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Protein
Submitted name:

3-oxoacyl-(Acyl-carrier-protein) reductase

Gene

fabG-1

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei244NADCombined sources1
Binding sitei360NADCombined sources1
Binding sitei364NADCombined sources1
Binding sitei390NADCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi223 – 225NADCombined sources3
Nucleotide bindingi267 – 268NADCombined sources2
Nucleotide bindingi295 – 297NADCombined sources3
Nucleotide bindingi395 – 396NADCombined sources2

GO - Molecular functioni

GO - Biological processi

  • long-chain fatty-acyl-CoA metabolic process Source: MTBBASE
  • response to antibiotic Source: MTBBASE
  • short-chain fatty acid metabolic process Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

NADCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciMTBCDC1551:GT3Z-4552-MONOMER.
BRENDAi1.1.1.100. 3445.

Names & Taxonomyi

Protein namesi
Submitted name:
3-oxoacyl-(Acyl-carrier-protein) reductaseImported (EC:1.1.1.100Imported)
Gene namesi
Name:fabG-1Imported
Ordered Locus Names:MT0256Imported
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)Imported
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: MTBBASE
  • extracellular region Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M1LX-ray2.52A/B17-448[»]
3Q6IX-ray2.59A/B/C/D17-454[»]
3V1TX-ray1.88C/D1-454[»]
3V1UX-ray2.50A1-454[»]
4FW8X-ray2.79A/B/C/D1-454[»]
ProteinModelPortaliO53665.
SMRiO53665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000245099.
KOiK00059.
OrthoDBiPOG091H012M.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKRSSDLF SQVVNSGPGS FLARQLGVPQ PETLRRYRAG EPPLTGSLLI
60 70 80 90 100
GGAGRVVEPL RAALEKDYDL VGNNLGGRWA DSFGGLVFDA TGITEPAGLK
110 120 130 140 150
GLHEFFTPVL RNLGRCGRVV VVGGTPEAAA STNERIAQRA LEGFTRSLGK
160 170 180 190 200
ELRRGATTAL VYLSPDAKPA ATGLESTMRF LLSAKSAYVD GQVFSVGADD
210 220 230 240 250
STPPADWEKP LDGKVAIVTG AARGIGATIA EVFARDGAHV VAIDVESAAE
260 270 280 290 300
NLAETASKVG GTALWLDVTA DDAVDKISEH LRDHHGGKAD ILVNNAGITR
310 320 330 340 350
DKLLANMDDA RWDAVLAVNL LAPLRLTEGL VGNGSIGEGG RVIGLSSIAG
360 370 380 390 400
IAGNRGQTNY ATTKAGMIGI TQALAPGLAA KGITINAVAP GFIETQMTAA
410 420 430 440 450
IPLATREVGR RLNSLLQGGQ PVDVAEAIAY FASPASNAVT GNVIRVCGQA

MIGA
Length:454
Mass (Da):46,830
Last modified:June 1, 1998 - v1
Checksum:iC5B89B6FEA38BD91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK44474.1.
PIRiF70938.
RefSeqiWP_003899869.1. NZ_KK341227.1.

Genome annotation databases

EnsemblBacteriaiAAK44474; AAK44474; MT0256.
KEGGimtc:MT0256.
PATRICi18122277. VBIMycTub22151_0273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK44474.1.
PIRiF70938.
RefSeqiWP_003899869.1. NZ_KK341227.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M1LX-ray2.52A/B17-448[»]
3Q6IX-ray2.59A/B/C/D17-454[»]
3V1TX-ray1.88C/D1-454[»]
3V1UX-ray2.50A1-454[»]
4FW8X-ray2.79A/B/C/D1-454[»]
ProteinModelPortaliO53665.
SMRiO53665.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK44474; AAK44474; MT0256.
KEGGimtc:MT0256.
PATRICi18122277. VBIMycTub22151_0273.

Phylogenomic databases

HOGENOMiHOG000245099.
KOiK00059.
OrthoDBiPOG091H012M.

Enzyme and pathway databases

BioCyciMTBCDC1551:GT3Z-4552-MONOMER.
BRENDAi1.1.1.100. 3445.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO53665_MYCTO
AccessioniPrimary (citable) accession number: O53665
Secondary accession number(s): F2GM42, Q7DA69
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.