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Protein
Submitted name:

Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB

Gene

nirB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • nitrate assimilation Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotation

Keywords - Ligandi

4Fe-4SSAAS annotation, HemeSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4374-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirBImported
Gene namesi
Name:nirBImported
Ordered Locus Names:Rv0252Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO53674.
PRIDEiO53674.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0252.

Structurei

3D structure databases

ProteinModelPortaliO53674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 302FAD/NAD-binding_domInterPro annotationAdd BLAST288
Domaini441 – 488Fer2_BFDInterPro annotationAdd BLAST48
Domaini573 – 633NIR_SIR_ferrInterPro annotationAdd BLAST61
Domaini645 – 782NIR_SIRInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4107QZF. Bacteria.
COG1251. LUCA.
HOGENOMiHOG000196164.
KOiK00362.
OMAiYREQARY.
PhylomeDBiO53674.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
3.90.480.10. 1 hit.
InterProiIPR007419. BFD-like_2Fe2S-bd_dom.
IPR023753. FAD/NAD-binding_dom.
IPR005117. NiRdtase/SiRdtase_haem-b_fer.
IPR012744. Nitri_red_NirB.
IPR017121. Nitrite_Rdtase_lsu.
IPR006067. NO2/SO3_Rdtase_4Fe4S_dom.
IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS.
[Graphical view]
PfamiPF04324. Fer2_BFD. 1 hit.
PF01077. NIR_SIR. 1 hit.
PF03460. NIR_SIR_ferr. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037149. NirB. 1 hit.
PRINTSiPR00397. SIROHAEM.
SUPFAMiSSF51905. SSF51905. 2 hits.
SSF55124. SSF55124. 1 hit.
TIGRFAMsiTIGR02374. nitri_red_nirB. 1 hit.
PROSITEiPS00365. NIR_SIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53674-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTAGSSRAP AAAREIVVVG HGMVGHRLVE AVRARDADGS LRITVLAEEG
60 70 80 90 100
DAAYDRVGLT SYTESWDRAL LALPGNDYAG DQRVRLLLNT RVTQIDRATK
110 120 130 140 150
SVVTAAGQRH RYDTLVLATG SYAFVPPVPG HDLPACHVYR TFDDLDAIRA
160 170 180 190 200
GAQRTLDGGH TDGGVVIGGG LLGLEAANAL RQFGLQTHVV EMMPRLMAQQ
210 220 230 240 250
IDEAGGALLA RMIADLGIAV HVGTGTESIE SVKHSDGSVW ARVRLSDGEV
260 270 280 290 300
IDAGVVIFAA GIRPRDELAR AAGLAIGDRG GVLTDLSCRT SDPDIYAVGE
310 320 330 340 350
VAAIDGRCYG LVGPGYTSAE VVADRLLDGS AEFPEADLST KLKLLGVDVA
360 370 380 390 400
SFGDAMGATE NCLEVVINDA VKRTYAKLVL SDDATTLLGG VLVGDASSYG
410 420 430 440 450
VLRPMVGAEL PGDPLALIAP AGSGAGAGAL GVGALPDSAQ ICSCNNVTKG
460 470 480 490 500
ELKCAIADGC GDVPALKSCT AAGTSCGSCV PLLKQLLEAE GVEQSKALCE
510 520 530 540 550
HFSQSRAELF EIITATEVRT FSGLLDRFGR GKGCDICKPV VASILASTGS
560 570 580 590 600
DHILDGEQAS LQDSNDHFLA NIQKNGSYSV VPRVPGGDIK PEHLILIGQI
610 620 630 640 650
AQDFGLYTKI TGGQRIDLFG ARVDQLPLIW QRLVDGGMES GHAYGKAVRT
660 670 680 690 700
VKSCVGSDWC RYGQQDSVQL AIDLELRYRG LRAPHKIKLG VSGCARECAE
710 720 730 740 750
ARGKDVGVIA TEKGWNLYVA GNGGMTPKHA QLLASDLDKE TLIRYIDRFL
760 770 780 790 800
IYYIRTADRL QRTAPWVESL GLDHVREVVC EDSLGLAEEF EAAMQRHVAN
810 820 830 840 850
YKCEWKGVLE DPDKLSRFVS FVNAPDAVDS TVTFTERAGR KVPVSIGIPR

VRS
Length:853
Mass (Da):90,353
Last modified:June 1, 1998 - v1
Checksum:i7731164FF56658A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42981.1.
RefSeqiNP_214766.1. NC_000962.3.
WP_003401336.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiCCP42981; CCP42981; Rv0252.
GeneIDi886665.
KEGGimtu:Rv0252.
mtv:RVBD_0252.
PATRICi18149058. VBIMycTub87468_0282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42981.1.
RefSeqiNP_214766.1. NC_000962.3.
WP_003401336.1. NC_000962.3.

3D structure databases

ProteinModelPortaliO53674.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0252.

Proteomic databases

PaxDbiO53674.
PRIDEiO53674.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP42981; CCP42981; Rv0252.
GeneIDi886665.
KEGGimtu:Rv0252.
mtv:RVBD_0252.
PATRICi18149058. VBIMycTub87468_0282.

Phylogenomic databases

eggNOGiENOG4107QZF. Bacteria.
COG1251. LUCA.
HOGENOMiHOG000196164.
KOiK00362.
OMAiYREQARY.
PhylomeDBiO53674.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4374-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
3.90.480.10. 1 hit.
InterProiIPR007419. BFD-like_2Fe2S-bd_dom.
IPR023753. FAD/NAD-binding_dom.
IPR005117. NiRdtase/SiRdtase_haem-b_fer.
IPR012744. Nitri_red_NirB.
IPR017121. Nitrite_Rdtase_lsu.
IPR006067. NO2/SO3_Rdtase_4Fe4S_dom.
IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS.
[Graphical view]
PfamiPF04324. Fer2_BFD. 1 hit.
PF01077. NIR_SIR. 1 hit.
PF03460. NIR_SIR_ferr. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037149. NirB. 1 hit.
PRINTSiPR00397. SIROHAEM.
SUPFAMiSSF51905. SSF51905. 2 hits.
SSF55124. SSF55124. 1 hit.
TIGRFAMsiTIGR02374. nitri_red_nirB. 1 hit.
PROSITEiPS00365. NIR_SIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO53674_MYCTU
AccessioniPrimary (citable) accession number: O53674
Secondary accession number(s): F2GM52, I6Y782, L0T645
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.