O53816 (O53816_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
PROBABLE METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE MMSA (METHYLMALONIC ACID SEMIALDEHYDE DEHYDROGENASE) (MMSDH) EMBL CAA17520.1
EC=1.2.1.27 EMBL CAA17520.1

Gene names

Name:	mmsA EMBL CAA17520.1
Ordered Locus Names:	Rv0753c

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the aldehyde dehydrogenase family. RuleBase RU003345

Ontologies

Keywords
Molecular function	Oxidoreductase RuleBase RU003344 EMBL CAA17520.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	plasma membrane Inferred from direct assay. Source: MTBBASE
Molecular function	methylmalonate-semialdehyde dehydrogenase (acylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O53816 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 1C4F4BB84B74A096	FASTA	510	54,454
	10 20 30 40 50 60 MTTQISHFID GQRTAGQSTR SADVFDPNTG QIQAKVPMAG KSDIDAAVAS AVEAQKGWAA 70 80 90 100 110 120 WNPQRRARVL MRFIELVNDT IDELAELLSR EHGKTLADAR GDVQRGIEVI EFCLGIPHLL 130 140 150 160 170 180 KGEYTEGAGP GIDVYSLRQP LGVVAGITPF NFPAMIPLWK AGPALACGNA FVLKPSERDP 190 200 210 220 230 240 SVPVRLAELF IEAGLPAGVF QVVHGDKEAV DAILHHPDIK AVGFVGSSDI AQYIYAGAAA 250 260 270 280 290 300 TGKRAQCFGG AKNHMIVMPD ADLDQAVDAL IGAGYGSAGE RCMAISVAVP VGDQTAERLR 310 320 330 340 350 360 ARLIERINNL RVGHSLDPKA DYGPLVTGAA LARVRDYIGQ GVAAGAELVV DGRDRASDDL 370 380 390 400 410 420 TFGLPEGDAN LEGGFFIGPT LFDHVAAHMS IYTDEIFGPV LCMVRARDYE EALRLPSEHE 430 440 450 460 470 480 YGNGVAIFTR DGDAARDFVS RVQVGMVGVN VPIPVPVAYH TFGGWKRSGF GDLNQHGPAA 490 500 510 IQFYTKVKTV TSRWPSGIKD GAEFVIPTMS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv." Camus J.-C., Pryor M.J., Medigue C., Cole S.T. Microbiology 148:2967-2973(2002) [PubMed: 12368430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842574 Genomic DNA. Translation: CAA17520.1.
PIR	D70825.
RefSeq	NP_215267.1. NC_000962.2.
3D structure databases
HSSP	HSSP built from PDB template 1O04 based on UniProtKB P05091.
ProteinModelPortal	O53816.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000000284; EBMYCP00000000284; EBMYCG00000000284.
GeneID	888707.
GenomeReviews	Gene locus Rv0753c in contig AL123456_GR.
KEGG	mtu:Rv0753c.
PATRIC	18150188. VBIMycTub87468_0842.
Organism-specific databases
TubercuList	Rv0753c.
Phylogenomic databases
GeneTree	EBGT00050000015660.
HOGENOM	HBG752218.
OMA	KWAATNP.
PhylomeDB	O53816.
ProtClustDB	CLSK790714.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR010061. MeMal-semiAld_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K00140.
PANTHER	PTHR11699:SF27. MMSDH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR01722. MMSDH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O53816_MYCTU

Accession

Primary (citable) accession number: O53816

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	December 14, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)