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O53366 (TYPH_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidine phosphorylase
EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:Rv3314c, MT3415
ORF Names:MTV016.14
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427Thymidine phosphorylase
PRO_0000059082

Sequences

Sequence LengthMass (Da)Tools
O53366 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 2253269754A96D60

FASTA42744,486
        10         20         30         40         50         60 
MTDFAFDAPT VIRTKRDGGR LSDAAIDWVV KAYTDGRVAD EQMSALLMAI VWRGMDRGEI 

        70         80         90        100        110        120 
ARWTAAMLAS GARLDFTDLP LATVDKHSTG GVGDKITLPL VPVVAACGGA VPQASGRGLG 

       130        140        150        160        170        180 
HTGGTLDKLE SITGFTANLS NQRVREQLCD VGAAIFAAGQ LAPADAKLYA LRDITGTVES 

       190        200        210        220        230        240 
LPLIASSIMS KKLAEGAGAL VLDVKVGSGA FMRSPVQARE LAHTMVELGA AHGVPTRALL 

       250        260        270        280        290        300 
TEMNCPLGRT VGNALEVAEA LEVLAGGGPP DVVELTLRLA GEMLELAGIH GRDPAQTLRD 

       310        320        330        340        350        360 
GTAMDRFRRL VAAQGGDLSK PLPIGSHSET VTAGASGTMG DIDAMAVGLA AWRLGAGRSR 

       370        380        390        400        410        420 
PGARVQHGAG VRIHRRPGEP VVVGEPLFTL YTNAPERFGA ARAELAGGWS IRDSPPQVRP 


LIVDRIV

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842582 Genomic DNA. Translation: CAA17086.1.
AE000516 Genomic DNA. Translation: AAK47757.1.
AL123456 Genomic DNA. Translation: CCP46134.1.
PIRA70843.
RefSeqNP_217831.1. NC_000962.3.
NP_337943.1. NC_002755.2.
YP_006516793.1. NC_018143.1.

3D structure databases

ProteinModelPortalO53366.
SMRO53366. Positions 11-427.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv3314c.

Proteomic databases

PRIDEO53366.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK47757; AAK47757; MT3415.
GeneID13318139.
887929.
926344.
KEGGmtc:MT3415.
mtu:Rv3314c.
mtv:RVBD_3314c.
PATRIC18129260. VBIMycTub22151_3726.

Organism-specific databases

TubercuListRv3314c.

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMALMAIYFR.
ProtClustDBPRK05820.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. Glyco_trans_3. 1 hit.
SSF52418. Glyco_trans_3. 1 hit.
SSF54680. PYNP_C. 1 hit.
TIGRFAMsTIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_MYCTU
AccessionPrimary (citable) accession number: O53366
Secondary accession number(s): L0TF92
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

SIMILARITY comments

Index of protein domains and families

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