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O54050

- O54050_RHOCA

UniProt

O54050 - O54050_RHOCA

Protein
Submitted name:

Xanthine dehydrogenase

Gene

xdhA

Organism
Rhodobacter capsulatus (Rhodopseudomonas capsulata)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi38 – 381Iron-sulfur (2Fe-2S) 1; via amide nitrogen
    Metal bindingi38 – 381Iron-sulfur(2Fe-2S) 1; via amide nitrogenImported
    Metal bindingi39 – 391Iron-sulfur (2Fe-2S) 1
    Metal bindingi39 – 391Iron-sulfur(2Fe-2S) 1Imported
    Metal bindingi40 – 401Iron-sulfur(2Fe-2S) 1; via amide nitrogenImported
    Metal bindingi44 – 441Iron-sulfur(2Fe-2S) 1Imported
    Metal bindingi45 – 451Iron-sulfur(2Fe-2S) 1; via amide nitrogenImported
    Metal bindingi47 – 471Iron-sulfur(2Fe-2S) 1Imported
    Metal bindingi63 – 631Iron-sulfur(2Fe-2S) 1Imported
    Metal bindingi103 – 1031Iron-sulfur(2Fe-2S) 2Imported
    Metal bindingi106 – 1061Iron-sulfur(2Fe-2S) 2Imported
    Metal bindingi134 – 1341Iron-sulfur(2Fe-2S) 2Imported
    Metal bindingi136 – 1361Iron-sulfur(2Fe-2S) 2Imported
    Binding sitei293 – 2931FADImported
    Binding sitei330 – 3301FADImported
    Binding sitei336 – 3361FAD; via amide nitrogen and carbonyl oxygenImported
    Binding sitei352 – 3521FADImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi201 – 2088FADImported
    Nucleotide bindingi270 – 2712FADImported
    Nucleotide bindingi280 – 2878FADImported

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. electron carrier activity Source: InterPro
    3. flavin adenine dinucleotide binding Source: InterPro
    4. metal ion binding Source: UniProtKB-KW
    5. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
    6. xanthine dehydrogenase activity Source: InterPro
    7. xanthine oxidase activity Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    2Fe-2SUniRule annotation, FADImported, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Nucleotide-bindingImported

    Enzyme and pathway databases

    SABIO-RKO54050.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Xanthine dehydrogenaseImported (EC:1.1.1.204Imported)
    Gene namesi
    Name:xdhAImported
    OrganismiRhodobacter capsulatus (Rhodopseudomonas capsulata)Imported
    Taxonomic identifieri1061 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JROX-ray2.70A/C/E/G1-462[»]
    1JRPX-ray3.00A/C/E/G1-462[»]
    2W3RX-ray2.90A/C/E/G1-462[»]
    2W3SX-ray2.60A/C/E/G1-462[»]
    2W54X-ray3.30A/C/E/G1-462[»]
    2W55X-ray3.40A/C/E/G1-462[»]
    ProteinModelPortaliO54050.
    SMRiO54050. Positions 1-462.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO54050.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.UniRule annotation

    Family and domain databases

    Gene3Di1.10.150.120. 1 hit.
    3.10.20.30. 1 hit.
    3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    InterProiIPR002888. 2Fe-2S-bd.
    IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR012675. Beta-grasp_dom.
    IPR005107. CO_DH_flav_C.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR002346. Mopterin_DH_FAD-bd.
    IPR012175. Xanth_DH_ssu_bac.
    IPR014307. Xanthine_DH_ssu.
    [Graphical view]
    PfamiPF03450. CO_deh_flav_C. 1 hit.
    PF00941. FAD_binding_5. 1 hit.
    PF00111. Fer2. 1 hit.
    PF01799. Fer2_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036557. XdhA_RC. 1 hit.
    SMARTiSM01092. CO_deh_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47741. SSF47741. 1 hit.
    SSF54292. SSF54292. 1 hit.
    SSF55447. SSF55447. 1 hit.
    SSF56176. SSF56176. 1 hit.
    TIGRFAMsiTIGR02963. xanthine_xdhA. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS51387. FAD_PCMH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54050-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIAFLLNGE TRRVRIEDPT QSLLELLRAE GLTGTKEGCN EGDCGACTVM    50
    IRDAAGSRAV NACLMMLPQI AGKALRTIEG IAAPDGRLHP VQQAMIDHHG 100
    SQCGFCTPGF IVSMAAAHDR DRKDYDDLLA GNLCRCTGYA PILRAAEAAA 150
    GEPPADWLQA DAAFTLAQLS SGVRGQTAPA FLPETSDALA DWYLAHPEAT 200
    LIAGGTDVSL WVTKALRDLP EVAFLSHCKD LAQIRETPDG YGIGAGVTIA 250
    ALRAFAEGPH PALAGLLRRF ASEQVRQVAT IGGNIANGSP IGDGPPALIA 300
    MGASLTLRRG QERRRMPLED FFLEYRKQDR RPGEFVESVT LPKSAPGLRC 350
    YKLSKRFDQD ISAVCGCLNL TLKGSKIETA RIAFGGMAGV PKRAAAFEAA 400
    LIGQDFREDT IAAALPLLAQ DFTPLSDMRA SAAYRMNAAQ AMALRYVREL 450
    SGEAVAVLEV MP 462
    Length:462
    Mass (Da):49,293
    Last modified:June 1, 1998 - v1
    Checksum:iC98DC831531377E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001013 Genomic DNA. Translation: CAA04469.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001013 Genomic DNA. Translation: CAA04469.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JRO X-ray 2.70 A/C/E/G 1-462 [» ]
    1JRP X-ray 3.00 A/C/E/G 1-462 [» ]
    2W3R X-ray 2.90 A/C/E/G 1-462 [» ]
    2W3S X-ray 2.60 A/C/E/G 1-462 [» ]
    2W54 X-ray 3.30 A/C/E/G 1-462 [» ]
    2W55 X-ray 3.40 A/C/E/G 1-462 [» ]
    ProteinModelPortali O54050.
    SMRi O54050. Positions 1-462.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK O54050.

    Miscellaneous databases

    EvolutionaryTracei O54050.

    Family and domain databases

    Gene3Di 1.10.150.120. 1 hit.
    3.10.20.30. 1 hit.
    3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    InterProi IPR002888. 2Fe-2S-bd.
    IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR012675. Beta-grasp_dom.
    IPR005107. CO_DH_flav_C.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR002346. Mopterin_DH_FAD-bd.
    IPR012175. Xanth_DH_ssu_bac.
    IPR014307. Xanthine_DH_ssu.
    [Graphical view ]
    Pfami PF03450. CO_deh_flav_C. 1 hit.
    PF00941. FAD_binding_5. 1 hit.
    PF00111. Fer2. 1 hit.
    PF01799. Fer2_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036557. XdhA_RC. 1 hit.
    SMARTi SM01092. CO_deh_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47741. SSF47741. 1 hit.
    SSF54292. SSF54292. 1 hit.
    SSF55447. SSF55447. 1 hit.
    SSF56176. SSF56176. 1 hit.
    TIGRFAMsi TIGR02963. xanthine_xdhA. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS51387. FAD_PCMH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Xanthine dehydrogenase from the phototrophic purple bacterium Rhodobacter capsulatus is more similar to its eukaryotic counterparts than to prokaryotic molybdenum enzymes."
      Leimkuhler S., Kern M., Solomon P., McEwan A., Schwarz G., Mendal R.R., Klipp W.
      Mol. Microbiol. 27:853-869(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B10Imported.
    2. Leimkuhler S.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B10Imported.
    3. "Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus."
      Truglio J.J., Theis K., Leimkuhler S., Rappa R., Rajagopalan K.V., Kisker C.
      Structure 10:115-125(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) IN COMPLEX WITH FAD AND IRON-SULFUR(2FE-2S).
    4. "Mechanism of Substrate and Inhibitor Binding of Rhodobacter capsulatus Xanthine Dehydrogenase."
      Dietzel U., Kuper J., Doebbler J.A., Schulte A., Truglio J.J., Leimkuhler S., Kisker C.
      J. Biol. Chem. 284:8768-8776(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH FAD AND IRON-SULFUR(2FE-2S).

    Entry informationi

    Entry nameiO54050_RHOCA
    AccessioniPrimary (citable) accession number: O54050
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3