Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O53521 (FAC15_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase FadD15

Short name=FACL
EC=6.2.1.3
Alternative name(s):
Acyl-CoA synthetase
Gene names
Name:fadD15
Ordered Locus Names:Rv2187
OrganismMycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [Reference proteome] [HAMAP]
Taxonomic identifier83332 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. Ref.2

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600Long-chain-fatty-acid--CoA ligase FadD15
PRO_0000406784

Sequences

Sequence LengthMass (Da)Tools
O53521 [UniParc].

Last modified July 5, 2004. Version 3.
Checksum: DCA7C09033C3CEBA

FASTA60064,035
        10         20         30         40         50         60 
MREISVPAPF TVGEHDNVAA MVFEHERDDP DYVIYQRLID GVWTDVTCAE AANQIRAAAL 

        70         80         90        100        110        120 
GLISLGVQAG DRVVIFSATR YEWAILDFAI LAVGAVTVPT YETSSAEQVR WVLQDSEAVV 

       130        140        150        160        170        180 
LFAETDSHAT MVAELSGSVP ALREVLQIAG SGPNALDRLT EAGASVDPAE LTARLAALRS 

       190        200        210        220        230        240 
TDPATLIYTS GTTGRPKGCQ LTQSNLVHEI KGARAYHPTL LRKGERLLVF LPLAHVLARA 

       250        260        270        280        290        300 
ISMAAFHSKV TVGFTSDIKN LLPMLAVFKP TVVVSVPRVF EKVYNTAEQN AANAGKGRIF 

       310        320        330        340        350        360 
AIAAQTAVDW SEACDRGGPG LLLRAKHAVF DRLVYRKLRA ALGGNCRAAV SGGAPLGARL 

       370        380        390        400        410        420 
GHFYRGAGLT IYEGYGLSGT SGGVAISQFN DLKIGTVGKP VPGNSLRIAD DGELLVRGGV 

       430        440        450        460        470        480 
VFSGYWRNEQ ATTEAFTDGW FKTGDLGAVD EDGFLTITGR KKEIIVTAGG KNVAPAVLED 

       490        500        510        520        530        540 
QLRAHPLISQ AVVVGDAKPF IGALITIDPE AFEGWKQRNS KTAGASVGDL ATDPDLIAEI 

       550        560        570        580        590        600 
DAAVKQANLA VSHAESIRKF RILPVDFTED TGELTPTMKV KRKVVAEKFA SDIEAIYNKE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL123456 Genomic DNA. Translation: CCP44964.1.
PIRE70937.
RefSeqNP_216703.1. NC_000962.3.
YP_006515606.1. NC_018143.2.

3D structure databases

ProteinModelPortalO53521.
SMRO53521. Positions 5-593.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING83332.Rv2187.

PTM databases

PhosSiteP12071722.

Proteomic databases

PRIDEO53521.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCP44964; CCP44964; Rv2187.
GeneID13318875.
887456.
KEGGmtu:Rv2187.
mtv:RVBD_2187.
PATRIC18153420. VBIMycTub87468_2438.

Organism-specific databases

TubercuListRv2187.

Phylogenomic databases

eggNOGCOG1022.
HOGENOMHOG000229985.
KOK01897.
OMANENIATM.
OrthoDBEOG64FKGZ.
ProtClustDBCLSK791686.

Enzyme and pathway databases

BioCycMTBRV:RV2187-MONOMER.
UniPathwayUPA00094.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFAC15_MYCTU
AccessionPrimary (citable) accession number: O53521
Secondary accession number(s): L0T8V6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways