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Protein
Submitted name:

Endopeptidase, peptidase family M13

Gene

MT0208

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi493 – 4931Zinc; via tele nitrogenCombined sources
Metal bindingi497 – 4971Zinc; via tele nitrogenCombined sources
Metal bindingi560 – 5601ZincCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyciMTBRV:RV0198C-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Endopeptidase, peptidase family M13Imported
Gene namesi
Ordered Locus Names:MT0208Imported
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)Imported
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZUKX-ray2.60A/B1-663[»]
ProteinModelPortaliO53649.
SMRiO53649. Positions 4-663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 400381Peptidase_M13_NInterPro annotationAdd
BLAST
Domaini452 – 659208Peptidase_M13InterPro annotationAdd
BLAST

Phylogenomic databases

HOGENOMiHOG000245572.
KOiK07386.
OrthoDBiEOG6V7BJT.

Family and domain databases

Gene3Di3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.

Sequencei

Sequence statusi: Complete.

O53649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLAIPSGID LSHIDADARP QDDLFGHVNG RWLAEHEIPA DRATDGAFRS
60 70 80 90 100
LFDRAETQVR DLIIQASQAG AAVGTDAQRI GDLYASFLDE EAVERAGVQP
110 120 130 140 150
LHDELATIDS AADATELAAA LGTLQRAGVG GGIGVYVDTD SKDSTRYLVH
160 170 180 190 200
FTQSGIGLPD ESYYRDEQHA AVLAAYPGHI ARMFGLVYGG ESRDHAKTAD
210 220 230 240 250
RIVALETKLA DAHWDVVKRR DADLGYNLRT FAQLQTEGAG FDWVSWVTAL
260 270 280 290 300
GSAPDAMTEL VVRQPDYLVT FASLWASVNV EDWKCWARWR LIRARAPWLT
310 320 330 340 350
RALVAEDFEF YGRTLTGAQQ LRDRWKRGVS LVENLMGDAV GKLYVQRHFP
360 370 380 390 400
PDAKSRIDTL VDNLQEAYRI SISELDWMTP QTRQRALAKL NKFTAKVGYP
410 420 430 440 450
IKWRDYSKLA IDRDDLYGNV QRGYAVNHDR ELAKLFGPVD RDEWFMTPQT
460 470 480 490 500
VNAYYNPGMN EIVFPAAILQ PPFFDPQADE AANYGGIGAV IGHEIGHGFD
510 520 530 540 550
DQGAKYDGDG NLVDWWTDDD RTEFAARTKA LIEQYHAYTP RDLVDHPGPP
560 570 580 590 600
HVQGAFTIGE NIGDLGGLSI ALLAYQLSLN GNPAPVIDGL TGMQRVFFGW
610 620 630 640 650
AQIWRTKSRA AEAIRRLAVD PHSPPEFRCN GVVRNVDAFY QAFDVTEDDA
660
LFLDPQRRVR IWN
Length:663
Mass (Da):73,914
Last modified:June 1, 1998 - v1
Checksum:i815DBAD9147D2AE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK44429.1.
PIRiC70838.
RefSeqiWP_003401172.1. NZ_KK341227.1.

Genome annotation databases

EnsemblBacteriaiAAK44429; AAK44429; MT0208.
KEGGimtc:MT0208.
PATRICi18122185. VBIMycTub22151_0227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK44429.1.
PIRiC70838.
RefSeqiWP_003401172.1. NZ_KK341227.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZUKX-ray2.60A/B1-663[»]
ProteinModelPortaliO53649.
SMRiO53649. Positions 4-663.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK44429; AAK44429; MT0208.
KEGGimtc:MT0208.
PATRICi18122185. VBIMycTub22151_0227.

Phylogenomic databases

HOGENOMiHOG000245572.
KOiK07386.
OrthoDBiEOG6V7BJT.

Enzyme and pathway databases

BioCyciMTBRV:RV0198C-MONOMER.

Family and domain databases

Gene3Di3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CDC 1551 / OshkoshImported.
  2. "Crystal structure of Mycobacterium tuberculosis zinc-dependent metalloprotease-1 (Zmp1), a metalloprotease involved in pathogenicity."
    Ferraris D.M., Sbardella D., Petrera A., Marini S., Amstutz B., Coletta M., Sander P., Rizzi M.
    J. Biol. Chem. 286:32475-32482(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiO53649_MYCTO
AccessioniPrimary (citable) accession number: O53649
Secondary accession number(s): F2GLZ6, Q7DAA5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.