Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O53611

- O53611_MYCTU

UniProt

O53611 - O53611_MYCTU

Protein
Submitted name:

Isocitrate dehydrogenase Icd2

Gene

icd2

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysisUniRule annotation
    Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei550 – 5501Substrate
    Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
    Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
    2. isocitrate dehydrogenase activity Source: MTBBASE
    3. magnesium ion binding Source: MTBBASE
    4. protein homodimerization activity Source: MTBBASE

    GO - Biological processi

    1. glyoxylate cycle Source: MTBBASE
    2. isocitrate metabolic process Source: MTBBASE
    3. tricarboxylic acid cycle Source: MTBBASE

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase Icd2Imported
    Submitted name:
    Probable isocitrate dehydrogenase [NADP] Icd2 (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)Imported
    Gene namesi
    Name:icd2Imported
    Ordered Locus Names:Rv0066cImported
    ORF Names:P425_00070Imported, RVBD_0066cImported
    OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
    Taxonomic identifieri83332 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001584: Chromosome, UP000003123: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cell wall Source: MTBBASE
    2. cytosol Source: MTBBASE
    3. extracellular region Source: MTBBASE
    4. plasma membrane Source: MTBBASE

    Interactioni

    Protein-protein interaction databases

    STRINGi83332.Rv0066c.

    Structurei

    3D structure databases

    SMRiO53611. Positions 6-740.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate binding

    Phylogenomic databases

    KOiK00031.
    OMAiEEQRIGD.
    OrthoDBiEOG6DVJPP.
    PhylomeDBiO53611.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O53611-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAEQPTIIY TLTDEAPLLA TYAFLPIVRA FAEPAGIKIE ASDISVAARI    50
    LAEFPDYLTE EQRVPDNLAE LGRLTQLPDT NIIKLPNISA SVPQLVAAIK 100
    ELQDKGYAVP DYPADPKTDQ EKAIKERYAR CLGSAVNPVL RQGNSDRRAP 150
    KAVKEYARKH PHSMGEWSMA SRTHVAHMRH GDFYAGEKSM TLDRARNVRM 200
    ELLAKSGKTI VLKPEVPLDD GDVIDSMFMS KKALCDFYEE QMQDAFETGV 250
    MFSLHVKATM MKVSHPIVFG HAVRIFYKDA FAKHQELFDD LGVNVNNGLS 300
    DLYSKIESLP ASQRDEIIED LHRCHEHRPE LAMVDSARGI SNFHSPSDVI 350
    VDASMPAMIR AGGKMYGADG KLKDTKAVNP ESTFSRIYQE IINFCKTNGQ 400
    FDPTTMGTVP NVGLMAQQAE EYGSHDKTFE IPEDGVANIV DVATGEVLLT 450
    ENVEAGDIWR MCIVKDAPIR DWVKLAVTRA RISGMPVLFW LDPYRPHENE 500
    LIKKVKTYLK DHDTEGLDIQ IMSQVRSMRY TCERLVRGLD TIAATGNILR 550
    DYLTDLFPIL ELGTSAKMLS VVPLMAGGGM YETGAGGSAP KHVKQLVEEN 600
    HLRWDSLGEF LALGAGFEDI GIKTGNERAK LLGKTLDAAI GKLLDNDKSP 650
    SRKTGELDNR GSQFYLAMYW AQELAAQTDD QQLAEHFASL ADVLTKNEDV 700
    IVRELTEVQG EPVDIGGYYA PDSDMTTAVM RPSKTFNAAL EAVQG 745
    Length:745
    Mass (Da):82,550
    Last modified:June 1, 1998 - v1
    Checksum:iA90FA68EDA105EF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003248 Genomic DNA. Translation: AFN47910.1.
    AL123456 Genomic DNA. Translation: CCP42789.1.
    JLDD01000001 Genomic DNA. Translation: KBJ41170.1.
    RefSeqiNP_214580.1. NC_000962.3.
    YP_006513381.1. NC_018143.2.

    Genome annotation databases

    EnsemblBacteriaiAFN47910; AFN47910; RVBD_0066c.
    GeneIDi13316045.
    887016.
    KEGGimtu:Rv0066c.
    mtv:RVBD_0066c.
    PATRICi18121883. VBIMycTub22151_0076.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003248 Genomic DNA. Translation: AFN47910.1 .
    AL123456 Genomic DNA. Translation: CCP42789.1 .
    JLDD01000001 Genomic DNA. Translation: KBJ41170.1 .
    RefSeqi NP_214580.1. NC_000962.3.
    YP_006513381.1. NC_018143.2.

    3D structure databases

    SMRi O53611. Positions 6-740.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 83332.Rv0066c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFN47910 ; AFN47910 ; RVBD_0066c .
    GeneIDi 13316045.
    887016.
    KEGGi mtu:Rv0066c.
    mtv:RVBD_0066c.
    PATRICi 18121883. VBIMycTub22151_0076.

    Phylogenomic databases

    KOi K00031.
    OMAi EEQRIGD.
    OrthoDBi EOG6DVJPP.
    PhylomeDBi O53611.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37RvImported and H37RvImported.
    2. "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv."
      Camus J.C., Pryor M.J., Medigue C., Cole S.T.
      Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    5. Lew J.M.
      Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37RvImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: H37RvImported.

    Entry informationi

    Entry nameiO53611_MYCTU
    AccessioniPrimary (citable) accession number: O53611
    Secondary accession number(s): F2GPS0, I6Y6T5, Q7DAI6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3