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Protein

Putative acyltransferase Rv0859

Gene

fadA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92Acyl-thioester intermediateBy similarity1
Active sitei359Proton acceptorPROSITE-ProRule annotation1
Active sitei389Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acyltransferase Rv0859 (EC:2.3.1.-)
Gene namesi
Name:fadA
Ordered Locus Names:Rv0859
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0859

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • plasma membrane Source: MTBBASE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003958831 – 403Putative acyltransferase Rv0859Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki189Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

Post-translational modificationi

Pupylated at Lys-189 by the prokaryotic ubiquitin-like protein Pup, which probably leads to its degradation by the proteasome.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiO53871
PRIDEiO53871

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0859

Structurei

Secondary structure

1403
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Beta strandi16 – 20Combined sources5
Turni22 – 25Combined sources4
Helixi28 – 42Combined sources15
Helixi48 – 50Combined sources3
Beta strandi51 – 57Combined sources7
Turni64 – 68Combined sources5
Helixi69 – 76Combined sources8
Beta strandi86 – 89Combined sources4
Helixi91 – 93Combined sources3
Helixi94 – 107Combined sources14
Beta strandi112 – 121Combined sources10
Turni122 – 124Combined sources3
Turni127 – 130Combined sources4
Helixi133 – 136Combined sources4
Helixi138 – 144Combined sources7
Helixi149 – 160Combined sources12
Helixi164 – 183Combined sources20
Turni184 – 190Combined sources7
Beta strandi201 – 203Combined sources3
Helixi215 – 220Combined sources6
Turni225 – 230Combined sources6
Helixi234 – 241Combined sources8
Beta strandi261 – 270Combined sources10
Helixi272 – 277Combined sources6
Beta strandi284 – 293Combined sources10
Turni296 – 298Combined sources3
Helixi303 – 313Combined sources11
Helixi318 – 320Combined sources3
Beta strandi322 – 326Combined sources5
Helixi331 – 341Combined sources11
Helixi345 – 347Combined sources3
Helixi354 – 357Combined sources4
Turni361 – 363Combined sources3
Helixi364 – 379Combined sources16
Beta strandi383 – 389Combined sources7
Helixi391 – 393Combined sources3
Beta strandi394 – 402Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B3HX-ray2.30C/D1-403[»]
4B3IX-ray2.63C/D1-403[»]
4B3JX-ray2.50C/D1-403[»]
ProteinModelPortaliO53871
SMRiO53871
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Phylogenomic databases

eggNOGiENOG4105CHU Bacteria
COG0183 LUCA
HOGENOMiHOG000012239
InParanoidiO53871
KOiK00626
OMAiCGGTESM
PhylomeDBiO53871

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 5 hits
InterProiView protein in InterPro
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

O53871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEAFIYEA IRTPRGKQKN GSLHEVKPLS LVVGLIDELR KRHPDLDENL
60 70 80 90 100
ISDVILGCVS PVGDQGGDIA RAAVLASGMP VTSGGVQLNR FCASGLEAVN
110 120 130 140 150
TAAQKVRSGW DDLVLAGGVE SMSRVPMGSD GGAMGLDPAT NYDVMFVPQS
160 170 180 190 200
IGADLIATIE GFSREDVDAY ALRSQQKAAE AWSGGYFAKS VVPVRDQNGL
210 220 230 240 250
LILDHDEHMR PDTTKEGLAK LKPAFEGLAA LGGFDDVALQ KYHWVEKINH
260 270 280 290 300
VHTGGNSSGI VDGAALVMIG SAAAGKLQGL TPRARIVATA TSGADPVIML
310 320 330 340 350
TGPTPATRKV LDRAGLTVDD IDLFELNEAF ASVVLKFQKD LNIPDEKLNV
360 370 380 390 400
NGGAIAMGHP LGATGAMILG TMVDELERRN ARRALITLCI GGGMGVATII

ERV
Length:403
Mass (Da):42,414
Last modified:June 1, 1998 - v1
Checksum:i840EABC43EB7FE94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43607.1
PIRiC70815
RefSeqiNP_215374.1, NC_000962.3
WP_009934956.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP43607; CCP43607; Rv0859
GeneIDi885774
KEGGimtu:Rv0859

Similar proteinsi

Entry informationi

Entry nameiY0859_MYCTU
AccessioniPrimary (citable) accession number: O53871
Secondary accession number(s): L0T7Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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