SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O53872

- O53872_MYCTU

UniProt

O53872 - O53872_MYCTU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Fatty oxidation protein FadB
Gene
fadB, Rv0860, P425_00900, RVBD_0860
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.SAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei175 – 1751Coenzyme AImported
Binding sitei308 – 3081Coenzyme AImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi629 – 6335ADPImported

GO - Molecular functioni

  1. 3-hydroxyacyl-CoA dehydrogenase activity Source: InterPro
  2. coenzyme binding Source: InterPro
  3. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotations

Keywords - Biological processi

Fatty acid metabolismSAAS annotations, Lipid metabolism

Keywords - Ligandi

NADSAAS annotations, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciMTBRV:RV0860-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Fatty oxidation protein FadBImported
Submitted name:
Probable fatty oxidation protein FadBImported
Gene namesi
Name:fadBImported
Ordered Locus Names:Rv0860Imported
ORF Names:P425_00900Imported, RVBD_0860Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001584: Chromosome, UP000003123: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cell wall Source: MTBBASE
  2. cytosol Source: MTBBASE
  3. plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiO53872.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0860.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B3HX-ray2.30A/B1-720[»]
4B3IX-ray2.63A/B1-720[»]
4B3JX-ray2.50A/B1-720[»]

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 716Coenzyme A bindingImported

Phylogenomic databases

KOiK01782.
OMAiPFRYMDT.
OrthoDBiEOG6M9F0M.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
3.90.226.10. 2 hits.
InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.

Sequencei

Sequence statusi: Complete.

O53872-1 [UniParc]FASTAAdd to Basket

« Hide

MPDNTIQWDK DADGIVTLTM DDPSGSTNVM NEAYIESMGK AVDRLVAEKD    50
SITGVVVASA KKTFFAGGDV KTMIQARPED AGDVFNTVET IKRQLRTLET 100
LGKPVVAAIN GAALGGGLEI ALACHHRIAA DVKGSQLGLP EVTLGLLPGG 150
GGVTRTVRMF GIQNAFVSVL AQGTRFKPAK AKEIGLVDEL VATVEELVPA 200
AKAWIKEELK ANPDGAGVQP WDKKGYKMPG GTPSSPGLAA ILPSFPSNLR 250
KQLKGAPMPA PRAILAAAVE GAQVDFDTAS RIESRYFASL VTGQVAKNMM 300
QAFFFDLQAI NAGGSRPEGI GKTPIKRIGV LGAGMMGAGI AYVSAKAGYE 350
VVLKDVSLEA AAKGKGYSEK LEAKALERGR TTQERSDALL ARITPTADAA 400
DFKGVDFVIE AVFENQELKH KVFGEIEDIV EPNAILGSNT STLPITGLAT 450
GVKRQEDFIG IHFFSPVDKM PLVEIIKGEK TSDEALARVF DYTLAIGKTP 500
IVVNDSRGFF TSRVIGTFVN EALAMLGEGV EPASIEQAGS QAGYPAPPLQ 550
LSDELNLELM HKIAVATRKG VEDAGGTYQP HPAEAVVEKM IELGRSGRLK 600
GAGFYEYADG KRSGLWPGLR ETFKSGSSQP PLQDMIDRML FAEALETQKC 650
LDEGVLTSTA DANIGSIMGI GFPPWTGGSA QFIVGYSGPA GTGKAAFVAR 700
ARELAAAYGD RFLPPESLLS 720
Length:720
Mass (Da):76,104
Last modified:June 1, 1998 - v1
Checksum:i52CB1865400F3BE5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003248 Genomic DNA. Translation: AFN48740.1.
AL123456 Genomic DNA. Translation: CCP43608.1.
JLDD01000008 Genomic DNA. Translation: KBJ39059.1.
RefSeqiNP_215375.1. NC_000962.3.
YP_006514211.1. NC_018143.2.

Genome annotation databases

EnsemblBacteriaiAFN48740; AFN48740; RVBD_0860.
CCP43608; CCP43608; Rv0860.
GeneIDi13318762.
885799.
KEGGimtu:Rv0860.
mtv:RVBD_0860.
PATRICi18150437. VBIMycTub87468_0961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003248 Genomic DNA. Translation: AFN48740.1 .
AL123456 Genomic DNA. Translation: CCP43608.1 .
JLDD01000008 Genomic DNA. Translation: KBJ39059.1 .
RefSeqi NP_215375.1. NC_000962.3.
YP_006514211.1. NC_018143.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4B3H X-ray 2.30 A/B 1-720 [» ]
4B3I X-ray 2.63 A/B 1-720 [» ]
4B3J X-ray 2.50 A/B 1-720 [» ]
ModBasei Search...

Protein-protein interaction databases

STRINGi 83332.Rv0860.

Proteomic databases

PRIDEi O53872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFN48740 ; AFN48740 ; RVBD_0860 .
CCP43608 ; CCP43608 ; Rv0860 .
GeneIDi 13318762.
885799.
KEGGi mtu:Rv0860.
mtv:RVBD_0860.
PATRICi 18150437. VBIMycTub87468_0961.

Phylogenomic databases

KOi K01782.
OMAi PFRYMDT.
OrthoDBi EOG6M9F0M.

Enzyme and pathway databases

BioCyci MTBRV:RV0860-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
3.90.226.10. 2 hits.
InterProi IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv and H37RvImported.
  2. "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv."
    Camus J.C., Pryor M.J., Medigue C., Cole S.T.
    Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  5. Lew J.M.
    Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  6. "Structure of mycobacterial ?-oxidation trifunctional enzyme reveals its altered assembly and putative substrate channeling pathway."
    Venkatesan R., Wierenga R.K.
    ACS Chem. Biol. 8:1063-1073(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH ADP AND COENZYME A.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.

Entry informationi

Entry nameiO53872_MYCTU
AccessioniPrimary (citable) accession number: O53872
Secondary accession number(s): F2GIZ3, I6Y8Y4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi