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Protein

Mycosin-5

Gene

mycP5

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei109Charge relay systemBy similarity1
Active sitei141Charge relay systemBy similarity1
Active sitei466Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5991-MONOMER.

Protein family/group databases

TCDBi3.A.24.4.1. type vii or esx protein secretion system (t7ss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mycosin-51 Publication (EC:3.4.21.-By similarity)
Alternative name(s):
MycP5 proteaseCurated
Gene namesi
Name:mycP51 Publication
Ordered Locus Names:Rv1796Imported
ORF Names:LH57_09820Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1796.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei552 – 572HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_500769696340 – 585Mycosin-5Add BLAST546

Proteomic databases

PRIDEiO53945.

Expressioni

Inductioni

Constitutively expressed during growth in culture.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1796.

Structurei

3D structure databases

ProteinModelPortaliO53945.
SMRiO53945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 513Peptidase S8Sequence analysisAdd BLAST246

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi159 – 266Pro-richPROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated
Contains 1 peptidase S8 domain.Sequence analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1404. LUCA.
HOGENOMiHOG000043842.
KOiK14743.
OMAiNSYCTEV.
OrthoDBiEOG6Z6FPQ.
PhylomeDBiO53945.

Family and domain databases

Gene3Di3.40.50.200. 2 hits.
InterProiIPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR023834. T7SS_pept_S8A_mycosin.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 4 hits.
PfamiPF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 2 hits.
TIGRFAMsiTIGR03921. T7SS_mycosin. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O53945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRFGTGSSR SWCGRAGTAT IAAVLLASGA LTGLPPAYAI SPPTIDPGAL
60 70 80 90 100
PPDGPPGPLA PMKQNAYCTE VGVLPGTDFQ LQPKYMEMLN LNEAWQFGRG
110 120 130 140 150
DGVKVAVIDT GVTPHPRLPR LIPGGDYVMA GGDGLSDCDA HGTLVASMIA
160 170 180 190 200
AVPANGAVPL PSVPRRPVTI PTTETPPPPQ TVTLSPVPPQ TVTVIPAPPP
210 220 230 240 250
EEGVPPGAPV PGPEPPPAPG PQPPAVDRGG GTVTVPSYSG GRKIAPIDNP
260 270 280 290 300
RNPHPSAPSP ALGPPPDAFS GIAPGVEIIS IRQSSQAFGL KDPYTGDEDP
310 320 330 340 350
QTAQKIDNVE TMARAIVHAA NMGASVINIS DVMCMSARNV IDQRALGAAV
360 370 380 390 400
HYAAVDKDAV IVAAAGDGSK KDCKQNPIFD PLQPDDPRAW NAVTTVVTPS
410 420 430 440 450
WFHDYVLTVG AVDANGQPLS KMSIAGPWVS ISAPGTDVVG LSPRDDGLIN
460 470 480 490 500
AIDGPDNSLL VPAGTSFSAA IVSGVAALVR AKFPELSAYQ IINRLIHTAR
510 520 530 540 550
PPARGVDNQV GYGVVDPVAA LTWDVPKGPA EPPKQLSAPL VVPQPPAPRD
560 570 580
MVPIWVAAGG LAGALLIGGA VFGTATLMRR SRKQQ
Length:585
Mass (Da):60,028
Last modified:June 1, 1998 - v1
Checksum:i854975AC9B5BC4F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14545.1.
AL123456 Genomic DNA. Translation: CCP44562.1.
RefSeqiNP_216312.1. NC_000962.3.
WP_003408854.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR14545; AIR14545; LH57_09820.
CCP44562; CCP44562; Rv1796.
GeneIDi885879.
KEGGimtu:Rv1796.
mtv:RVBD_1796.
PATRICi18125829. VBIMycTub22151_2027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14545.1.
AL123456 Genomic DNA. Translation: CCP44562.1.
RefSeqiNP_216312.1. NC_000962.3.
WP_003408854.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliO53945.
SMRiO53945.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1796.

Protein family/group databases

TCDBi3.A.24.4.1. type vii or esx protein secretion system (t7ss) family.

Proteomic databases

PRIDEiO53945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR14545; AIR14545; LH57_09820.
CCP44562; CCP44562; Rv1796.
GeneIDi885879.
KEGGimtu:Rv1796.
mtv:RVBD_1796.
PATRICi18125829. VBIMycTub22151_2027.

Organism-specific databases

TubercuListiRv1796.

Phylogenomic databases

eggNOGiCOG1404. LUCA.
HOGENOMiHOG000043842.
KOiK14743.
OMAiNSYCTEV.
OrthoDBiEOG6Z6FPQ.
PhylomeDBiO53945.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5991-MONOMER.

Family and domain databases

Gene3Di3.40.50.200. 2 hits.
InterProiIPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR023834. T7SS_pept_S8A_mycosin.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 4 hits.
PfamiPF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 2 hits.
TIGRFAMsiTIGR03921. T7SS_mycosin. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYCP5_MYCTU
AccessioniPrimary (citable) accession number: O53945
Secondary accession number(s): F2GIW7, I6YBM3, Q7D7Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2016
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.