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Protein
Submitted name:

Peptidase S1

Gene

pepD

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: MTBBASE

GO - Biological processi

  • pathogenesis Source: MTBBASE
  • protein catabolic process Source: MTBBASE
  • proteolysis Source: MTBBASE
  • response to stress Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, ProteaseImported

Enzyme and pathway databases

BioCyciMTBRV:RV0983-MONOMER.

Protein family/group databases

MEROPSiS01.494.

Names & Taxonomyi

Protein namesi
Submitted name:
Peptidase S1Imported
Submitted name:
Probable serine protease PepD (Serine proteinase) (MTB32B)Imported
Gene namesi
Name:pepDImported
Ordered Locus Names:Rv0983Imported
ORF Names:LH57_05360Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei102 – 12625HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular region Source: MTBBASE
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0983.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y8TX-ray2.00A/B/C149-464[»]
2Z9IX-ray2.00A/B/C149-464[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini368 – 44982PDZ (DHR)InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105C0H. Bacteria.
COG0265. LUCA.
HOGENOMiHOG000223641.
KOiK08372.
OMAiRAIRTHK.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLARVVGL VQEEQPSDMT NHPRYSPPPQ QPGTPGYAQG QQQTYSQQFD
60 70 80 90 100
WRYPPSPPPQ PTQYRQPYEA LGGTRPGLIP GVIPTMTPPP GMVRQRPRAG
110 120 130 140 150
MLAIGAVTIA VVSAGIGGAA ASLVGFNRAP AGPSGGPVAA SAAPSIPAAN
160 170 180 190 200
MPPGSVEQVA AKVVPSVVML ETDLGRQSEE GSGIILSAEG LILTNNHVIA
210 220 230 240 250
AAAKPPLGSP PPKTTVTFSD GRTAPFTVVG ADPTSDIAVV RVQGVSGLTP
260 270 280 290 300
ISLGSSSDLR VGQPVLAIGS PLGLEGTVTT GIVSALNRPV STTGEAGNQN
310 320 330 340 350
TVLDAIQTDA AINPGNSGGA LVNMNAQLVG VNSAIATLGA DSADAQSGSI
360 370 380 390 400
GLGFAIPVDQ AKRIADELIS TGKASHASLG VQVTNDKDTL GAKIVEVVAG
410 420 430 440 450
GAAANAGVPK GVVVTKVDDR PINSADALVA AVRSKAPGAT VALTFQDPSG
460
GSRTVQVTLG KAEQ
Length:464
Mass (Da):46,453
Last modified:June 1, 1998 - v1
Checksum:iAE93BFCC53E1EC8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13718.1.
AL123456 Genomic DNA. Translation: CCP43733.1.
RefSeqiNP_215498.1. NC_000962.3.
WP_010886101.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR13718; AIR13718; LH57_05360.
CCP43733; CCP43733; Rv0983.
GeneIDi885382.
KEGGimtu:Rv0983.
mtv:RVBD_0983.
PATRICi18150710. VBIMycTub87468_1096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13718.1.
AL123456 Genomic DNA. Translation: CCP43733.1.
RefSeqiNP_215498.1. NC_000962.3.
WP_010886101.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y8TX-ray2.00A/B/C149-464[»]
2Z9IX-ray2.00A/B/C149-464[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0983.

Protein family/group databases

MEROPSiS01.494.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR13718; AIR13718; LH57_05360.
CCP43733; CCP43733; Rv0983.
GeneIDi885382.
KEGGimtu:Rv0983.
mtv:RVBD_0983.
PATRICi18150710. VBIMycTub87468_1096.

Phylogenomic databases

eggNOGiENOG4105C0H. Bacteria.
COG0265. LUCA.
HOGENOMiHOG000223641.
KOiK08372.
OMAiRAIRTHK.

Enzyme and pathway databases

BioCyciMTBRV:RV0983-MONOMER.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO53896_MYCTU
AccessioniPrimary (citable) accession number: O53896
Secondary accession number(s): I6Y5B5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.