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Protein
Submitted name:

Thiol:disulfide interchange protein, putative

Gene

MT1716

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • antioxidant activity Source: InterPro
  • thiol oxidase activity Source: MTBBASE

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • oxidation-reduction process Source: MTBBASE
Complete GO annotation...

Enzyme and pathway databases

BioCyciMTBRV:RV1677-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Thiol:disulfide interchange protein, putativeImported
Gene namesi
Ordered Locus Names:MT1716Imported
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)Imported
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 182151Sequence analysisPRO_5004158962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 86Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZZOX-ray1.60A47-182[»]
3IOSX-ray1.60A47-182[»]
ProteinModelPortaliO53924.
SMRiO53924. Positions 47-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 181140ThioredoxinInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000047189.
OrthoDBiEOG6QG8RK.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00578. AhpC-TSA. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHSRLIGAL TVVAIIVTAC GSQPKSQPAV APTGDAAAAT QVPAGQTVPA
60 70 80 90 100
QLQFSAKTLD GHDFHGESLL GKPAVLWFWA PWCPTCQGEA PVVGQVAASH
110 120 130 140 150
PEVTFVGVAG LDQVPAMQEF VNKYPVKTFT QLADTDGSVW ANFGVTQQPA
160 170 180
YAFVDPHGNV DVVRGRMSQD ELTRRVTALT SR
Length:182
Mass (Da):19,238
Last modified:June 1, 1998 - v1
Checksum:i22BBCE3832C0DCFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK45984.1.
PIRiH70818.
RefSeqiWP_003408271.1. NZ_KK341227.1.

Genome annotation databases

EnsemblBacteriaiAAK45984; AAK45984; MT1716.
KEGGimtc:MT1716.
PATRICi18125528. VBIMycTub22151_1878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK45984.1.
PIRiH70818.
RefSeqiWP_003408271.1. NZ_KK341227.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZZOX-ray1.60A47-182[»]
3IOSX-ray1.60A47-182[»]
ProteinModelPortaliO53924.
SMRiO53924. Positions 47-180.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK45984; AAK45984; MT1716.
KEGGimtc:MT1716.
PATRICi18125528. VBIMycTub22151_1878.

Phylogenomic databases

HOGENOMiHOG000047189.
OrthoDBiEOG6QG8RK.

Enzyme and pathway databases

BioCyciMTBRV:RV1677-MONOMER.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00578. AhpC-TSA. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CDC 1551 / OshkoshImported.
  2. "Structure of Mtb DsbF in its oxidized form."
    Goulding C.W., Eisenberg D.S., Lekin T., Segelke B., Hung L.W., Yu M., Im S.
    Submitted (JUN-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 47-182.
  3. "An extracellular disulfide bond forming protein (DsbF) from Mycobacterium tuberculosis: structural, biochemical, and gene expression analysis."
    Chim N., Riley R., The J., Im S., Segelke B., Lekin T., Yu M., Hung L.W., Terwilliger T., Whitelegge J.P., Goulding C.W.
    J. Mol. Biol. 396:1211-1226(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 47-182, DISULFIDE BONDS.

Entry informationi

Entry nameiO53924_MYCTO
AccessioniPrimary (citable) accession number: O53924
Secondary accession number(s): F2GK59, Q7D862
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.