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Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (bacterial route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase flavoprotein subunit (LH57_18135), Succinate dehydrogenase flavoprotein subunit (sdhA)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (bacterial route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunitUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:sdhAImported
Ordered Locus Names:Rv3318Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3318.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiO53370.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3318.

Structurei

3D structure databases

ProteinModelPortaliO53370.
SMRiO53370. Positions 32-590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 401394FAD_binding_2InterPro annotationAdd
BLAST
Domaini456 – 590135Succ_DH_flav_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C00. Bacteria.
COG1053. LUCA.
HOGENOMiHOG000160475.
KOiK00239.
OMAiHIDAKLP.
OrthoDBiEOG6M3PC4.
PhylomeDBiO53370.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICQHRYDVV IVGAGGAGMR AAVEAGPRVR TAVLTKLYPT RSHTGAAQGG
60 70 80 90 100
MCAALANVED DNWEWHTFDT VKGGDYLADQ DAVEIMCKEA IDAVLDLEKM
110 120 130 140 150
GMPFNRTPEG RIDQRRFGGH TRDHGKAPVR RACYAADRTG HMILQTLYQN
160 170 180 190 200
CVKHDVEFFN EFYALDLALT QTPSGPVATG VIAYELATGD IHVFHAKAVV
210 220 230 240 250
IATGGSGRMY KTTSNAHTLT GDGIGIVFRK GLPLEDMEFH QFHPTGLAGL
260 270 280 290 300
GILISEAVRG EGGRLLNGEG ERFMERYAPT IVDLAPRDIV ARSMVLEVLE
310 320 330 340 350
GRGAGPLKDY VYIDVRHLGE EVLEAKLPDI TEFARTYLGV DPVTELVPVY
360 370 380 390 400
PTCHYLMGGI PTTVTGQVLR DNTSVVPGLY AAGECACVSV HGANRLGTNS
410 420 430 440 450
LLDINVFGRR AGIAAASYAQ GHDFVDMPPN PEAMVVGWVS DILSEHGNER
460 470 480 490 500
VADIRGALQQ SMDNNAAVFR TEETLKQALT DIHALKERYS RITVHDKGKR
510 520 530 540 550
FNTDLLEAIE LGFLLELAEV TVVGALNRKE SRGGHAREDY PNRDDVNYMR
560 570 580 590
HTMAYKEIGA DKEGPELRSD VRLDFKPVVQ TRYEPKERKY
Length:590
Mass (Da):64,826
Last modified:June 1, 1998 - v1
Checksum:i63AB833980D73AC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46138.1.
RefSeqiNP_217835.1. NC_000962.3.
WP_003417273.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP46138; CCP46138; Rv3318.
GeneIDi887639.
KEGGimtu:Rv3318.
mtv:RVBD_3318.
PATRICi18129268. VBIMycTub22151_3730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46138.1.
RefSeqiNP_217835.1. NC_000962.3.
WP_003417273.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliO53370.
SMRiO53370. Positions 32-590.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3318.

Proteomic databases

PaxDbiO53370.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP46138; CCP46138; Rv3318.
GeneIDi887639.
KEGGimtu:Rv3318.
mtv:RVBD_3318.
PATRICi18129268. VBIMycTub22151_3730.

Organism-specific databases

TubercuListiRv3318.

Phylogenomic databases

eggNOGiENOG4105C00. Bacteria.
COG1053. LUCA.
HOGENOMiHOG000160475.
KOiK00239.
OMAiHIDAKLP.
OrthoDBiEOG6M3PC4.
PhylomeDBiO53370.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01005.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiO53370_MYCTU
AccessioniPrimary (citable) accession number: O53370
Secondary accession number(s): F2GE62, I6X6Z4, Q7D5Q2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.