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O53871

- Y0859_MYCTU

UniProt

O53871 - Y0859_MYCTU

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Protein

Putative acyltransferase Rv0859

Gene

fadA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921Acyl-thioester intermediateBy similarity
Active sitei359 – 3591Proton acceptorPROSITE-ProRule annotation
Active sitei389 – 3891Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. transferase activity, transferring acyl groups other than amino-acyl groups Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciMTBRV:RV0859-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acyltransferase Rv0859 (EC:2.3.1.-)
Gene namesi
Name:fadA
Ordered Locus Names:Rv0859
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001584: Chromosome

Organism-specific databases

TubercuListiRv0859.

Subcellular locationi

GO - Cellular componenti

  1. cell wall Source: MTBBASE
  2. plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Putative acyltransferase Rv0859PRO_0000395883Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki189 – 189Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein pup)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiO53871.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0859.

Structurei

Secondary structure

1
403
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 127Combined sources
Beta strandi16 – 205Combined sources
Turni22 – 254Combined sources
Helixi28 – 4215Combined sources
Helixi48 – 503Combined sources
Beta strandi51 – 577Combined sources
Turni64 – 685Combined sources
Helixi69 – 768Combined sources
Beta strandi86 – 894Combined sources
Helixi91 – 933Combined sources
Helixi94 – 10714Combined sources
Beta strandi112 – 12110Combined sources
Turni122 – 1243Combined sources
Turni127 – 1304Combined sources
Helixi133 – 1364Combined sources
Helixi138 – 1447Combined sources
Helixi149 – 16012Combined sources
Helixi164 – 18320Combined sources
Turni184 – 1907Combined sources
Beta strandi201 – 2033Combined sources
Helixi215 – 2206Combined sources
Turni225 – 2306Combined sources
Helixi234 – 2418Combined sources
Beta strandi261 – 27010Combined sources
Helixi272 – 2776Combined sources
Beta strandi284 – 29310Combined sources
Turni296 – 2983Combined sources
Helixi303 – 31311Combined sources
Helixi318 – 3203Combined sources
Beta strandi322 – 3265Combined sources
Helixi331 – 34111Combined sources
Helixi345 – 3473Combined sources
Helixi354 – 3574Combined sources
Turni361 – 3633Combined sources
Helixi364 – 37916Combined sources
Beta strandi383 – 3897Combined sources
Helixi391 – 3933Combined sources
Beta strandi394 – 4029Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B3HX-ray2.30C/D1-403[»]
4B3IX-ray2.63C/D1-403[»]
4B3JX-ray2.50C/D1-403[»]
ProteinModelPortaliO53871.
SMRiO53871. Positions 2-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Phylogenomic databases

eggNOGiCOG0183.
HOGENOMiHOG000012239.
InParanoidiO53871.
KOiK00626.
OMAiDIIMGCV.
OrthoDBiEOG68M4GV.
PhylomeDBiO53871.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53871-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEEAFIYEA IRTPRGKQKN GSLHEVKPLS LVVGLIDELR KRHPDLDENL
60 70 80 90 100
ISDVILGCVS PVGDQGGDIA RAAVLASGMP VTSGGVQLNR FCASGLEAVN
110 120 130 140 150
TAAQKVRSGW DDLVLAGGVE SMSRVPMGSD GGAMGLDPAT NYDVMFVPQS
160 170 180 190 200
IGADLIATIE GFSREDVDAY ALRSQQKAAE AWSGGYFAKS VVPVRDQNGL
210 220 230 240 250
LILDHDEHMR PDTTKEGLAK LKPAFEGLAA LGGFDDVALQ KYHWVEKINH
260 270 280 290 300
VHTGGNSSGI VDGAALVMIG SAAAGKLQGL TPRARIVATA TSGADPVIML
310 320 330 340 350
TGPTPATRKV LDRAGLTVDD IDLFELNEAF ASVVLKFQKD LNIPDEKLNV
360 370 380 390 400
NGGAIAMGHP LGATGAMILG TMVDELERRN ARRALITLCI GGGMGVATII

ERV
Length:403
Mass (Da):42,414
Last modified:June 1, 1998 - v1
Checksum:i840EABC43EB7FE94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43607.1.
PIRiC70815.
RefSeqiNP_215374.1. NC_000962.3.
YP_006514210.1. NC_018143.2.

Genome annotation databases

EnsemblBacteriaiCCP43607; CCP43607; Rv0859.
GeneIDi13318761.
885774.
KEGGimtu:Rv0859.
mtv:RVBD_0859.
PATRICi18150435. VBIMycTub87468_0960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43607.1 .
PIRi C70815.
RefSeqi NP_215374.1. NC_000962.3.
YP_006514210.1. NC_018143.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4B3H X-ray 2.30 C/D 1-403 [» ]
4B3I X-ray 2.63 C/D 1-403 [» ]
4B3J X-ray 2.50 C/D 1-403 [» ]
ProteinModelPortali O53871.
SMRi O53871. Positions 2-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 83332.Rv0859.

Proteomic databases

PRIDEi O53871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCP43607 ; CCP43607 ; Rv0859 .
GeneIDi 13318761.
885774.
KEGGi mtu:Rv0859.
mtv:RVBD_0859.
PATRICi 18150435. VBIMycTub87468_0960.

Organism-specific databases

TubercuListi Rv0859.

Phylogenomic databases

eggNOGi COG0183.
HOGENOMi HOG000012239.
InParanoidi O53871.
KOi K00626.
OMAi DIIMGCV.
OrthoDBi EOG68M4GV.
PhylomeDBi O53871.

Enzyme and pathway databases

BioCyci MTBRV:RV0859-MONOMER.

Family and domain databases

Gene3Di 3.40.47.10. 4 hits.
InterProi IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view ]
Pfami PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
TIGRFAMsi TIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEi PS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. "Prokayrotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis."
    Festa R.A., McAllister F., Pearce M.J., Mintseris J., Burns K.E., Gygi S.P., Darwin K.H.
    PLoS ONE 5:E8589-E8589(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PUPYLATION AT LYS-189, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: ATCC 25618 / H37Rv.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.

Entry informationi

Entry nameiY0859_MYCTU
AccessioniPrimary (citable) accession number: O53871
Secondary accession number(s): L0T7Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3