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Protein

Putative acyltransferase Rv0859

Gene

fadA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92Acyl-thioester intermediateBy similarity1
Active sitei359Proton acceptorPROSITE-ProRule annotation1
Active sitei389Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5013-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acyltransferase Rv0859 (EC:2.3.1.-)
Gene namesi
Name:fadA
Ordered Locus Names:Rv0859
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0859.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003958831 – 403Putative acyltransferase Rv0859Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki189Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein pup)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiO53871.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0859.

Structurei

Secondary structure

1403
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Beta strandi16 – 20Combined sources5
Turni22 – 25Combined sources4
Helixi28 – 42Combined sources15
Helixi48 – 50Combined sources3
Beta strandi51 – 57Combined sources7
Turni64 – 68Combined sources5
Helixi69 – 76Combined sources8
Beta strandi86 – 89Combined sources4
Helixi91 – 93Combined sources3
Helixi94 – 107Combined sources14
Beta strandi112 – 121Combined sources10
Turni122 – 124Combined sources3
Turni127 – 130Combined sources4
Helixi133 – 136Combined sources4
Helixi138 – 144Combined sources7
Helixi149 – 160Combined sources12
Helixi164 – 183Combined sources20
Turni184 – 190Combined sources7
Beta strandi201 – 203Combined sources3
Helixi215 – 220Combined sources6
Turni225 – 230Combined sources6
Helixi234 – 241Combined sources8
Beta strandi261 – 270Combined sources10
Helixi272 – 277Combined sources6
Beta strandi284 – 293Combined sources10
Turni296 – 298Combined sources3
Helixi303 – 313Combined sources11
Helixi318 – 320Combined sources3
Beta strandi322 – 326Combined sources5
Helixi331 – 341Combined sources11
Helixi345 – 347Combined sources3
Helixi354 – 357Combined sources4
Turni361 – 363Combined sources3
Helixi364 – 379Combined sources16
Beta strandi383 – 389Combined sources7
Helixi391 – 393Combined sources3
Beta strandi394 – 402Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B3HX-ray2.30C/D1-403[»]
4B3IX-ray2.63C/D1-403[»]
4B3JX-ray2.50C/D1-403[»]
ProteinModelPortaliO53871.
SMRiO53871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Phylogenomic databases

eggNOGiENOG4105CHU. Bacteria.
COG0183. LUCA.
HOGENOMiHOG000012239.
InParanoidiO53871.
KOiK00626.
OMAiGCAILGT.
PhylomeDBiO53871.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEAFIYEA IRTPRGKQKN GSLHEVKPLS LVVGLIDELR KRHPDLDENL
60 70 80 90 100
ISDVILGCVS PVGDQGGDIA RAAVLASGMP VTSGGVQLNR FCASGLEAVN
110 120 130 140 150
TAAQKVRSGW DDLVLAGGVE SMSRVPMGSD GGAMGLDPAT NYDVMFVPQS
160 170 180 190 200
IGADLIATIE GFSREDVDAY ALRSQQKAAE AWSGGYFAKS VVPVRDQNGL
210 220 230 240 250
LILDHDEHMR PDTTKEGLAK LKPAFEGLAA LGGFDDVALQ KYHWVEKINH
260 270 280 290 300
VHTGGNSSGI VDGAALVMIG SAAAGKLQGL TPRARIVATA TSGADPVIML
310 320 330 340 350
TGPTPATRKV LDRAGLTVDD IDLFELNEAF ASVVLKFQKD LNIPDEKLNV
360 370 380 390 400
NGGAIAMGHP LGATGAMILG TMVDELERRN ARRALITLCI GGGMGVATII

ERV
Length:403
Mass (Da):42,414
Last modified:June 1, 1998 - v1
Checksum:i840EABC43EB7FE94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43607.1.
PIRiC70815.
RefSeqiNP_215374.1. NC_000962.3.
WP_009934956.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP43607; CCP43607; Rv0859.
GeneIDi885774.
KEGGimtu:Rv0859.
PATRICi18150435. VBIMycTub87468_0960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43607.1.
PIRiC70815.
RefSeqiNP_215374.1. NC_000962.3.
WP_009934956.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B3HX-ray2.30C/D1-403[»]
4B3IX-ray2.63C/D1-403[»]
4B3JX-ray2.50C/D1-403[»]
ProteinModelPortaliO53871.
SMRiO53871.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0859.

Proteomic databases

PaxDbiO53871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP43607; CCP43607; Rv0859.
GeneIDi885774.
KEGGimtu:Rv0859.
PATRICi18150435. VBIMycTub87468_0960.

Organism-specific databases

TubercuListiRv0859.

Phylogenomic databases

eggNOGiENOG4105CHU. Bacteria.
COG0183. LUCA.
HOGENOMiHOG000012239.
InParanoidiO53871.
KOiK00626.
OMAiGCAILGT.
PhylomeDBiO53871.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5013-MONOMER.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY0859_MYCTU
AccessioniPrimary (citable) accession number: O53871
Secondary accession number(s): L0T7Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.