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O53611 (O53611_MYCTU) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Probable isocitrate dehydrogenase [NADP] Icd2 (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) EMBL CCP42789.1
Gene names
Name:icd2 EMBL CCP42789.1
Ordered Locus Names:Rv0066c EMBL CCP42789.1
ORF Names:RVBD_0066c EMBL AFN47910.1
OrganismMycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [Reference proteome] [HAMAP] EMBL AFN47910.1
Taxonomic identifier83332 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length745 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region134 – 1418Substrate binding By similarity PIRSR PIRSR009407-2

Sites

Metal binding3521Magnesium or manganese By similarity
Metal binding5511Magnesium or manganese By similarity
Metal binding5551Magnesium or manganese By similarity
Binding site1471Substrate By similarity PIRSR PIRSR009407-2
Binding site5501Substrate By similarity PIRSR PIRSR009407-2
Site2571Critical for catalysis By similarity PIRSR PIRSR009407-1
Site4221Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

Sequence LengthMass (Da)Tools
O53611 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: A90FA68EDA105EF3

FASTA74582,550
        10         20         30         40         50         60 
MSAEQPTIIY TLTDEAPLLA TYAFLPIVRA FAEPAGIKIE ASDISVAARI LAEFPDYLTE 

        70         80         90        100        110        120 
EQRVPDNLAE LGRLTQLPDT NIIKLPNISA SVPQLVAAIK ELQDKGYAVP DYPADPKTDQ 

       130        140        150        160        170        180 
EKAIKERYAR CLGSAVNPVL RQGNSDRRAP KAVKEYARKH PHSMGEWSMA SRTHVAHMRH 

       190        200        210        220        230        240 
GDFYAGEKSM TLDRARNVRM ELLAKSGKTI VLKPEVPLDD GDVIDSMFMS KKALCDFYEE 

       250        260        270        280        290        300 
QMQDAFETGV MFSLHVKATM MKVSHPIVFG HAVRIFYKDA FAKHQELFDD LGVNVNNGLS 

       310        320        330        340        350        360 
DLYSKIESLP ASQRDEIIED LHRCHEHRPE LAMVDSARGI SNFHSPSDVI VDASMPAMIR 

       370        380        390        400        410        420 
AGGKMYGADG KLKDTKAVNP ESTFSRIYQE IINFCKTNGQ FDPTTMGTVP NVGLMAQQAE 

       430        440        450        460        470        480 
EYGSHDKTFE IPEDGVANIV DVATGEVLLT ENVEAGDIWR MCIVKDAPIR DWVKLAVTRA 

       490        500        510        520        530        540 
RISGMPVLFW LDPYRPHENE LIKKVKTYLK DHDTEGLDIQ IMSQVRSMRY TCERLVRGLD 

       550        560        570        580        590        600 
TIAATGNILR DYLTDLFPIL ELGTSAKMLS VVPLMAGGGM YETGAGGSAP KHVKQLVEEN 

       610        620        630        640        650        660 
HLRWDSLGEF LALGAGFEDI GIKTGNERAK LLGKTLDAAI GKLLDNDKSP SRKTGELDNR 

       670        680        690        700        710        720 
GSQFYLAMYW AQELAAQTDD QQLAEHFASL ADVLTKNEDV IVRELTEVQG EPVDIGGYYA 

       730        740 
PDSDMTTAVM RPSKTFNAAL EAVQG 

« Hide

References

« Hide 'large scale' references
[1]"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. expand/collapse author list , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.
Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv and H37Rv EMBL CCP42789.1.
[2]"Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv."
Camus J.C., Pryor M.J., Medigue C., Cole S.T.
Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL CCP42789.1.
[3]"TubercuList--10 years after."
Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
Tuberculosis 91:1-7(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL CCP42789.1.
[4]Lew J.M.
Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL CCP42789.1.
[5]"The genome sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genome Sequencing Platform
Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M. expand/collapse author list , Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.
[6]"The Genome Sequence of Mycobacterium tuberculosis H37Rv."
The Broad Institute Genome Sequencing Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M. expand/collapse author list , Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: H37Rv EMBL AFN47910.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003248 Genomic DNA. Translation: AFN47910.1.
AL123456 Genomic DNA. Translation: CCP42789.1.
RefSeqNP_214580.1. NC_000962.3.
NP_334482.1. NC_002755.2.
YP_006513381.1. NC_018143.2.

3D structure databases

ProteinModelPortalO53611.
SMRO53611. Positions 6-740.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING83332.Rv0066c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK44296; AAK44296; MT0072.
AFN47910; AFN47910; RVBD_0066c.
CCP42789; CCP42789; Rv0066c.
GeneID13316045.
887016.
922800.
KEGGmtc:MT0072.
mtu:Rv0066c.
mtv:RVBD_0066c.
PATRIC18121883. VBIMycTub22151_0076.

Phylogenomic databases

KOK00031.
OMAGYLRWDS.
OrthoDBEOG6DVJPP.
ProtClustDBCLSK867411.

Enzyme and pathway databases

BioCycMTBCDC:MT0072-MONOMER.
MTBRV:RV0066C-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 3 hits.
InterProIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamPF03971. IDH. 1 hit.
[Graphical view]
PIRSFPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsTIGR00178. monomer_idh. 1 hit.
ProtoNetSearch...

Entry information

Entry nameO53611_MYCTU
AccessionPrimary (citable) accession number: O53611
Secondary accession number(s): F2GPS0, I6Y6T5, Q7DAI6
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)