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Protein
Submitted name:

Dehydratase

Gene

htdX

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity Source: MTBBASE
  • 3-hydroxyacyl-CoA dehydratase activity Source: MTBBASE
  • fatty acid synthase activity Source: InterPro

GO - Biological processi

  • fatty acid biosynthetic process Source: MTBBASE
  • fatty acid metabolic process Source: MTBBASE
  • oxidation-reduction process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4362-MONOMER.

Chemistry databases

SwissLipidsiSLP:000001024.

Names & Taxonomyi

Protein namesi
Submitted name:
DehydrataseImported
Submitted name:
Probable 3-hydroxyacyl-thioester dehydratase HtdXImported
Gene namesi
Name:htdXImported
Ordered Locus Names:Rv0241cImported
ORF Names:LH57_01325Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0241c.

Subcellular locationi

GO - Cellular componenti

  • fatty acid synthase complex Source: InterPro
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0241c.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WEWX-ray2.40A29-280[»]
4OOBX-ray2.30A29-280[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 256MaoC-likeInterPro annotationAdd BLAST95

Phylogenomic databases

eggNOGiENOG4108KR6. Bacteria.
COG2030. LUCA.
HOGENOMiHOG000245110.
OMAiGMWTKAR.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
InterProiIPR003965. Fatty_acid_synthase.
IPR029069. HotDog_dom.
IPR002539. MaoC_dom.
[Graphical view]
PfamiPF01575. MaoC_dehydratas. 1 hit.
[Graphical view]
PRINTSiPR01483. FASYNTHASE.
SUPFAMiSSF54637. SSF54637. 2 hits.

Sequencei

Sequence statusi: Complete.

O53664-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQPSGLKNL LRAAAGALPV VPRTDQLPNR TVTVEELPID PANVAAYAAV
60 70 80 90 100
TGLRYGNQVP LTYPFALTFP SVMSLVTGFD FPFAAMGAIH TENHITQYRP
110 120 130 140 150
IAVTDAVGVR VRAENLREHR RGLLVDLVTN VSVGNDVAWH QVTTFLHQQR
160 170 180 190 200
TSLSGEPKPP PQKKPKLPPP AAVLRITPAK IRRYAAVGGD HNPIHTNPIA
210 220 230 240 250
AKLFGFPTVI AHGMFTAAAV LANIEARFPD AVRYSVRFAK PVLLPATAGL
260 270 280
YVAEGDGGWD LTLRNMAKGY PHLTATVRGL
Length:280
Mass (Da):30,195
Last modified:June 1, 1998 - v1
Checksum:iAE356A650624FB8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR12966.1.
AL123456 Genomic DNA. Translation: CCP42970.1.
RefSeqiNP_214755.1. NC_000962.3.
WP_003401305.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR12966; AIR12966; LH57_01325.
CCP42970; CCP42970; Rv0241c.
GeneIDi886686.
KEGGimtu:Rv0241c.
mtv:RVBD_0241c.
PATRICi18122275. VBIMycTub22151_0272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR12966.1.
AL123456 Genomic DNA. Translation: CCP42970.1.
RefSeqiNP_214755.1. NC_000962.3.
WP_003401305.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WEWX-ray2.40A29-280[»]
4OOBX-ray2.30A29-280[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0241c.

Chemistry databases

SwissLipidsiSLP:000001024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR12966; AIR12966; LH57_01325.
CCP42970; CCP42970; Rv0241c.
GeneIDi886686.
KEGGimtu:Rv0241c.
mtv:RVBD_0241c.
PATRICi18122275. VBIMycTub22151_0272.

Organism-specific databases

TubercuListiRv0241c.

Phylogenomic databases

eggNOGiENOG4108KR6. Bacteria.
COG2030. LUCA.
HOGENOMiHOG000245110.
OMAiGMWTKAR.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4362-MONOMER.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
InterProiIPR003965. Fatty_acid_synthase.
IPR029069. HotDog_dom.
IPR002539. MaoC_dom.
[Graphical view]
PfamiPF01575. MaoC_dehydratas. 1 hit.
[Graphical view]
PRINTSiPR01483. FASYNTHASE.
SUPFAMiSSF54637. SSF54637. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiO53664_MYCTU
AccessioniPrimary (citable) accession number: O53664
Secondary accession number(s): F2GM41, I6X8T8, Q7DA70
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.