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Protein
Submitted name:

LuxR family transcriptional regulator

Gene

Rv0386

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • adenylate cyclase activity Source: MTBBASE
  • DNA binding Source: UniProtKB-KW
  • guanylate cyclase activity Source: MTBBASE
  • manganese ion binding Source: MTBBASE

GO - Biological processi

  • cAMP biosynthetic process Source: MTBBASE
  • intracellular signal transduction Source: InterPro
  • pathogenesis Source: MTBBASE
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4510-MONOMER.
BRENDAi4.6.1.1. 3445.

Names & Taxonomyi

Protein namesi
Submitted name:
LuxR family transcriptional regulatorImported
Submitted name:
Probable transcriptional regulatory protein (Probably LuxR/UhpA-family)Imported
Gene namesi
Ordered Locus Names:Rv0386Imported
ORF Names:LH57_02070Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • intracellular Source: GOC
  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiO53720.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0386.

Structurei

3D structure databases

ProteinModelPortaliO53720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 119Guanylate cyclaseInterPro annotationAdd BLAST109
Domaini1020 – 1085HTH luxR-type DNA-bindingInterPro annotationAdd BLAST66

Phylogenomic databases

eggNOGiENOG4105CQF. Bacteria.
COG2114. LUCA.
COG2771. LUCA.
COG3903. LUCA.
HOGENOMiHOG000053696.
OMAiLYPFWLS.
PhylomeDBiO53720.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 2 hits.
3.30.70.1230. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
IPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLLPRGTV TLLLADVEGS TWLWETHPDD MGAAVARLDK AVSGVIAAHD
60 70 80 90 100
GVRPVEQGEG DSFVLAFACA SDAVAAALDL QRARLAPIRL RIGVHTGEVA
110 120 130 140 150
LRDEGNYAGP TINRTARLRD LAHGGQTVLS GVTESLVIDR LPDKAWLVDL
160 170 180 190 200
GTHALRDLSR PERVMQLCHP ELRIDFPPLR VANDDVAHGL PVHLTRFVGR
210 220 230 240 250
GAQITEVHRL VTDNRLVTLT GAGGVGKTRL AAQLAAQIAG EFGRAWFVDL
260 270 280 290 300
APITDPDLVP VTVAGALGLH DQPGRSTTDT VLRFLGGRPA LVVLDNCEHL
310 320 330 340 350
LDATAALVLA LVKACRGVRL LATCREPLRV EGEVSYRVPS LSLSDEAVEM
360 370 380 390 400
FCYRAQRVRP DFRLTDDNSA AVTEICKRLD GLPLAIELAA ARLRSMTLDE
410 420 430 440 450
IIDGLRDRFA LLTGGARTAA HRQQTLWASV DWSYTLLTEP ERTLFRRLAV
460 470 480 490 500
FVGCFFVDDA QAVACSGDVQ RYQVLDEITL LVDKSLVMAD DNSGRTCYRL
510 520 530 540 550
CETMRHYALE KLSEAGEVDA VFARHRDYYT ALAARVDNPG PSDYSHCLDQ
560 570 580 590 600
AETEIDNLRA AFVWNRENSD TEGALALASS LLRVWMTRGR IQEGRAWFDS
610 620 630 640 650
ILADENARHL EVAAAVRARA LADKALLDIF VDAAAGMEQA QQALVIAREV
660 670 680 690 700
DEPALLSRAL TACGLIAVAV ARADAAASYF AEAIDLARAV DDRWRLAQIL
710 720 730 740 750
TFQAVDAVVA GDPVAARPAA QEARELAAAI GDHSNALWCR WCLGYAQLMR
760 770 780 790 800
GELAAAAAQF GEVVDEAEAS QEVLHKANSL QGLAFALAYQ GELSAARAAA
810 820 830 840 850
DAALEAAELG EYFAGMGYSA LTTAALAAGD VQTAQHASEA AWRNLSLALP
860 870 880 890 900
LSAAVQRAFN AQAALAGGDL SAARRWCDDA VQSMTGHHLA MALATRARIA
910 920 930 940 950
VAEGKREEAE RDAHKALACA AESGAHLDLP DVLECLAGLA SDAGTHHAAA
960 970 980 990 1000
RLFGAAEAIR QQIGSVRFAI YRSDYVQSVT ALRDAMGEKD FDAAWAEGAA
1010 1020 1030 1040 1050
LSIKETIAYA QRGHSWRKRP ATGWESLTPT EIDVVRLVGE GLANKDIATR
1060 1070 1080
LFVSPRTVQT HLTHVYTKLG FTSRLQLAQA AARRT
Length:1,085
Mass (Da):116,792
Last modified:July 5, 2004 - v3
Checksum:iC93B772E03B347D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13106.1.
AL123456 Genomic DNA. Translation: CCP43116.1.
RefSeqiNP_214900.1. NC_000962.3.
WP_003401912.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR13106; AIR13106; LH57_02070.
CCP43116; CCP43116; Rv0386.
GeneIDi886030.
KEGGimtu:Rv0386.
mtv:RVBD_0386.
PATRICi18149342. VBIMycTub87468_0423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13106.1.
AL123456 Genomic DNA. Translation: CCP43116.1.
RefSeqiNP_214900.1. NC_000962.3.
WP_003401912.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliO53720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0386.

Proteomic databases

PRIDEiO53720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR13106; AIR13106; LH57_02070.
CCP43116; CCP43116; Rv0386.
GeneIDi886030.
KEGGimtu:Rv0386.
mtv:RVBD_0386.
PATRICi18149342. VBIMycTub87468_0423.

Phylogenomic databases

eggNOGiENOG4105CQF. Bacteria.
COG2114. LUCA.
COG2771. LUCA.
COG3903. LUCA.
HOGENOMiHOG000053696.
OMAiLYPFWLS.
PhylomeDBiO53720.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4510-MONOMER.
BRENDAi4.6.1.1. 3445.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 2 hits.
3.30.70.1230. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
IPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO53720_MYCTU
AccessioniPrimary (citable) accession number: O53720
Secondary accession number(s): F2GN73, I6WY98, L0T3I7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.