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Protein

Mycosin-3

Gene

mycP3

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Charge relay systemBy similarity1
Active sitei126Charge relay systemBy similarity1
Active sitei342Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

  • growth Source: MTBBASE

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS08.131.

Names & Taxonomyi

Protein namesi
Recommended name:
Mycosin-31 Publication (EC:3.4.21.-By similarity)
Alternative name(s):
MycP3 proteaseCurated
Gene namesi
Name:mycP31 Publication
Ordered Locus Names:Rv0291Imported
ORF Names:LH57_01590Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0291.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • extracellular region Source: MTBBASE
  • integral component of plasma membrane Source: MTBBASE
  • plasma membrane Source: MTBBASE

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500769706226 – 461Mycosin-3Add BLAST436

Proteomic databases

PaxDbiO53695.
PRIDEiO53695.

Expressioni

Inductioni

Constitutively expressed during growth in culture.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0291.

Structurei

3D structure databases

ProteinModelPortaliO53695.
SMRiO53695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 389Peptidase S8Sequence analysisAdd BLAST304

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41090GG. Bacteria.
COG1404. LUCA.
HOGENOMiHOG000043842.
KOiK14743.
OMAiITATAHN.
PhylomeDBiO53695.

Family and domain databases

Gene3Di3.40.50.200. 1 hit.
InterProiView protein in InterPro
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR023834. T7SS_pept_S8A_mycosin.
PfamiView protein in Pfam
PF00082. Peptidase_S8. 1 hit.
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 2 hits.
TIGRFAMsiTIGR03921. T7SS_mycosin. 1 hit.
PROSITEiView protein in PROSITE
PS00137. SUBTILASE_HIS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O53695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRAAFACLA ATVVVAGWWT PPAWAIGPPV VDAAAQPPSG DPGPVAPMEQ
60 70 80 90 100
RGACSVSGVI PGTDPGVPTP SQTMLNLPAA WQFSRGEGQL VAIIDTGVQP
110 120 130 140 150
GPRLPNVDAG GDFVESTDGL TDCDGHGTLV AGIVAGQPGN DGFSGVAPAA
160 170 180 190 200
RLLSIRAMST KFSPRTSGGD PQLAQATLDV AVLAGAIVHA ADLGAKVINV
210 220 230 240 250
STITCLPADR MVDQAALGAA IRYAAVDKDA VIVAAAGNTG ASGSVSASCD
260 270 280 290 300
SNPLTDLSRP DDPRNWAGVT SVSIPSWWQP YVLSVASLTS AGQPSKFSMP
310 320 330 340 350
GPWVGIAAPG ENIASVSNSG DGALANGLPD AHQKLVALSG TSYAAGYVSG
360 370 380 390 400
VAALVRSRYP GLNATEVVRR LTATAHRGAR ESSNIVGAGN LDAVAALTWQ
410 420 430 440 450
LPAEPGGGAA PAKPVADPPV PAPKDTTPRN VAFAGAAALS VLVGLTAATV
460
AIARRRREPT E
Length:461
Mass (Da):46,127
Last modified:June 1, 1998 - v1
Checksum:i7380B819B9356C2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13014.1.
AL123456 Genomic DNA. Translation: CCP43021.1.
RefSeqiNP_214805.1. NC_000962.3.
WP_003401528.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR13014; AIR13014; LH57_01590.
CCP43021; CCP43021; Rv0291.
GeneIDi886615.
KEGGimtu:Rv0291.
mtv:RVBD_0291.
PATRICifig|83332.111.peg.327.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMYCP3_MYCTU
AccessioniPrimary (citable) accession number: O53695
Secondary accession number(s): F2GM95, I6WY21, L0T376
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2016
Last sequence update: June 1, 1998
Last modified: June 7, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families