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Protein

HTH-type transcriptional regulator Rv2034

Gene

Rv2034

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of lipid metabolism and hypoxic response. Positively regulates transcription of various genes, such as phoP, groEL2 and dosR. Negatively regulates its own transcription. Acts by binding to a specific palindromic sequence motif in promoter regions.2 Publications

Enzyme regulationi

DNA-binding ability is not susceptible to zinc, nickel, cobalt, cadmium, lead, copper and manganese ions.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 56H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • DNA binding Source: MTBBASE
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • regulation of chaperone-mediated protein complex assembly Source: MTBBASE
  • regulation of fatty acid metabolic process Source: MTBBASE
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6237-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator Rv2034
Gene namesi
Ordered Locus Names:Rv2034
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2034.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi32A → G: Does not bind DNA, but retains the capacity to form dimers; when associated with G-35. 1 Publication1
Mutagenesisi35E → G: Does not bind DNA, but retains the capacity to form dimers; when associated with G-32. 1 Publication1
Mutagenesisi61C → A: Does not bind DNA and does not form dimers. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004191771 – 107HTH-type transcriptional regulator Rv2034Add BLAST107

Proteomic databases

PaxDbiO53478.

Expressioni

Inductioni

Negatively autoregulated.1 Publication

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi83332.Rv2034.

Structurei

3D structure databases

ProteinModelPortaliO53478.
SMRiO53478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 93HTH arsR-typePROSITE-ProRule annotationAdd BLAST93

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105MHT. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144508.
InParanoidiO53478.
OMAiVGTYRTE.
PhylomeDBiO53478.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTYRSPDRA WQALADGTRR AIVERLAHGP LAVGELARDL PVSRPAVSQH
60 70 80 90 100
LKVLKTARLV CDRPAGTRRV YQLDPTGLAA LRTDLDRFWT RALTGYAQLI

DSEGDDT
Length:107
Mass (Da):11,856
Last modified:July 5, 2004 - v3
Checksum:i975FB95505F826E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44807.1.
PIRiA70943.
RefSeqiNP_216550.1. NC_000962.3.
WP_003410200.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP44807; CCP44807; Rv2034.
GeneIDi887859.
KEGGimtu:Rv2034.
PATRICi18153088. VBIMycTub87468_2273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44807.1.
PIRiA70943.
RefSeqiNP_216550.1. NC_000962.3.
WP_003410200.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliO53478.
SMRiO53478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv2034.

Proteomic databases

PaxDbiO53478.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP44807; CCP44807; Rv2034.
GeneIDi887859.
KEGGimtu:Rv2034.
PATRICi18153088. VBIMycTub87468_2273.

Organism-specific databases

TubercuListiRv2034.

Phylogenomic databases

eggNOGiENOG4105MHT. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144508.
InParanoidiO53478.
OMAiVGTYRTE.
PhylomeDBiO53478.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6237-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHTHAR_MYCTU
AccessioniPrimary (citable) accession number: O53478
Secondary accession number(s): L0T8F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.