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O53872

- O53872_MYCTU

UniProt

O53872 - O53872_MYCTU

Protein
Submitted name:

Fatty oxidation protein FadB

Gene

fadB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.SAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei175 – 1751CoenzymeAImported
    Binding sitei308 – 3081CoenzymeAImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi629 – 6335ADPImported

    GO - Molecular functioni

    1. 3-hydroxyacyl-CoA dehydrogenase activity Source: InterPro
    2. coenzyme binding Source: InterPro
    3. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. fatty acid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseSAAS annotation

    Keywords - Biological processi

    Fatty acid metabolismSAAS annotation, Lipid metabolism

    Keywords - Ligandi

    NADSAAS annotation, Nucleotide-bindingImported

    Enzyme and pathway databases

    BioCyciMTBRV:RV0860-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Fatty oxidation protein FadBImported
    Submitted name:
    Probable fatty oxidation protein FadBImported
    Gene namesi
    Name:fadBImported
    Ordered Locus Names:Rv0860Imported
    ORF Names:P425_00900Imported, RVBD_0860Imported
    OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
    Taxonomic identifieri83332 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001584: Chromosome, UP000003123: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cell wall Source: MTBBASE
    2. cytosol Source: MTBBASE
    3. plasma membrane Source: MTBBASE

    PTM / Processingi

    Proteomic databases

    PRIDEiO53872.

    Interactioni

    Protein-protein interaction databases

    STRINGi83332.Rv0860.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4B3HX-ray2.30A/B1-720[»]
    4B3IX-ray2.63A/B1-720[»]
    4B3JX-ray2.50A/B1-720[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni66 – 716CoenzymeA bindingImported

    Phylogenomic databases

    KOiK01782.
    OMAiPFRYMDT.
    OrthoDBiEOG6M9F0M.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.226.10. 2 hits.
    InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 2 hits.
    SSF52096. SSF52096. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O53872-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDNTIQWDK DADGIVTLTM DDPSGSTNVM NEAYIESMGK AVDRLVAEKD    50
    SITGVVVASA KKTFFAGGDV KTMIQARPED AGDVFNTVET IKRQLRTLET 100
    LGKPVVAAIN GAALGGGLEI ALACHHRIAA DVKGSQLGLP EVTLGLLPGG 150
    GGVTRTVRMF GIQNAFVSVL AQGTRFKPAK AKEIGLVDEL VATVEELVPA 200
    AKAWIKEELK ANPDGAGVQP WDKKGYKMPG GTPSSPGLAA ILPSFPSNLR 250
    KQLKGAPMPA PRAILAAAVE GAQVDFDTAS RIESRYFASL VTGQVAKNMM 300
    QAFFFDLQAI NAGGSRPEGI GKTPIKRIGV LGAGMMGAGI AYVSAKAGYE 350
    VVLKDVSLEA AAKGKGYSEK LEAKALERGR TTQERSDALL ARITPTADAA 400
    DFKGVDFVIE AVFENQELKH KVFGEIEDIV EPNAILGSNT STLPITGLAT 450
    GVKRQEDFIG IHFFSPVDKM PLVEIIKGEK TSDEALARVF DYTLAIGKTP 500
    IVVNDSRGFF TSRVIGTFVN EALAMLGEGV EPASIEQAGS QAGYPAPPLQ 550
    LSDELNLELM HKIAVATRKG VEDAGGTYQP HPAEAVVEKM IELGRSGRLK 600
    GAGFYEYADG KRSGLWPGLR ETFKSGSSQP PLQDMIDRML FAEALETQKC 650
    LDEGVLTSTA DANIGSIMGI GFPPWTGGSA QFIVGYSGPA GTGKAAFVAR 700
    ARELAAAYGD RFLPPESLLS 720
    Length:720
    Mass (Da):76,104
    Last modified:June 1, 1998 - v1
    Checksum:i52CB1865400F3BE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003248 Genomic DNA. Translation: AFN48740.1.
    AL123456 Genomic DNA. Translation: CCP43608.1.
    JLDD01000008 Genomic DNA. Translation: KBJ39059.1.
    RefSeqiNP_215375.1. NC_000962.3.
    YP_006514211.1. NC_018143.2.

    Genome annotation databases

    EnsemblBacteriaiAFN48740; AFN48740; RVBD_0860.
    CCP43608; CCP43608; Rv0860.
    GeneIDi13318762.
    885799.
    KEGGimtu:Rv0860.
    mtv:RVBD_0860.
    PATRICi18150437. VBIMycTub87468_0961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003248 Genomic DNA. Translation: AFN48740.1 .
    AL123456 Genomic DNA. Translation: CCP43608.1 .
    JLDD01000008 Genomic DNA. Translation: KBJ39059.1 .
    RefSeqi NP_215375.1. NC_000962.3.
    YP_006514211.1. NC_018143.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4B3H X-ray 2.30 A/B 1-720 [» ]
    4B3I X-ray 2.63 A/B 1-720 [» ]
    4B3J X-ray 2.50 A/B 1-720 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 83332.Rv0860.

    Proteomic databases

    PRIDEi O53872.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFN48740 ; AFN48740 ; RVBD_0860 .
    CCP43608 ; CCP43608 ; Rv0860 .
    GeneIDi 13318762.
    885799.
    KEGGi mtu:Rv0860.
    mtv:RVBD_0860.
    PATRICi 18150437. VBIMycTub87468_0961.

    Phylogenomic databases

    KOi K01782.
    OMAi PFRYMDT.
    OrthoDBi EOG6M9F0M.

    Enzyme and pathway databases

    BioCyci MTBRV:RV0860-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.226.10. 2 hits.
    InterProi IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 2 hits.
    SSF52096. SSF52096. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37RvImported and H37RvImported.
    2. "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv."
      Camus J.C., Pryor M.J., Medigue C., Cole S.T.
      Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    5. Lew J.M.
      Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    6. "Structure of mycobacterial ?-oxidation trifunctional enzyme reveals its altered assembly and putative substrate channeling pathway."
      Venkatesan R., Wierenga R.K.
      ACS Chem. Biol. 8:1063-1073(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH ADP AND COENZYMEA.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37RvImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.

    Entry informationi

    Entry nameiO53872_MYCTU
    AccessioniPrimary (citable) accession number: O53872
    Secondary accession number(s): F2GIZ3, I6Y8Y4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3