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O53611

- O53611_MYCTU

UniProt

O53611 - O53611_MYCTU

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Protein
Submitted name: Isocitrate dehydrogenase Icd2
Gene
icd2, Rv0066c, P425_00070, RVBD_0066c
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate By similarityUniRule annotation
Sitei257 – 2571Critical for catalysis By similarityUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese By similarityUniRule annotation
Sitei422 – 4221Critical for catalysis By similarityUniRule annotation
Binding sitei550 – 5501Substrate By similarityUniRule annotation
Metal bindingi551 – 5511Magnesium or manganese By similarityUniRule annotation
Metal bindingi555 – 5551Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. isocitrate dehydrogenase activity Source: MTBBASE
  3. magnesium ion binding Source: MTBBASE
  4. protein homodimerization activity Source: MTBBASE
Complete GO annotation...

GO - Biological processi

  1. glyoxylate cycle Source: MTBBASE
  2. isocitrate metabolic process Source: MTBBASE
  3. tricarboxylic acid cycle Source: MTBBASE
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase Icd2Imported
Submitted name:
Probable isocitrate dehydrogenase [NADP] Icd2 (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)Imported
Gene namesi
Name:icd2Imported
Ordered Locus Names:Rv0066cImported
ORF Names:P425_00070Imported, RVBD_0066cImported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001584: Chromosome, UP000003123: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cell wall Source: MTBBASE
  2. cytosol Source: MTBBASE
  3. extracellular region Source: MTBBASE
  4. plasma membrane Source: MTBBASE
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0066c.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarityUniRule annotation

Phylogenomic databases

KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

O53611-1 [UniParc]FASTAAdd to Basket

« Hide

MSAEQPTIIY TLTDEAPLLA TYAFLPIVRA FAEPAGIKIE ASDISVAARI    50
LAEFPDYLTE EQRVPDNLAE LGRLTQLPDT NIIKLPNISA SVPQLVAAIK 100
ELQDKGYAVP DYPADPKTDQ EKAIKERYAR CLGSAVNPVL RQGNSDRRAP 150
KAVKEYARKH PHSMGEWSMA SRTHVAHMRH GDFYAGEKSM TLDRARNVRM 200
ELLAKSGKTI VLKPEVPLDD GDVIDSMFMS KKALCDFYEE QMQDAFETGV 250
MFSLHVKATM MKVSHPIVFG HAVRIFYKDA FAKHQELFDD LGVNVNNGLS 300
DLYSKIESLP ASQRDEIIED LHRCHEHRPE LAMVDSARGI SNFHSPSDVI 350
VDASMPAMIR AGGKMYGADG KLKDTKAVNP ESTFSRIYQE IINFCKTNGQ 400
FDPTTMGTVP NVGLMAQQAE EYGSHDKTFE IPEDGVANIV DVATGEVLLT 450
ENVEAGDIWR MCIVKDAPIR DWVKLAVTRA RISGMPVLFW LDPYRPHENE 500
LIKKVKTYLK DHDTEGLDIQ IMSQVRSMRY TCERLVRGLD TIAATGNILR 550
DYLTDLFPIL ELGTSAKMLS VVPLMAGGGM YETGAGGSAP KHVKQLVEEN 600
HLRWDSLGEF LALGAGFEDI GIKTGNERAK LLGKTLDAAI GKLLDNDKSP 650
SRKTGELDNR GSQFYLAMYW AQELAAQTDD QQLAEHFASL ADVLTKNEDV 700
IVRELTEVQG EPVDIGGYYA PDSDMTTAVM RPSKTFNAAL EAVQG 745
Length:745
Mass (Da):82,550
Last modified:June 1, 1998 - v1
Checksum:iA90FA68EDA105EF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003248 Genomic DNA. Translation: AFN47910.1.
AL123456 Genomic DNA. Translation: CCP42789.1.
JLDD01000001 Genomic DNA. Translation: KBJ41170.1.
RefSeqiNP_214580.1. NC_000962.3.
YP_006513381.1. NC_018143.2.

Genome annotation databases

EnsemblBacteriaiAFN47910; AFN47910; RVBD_0066c.
GeneIDi13316045.
887016.
KEGGimtu:Rv0066c.
mtv:RVBD_0066c.
PATRICi18121883. VBIMycTub22151_0076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003248 Genomic DNA. Translation: AFN47910.1 .
AL123456 Genomic DNA. Translation: CCP42789.1 .
JLDD01000001 Genomic DNA. Translation: KBJ41170.1 .
RefSeqi NP_214580.1. NC_000962.3.
YP_006513381.1. NC_018143.2.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 83332.Rv0066c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFN47910 ; AFN47910 ; RVBD_0066c .
GeneIDi 13316045.
887016.
KEGGi mtu:Rv0066c.
mtv:RVBD_0066c.
PATRICi 18121883. VBIMycTub22151_0076.

Phylogenomic databases

KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv and H37RvImported.
  2. "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv."
    Camus J.C., Pryor M.J., Medigue C., Cole S.T.
    Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  5. Lew J.M.
    Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.

Entry informationi

Entry nameiO53611_MYCTU
AccessioniPrimary (citable) accession number: O53611
Secondary accession number(s): F2GPS0, I6Y6T5, Q7DAI6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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