SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O53521

- FAC15_MYCTU

UniProt

O53521 - FAC15_MYCTU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Long-chain-fatty-acid--CoA ligase FadD15
Gene
fadD15, Rv2187
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: MTBBASE

GO - Biological processi

  1. Actinobacterium-type cell wall biogenesis Source: UniProtKB
  2. fatty acid biosynthetic process Source: UniProtKB-UniPathway
  3. lipid biosynthetic process Source: UniProtKB
  4. long-chain fatty acid metabolic process Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTBRV:RV2187-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase FadD15 (EC:6.2.1.3)
Short name:
FACL
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD15
Ordered Locus Names:Rv2187
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001584: Chromosome

Organism-specific databases

TubercuListiRv2187.

Subcellular locationi

GO - Cellular componenti

  1. cell wall Source: MTBBASE
  2. plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Long-chain-fatty-acid--CoA ligase FadD15
PRO_0000406784Add
BLAST

Proteomic databases

PRIDEiO53521.

PTM databases

PhosSiteiP12071722.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2187.

Structurei

3D structure databases

ProteinModelPortaliO53521.
SMRiO53521. Positions 29-545.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
HOGENOMiHOG000229985.
KOiK01897.
OMAiFRELAIN.
OrthoDBiEOG64FKGZ.
PhylomeDBiO53521.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53521-1 [UniParc]FASTAAdd to Basket

« Hide

MREISVPAPF TVGEHDNVAA MVFEHERDDP DYVIYQRLID GVWTDVTCAE    50
AANQIRAAAL GLISLGVQAG DRVVIFSATR YEWAILDFAI LAVGAVTVPT 100
YETSSAEQVR WVLQDSEAVV LFAETDSHAT MVAELSGSVP ALREVLQIAG 150
SGPNALDRLT EAGASVDPAE LTARLAALRS TDPATLIYTS GTTGRPKGCQ 200
LTQSNLVHEI KGARAYHPTL LRKGERLLVF LPLAHVLARA ISMAAFHSKV 250
TVGFTSDIKN LLPMLAVFKP TVVVSVPRVF EKVYNTAEQN AANAGKGRIF 300
AIAAQTAVDW SEACDRGGPG LLLRAKHAVF DRLVYRKLRA ALGGNCRAAV 350
SGGAPLGARL GHFYRGAGLT IYEGYGLSGT SGGVAISQFN DLKIGTVGKP 400
VPGNSLRIAD DGELLVRGGV VFSGYWRNEQ ATTEAFTDGW FKTGDLGAVD 450
EDGFLTITGR KKEIIVTAGG KNVAPAVLED QLRAHPLISQ AVVVGDAKPF 500
IGALITIDPE AFEGWKQRNS KTAGASVGDL ATDPDLIAEI DAAVKQANLA 550
VSHAESIRKF RILPVDFTED TGELTPTMKV KRKVVAEKFA SDIEAIYNKE 600
Length:600
Mass (Da):64,035
Last modified:July 5, 2004 - v3
Checksum:iDCA7C09033C3CEBA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL123456 Genomic DNA. Translation: CCP44964.1.
PIRiE70937.
RefSeqiNP_216703.1. NC_000962.3.
YP_006515606.1. NC_018143.2.

Genome annotation databases

EnsemblBacteriaiCCP44964; CCP44964; Rv2187.
GeneIDi13318875.
887456.
KEGGimtu:Rv2187.
mtv:RVBD_2187.
PATRICi18153420. VBIMycTub87468_2438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL123456 Genomic DNA. Translation: CCP44964.1 .
PIRi E70937.
RefSeqi NP_216703.1. NC_000962.3.
YP_006515606.1. NC_018143.2.

3D structure databases

ProteinModelPortali O53521.
SMRi O53521. Positions 29-545.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 83332.Rv2187.

PTM databases

PhosSitei P12071722.

Proteomic databases

PRIDEi O53521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCP44964 ; CCP44964 ; Rv2187 .
GeneIDi 13318875.
887456.
KEGGi mtu:Rv2187.
mtv:RVBD_2187.
PATRICi 18153420. VBIMycTub87468_2438.

Organism-specific databases

TubercuListi Rv2187.

Phylogenomic databases

eggNOGi COG1022.
HOGENOMi HOG000229985.
KOi K01897.
OMAi FRELAIN.
OrthoDBi EOG64FKGZ.
PhylomeDBi O53521.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci MTBRV:RV2187-MONOMER.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. "Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria."
    Trivedi O.A., Arora P., Sridharan V., Tickoo R., Mohanty D., Gokhale R.S.
    Nature 428:441-445(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN ACYL-COA SYNTHETASE.
    Strain: ATCC 25618 / H37Rv.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.

Entry informationi

Entry nameiFAC15_MYCTU
AccessioniPrimary (citable) accession number: O53521
Secondary accession number(s): L0T8V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi