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O54050 (O54050_RHOCA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
EC=1.1.1.204 EMBL CAA04469.1
Gene names
Name:xdhA EMBL CAA04469.1
OrganismRhodobacter capsulatus (Rhodopseudomonas capsulata) EMBL CAA04469.1
Taxonomic identifier1061 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 2Fe-2S ferredoxin-type domain. RuleBase RU000392

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding201 – 2088FAD PDB 1JRP PDB 2W3R PDB 1JRO PDB 2W3S PDB 2W54 PDB 2W55
Nucleotide binding270 – 2712FAD PDB 1JRP PDB 2W3R PDB 1JRO PDB 2W3S PDB 2W54 PDB 2W55
Nucleotide binding280 – 2878FAD PDB 1JRP PDB 2W3R PDB 1JRO PDB 2W3S PDB 2W54 PDB 2W55

Sites

Metal binding381Iron-sulfur (2Fe-2S) 1; via amide nitrogen
Metal binding391Iron-sulfur (2Fe-2S) 1
Metal binding401Iron-sulfur (2Fe-2S) 1; via amide nitrogen PDB 2W3S PDB 2W54 PDB 2W55
Metal binding441Iron-sulfur (2Fe-2S) 1 PDB 1JRP PDB 2W3R PDB 1JRO PDB 2W3S PDB 2W54 PDB 2W55
Metal binding451Iron-sulfur (2Fe-2S) 1; via amide nitrogen PDB 2W55
Metal binding471Iron-sulfur (2Fe-2S) 1 PDB 1JRP PDB 2W3R PDB 1JRO PDB 2W3S PDB 2W54 PDB 2W55
Metal binding631Iron-sulfur (2Fe-2S) 1 PDB 1JRP PDB 2W3R PDB 1JRO PDB 2W3S PDB 2W54 PDB 2W55
Metal binding1031Iron-sulfur (2Fe-2S) 2 PDB 1JRP PDB 2W3R PDB 1JRO PDB 2W3S PDB 2W54 PDB 2W55
Metal binding1061Iron-sulfur (2Fe-2S) 2 PDB 1JRP PDB 2W3R PDB 1JRO PDB 2W3S PDB 2W54 PDB 2W55
Metal binding1341Iron-sulfur (2Fe-2S) 2 PDB 1JRP PDB 2W3R PDB 1JRO PDB 2W3S PDB 2W54 PDB 2W55
Metal binding1361Iron-sulfur (2Fe-2S) 2 PDB 1JRP PDB 2W3R PDB 1JRO PDB 2W3S PDB 2W54 PDB 2W55
Binding site2931FAD PDB 1JRP PDB 2W3R PDB 1JRO PDB 2W3S PDB 2W54 PDB 2W55
Binding site3301FAD PDB 2W3S PDB 2W54 PDB 2W55
Binding site3361FAD; via amide nitrogen and carbonyl oxygen PDB 1JRP PDB 2W3R PDB 1JRO PDB 2W3S PDB 2W54 PDB 2W55
Binding site3521FAD

Sequences

Sequence LengthMass (Da)Tools
O54050 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: C98DC831531377E9

FASTA46249,293
        10         20         30         40         50         60 
MEIAFLLNGE TRRVRIEDPT QSLLELLRAE GLTGTKEGCN EGDCGACTVM IRDAAGSRAV 

        70         80         90        100        110        120 
NACLMMLPQI AGKALRTIEG IAAPDGRLHP VQQAMIDHHG SQCGFCTPGF IVSMAAAHDR 

       130        140        150        160        170        180 
DRKDYDDLLA GNLCRCTGYA PILRAAEAAA GEPPADWLQA DAAFTLAQLS SGVRGQTAPA 

       190        200        210        220        230        240 
FLPETSDALA DWYLAHPEAT LIAGGTDVSL WVTKALRDLP EVAFLSHCKD LAQIRETPDG 

       250        260        270        280        290        300 
YGIGAGVTIA ALRAFAEGPH PALAGLLRRF ASEQVRQVAT IGGNIANGSP IGDGPPALIA 

       310        320        330        340        350        360 
MGASLTLRRG QERRRMPLED FFLEYRKQDR RPGEFVESVT LPKSAPGLRC YKLSKRFDQD 

       370        380        390        400        410        420 
ISAVCGCLNL TLKGSKIETA RIAFGGMAGV PKRAAAFEAA LIGQDFREDT IAAALPLLAQ 

       430        440        450        460 
DFTPLSDMRA SAAYRMNAAQ AMALRYVREL SGEAVAVLEV MP 

« Hide

References

[1]"Xanthine dehydrogenase from the phototrophic purple bacterium Rhodobacter capsulatus is more similar to its eukaryotic counterparts than to prokaryotic molybdenum enzymes."
Leimkuhler S., Kern M., Solomon P., McEwan A., Schwarz G., Mendal R.R., Klipp W.
Mol. Microbiol. 27:853-869(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: B10 EMBL CAA04469.1.
[2]Leimkuhler S.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: B10 EMBL CAA04469.1.
[3]"Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus."
Truglio J.J., Theis K., Leimkuhler S., Rappa R., Rajagopalan K.V., Kisker C.
Structure 10:115-125(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) IN COMPLEX WITH FAD AND IRON-SULFUR (2FE-2S).
[4]"Mechanism of Substrate and Inhibitor Binding of Rhodobacter capsulatus Xanthine Dehydrogenase."
Dietzel U., Kuper J., Doebbler J.A., Schulte A., Truglio J.J., Leimkuhler S., Kisker C.
J. Biol. Chem. 284:8768-8776(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH FAD AND IRON-SULFUR (2FE-2S).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ001013 Genomic DNA. Translation: CAA04469.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JROX-ray2.70A/C/E/G1-462[»]
1JRPX-ray3.00A/C/E/G1-462[»]
2W3RX-ray2.90A/C/E/G1-462[»]
2W3SX-ray2.60A/C/E/G1-462[»]
2W54X-ray3.30A/C/E/G1-462[»]
2W55X-ray3.40A/C/E/G1-462[»]
ProteinModelPortalO54050.
SMRO54050. Positions 1-462.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKO54050.

Family and domain databases

Gene3D1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProIPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
IPR012175. Xanth_DH_ssu_bac.
IPR014307. Xanthine_DH_ssu.
[Graphical view]
PfamPF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
PIRSFPIRSF036557. XdhA_RC. 1 hit.
SMARTSM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsTIGR02963. xanthine_xdhA. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO54050.

Entry information

Entry nameO54050_RHOCA
AccessionPrimary (citable) accession number: O54050
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)