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Protein
Submitted name:

Xanthine dehydrogenase

Gene

xdhA

Organism
Rhodobacter capsulatus (Rhodopseudomonas capsulata)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Iron-sulfur (2Fe-2S) 1; via amide nitrogenCombined sources1
Metal bindingi39Iron-sulfur (2Fe-2S) 1Combined sources1
Metal bindingi40Iron-sulfur (2Fe-2S) 1; via amide nitrogenCombined sources1
Metal bindingi42Iron-sulfur (2Fe-2S) 1Combined sources1
Metal bindingi44Iron-sulfur (2Fe-2S) 1Combined sources1
Metal bindingi45Iron-sulfur (2Fe-2S) 1; via amide nitrogenCombined sources1
Metal bindingi47Iron-sulfur (2Fe-2S) 1Combined sources1
Metal bindingi63Iron-sulfur (2Fe-2S) 1Combined sources1
Metal bindingi102Iron-sulfur (2Fe-2S) 2; via amide nitrogenCombined sources1
Binding sitei102MolybdopterinCombined sources1
Metal bindingi103Iron-sulfur (2Fe-2S) 2Combined sources1
Metal bindingi106Iron-sulfur (2Fe-2S) 2Combined sources1
Metal bindingi134Iron-sulfur (2Fe-2S) 2Combined sources1
Metal bindingi136Iron-sulfur (2Fe-2S) 2Combined sources1
Binding sitei136MolybdopterinCombined sources1
Binding sitei293FADCombined sources1
Binding sitei330FADCombined sources1
Binding sitei336FAD; via amide nitrogen and carbonyl oxygenCombined sources1
Binding sitei352FADCombined sources1
Binding sitei360FAD; via carbonyl oxygenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi201 – 208FADCombined sources8
Nucleotide bindingi270 – 271FADCombined sources2
Nucleotide bindingi280 – 287FADCombined sources8

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseImported
Ligand2Fe-2SCombined sources, FADCombined sources, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDAi1.17.1.4. 5381.
SABIO-RKiO54050.

Names & Taxonomyi

Protein namesi
Submitted name:
Xanthine dehydrogenaseImported (EC:1.1.1.204Imported)
Gene namesi
Name:xdhAImported
OrganismiRhodobacter capsulatus (Rhodopseudomonas capsulata)Imported
Taxonomic identifieri1061 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3313837.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi103 ↔ 136Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JROX-ray2.70A/C/E/G1-462[»]
1JRPX-ray3.00A/C/E/G1-462[»]
2W3RX-ray2.90A/C/E/G1-462[»]
2W3SX-ray2.60A/C/E/G1-462[»]
2W54X-ray3.30A/C/E/G1-462[»]
2W55X-ray3.40A/C/E/G1-462[»]
ProteinModelPortaliO54050.
SMRiO54050.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO54050.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 812Fe-2S ferredoxin-typeInterPro annotationAdd BLAST81
Domaini173 – 346FAD-binding PCMH-typeInterPro annotationAdd BLAST174

Phylogenomic databases

eggNOGiENOG4105DCJ. Bacteria.
COG4630. LUCA.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiView protein in InterPro
IPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
IPR012175. Xanth_DH_ssu_bac.
IPR014307. Xanthine_DH_ssu.
PfamiView protein in Pfam
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
PIRSFiPIRSF036557. XdhA_RC. 1 hit.
SMARTiView protein in SMART
SM01092. CO_deh_flav_C. 1 hit.
SUPFAMiSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR02963. xanthine_xdhA. 1 hit.
PROSITEiView protein in PROSITE
PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.

Sequencei

Sequence statusi: Complete.

O54050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIAFLLNGE TRRVRIEDPT QSLLELLRAE GLTGTKEGCN EGDCGACTVM
60 70 80 90 100
IRDAAGSRAV NACLMMLPQI AGKALRTIEG IAAPDGRLHP VQQAMIDHHG
110 120 130 140 150
SQCGFCTPGF IVSMAAAHDR DRKDYDDLLA GNLCRCTGYA PILRAAEAAA
160 170 180 190 200
GEPPADWLQA DAAFTLAQLS SGVRGQTAPA FLPETSDALA DWYLAHPEAT
210 220 230 240 250
LIAGGTDVSL WVTKALRDLP EVAFLSHCKD LAQIRETPDG YGIGAGVTIA
260 270 280 290 300
ALRAFAEGPH PALAGLLRRF ASEQVRQVAT IGGNIANGSP IGDGPPALIA
310 320 330 340 350
MGASLTLRRG QERRRMPLED FFLEYRKQDR RPGEFVESVT LPKSAPGLRC
360 370 380 390 400
YKLSKRFDQD ISAVCGCLNL TLKGSKIETA RIAFGGMAGV PKRAAAFEAA
410 420 430 440 450
LIGQDFREDT IAAALPLLAQ DFTPLSDMRA SAAYRMNAAQ AMALRYVREL
460
SGEAVAVLEV MP
Length:462
Mass (Da):49,293
Last modified:June 1, 1998 - v1
Checksum:iC98DC831531377E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001013 Genomic DNA. Translation: CAA04469.1.

Similar proteinsi

Entry informationi

Entry nameiO54050_RHOCA
AccessioniPrimary (citable) accession number: O54050
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: August 30, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources