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Protein

Long-chain-fatty-acid--CoA ligase FadD15

Gene

fadD15

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

  • Actinobacterium-type cell wall biogenesis Source: UniProtKB
  • fatty acid biosynthetic process Source: UniProtKB-UniPathway
  • lipid biosynthetic process Source: UniProtKB
  • long-chain fatty acid metabolic process Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTBRV:RV2187-MONOMER.
UniPathwayiUPA00094.

Chemistry

SwissLipidsiSLP:000000981.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase FadD15 (EC:6.2.1.3)
Short name:
FACL
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:fadD15
Ordered Locus Names:Rv2187
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2187.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Long-chain-fatty-acid--CoA ligase FadD15PRO_0000406784Add
BLAST

Proteomic databases

PaxDbiO53521.
PRIDEiO53521.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2187.

Structurei

3D structure databases

ProteinModelPortaliO53521.
SMRiO53521. Positions 14-545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IQE. Bacteria.
COG1022. LUCA.
HOGENOMiHOG000229985.
InParanoidiO53521.
KOiK01897.
OMAiVGEQAQY.
PhylomeDBiO53521.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREISVPAPF TVGEHDNVAA MVFEHERDDP DYVIYQRLID GVWTDVTCAE
60 70 80 90 100
AANQIRAAAL GLISLGVQAG DRVVIFSATR YEWAILDFAI LAVGAVTVPT
110 120 130 140 150
YETSSAEQVR WVLQDSEAVV LFAETDSHAT MVAELSGSVP ALREVLQIAG
160 170 180 190 200
SGPNALDRLT EAGASVDPAE LTARLAALRS TDPATLIYTS GTTGRPKGCQ
210 220 230 240 250
LTQSNLVHEI KGARAYHPTL LRKGERLLVF LPLAHVLARA ISMAAFHSKV
260 270 280 290 300
TVGFTSDIKN LLPMLAVFKP TVVVSVPRVF EKVYNTAEQN AANAGKGRIF
310 320 330 340 350
AIAAQTAVDW SEACDRGGPG LLLRAKHAVF DRLVYRKLRA ALGGNCRAAV
360 370 380 390 400
SGGAPLGARL GHFYRGAGLT IYEGYGLSGT SGGVAISQFN DLKIGTVGKP
410 420 430 440 450
VPGNSLRIAD DGELLVRGGV VFSGYWRNEQ ATTEAFTDGW FKTGDLGAVD
460 470 480 490 500
EDGFLTITGR KKEIIVTAGG KNVAPAVLED QLRAHPLISQ AVVVGDAKPF
510 520 530 540 550
IGALITIDPE AFEGWKQRNS KTAGASVGDL ATDPDLIAEI DAAVKQANLA
560 570 580 590 600
VSHAESIRKF RILPVDFTED TGELTPTMKV KRKVVAEKFA SDIEAIYNKE
Length:600
Mass (Da):64,035
Last modified:July 5, 2004 - v3
Checksum:iDCA7C09033C3CEBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44964.1.
PIRiE70937.
RefSeqiNP_216703.1. NC_000962.3.
WP_003906768.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP44964; CCP44964; Rv2187.
GeneIDi887456.
KEGGimtu:Rv2187.
PATRICi18153420. VBIMycTub87468_2438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44964.1.
PIRiE70937.
RefSeqiNP_216703.1. NC_000962.3.
WP_003906768.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliO53521.
SMRiO53521. Positions 14-545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv2187.

Chemistry

SwissLipidsiSLP:000000981.

Proteomic databases

PaxDbiO53521.
PRIDEiO53521.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP44964; CCP44964; Rv2187.
GeneIDi887456.
KEGGimtu:Rv2187.
PATRICi18153420. VBIMycTub87468_2438.

Organism-specific databases

TubercuListiRv2187.

Phylogenomic databases

eggNOGiENOG4108IQE. Bacteria.
COG1022. LUCA.
HOGENOMiHOG000229985.
InParanoidiO53521.
KOiK01897.
OMAiVGEQAQY.
PhylomeDBiO53521.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciMTBRV:RV2187-MONOMER.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFAC15_MYCTU
AccessioniPrimary (citable) accession number: O53521
Secondary accession number(s): L0T8V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.