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O53551 (FAC17_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase FadD17

Short name=FACL
EC=6.2.1.3
Alternative name(s):
Acyl-CoA synthetase
Gene names
Name:fadD17
Ordered Locus Names:Rv3506
OrganismMycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [Reference proteome] [HAMAP]
Taxonomic identifier83332 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. Ref.2

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Long-chain-fatty-acid--CoA ligase FadD17
PRO_0000406787

Sequences

Sequence LengthMass (Da)Tools
O53551 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 0AF9A7B3B9C83A4D

FASTA50253,739
        10         20         30         40         50         60 
MTPTHPTVTE LLLPLSEIDD RGVYFEDSFT SWRDHIRHGA AIAAALRERL DPARPPHVGV 

        70         80         90        100        110        120 
LLQNTPFFSA TLVAGALSGI VPVGLNPVRR GAALAGDIAK ADCQLVLTGS GSAEVPADVE 

       130        140        150        160        170        180 
HINVDSPEWT DEVAAHRDTE VRFRSADLAD LFMLIFTSGT SGDPKAVKCS HRKVAIAGVT 

       190        200        210        220        230        240 
ITQRFSLGRD DVCYVSMPLF HSNAVLVGWA VAAACQGSMA LRRKFSASQF LADVRRYGAT 

       250        260        270        280        290        300 
YANYVGKPLS YVLATPELPD DADNPLRAVY GNEGVPGDID RFGRRFGCVV MDGFGSTEGG 

       310        320        330        340        350        360 
VAITRTLDTP AGALGPLPGG IQIVDPDTGE PCPTGVVGEL VNTAGPGGFE GYYNDEAAEA 

       370        380        390        400        410        420 
ERMAGGVYHS GDLAYRDDAG YAYFAGRLGD WMRVDGENLG TAPIERVLMR YPDATEVAVY 

       430        440        450        460        470        480 
PVPDPVVGDQ VMAALVLAPG TKFDADKFRA FLTEQPDLGH KQWPSYVRVS AGLPRTMTFK 

       490        500 
VIKRQLSAEG VACADPVWPI RR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL123456 Genomic DNA. Translation: CCP46328.1.
PIRD70806.
RefSeqNP_218023.1. NC_000962.3.
YP_006516995.1. NC_018143.2.

3D structure databases

ProteinModelPortalO53551.
SMRO53551. Positions 3-491.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING83332.Rv3506.

Chemistry

ChEMBLCHEMBL5783.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCP46328; CCP46328; Rv3506.
GeneID13317113.
888251.
KEGGmtu:Rv3506.
mtv:RVBD_3506.
PATRIC18156406. VBIMycTub87468_3913.

Organism-specific databases

TubercuListRv3506.

Phylogenomic databases

eggNOGCOG0318.
HOGENOMHOG000052047.
KOK00666.
OMAKAVRCTH.
OrthoDBEOG6VF30G.
ProtClustDBPRK07867.

Enzyme and pathway databases

BioCycMTBRV:RV3506-MONOMER.
UniPathwayUPA00094.

Family and domain databases

InterProIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFAC17_MYCTU
AccessionPrimary (citable) accession number: O53551
Secondary accession number(s): L0TCQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways