O53896 (O53896_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
PROBABLE SERINE PROTEASE PEPD (SERINE PROTEINASE) (MTB32B) EMBL CAA17582.1
EC=3.4.21.- EMBL CAA17582.1

Gene names

Name:	pepD EMBL CAA17582.1
Ordered Locus Names:	Rv0983

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Hydrolase Protease EMBL CAA17582.1
Technical term	3D-structure PDB 2Z9I PDB 1Y8T Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pathogenesis Inferred from direct assay Ref.2. Source: MTBBASE protein catabolic process Inferred from direct assay Ref.2. Source: MTBBASE proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from direct assay. Source: MTBBASE
Molecular function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O53896 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: AE93BFCC53E1EC8F	FASTA	464	46,453
	10 20 30 40 50 60 MAKLARVVGL VQEEQPSDMT NHPRYSPPPQ QPGTPGYAQG QQQTYSQQFD WRYPPSPPPQ 70 80 90 100 110 120 PTQYRQPYEA LGGTRPGLIP GVIPTMTPPP GMVRQRPRAG MLAIGAVTIA VVSAGIGGAA 130 140 150 160 170 180 ASLVGFNRAP AGPSGGPVAA SAAPSIPAAN MPPGSVEQVA AKVVPSVVML ETDLGRQSEE 190 200 210 220 230 240 GSGIILSAEG LILTNNHVIA AAAKPPLGSP PPKTTVTFSD GRTAPFTVVG ADPTSDIAVV 250 260 270 280 290 300 RVQGVSGLTP ISLGSSSDLR VGQPVLAIGS PLGLEGTVTT GIVSALNRPV STTGEAGNQN 310 320 330 340 350 360 TVLDAIQTDA AINPGNSGGA LVNMNAQLVG VNSAIATLGA DSADAQSGSI GLGFAIPVDQ 370 380 390 400 410 420 AKRIADELIS TGKASHASLG VQVTNDKDTL GAKIVEVVAG GAAANAGVPK GVVVTKVDDR 430 440 450 460 PINSADALVA AVRSKAPGAT VALTFQDPSG GSRTVQVTLG KAEQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis." Mohamedmohaideen N.N., Palaninathan S.K., Morin P.M., Williams B.J., Braunstein M., Tichy S.E., Locker J., Russell D.H., Jacobs W.R., Sacchettini J.C. Biochemistry 47:6092-6102(2008) [PubMed: 18479146] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 149-464.
[3]	"Possible role for HtrA homologs in mycobacterium tuberculosis." Palaninathan S.K., MohamedMohaideen N.N., Sacchettini J.C. Submitted (DEC-2004) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 149-464.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BX842575 Genomic DNA. Translation: CAA17582.1.

PIR

C70821.

RefSeq

NP_215498.1. NC_000962.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1Y8T	X-ray	2.00	A/B/C	149-464	[»]
2Z9I	X-ray	2.00	A/B/C	149-464	[»]

ProteinModelPortal

O53896.

SMR

O53896. Positions 154-462.

ModBase

Search...

Protein family/group databases

MEROPS

S01.494.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBMYCT00000000115; EBMYCP00000000115; EBMYCG00000000115.

GeneID

885382.

GenomeReviews

Gene locus Rv0983 in contig AL123456_GR.

KEGG

mtu:Rv0983.

PATRIC

18150710. VBIMycTub87468_1096.

Organism-specific databases

TubercuList

Rv0983.

Phylogenomic databases

GeneTree

EBGT00050000015355.

HOGENOM

HBG585708.

OMA

DRAITSA.

PhylomeDB

O53896.

ProtClustDB

CLSK790871.

Family and domain databases

InterPro

IPR001478. PDZ/DHR/GLGF.
IPR009003. Pept_cys/ser_Trypsin-like.
IPR001254. Peptidase_S1_S6.
IPR001940. Peptidase_S1C.
[Graphical view]

KO

K08372.

Pfam

PF00089. Trypsin. 1 hit.
[Graphical view]

PRINTS

PR00834. PROTEASES2C.

SMART

SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 1 hit.
SSF50494. Pept_Ser_Cys. 1 hit.

PROSITE

PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

O53896_MYCTU

Accession

Primary (citable) accession number: O53896

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	December 14, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)