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Protein
Submitted name:

Probable serine protease PepD (Serine proteinase) (MTB32B)

Gene

pepD

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: MTBBASE

GO - Biological processi

  • pathogenesis Source: MTBBASE
  • protein catabolic process Source: MTBBASE
  • proteolysis Source: MTBBASE
  • response to stress Source: MTBBASE

Keywordsi

Molecular functionHydrolase, ProteaseImported

Protein family/group databases

MEROPSiS01.494.

Names & Taxonomyi

Protein namesi
Submitted name:
Probable serine protease PepD (Serine proteinase) (MTB32B)Imported
Gene namesi
Name:pepDImported
Ordered Locus Names:Rv0983Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei102 – 126HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

  • extracellular region Source: MTBBASE
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0983.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y8TX-ray2.00A/B/C149-464[»]
2Z9IX-ray2.00A/B/C149-464[»]
SMRiO53896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini368 – 449PDZInterPro annotationAdd BLAST82

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105C0H. Bacteria.
COG0265. LUCA.
HOGENOMiHOG000223641.
KOiK08372.
OMAiWRYATEQ.

Family and domain databases

InterProiView protein in InterPro
IPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
PfamiView protein in Pfam
PF13180. PDZ_2. 1 hit.
PRINTSiPR00834. PROTEASES2C.
SMARTiView protein in SMART
SM00228. PDZ. 1 hit.
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50106. PDZ. 1 hit.

Sequencei

Sequence statusi: Complete.

O53896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLARVVGL VQEEQPSDMT NHPRYSPPPQ QPGTPGYAQG QQQTYSQQFD
60 70 80 90 100
WRYPPSPPPQ PTQYRQPYEA LGGTRPGLIP GVIPTMTPPP GMVRQRPRAG
110 120 130 140 150
MLAIGAVTIA VVSAGIGGAA ASLVGFNRAP AGPSGGPVAA SAAPSIPAAN
160 170 180 190 200
MPPGSVEQVA AKVVPSVVML ETDLGRQSEE GSGIILSAEG LILTNNHVIA
210 220 230 240 250
AAAKPPLGSP PPKTTVTFSD GRTAPFTVVG ADPTSDIAVV RVQGVSGLTP
260 270 280 290 300
ISLGSSSDLR VGQPVLAIGS PLGLEGTVTT GIVSALNRPV STTGEAGNQN
310 320 330 340 350
TVLDAIQTDA AINPGNSGGA LVNMNAQLVG VNSAIATLGA DSADAQSGSI
360 370 380 390 400
GLGFAIPVDQ AKRIADELIS TGKASHASLG VQVTNDKDTL GAKIVEVVAG
410 420 430 440 450
GAAANAGVPK GVVVTKVDDR PINSADALVA AVRSKAPGAT VALTFQDPSG
460
GSRTVQVTLG KAEQ
Length:464
Mass (Da):46,453
Last modified:June 1, 1998 - v1
Checksum:iAE93BFCC53E1EC8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43733.1.
RefSeqiNP_215498.1. NC_000962.3.
WP_010886101.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR13718; AIR13718; LH57_05360.
CCP43733; CCP43733; Rv0983.
GeneIDi885382.
KEGGimtu:Rv0983.
mtv:RVBD_0983.
PATRICifig|83332.111.peg.1091.

Similar proteinsi

Entry informationi

Entry nameiO53896_MYCTU
AccessioniPrimary (citable) accession number: O53896
Secondary accession number(s): I6Y5B5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 27, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported