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O53871

- Y0859_MYCTU

UniProt

O53871 - Y0859_MYCTU

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Protein
Putative acyltransferase Rv0859
Gene
fadA, Rv0859
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921Acyl-thioester intermediate By similarity
Active sitei359 – 3591Proton acceptor By similarity
Active sitei389 – 3891Proton acceptor By similarity

GO - Molecular functioni

  1. transferase activity, transferring acyl groups other than amino-acyl groups Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciMTBRV:RV0859-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative acyltransferase Rv0859 (EC:2.3.1.-)
    Gene namesi
    Name:fadA
    Ordered Locus Names:Rv0859
    OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    Taxonomic identifieri83332 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001584: Chromosome

    Organism-specific databases

    TubercuListiRv0859.

    Subcellular locationi

    GO - Cellular componenti

    1. cell wall Source: MTBBASE
    2. plasma membrane Source: MTBBASE
    Complete GO annotation...

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403Putative acyltransferase Rv0859
    PRO_0000395883Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki189 – 189Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein pup)

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PRIDEiO53871.

    Interactioni

    Protein-protein interaction databases

    STRINGi83332.Rv0859.

    Structurei

    Secondary structure

    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 127
    Beta strandi16 – 205
    Turni22 – 254
    Helixi28 – 4215
    Helixi48 – 503
    Beta strandi51 – 577
    Turni64 – 685
    Helixi69 – 768
    Beta strandi86 – 894
    Helixi91 – 933
    Helixi94 – 10714
    Beta strandi112 – 12110
    Turni122 – 1243
    Turni127 – 1304
    Helixi133 – 1364
    Helixi138 – 1447
    Helixi149 – 16012
    Helixi164 – 18320
    Turni184 – 1907
    Beta strandi201 – 2033
    Helixi215 – 2206
    Turni225 – 2306
    Helixi234 – 2418
    Beta strandi261 – 27010
    Helixi272 – 2776
    Beta strandi284 – 29310
    Turni296 – 2983
    Helixi303 – 31311
    Helixi318 – 3203
    Beta strandi322 – 3265
    Helixi331 – 34111
    Helixi345 – 3473
    Helixi354 – 3574
    Turni361 – 3633
    Helixi364 – 37916
    Beta strandi383 – 3897
    Helixi391 – 3933
    Beta strandi394 – 4029

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4B3HX-ray2.30C/D1-403[»]
    4B3IX-ray2.63C/D1-403[»]
    4B3JX-ray2.50C/D1-403[»]
    ProteinModelPortaliO53871.
    SMRiO53871. Positions 2-403.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thiolase family.

    Phylogenomic databases

    eggNOGiCOG0183.
    HOGENOMiHOG000012239.
    KOiK00626.
    OMAiDIIMGCV.
    OrthoDBiEOG68M4GV.
    PhylomeDBiO53871.

    Family and domain databases

    Gene3Di3.40.47.10. 4 hits.
    InterProiIPR002155. Thiolase.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    IPR020615. Thiolase_acyl_enz_int_AS.
    IPR020610. Thiolase_AS.
    IPR020617. Thiolase_C.
    IPR020613. Thiolase_CS.
    IPR020616. Thiolase_N.
    [Graphical view]
    PfamiPF02803. Thiolase_C. 1 hit.
    PF00108. Thiolase_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
    PROSITEiPS00098. THIOLASE_1. 1 hit.
    PS00737. THIOLASE_2. 1 hit.
    PS00099. THIOLASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O53871-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEEAFIYEA IRTPRGKQKN GSLHEVKPLS LVVGLIDELR KRHPDLDENL    50
    ISDVILGCVS PVGDQGGDIA RAAVLASGMP VTSGGVQLNR FCASGLEAVN 100
    TAAQKVRSGW DDLVLAGGVE SMSRVPMGSD GGAMGLDPAT NYDVMFVPQS 150
    IGADLIATIE GFSREDVDAY ALRSQQKAAE AWSGGYFAKS VVPVRDQNGL 200
    LILDHDEHMR PDTTKEGLAK LKPAFEGLAA LGGFDDVALQ KYHWVEKINH 250
    VHTGGNSSGI VDGAALVMIG SAAAGKLQGL TPRARIVATA TSGADPVIML 300
    TGPTPATRKV LDRAGLTVDD IDLFELNEAF ASVVLKFQKD LNIPDEKLNV 350
    NGGAIAMGHP LGATGAMILG TMVDELERRN ARRALITLCI GGGMGVATII 400
    ERV 403
    Length:403
    Mass (Da):42,414
    Last modified:June 1, 1998 - v1
    Checksum:i840EABC43EB7FE94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL123456 Genomic DNA. Translation: CCP43607.1.
    PIRiC70815.
    RefSeqiNP_215374.1. NC_000962.3.
    WP_009934956.1. NC_018143.2.
    YP_006514210.1. NC_018143.2.

    Genome annotation databases

    EnsemblBacteriaiCCP43607; CCP43607; Rv0859.
    GeneIDi13318761.
    885774.
    KEGGimtu:Rv0859.
    mtv:RVBD_0859.
    PATRICi18150435. VBIMycTub87468_0960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL123456 Genomic DNA. Translation: CCP43607.1 .
    PIRi C70815.
    RefSeqi NP_215374.1. NC_000962.3.
    WP_009934956.1. NC_018143.2.
    YP_006514210.1. NC_018143.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4B3H X-ray 2.30 C/D 1-403 [» ]
    4B3I X-ray 2.63 C/D 1-403 [» ]
    4B3J X-ray 2.50 C/D 1-403 [» ]
    ProteinModelPortali O53871.
    SMRi O53871. Positions 2-403.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 83332.Rv0859.

    Proteomic databases

    PRIDEi O53871.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCP43607 ; CCP43607 ; Rv0859 .
    GeneIDi 13318761.
    885774.
    KEGGi mtu:Rv0859.
    mtv:RVBD_0859.
    PATRICi 18150435. VBIMycTub87468_0960.

    Organism-specific databases

    TubercuListi Rv0859.

    Phylogenomic databases

    eggNOGi COG0183.
    HOGENOMi HOG000012239.
    KOi K00626.
    OMAi DIIMGCV.
    OrthoDBi EOG68M4GV.
    PhylomeDBi O53871.

    Enzyme and pathway databases

    BioCyci MTBRV:RV0859-MONOMER.

    Family and domain databases

    Gene3Di 3.40.47.10. 4 hits.
    InterProi IPR002155. Thiolase.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    IPR020615. Thiolase_acyl_enz_int_AS.
    IPR020610. Thiolase_AS.
    IPR020617. Thiolase_C.
    IPR020613. Thiolase_CS.
    IPR020616. Thiolase_N.
    [Graphical view ]
    Pfami PF02803. Thiolase_C. 1 hit.
    PF00108. Thiolase_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000429. Ac-CoA_Ac_transf. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    TIGRFAMsi TIGR01930. AcCoA-C-Actrans. 1 hit.
    PROSITEi PS00098. THIOLASE_1. 1 hit.
    PS00737. THIOLASE_2. 1 hit.
    PS00099. THIOLASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37Rv.
    2. "Prokayrotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis."
      Festa R.A., McAllister F., Pearce M.J., Mintseris J., Burns K.E., Gygi S.P., Darwin K.H.
      PLoS ONE 5:E8589-E8589(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PUPYLATION AT LYS-189, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: ATCC 25618 / H37Rv.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ATCC 25618 / H37Rv.

    Entry informationi

    Entry nameiY0859_MYCTU
    AccessioniPrimary (citable) accession number: O53871
    Secondary accession number(s): L0T7Y0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: June 1, 1998
    Last modified: September 3, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
      Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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