Isocitrate dehydrogenase, NADP-dependent - Mycobacterium tuberculosis H37Rv

Preferred order of sections

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase, NADP-dependent EMBL AFN47910.1

Gene names

ORF Names:

RVBD_0066c EMBL AFN47910.1

Organism

Mycobacterium tuberculosis H37Rv EMBL AFN47910.1

Taxonomic identifier

83332 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›

Protein attributes

Sequence length	745 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Gene Ontology (GO)
Biological_process	glyoxylate cycle Inferred from direct assay PubMed 16194279. Source: MTBBASE isocitrate metabolic process Inferred from direct assay PubMed 16194279. Source: MTBBASE tricarboxylic acid cycle Inferred from direct assay PubMed 16194279. Source: MTBBASE
Cellular_component	cell wall Inferred from direct assay PubMed 20825248. Source: MTBBASE cytosol Inferred from direct assay PubMed 15525680. Source: MTBBASE extracellular region Inferred from direct assay PubMed 17443846. Source: MTBBASE plasma membrane Inferred from direct assay PubMed 14532352 PubMed 15525680. Source: MTBBASE
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro isocitrate dehydrogenase activity Inferred from direct assay PubMed 16194279. Source: MTBBASE magnesium ion binding Inferred from direct assay PubMed 16194279. Source: MTBBASE
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

O53611 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: A90FA68EDA105EF3
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FASTA

745

82,550

        10         20         30         40         50         60 
MSAEQPTIIY TLTDEAPLLA TYAFLPIVRA FAEPAGIKIE ASDISVAARI LAEFPDYLTE 

        70         80         90        100        110        120 
EQRVPDNLAE LGRLTQLPDT NIIKLPNISA SVPQLVAAIK ELQDKGYAVP DYPADPKTDQ 

       130        140        150        160        170        180 
EKAIKERYAR CLGSAVNPVL RQGNSDRRAP KAVKEYARKH PHSMGEWSMA SRTHVAHMRH 

       190        200        210        220        230        240 
GDFYAGEKSM TLDRARNVRM ELLAKSGKTI VLKPEVPLDD GDVIDSMFMS KKALCDFYEE 

       250        260        270        280        290        300 
QMQDAFETGV MFSLHVKATM MKVSHPIVFG HAVRIFYKDA FAKHQELFDD LGVNVNNGLS 

       310        320        330        340        350        360 
DLYSKIESLP ASQRDEIIED LHRCHEHRPE LAMVDSARGI SNFHSPSDVI VDASMPAMIR 

       370        380        390        400        410        420 
AGGKMYGADG KLKDTKAVNP ESTFSRIYQE IINFCKTNGQ FDPTTMGTVP NVGLMAQQAE 

       430        440        450        460        470        480 
EYGSHDKTFE IPEDGVANIV DVATGEVLLT ENVEAGDIWR MCIVKDAPIR DWVKLAVTRA 

       490        500        510        520        530        540 
RISGMPVLFW LDPYRPHENE LIKKVKTYLK DHDTEGLDIQ IMSQVRSMRY TCERLVRGLD 

       550        560        570        580        590        600 
TIAATGNILR DYLTDLFPIL ELGTSAKMLS VVPLMAGGGM YETGAGGSAP KHVKQLVEEN 

       610        620        630        640        650        660 
HLRWDSLGEF LALGAGFEDI GIKTGNERAK LLGKTLDAAI GKLLDNDKSP SRKTGELDNR 

       670        680        690        700        710        720 
GSQFYLAMYW AQELAAQTDD QQLAEHFASL ADVLTKNEDV IVRELTEVQG EPVDIGGYYA 

       730        740 
PDSDMTTAVM RPSKTFNAAL EAVQG

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References

[1]

"The Genome Sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genome Sequencing Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Galagan J., Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.

Birren B.
Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL AFN47910.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003248 Genomic DNA. Translation: AFN47910.1.
RefSeq	NP_214580.1. NC_000962.3. YP_006513381.1. NC_018143.1.
3D structure databases
SMR	O53611. Positions 6-740.
ModBase	Search...
Protein-protein interaction databases
STRING	83332.Rv0066c.
Proteomic databases
PRIDE	O53611.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK44296; AAK44296; MT0072.
GeneID	13316045. 887016.
KEGG	mtc:MT0072. mtu:Rv0066c. mtv:RVBD_0066c.
PATRIC	18121883. VBIMycTub22151_0076.
Phylogenomic databases
KO	K00031.
OMA	PRTMGTV.
ProtClustDB	CLSK867411.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

O53611_MYCTU

Accession

Primary (citable) accession number: O53611
Secondary accession number(s): F2GPS0, I6Y6T5, Q7DAI6

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Preferred order of sections

Names and origin

Protein attributes

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry information