PfamiView protein in Pfam
PF00543 P-II, 1 hit
PIRSFiPIRSF039144 GlnB, 1 hit
PRINTSiPR00340 PIIGLNB
SMARTiView protein in SMART
SM00938 P-II, 1 hit
SUPFAMiSSF54913 SSF54913, 1 hit
PROSITEiView protein in PROSITE
PS00638 PII_GLNB_CTER, 1 hit
PS51343 PII_GLNB_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

O54053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVMAIIKP FKLDEVREAL TAIGIQGLTV TEVKGYGRQK GHTEIYRGTE
60 70 80 90 100
YAVSFLPKLK IEIAVASELV DRAVEAIAAS AKTGQIGDGK IFVYSIDHAV
110
RIRTGETDSE AL
Length:112
Mass (Da):12,178
Last modified:September 21, 2011 - v3
Checksum:iDFAE526476C82DA3
GO

Sequence cautioni

The sequence CAA05496 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50E → V in CAA05496 (PubMed:9487694).Curated1
Sequence conflicti78A → G in CAA05496 (PubMed:9487694).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002489 Genomic DNA Translation: CAA05496.1 Different initiation.
CP000133 Genomic DNA Translation: ABC92719.1
RefSeqiWP_007632398.1, NC_007761.1

Genome annotation databases

EnsemblBacteriaiABC92719; ABC92719; RHE_CH03974
GeneIDi34191187
KEGGiret:RHE_CH03974

Similar proteinsi

Entry informationi

Entry nameiGLNB_RHIEC
AccessioniPrimary (citable) accession number: O54053
Secondary accession number(s): Q2K367
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 93 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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