ID   O53516_MYCTU            Unreviewed;       247 AA.
AC   O53516; F2GJY9; I6YCR4; Q7D7E3;
DT   01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JUN-1998, sequence version 1.
DT   27-MAR-2024, entry version 145.
DE   SubName: Full=1-acylglycerol-3-phosphate O-acyltransferase {ECO:0000313|EMBL:CCP44959.1};
GN   OrderedLocusNames=Rv2182c {ECO:0000313|EMBL:CCP44959.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP44959.1, ECO:0000313|Proteomes:UP000001584};
RN   [1] {ECO:0000313|EMBL:CCP44959.1, ECO:0000313|Proteomes:UP000001584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
RA   Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2] {ECO:0007829|PubMed:21969609}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21969609; DOI=10.1074/mcp.M111.011445;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Converts lysophosphatidic acid (LPA) into phosphatidic acid
CC       by incorporating acyl moiety at the 2 position.
CC       {ECO:0000256|ARBA:ARBA00037183}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-
CC         sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342,
CC         ChEBI:CHEBI:58608; EC=2.3.1.51;
CC         Evidence={ECO:0000256|ARBA:ARBA00001141};
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DR   EMBL; AL123456; CCP44959.1; -; Genomic_DNA.
DR   RefSeq; NP_216698.1; NC_000962.3.
DR   RefSeq; WP_003411341.1; NZ_NVQJ01000008.1.
DR   AlphaFoldDB; O53516; -.
DR   SMR; O53516; -.
DR   STRING; 83332.Rv2182c; -.
DR   PaxDb; 83332-Rv2182c; -.
DR   DNASU; 888625; -.
DR   GeneID; 45426158; -.
DR   GeneID; 888625; -.
DR   KEGG; mtu:Rv2182c; -.
DR   PATRIC; fig|83332.111.peg.2429; -.
DR   TubercuList; Rv2182c; -.
DR   eggNOG; COG0204; Bacteria.
DR   InParanoid; O53516; -.
DR   OrthoDB; 9808424at2; -.
DR   PhylomeDB; O53516; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0003841; F:1-acylglycerol-3-phosphate O-acyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006654; P:phosphatidic acid biosynthetic process; IBA:GO_Central.
DR   CDD; cd07989; LPLAT_AGPAT-like; 1.
DR   InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR   PANTHER; PTHR10434; 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR10434:SF60; 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE LPAT1, CHLOROPLASTIC; 1.
DR   Pfam; PF01553; Acyltransferase; 1.
DR   SMART; SM00563; PlsC; 1.
DR   SUPFAM; SSF69593; Glycerol-3-phosphate (1)-acyltransferase; 1.
PE   1: Evidence at protein level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001584}.
FT   DOMAIN          35..154
FT                   /note="Phospholipid/glycerol acyltransferase"
FT                   /evidence="ECO:0000259|SMART:SM00563"
FT   REGION          226..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   247 AA;  26955 MW;  FB1094228A340BDB CRC64;
     MWYYLFKYIF MGPLFTLLGR PKVEGLEYIP SSGPAILASN HLAVADSFYL PLVVRRRIWF
     LAKSEYFTGT GLKGWINRWF YSVSGQVPID RTNADSAQGA LQTAVVLLGQ GKLLGMYPEG
     TRSPDGRLYK GKTGLARLAL HTGVPVIPVA MIGTNVVNPP GRKMLRFGRV TVRFGKPMDF
     SRFEGLAGNH FIERAVTDEV IYELMGLSGQ EYVDIYAASV KDGRNAGGAG ANPNSTDAAR
     IPETAAG
//