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O53871 (Y0859_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative acyltransferase Rv0859

EC=2.3.1.-
Gene names
Name:fadA
Ordered Locus Names:Rv0859
OrganismMycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [Reference proteome] [HAMAP]
Taxonomic identifier83332 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the thiolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Putative acyltransferase Rv0859
PRO_0000395883

Sites

Active site921Acyl-thioester intermediate By similarity
Active site3591Proton acceptor By similarity
Active site3891Proton acceptor By similarity

Amino acid modifications

Cross-link189Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein pup)

Secondary structure

...................................................................... 403
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O53871 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 840EABC43EB7FE94

FASTA40342,414
        10         20         30         40         50         60 
MSEEAFIYEA IRTPRGKQKN GSLHEVKPLS LVVGLIDELR KRHPDLDENL ISDVILGCVS 

        70         80         90        100        110        120 
PVGDQGGDIA RAAVLASGMP VTSGGVQLNR FCASGLEAVN TAAQKVRSGW DDLVLAGGVE 

       130        140        150        160        170        180 
SMSRVPMGSD GGAMGLDPAT NYDVMFVPQS IGADLIATIE GFSREDVDAY ALRSQQKAAE 

       190        200        210        220        230        240 
AWSGGYFAKS VVPVRDQNGL LILDHDEHMR PDTTKEGLAK LKPAFEGLAA LGGFDDVALQ 

       250        260        270        280        290        300 
KYHWVEKINH VHTGGNSSGI VDGAALVMIG SAAAGKLQGL TPRARIVATA TSGADPVIML 

       310        320        330        340        350        360 
TGPTPATRKV LDRAGLTVDD IDLFELNEAF ASVVLKFQKD LNIPDEKLNV NGGAIAMGHP 

       370        380        390        400 
LGATGAMILG TMVDELERRN ARRALITLCI GGGMGVATII ERV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL123456 Genomic DNA. Translation: CCP43607.1.
PIRC70815.
RefSeqNP_215374.1. NC_000962.3.
YP_006514210.1. NC_018143.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4B3HX-ray2.30C/D1-403[»]
4B3IX-ray2.63C/D1-403[»]
4B3JX-ray2.50C/D1-403[»]
ProteinModelPortalO53871.
SMRO53871. Positions 2-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING83332.Rv0859.

Proteomic databases

PRIDEO53871.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCP43607; CCP43607; Rv0859.
GeneID13318761.
885774.
KEGGmtu:Rv0859.
mtv:RVBD_0859.
PATRIC18150435. VBIMycTub87468_0960.

Organism-specific databases

TubercuListRv0859.

Phylogenomic databases

eggNOGCOG0183.
HOGENOMHOG000012239.
KOK00626.
OMAVYSHVER.
OrthoDBEOG68M4GV.
ProtClustDBPRK08242.

Enzyme and pathway databases

BioCycMTBRV:RV0859-MONOMER.

Family and domain databases

Gene3D3.40.47.10. 4 hits.
InterProIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PANTHERPTHR18919. PTHR18919. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY0859_MYCTU
AccessionPrimary (citable) accession number: O53871
Secondary accession number(s): L0T7Y0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references