O53674 (O53674_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
PROBABLE NITRITE REDUCTASE [NAD(P)H] LARGE SUBUNIT [FAD FLAVOPROTEIN] NIRB EMBL CAA17344.1
EC=1.6.6.4 EMBL CAA17344.1

Gene names

Name:	nirB EMBL CAA17344.1
Ordered Locus Names:	Rv0252

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	853 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	4Fe-4S SAAS SAAS006066 Heme SAAS SAAS006066 Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase SAAS SAAS006066 EMBL CAA17344.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nitrate assimilation Inferred from mutant phenotype. Source: MTBBASE
Cellular component	cytosol Inferred from direct assay. Source: MTBBASE plasma membrane Inferred from direct assay. Source: MTBBASE
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW NADP binding Inferred from electronic annotation. Source: InterPro flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro nitrite reductase [NAD(P)H] activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O53674 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 7731164FF56658A8	FASTA	853	90,353
	10 20 30 40 50 60 MPTAGSSRAP AAAREIVVVG HGMVGHRLVE AVRARDADGS LRITVLAEEG DAAYDRVGLT 70 80 90 100 110 120 SYTESWDRAL LALPGNDYAG DQRVRLLLNT RVTQIDRATK SVVTAAGQRH RYDTLVLATG 130 140 150 160 170 180 SYAFVPPVPG HDLPACHVYR TFDDLDAIRA GAQRTLDGGH TDGGVVIGGG LLGLEAANAL 190 200 210 220 230 240 RQFGLQTHVV EMMPRLMAQQ IDEAGGALLA RMIADLGIAV HVGTGTESIE SVKHSDGSVW 250 260 270 280 290 300 ARVRLSDGEV IDAGVVIFAA GIRPRDELAR AAGLAIGDRG GVLTDLSCRT SDPDIYAVGE 310 320 330 340 350 360 VAAIDGRCYG LVGPGYTSAE VVADRLLDGS AEFPEADLST KLKLLGVDVA SFGDAMGATE 370 380 390 400 410 420 NCLEVVINDA VKRTYAKLVL SDDATTLLGG VLVGDASSYG VLRPMVGAEL PGDPLALIAP 430 440 450 460 470 480 AGSGAGAGAL GVGALPDSAQ ICSCNNVTKG ELKCAIADGC GDVPALKSCT AAGTSCGSCV 490 500 510 520 530 540 PLLKQLLEAE GVEQSKALCE HFSQSRAELF EIITATEVRT FSGLLDRFGR GKGCDICKPV 550 560 570 580 590 600 VASILASTGS DHILDGEQAS LQDSNDHFLA NIQKNGSYSV VPRVPGGDIK PEHLILIGQI 610 620 630 640 650 660 AQDFGLYTKI TGGQRIDLFG ARVDQLPLIW QRLVDGGMES GHAYGKAVRT VKSCVGSDWC 670 680 690 700 710 720 RYGQQDSVQL AIDLELRYRG LRAPHKIKLG VSGCARECAE ARGKDVGVIA TEKGWNLYVA 730 740 750 760 770 780 GNGGMTPKHA QLLASDLDKE TLIRYIDRFL IYYIRTADRL QRTAPWVESL GLDHVREVVC 790 800 810 820 830 840 EDSLGLAEEF EAAMQRHVAN YKCEWKGVLE DPDKLSRFVS FVNAPDAVDS TVTFTERAGR 850 KVPVSIGIPR VRS

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842572 Genomic DNA. Translation: CAA17344.1.
PIR	H70939.
RefSeq	NP_214766.1. NC_000962.2.
3D structure databases
HSSP	HSSP built from PDB template 1D7Y based on UniProtKB Q52437.
ProteinModelPortal	O53674.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000001598; EBMYCP00000001598; EBMYCG00000001598.
GeneID	886665.
GenomeReviews	Gene locus Rv0252 in contig AL123456_GR.
KEGG	mtu:Rv0252.
PATRIC	18149058. VBIMycTub87468_0282.
Organism-specific databases
TubercuList	Rv0252.
Phylogenomic databases
GeneTree	EBGT00050000014576.
HOGENOM	HBG285339.
OMA	QRNGTFS.
PhylomeDB	O53674.
ProtClustDB	CLSK2299977.
Family and domain databases
InterPro	IPR007419. BFD-like_2Fe2S-bd_dom. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR005117. NiRdtase/SiRdtase_haem-b_fer. IPR012744. Nitri_red_NirB. IPR017121. Nitrite_Rdtase_lsu. IPR006067. NO2/SO3_Rdtase_4Fe4S_dom. IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. [Graphical view]
Gene3D	G3DSA:3.90.480.10. G3DSA:3.90.480.10. 1 hit.
KO	K00362.
Pfam	PF04324. Fer2_BFD. 1 hit. PF01077. NIR_SIR. 1 hit. PF03460. NIR_SIR_ferr. 1 hit. PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 2 hits. [Graphical view]
PIRSF	PIRSF037149. NirB. 1 hit.
PRINTS	PR00368. FADPNR. PR00397. SIROHAEM.
SUPFAM	SSF55124. NiR_SiRalpha_1/3. 1 hit.
TIGRFAMs	TIGR02374. Nitri_red_nirB. 1 hit.
PROSITE	PS00365. NIR_SIR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O53674_MYCTU

Accession

Primary (citable) accession number: O53674

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	December 14, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)