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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd2

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei147SubstrateUniRule annotation1
Sitei257Critical for catalysisUniRule annotation1
Metal bindingi352Magnesium or manganeseUniRule annotation1
Sitei422Critical for catalysisUniRule annotation1
Binding sitei550SubstrateUniRule annotation1
Metal bindingi551Magnesium or manganeseUniRule annotation1
Metal bindingi555Magnesium or manganeseUniRule annotation1

GO - Molecular functioni

  • isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  • isocitrate dehydrogenase activity Source: MTBBASE
  • magnesium ion binding Source: MTBBASE
  • protein homodimerization activity Source: MTBBASE

GO - Biological processi

  • glyoxylate cycle Source: MTBBASE
  • isocitrate metabolic process Source: MTBBASE
  • tricarboxylic acid cycle Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4181-MONOMER.
BRENDAi1.1.1.42. 3445.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Submitted name:
Probable isocitrate dehydrogenase [NADP] Icd2 (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)Imported
Gene namesi
Name:icd2Imported
Ordered Locus Names:Rv0066cImported
ORF Names:LH57_00380Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0066c.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: MTBBASE
  • extracellular region Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: MTBBASE

Protein-protein interaction databases

STRINGi83332.Rv0066c.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni134 – 141Substrate bindingUniRule annotation8

Phylogenomic databases

eggNOGiENOG4105E9K. Bacteria.
COG2838. LUCA.
HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

O53611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEQPTIIY TLTDEAPLLA TYAFLPIVRA FAEPAGIKIE ASDISVAARI
60 70 80 90 100
LAEFPDYLTE EQRVPDNLAE LGRLTQLPDT NIIKLPNISA SVPQLVAAIK
110 120 130 140 150
ELQDKGYAVP DYPADPKTDQ EKAIKERYAR CLGSAVNPVL RQGNSDRRAP
160 170 180 190 200
KAVKEYARKH PHSMGEWSMA SRTHVAHMRH GDFYAGEKSM TLDRARNVRM
210 220 230 240 250
ELLAKSGKTI VLKPEVPLDD GDVIDSMFMS KKALCDFYEE QMQDAFETGV
260 270 280 290 300
MFSLHVKATM MKVSHPIVFG HAVRIFYKDA FAKHQELFDD LGVNVNNGLS
310 320 330 340 350
DLYSKIESLP ASQRDEIIED LHRCHEHRPE LAMVDSARGI SNFHSPSDVI
360 370 380 390 400
VDASMPAMIR AGGKMYGADG KLKDTKAVNP ESTFSRIYQE IINFCKTNGQ
410 420 430 440 450
FDPTTMGTVP NVGLMAQQAE EYGSHDKTFE IPEDGVANIV DVATGEVLLT
460 470 480 490 500
ENVEAGDIWR MCIVKDAPIR DWVKLAVTRA RISGMPVLFW LDPYRPHENE
510 520 530 540 550
LIKKVKTYLK DHDTEGLDIQ IMSQVRSMRY TCERLVRGLD TIAATGNILR
560 570 580 590 600
DYLTDLFPIL ELGTSAKMLS VVPLMAGGGM YETGAGGSAP KHVKQLVEEN
610 620 630 640 650
HLRWDSLGEF LALGAGFEDI GIKTGNERAK LLGKTLDAAI GKLLDNDKSP
660 670 680 690 700
SRKTGELDNR GSQFYLAMYW AQELAAQTDD QQLAEHFASL ADVLTKNEDV
710 720 730 740
IVRELTEVQG EPVDIGGYYA PDSDMTTAVM RPSKTFNAAL EAVQG
Length:745
Mass (Da):82,550
Last modified:June 1, 1998 - v1
Checksum:iA90FA68EDA105EF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR12786.1.
AL123456 Genomic DNA. Translation: CCP42789.1.
RefSeqiNP_214580.1. NC_000962.3.
WP_003899797.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR12786; AIR12786; LH57_00380.
CCP42789; CCP42789; Rv0066c.
GeneIDi887016.
KEGGimtu:Rv0066c.
mtv:RVBD_0066c.
PATRICi18121883. VBIMycTub22151_0076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR12786.1.
AL123456 Genomic DNA. Translation: CCP42789.1.
RefSeqiNP_214580.1. NC_000962.3.
WP_003899797.1. NZ_KK339370.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0066c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR12786; AIR12786; LH57_00380.
CCP42789; CCP42789; Rv0066c.
GeneIDi887016.
KEGGimtu:Rv0066c.
mtv:RVBD_0066c.
PATRICi18121883. VBIMycTub22151_0076.

Organism-specific databases

TubercuListiRv0066c.

Phylogenomic databases

eggNOGiENOG4105E9K. Bacteria.
COG2838. LUCA.
HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4181-MONOMER.
BRENDAi1.1.1.42. 3445.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO53611_MYCTU
AccessioniPrimary (citable) accession number: O53611
Secondary accession number(s): F2GPS0, I6Y6T5, Q7DAI6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.