Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB

Gene

nirB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • nitrate assimilation Source: MTBBASE

Keywordsi

Molecular functionOxidoreductaseSAAS annotation
Ligand4Fe-4SSAAS annotation, HemeSAAS annotation, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirBImported
Gene namesi
Name:nirBImported
Ordered Locus Names:Rv0252Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: MTBBASE
  • plasma membrane Source: MTBBASE

PTM / Processingi

Proteomic databases

PaxDbiO53674

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0252

Structurei

3D structure databases

ProteinModelPortaliO53674
SMRiO53674
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 302FAD/NAD-binding_domInterPro annotationAdd BLAST288
Domaini441 – 488Fer2_BFDInterPro annotationAdd BLAST48
Domaini573 – 633NIR_SIR_ferrInterPro annotationAdd BLAST61
Domaini645 – 782NIR_SIRInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4107QZF Bacteria
COG1251 LUCA
HOGENOMiHOG000196164
KOiK00362
OMAiMYYIRTA
PhylomeDBiO53674

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR007419 BFD-like_2Fe2S-bd_dom
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR005117 NiRdtase/SiRdtase_haem-b_fer
IPR036136 Nit/Sulf_reduc_fer_like_dom_sf
IPR012744 Nitri_red_NirB
IPR017121 Nitrite_Rdtase_lsu
IPR006067 NO2/SO3_Rdtase_4Fe4S_dom
IPR006066 NO2/SO3_Rdtase_FeS/sirohaem_BS
PfamiView protein in Pfam
PF04324 Fer2_BFD, 1 hit
PF01077 NIR_SIR, 1 hit
PF03460 NIR_SIR_ferr, 1 hit
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF037149 NirB, 1 hit
PRINTSiPR00397 SIROHAEM
SUPFAMiSSF51905 SSF51905, 2 hits
SSF55124 SSF55124, 1 hit
TIGRFAMsiTIGR02374 nitri_red_nirB, 1 hit
PROSITEiView protein in PROSITE
PS00365 NIR_SIR, 1 hit

Sequencei

Sequence statusi: Complete.

O53674-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTAGSSRAP AAAREIVVVG HGMVGHRLVE AVRARDADGS LRITVLAEEG
60 70 80 90 100
DAAYDRVGLT SYTESWDRAL LALPGNDYAG DQRVRLLLNT RVTQIDRATK
110 120 130 140 150
SVVTAAGQRH RYDTLVLATG SYAFVPPVPG HDLPACHVYR TFDDLDAIRA
160 170 180 190 200
GAQRTLDGGH TDGGVVIGGG LLGLEAANAL RQFGLQTHVV EMMPRLMAQQ
210 220 230 240 250
IDEAGGALLA RMIADLGIAV HVGTGTESIE SVKHSDGSVW ARVRLSDGEV
260 270 280 290 300
IDAGVVIFAA GIRPRDELAR AAGLAIGDRG GVLTDLSCRT SDPDIYAVGE
310 320 330 340 350
VAAIDGRCYG LVGPGYTSAE VVADRLLDGS AEFPEADLST KLKLLGVDVA
360 370 380 390 400
SFGDAMGATE NCLEVVINDA VKRTYAKLVL SDDATTLLGG VLVGDASSYG
410 420 430 440 450
VLRPMVGAEL PGDPLALIAP AGSGAGAGAL GVGALPDSAQ ICSCNNVTKG
460 470 480 490 500
ELKCAIADGC GDVPALKSCT AAGTSCGSCV PLLKQLLEAE GVEQSKALCE
510 520 530 540 550
HFSQSRAELF EIITATEVRT FSGLLDRFGR GKGCDICKPV VASILASTGS
560 570 580 590 600
DHILDGEQAS LQDSNDHFLA NIQKNGSYSV VPRVPGGDIK PEHLILIGQI
610 620 630 640 650
AQDFGLYTKI TGGQRIDLFG ARVDQLPLIW QRLVDGGMES GHAYGKAVRT
660 670 680 690 700
VKSCVGSDWC RYGQQDSVQL AIDLELRYRG LRAPHKIKLG VSGCARECAE
710 720 730 740 750
ARGKDVGVIA TEKGWNLYVA GNGGMTPKHA QLLASDLDKE TLIRYIDRFL
760 770 780 790 800
IYYIRTADRL QRTAPWVESL GLDHVREVVC EDSLGLAEEF EAAMQRHVAN
810 820 830 840 850
YKCEWKGVLE DPDKLSRFVS FVNAPDAVDS TVTFTERAGR KVPVSIGIPR

VRS
Length:853
Mass (Da):90,353
Last modified:June 1, 1998 - v1
Checksum:i7731164FF56658A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP42981.1
RefSeqiNP_214766.1, NC_000962.3
WP_003401336.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP42981; CCP42981; Rv0252
GeneIDi886665
KEGGimtu:Rv0252
mtv:RVBD_0252
PATRICifig|83332.111.peg.285

Entry informationi

Entry nameiO53674_MYCTU
AccessioniPrimary (citable) accession number: O53674
Secondary accession number(s): F2GM52, I6Y782, L0T645
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health