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Protein
Submitted name:

Peptidase S8

Gene

mycP5

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, ProteaseImported

Protein family/group databases

TCDBi3.A.24.4.1. type vii or esx protein secretion system (t7ss) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Peptidase S8Imported
Submitted name:
Probable proline rich membrane-anchored mycosin MycP5 (Serine protease) (Subtilisin-like protease) (Subtilase-like) (Mycosin-5)Imported
Gene namesi
Name:mycP5Imported
Ordered Locus Names:Rv1796Imported
ORF Names:LH57_09820Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1796.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei554 – 57825HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence analysisAdd
BLAST
Chaini40 – 585546Sequence analysisPRO_5006963581Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1796.

Structurei

3D structure databases

SMRiO53945. Positions 40-151, 264-524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini268 – 513246Peptidase S8InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiCOG1404. LUCA.
HOGENOMiHOG000043842.
KOiK14743.
OMAiNSYCTEV.
OrthoDBiEOG6Z6FPQ.
PhylomeDBiO53945.

Family and domain databases

Gene3Di3.40.50.200. 2 hits.
InterProiIPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR023834. T7SS_pept_S8A_mycosin-1.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 4 hits.
PfamiPF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 2 hits.
TIGRFAMsiTIGR03921. T7SS_mycosin. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRFGTGSSR SWCGRAGTAT IAAVLLASGA LTGLPPAYAI SPPTIDPGAL
60 70 80 90 100
PPDGPPGPLA PMKQNAYCTE VGVLPGTDFQ LQPKYMEMLN LNEAWQFGRG
110 120 130 140 150
DGVKVAVIDT GVTPHPRLPR LIPGGDYVMA GGDGLSDCDA HGTLVASMIA
160 170 180 190 200
AVPANGAVPL PSVPRRPVTI PTTETPPPPQ TVTLSPVPPQ TVTVIPAPPP
210 220 230 240 250
EEGVPPGAPV PGPEPPPAPG PQPPAVDRGG GTVTVPSYSG GRKIAPIDNP
260 270 280 290 300
RNPHPSAPSP ALGPPPDAFS GIAPGVEIIS IRQSSQAFGL KDPYTGDEDP
310 320 330 340 350
QTAQKIDNVE TMARAIVHAA NMGASVINIS DVMCMSARNV IDQRALGAAV
360 370 380 390 400
HYAAVDKDAV IVAAAGDGSK KDCKQNPIFD PLQPDDPRAW NAVTTVVTPS
410 420 430 440 450
WFHDYVLTVG AVDANGQPLS KMSIAGPWVS ISAPGTDVVG LSPRDDGLIN
460 470 480 490 500
AIDGPDNSLL VPAGTSFSAA IVSGVAALVR AKFPELSAYQ IINRLIHTAR
510 520 530 540 550
PPARGVDNQV GYGVVDPVAA LTWDVPKGPA EPPKQLSAPL VVPQPPAPRD
560 570 580
MVPIWVAAGG LAGALLIGGA VFGTATLMRR SRKQQ
Length:585
Mass (Da):60,028
Last modified:June 1, 1998 - v1
Checksum:i854975AC9B5BC4F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14545.1.
AL123456 Genomic DNA. Translation: CCP44562.1.
RefSeqiNP_216312.1. NC_000962.3.
WP_003408854.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR14545; AIR14545; LH57_09820.
CCP44562; CCP44562; Rv1796.
GeneIDi885879.
KEGGimtu:Rv1796.
mtv:RVBD_1796.
PATRICi18125829. VBIMycTub22151_2027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14545.1.
AL123456 Genomic DNA. Translation: CCP44562.1.
RefSeqiNP_216312.1. NC_000962.3.
WP_003408854.1. NZ_KK339370.1.

3D structure databases

SMRiO53945. Positions 40-151, 264-524.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1796.

Protein family/group databases

TCDBi3.A.24.4.1. type vii or esx protein secretion system (t7ss) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR14545; AIR14545; LH57_09820.
CCP44562; CCP44562; Rv1796.
GeneIDi885879.
KEGGimtu:Rv1796.
mtv:RVBD_1796.
PATRICi18125829. VBIMycTub22151_2027.

Organism-specific databases

TubercuListiRv1796.

Phylogenomic databases

eggNOGiCOG1404. LUCA.
HOGENOMiHOG000043842.
KOiK14743.
OMAiNSYCTEV.
OrthoDBiEOG6Z6FPQ.
PhylomeDBiO53945.

Family and domain databases

Gene3Di3.40.50.200. 2 hits.
InterProiIPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR023834. T7SS_pept_S8A_mycosin-1.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 4 hits.
PfamiPF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 2 hits.
TIGRFAMsiTIGR03921. T7SS_mycosin. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported and H37RvImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported and H37RvImported.

Entry informationi

Entry nameiO53945_MYCTU
AccessioniPrimary (citable) accession number: O53945
Secondary accession number(s): F2GIW7, I6YBM3, Q7D7Y3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.