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O53872 (O53872_MYCTU) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Probable fatty oxidation protein FadB EMBL CCP43608.1
Gene names
Name:fadB EMBL CCP43608.1
Ordered Locus Names:Rv0860 EMBL CCP43608.1
ORF Names:P425_00900 EMBL KBJ39059.1, RVBD_0860 EMBL AFN48740.1
OrganismMycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [Reference proteome] [HAMAP]
Taxonomic identifier83332 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length720 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH. SAAS SAAS006176

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding629 – 6335ADP PDB 4B3I PDB 4B3J
Region66 – 716Coenzyme A binding PDB 4B3I PDB 4B3J
Region294 – 2952Sulfate 3 binding PDB 4B3I PDB 4B3J PDB 4B3H
Region694 – 6952Sulfate 13 binding PDB 4B3I PDB 4B3J PDB 4B3H

Sites

Binding site1751Coenzyme A PDB 4B3I PDB 4B3J
Binding site2201Sulfate 2 PDB 4B3I PDB 4B3H
Binding site2751Sulfate 4 PDB 4B3I PDB 4B3J PDB 4B3H
Binding site3081Coenzyme A PDB 4B3I PDB 4B3J
Binding site3271Sulfate 5 PDB 4B3I PDB 4B3J PDB 4B3H
Binding site3271Sulfate 6 PDB 4B3I PDB 4B3J PDB 4B3H
Binding site4031Sulfate 6 PDB 4B3I
Binding site5981Sulfate 7 PDB 4B3J
Binding site5981Sulfate 8 PDB 4B3I PDB 4B3J PDB 4B3H
Binding site6001Sulfate 9 PDB 4B3I PDB 4B3J PDB 4B3H
Binding site6121Sulfate 7; via amide nitrogen PDB 4B3J
Binding site6121Sulfate 8; via amide nitrogen PDB 4B3I PDB 4B3J PDB 4B3H
Binding site6321Sulfate 10; via amide nitrogen PDB 4B3H
Binding site6591Sulfate 11 PDB 4B3I
Binding site6591Sulfate 12 PDB 4B3J PDB 4B3H
Binding site7021Sulfate 14 PDB 4B3I
Binding site7201Sulfate 14; via amide nitrogen PDB 4B3I

Sequences

Sequence LengthMass (Da)Tools
O53872 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 52CB1865400F3BE5

FASTA72076,104
        10         20         30         40         50         60 
MPDNTIQWDK DADGIVTLTM DDPSGSTNVM NEAYIESMGK AVDRLVAEKD SITGVVVASA 

        70         80         90        100        110        120 
KKTFFAGGDV KTMIQARPED AGDVFNTVET IKRQLRTLET LGKPVVAAIN GAALGGGLEI 

       130        140        150        160        170        180 
ALACHHRIAA DVKGSQLGLP EVTLGLLPGG GGVTRTVRMF GIQNAFVSVL AQGTRFKPAK 

       190        200        210        220        230        240 
AKEIGLVDEL VATVEELVPA AKAWIKEELK ANPDGAGVQP WDKKGYKMPG GTPSSPGLAA 

       250        260        270        280        290        300 
ILPSFPSNLR KQLKGAPMPA PRAILAAAVE GAQVDFDTAS RIESRYFASL VTGQVAKNMM 

       310        320        330        340        350        360 
QAFFFDLQAI NAGGSRPEGI GKTPIKRIGV LGAGMMGAGI AYVSAKAGYE VVLKDVSLEA 

       370        380        390        400        410        420 
AAKGKGYSEK LEAKALERGR TTQERSDALL ARITPTADAA DFKGVDFVIE AVFENQELKH 

       430        440        450        460        470        480 
KVFGEIEDIV EPNAILGSNT STLPITGLAT GVKRQEDFIG IHFFSPVDKM PLVEIIKGEK 

       490        500        510        520        530        540 
TSDEALARVF DYTLAIGKTP IVVNDSRGFF TSRVIGTFVN EALAMLGEGV EPASIEQAGS 

       550        560        570        580        590        600 
QAGYPAPPLQ LSDELNLELM HKIAVATRKG VEDAGGTYQP HPAEAVVEKM IELGRSGRLK 

       610        620        630        640        650        660 
GAGFYEYADG KRSGLWPGLR ETFKSGSSQP PLQDMIDRML FAEALETQKC LDEGVLTSTA 

       670        680        690        700        710        720 
DANIGSIMGI GFPPWTGGSA QFIVGYSGPA GTGKAAFVAR ARELAAAYGD RFLPPESLLS 

« Hide

References

« Hide 'large scale' references
[1]"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. expand/collapse author list , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.
Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv and H37Rv EMBL CCP43608.1.
[2]"Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv."
Camus J.C., Pryor M.J., Medigue C., Cole S.T.
Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL CCP43608.1.
[3]"Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry."
Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K., Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R., Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M., Kumar P. expand/collapse author list , Chaerkady R., Ramachandran S., Dash D., Pandey A.
Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]"TubercuList--10 years after."
Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
Tuberculosis 91:1-7(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL CCP43608.1.
[5]Lew J.M.
Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL CCP43608.1.
[6]"Structure of mycobacterial ?-oxidation trifunctional enzyme reveals its altered assembly and putative substrate channeling pathway."
Venkatesan R., Wierenga R.K.
ACS Chem. Biol. 8:1063-1073(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH ADP; COENZYME A AND SULFATE.
[7]"The Genome Sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genome Sequencing Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M. expand/collapse author list , Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL AFN48740.1.
[8]"The genome sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genome Sequencing Platform
Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M. expand/collapse author list , Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.
[9]"The Genome Sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genomics Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Earl A.M., Kreiswirth B., Gomez J., Victor T., Desjardins C., Abeel T., Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C. expand/collapse author list , Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL KBJ39059.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003248 Genomic DNA. Translation: AFN48740.1.
AL123456 Genomic DNA. Translation: CCP43608.1.
JLDD01000008 Genomic DNA. Translation: KBJ39059.1.
RefSeqNP_215375.1. NC_000962.3.
YP_006514211.1. NC_018143.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4B3HX-ray2.30A/B1-720[»]
4B3IX-ray2.63A/B1-720[»]
4B3JX-ray2.50A/B1-720[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING83332.Rv0860.

Proteomic databases

PRIDEO53872.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFN48740; AFN48740; RVBD_0860.
CCP43608; CCP43608; Rv0860.
GeneID885799.
KEGGmtu:Rv0860.
mtv:RVBD_0860.
PATRIC18150437. VBIMycTub87468_0961.

Phylogenomic databases

KOK01782.
OMAPFRYMDT.
OrthoDBEOG6M9F0M.

Enzyme and pathway databases

BioCycMTBRV:RV0860-MONOMER.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
3.90.226.10. 2 hits.
InterProIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
ProtoNetSearch...

Entry information

Entry nameO53872_MYCTU
AccessionPrimary (citable) accession number: O53872
Secondary accession number(s): F2GIZ3, I6Y8Y4
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)