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O53551

- FAC17_MYCTU

UniProt

O53551 - FAC17_MYCTU

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Protein

Long-chain-fatty-acid--CoA ligase FadD17

Gene
fadD17, Rv3506
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: MTBBASE

GO - Biological processi

  1. Actinobacterium-type cell wall biogenesis Source: UniProtKB
  2. lipid biosynthetic process Source: UniProtKB
  3. long-chain fatty acid biosynthetic process Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTBRV:RV3506-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase FadD17 (EC:6.2.1.3)
Short name:
FACL
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD17
Ordered Locus Names:Rv3506
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001584: Chromosome

Organism-specific databases

TubercuListiRv3506.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MTBBASE
  2. plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Long-chain-fatty-acid--CoA ligase FadD17PRO_0000406787Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3506.

Structurei

3D structure databases

ProteinModelPortaliO53551.
SMRiO53551. Positions 42-491.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000052047.
KOiK00666.
OMAiNTHKEMA.
OrthoDBiEOG6VF30G.
PhylomeDBiO53551.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53551-1 [UniParc]FASTAAdd to Basket

« Hide

MTPTHPTVTE LLLPLSEIDD RGVYFEDSFT SWRDHIRHGA AIAAALRERL    50
DPARPPHVGV LLQNTPFFSA TLVAGALSGI VPVGLNPVRR GAALAGDIAK 100
ADCQLVLTGS GSAEVPADVE HINVDSPEWT DEVAAHRDTE VRFRSADLAD 150
LFMLIFTSGT SGDPKAVKCS HRKVAIAGVT ITQRFSLGRD DVCYVSMPLF 200
HSNAVLVGWA VAAACQGSMA LRRKFSASQF LADVRRYGAT YANYVGKPLS 250
YVLATPELPD DADNPLRAVY GNEGVPGDID RFGRRFGCVV MDGFGSTEGG 300
VAITRTLDTP AGALGPLPGG IQIVDPDTGE PCPTGVVGEL VNTAGPGGFE 350
GYYNDEAAEA ERMAGGVYHS GDLAYRDDAG YAYFAGRLGD WMRVDGENLG 400
TAPIERVLMR YPDATEVAVY PVPDPVVGDQ VMAALVLAPG TKFDADKFRA 450
FLTEQPDLGH KQWPSYVRVS AGLPRTMTFK VIKRQLSAEG VACADPVWPI 500
RR 502
Length:502
Mass (Da):53,739
Last modified:June 1, 1998 - v1
Checksum:i0AF9A7B3B9C83A4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL123456 Genomic DNA. Translation: CCP46328.1.
PIRiD70806.
RefSeqiNP_218023.1. NC_000962.3.
YP_006516995.1. NC_018143.2.

Genome annotation databases

EnsemblBacteriaiCCP46328; CCP46328; Rv3506.
GeneIDi13317113.
888251.
KEGGimtu:Rv3506.
mtv:RVBD_3506.
PATRICi18156406. VBIMycTub87468_3913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL123456 Genomic DNA. Translation: CCP46328.1 .
PIRi D70806.
RefSeqi NP_218023.1. NC_000962.3.
YP_006516995.1. NC_018143.2.

3D structure databases

ProteinModelPortali O53551.
SMRi O53551. Positions 42-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 83332.Rv3506.

Chemistry

ChEMBLi CHEMBL5783.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCP46328 ; CCP46328 ; Rv3506 .
GeneIDi 13317113.
888251.
KEGGi mtu:Rv3506.
mtv:RVBD_3506.
PATRICi 18156406. VBIMycTub87468_3913.

Organism-specific databases

TubercuListi Rv3506.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000052047.
KOi K00666.
OMAi NTHKEMA.
OrthoDBi EOG6VF30G.
PhylomeDBi O53551.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci MTBRV:RV3506-MONOMER.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. "Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria."
    Trivedi O.A., Arora P., Sridharan V., Tickoo R., Mohanty D., Gokhale R.S.
    Nature 428:441-445(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN ACYL-COA SYNTHETASE.
    Strain: ATCC 25618 / H37Rv.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.

Entry informationi

Entry nameiFAC17_MYCTU
AccessioniPrimary (citable) accession number: O53551
Secondary accession number(s): L0TCQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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