Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Xanthine dehydrogenase

Gene

xdhA

Organism
Rhodobacter capsulatus (Rhodopseudomonas capsulata)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Iron-sulfur (2Fe-2S) 1; via amide nitrogenCombined sources
Metal bindingi39 – 391Iron-sulfur (2Fe-2S) 1Combined sources
Metal bindingi40 – 401Iron-sulfur (2Fe-2S) 1; via amide nitrogenCombined sources
Metal bindingi44 – 441Iron-sulfur (2Fe-2S) 1Combined sources
Metal bindingi45 – 451Iron-sulfur (2Fe-2S) 1; via amide nitrogenCombined sources
Metal bindingi47 – 471Iron-sulfur (2Fe-2S) 1Combined sources
Metal bindingi63 – 631Iron-sulfur (2Fe-2S) 1Combined sources
Binding sitei102 – 1021MolybdopterinCombined sources
Metal bindingi103 – 1031Iron-sulfur (2Fe-2S) 2Combined sources
Metal bindingi106 – 1061Iron-sulfur (2Fe-2S) 2Combined sources
Metal bindingi134 – 1341Iron-sulfur (2Fe-2S) 2Combined sources
Metal bindingi136 – 1361Iron-sulfur (2Fe-2S) 2Combined sources
Binding sitei136 – 1361MolybdopterinCombined sources
Binding sitei293 – 2931FADCombined sources
Binding sitei330 – 3301FADCombined sources
Binding sitei336 – 3361FAD; via amide nitrogen and carbonyl oxygenCombined sources
Binding sitei352 – 3521FADCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2088FADCombined sources
Nucleotide bindingi270 – 2712FADCombined sources
Nucleotide bindingi280 – 2878FADCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

2Fe-2SUniRule annotationCombined sources, FADCombined sources, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDAi1.17.1.4. 5381.
SABIO-RKO54050.

Names & Taxonomyi

Protein namesi
Submitted name:
Xanthine dehydrogenaseImported (EC:1.1.1.204Imported)
Gene namesi
Name:xdhAImported
OrganismiRhodobacter capsulatus (Rhodopseudomonas capsulata)Imported
Taxonomic identifieri1061 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3313837.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi103 ↔ 136Combined sources

Interactioni

Protein-protein interaction databases

STRINGi272942.RCAP_rcc00792.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JROX-ray2.70A/C/E/G1-462[»]
1JRPX-ray3.00A/C/E/G1-462[»]
2W3RX-ray2.90A/C/E/G1-462[»]
2W3SX-ray2.60A/C/E/G1-462[»]
2W54X-ray3.30A/C/E/G1-462[»]
2W55X-ray3.40A/C/E/G1-462[»]
ProteinModelPortaliO54050.
SMRiO54050. Positions 1-462.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO54050.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 81812Fe-2S ferredoxin-typeInterPro annotationAdd
BLAST
Domaini173 – 346174FAD-binding PCMH-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DCJ. Bacteria.
COG4630. LUCA.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
IPR012175. Xanth_DH_ssu_bac.
IPR014307. Xanthine_DH_ssu.
[Graphical view]
PfamiPF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
PIRSFiPIRSF036557. XdhA_RC. 1 hit.
SMARTiSM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR02963. xanthine_xdhA. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIAFLLNGE TRRVRIEDPT QSLLELLRAE GLTGTKEGCN EGDCGACTVM
60 70 80 90 100
IRDAAGSRAV NACLMMLPQI AGKALRTIEG IAAPDGRLHP VQQAMIDHHG
110 120 130 140 150
SQCGFCTPGF IVSMAAAHDR DRKDYDDLLA GNLCRCTGYA PILRAAEAAA
160 170 180 190 200
GEPPADWLQA DAAFTLAQLS SGVRGQTAPA FLPETSDALA DWYLAHPEAT
210 220 230 240 250
LIAGGTDVSL WVTKALRDLP EVAFLSHCKD LAQIRETPDG YGIGAGVTIA
260 270 280 290 300
ALRAFAEGPH PALAGLLRRF ASEQVRQVAT IGGNIANGSP IGDGPPALIA
310 320 330 340 350
MGASLTLRRG QERRRMPLED FFLEYRKQDR RPGEFVESVT LPKSAPGLRC
360 370 380 390 400
YKLSKRFDQD ISAVCGCLNL TLKGSKIETA RIAFGGMAGV PKRAAAFEAA
410 420 430 440 450
LIGQDFREDT IAAALPLLAQ DFTPLSDMRA SAAYRMNAAQ AMALRYVREL
460
SGEAVAVLEV MP
Length:462
Mass (Da):49,293
Last modified:June 1, 1998 - v1
Checksum:iC98DC831531377E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001013 Genomic DNA. Translation: CAA04469.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001013 Genomic DNA. Translation: CAA04469.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JROX-ray2.70A/C/E/G1-462[»]
1JRPX-ray3.00A/C/E/G1-462[»]
2W3RX-ray2.90A/C/E/G1-462[»]
2W3SX-ray2.60A/C/E/G1-462[»]
2W54X-ray3.30A/C/E/G1-462[»]
2W55X-ray3.40A/C/E/G1-462[»]
ProteinModelPortaliO54050.
SMRiO54050. Positions 1-462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272942.RCAP_rcc00792.

Chemistry

ChEMBLiCHEMBL3313837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105DCJ. Bacteria.
COG4630. LUCA.

Enzyme and pathway databases

BRENDAi1.17.1.4. 5381.
SABIO-RKO54050.

Miscellaneous databases

EvolutionaryTraceiO54050.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
IPR012175. Xanth_DH_ssu_bac.
IPR014307. Xanthine_DH_ssu.
[Graphical view]
PfamiPF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
PIRSFiPIRSF036557. XdhA_RC. 1 hit.
SMARTiSM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR02963. xanthine_xdhA. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO54050_RHOCA
AccessioniPrimary (citable) accession number: O54050
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.