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Protein
Submitted name:

Probable transcriptional regulatory protein (Probably TetR/AcrR-family)

Gene

Rv3173c

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7438-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Probable transcriptional regulatory protein (Probably TetR/AcrR-family)Imported
Submitted name:
TetR family transcriptional regulatorImported
Gene namesi
Ordered Locus Names:Rv3173cImported
ORF Names:LH57_17315Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3173c.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiO53323.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3173c.

Structurei

3D structure databases

ProteinModelPortaliO53323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 76HTH tetR-type DNA-bindingInterPro annotationAdd BLAST61

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107YHM. Bacteria.
ENOG410ZWCT. LUCA.
HOGENOMiHOG000161260.
OMAiREGYHAT.
PhylomeDBiO53323.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53323-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPVTRTTEP PRRGGRGARQ RILKAAAELF YCEGINATGV ELIANKASVS
60 70 80 90 100
KRTLYQHFPS KSALVEEYLR GLRQAAGEAD KMPKASNATP RERLLALFDR
110 120 130 140 150
PNRGDGRMRG CPFHNAAVEA AGEMPGVERI VHSHKRDYIK GLARLAREAG
160 170 180 190 200
AAHPRSLGNQ LAVLFEGAAA LSTSLDDAGP WAHARAAAEV LIDQATARPV
Length:200
Mass (Da):21,567
Last modified:June 1, 1998 - v1
Checksum:i3642FF9D29D70186
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR15957.1.
AL123456 Genomic DNA. Translation: CCP45984.1.
RefSeqiNP_217689.1. NC_000962.3.
WP_003416617.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR15957; AIR15957; LH57_17315.
CCP45984; CCP45984; Rv3173c.
GeneIDi888844.
KEGGimtu:Rv3173c.
mtv:RVBD_3173c.
PATRICi18128932. VBIMycTub22151_3563.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR15957.1.
AL123456 Genomic DNA. Translation: CCP45984.1.
RefSeqiNP_217689.1. NC_000962.3.
WP_003416617.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliO53323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3173c.

Proteomic databases

PRIDEiO53323.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR15957; AIR15957; LH57_17315.
CCP45984; CCP45984; Rv3173c.
GeneIDi888844.
KEGGimtu:Rv3173c.
mtv:RVBD_3173c.
PATRICi18128932. VBIMycTub22151_3563.

Organism-specific databases

TubercuListiRv3173c.

Phylogenomic databases

eggNOGiENOG4107YHM. Bacteria.
ENOG410ZWCT. LUCA.
HOGENOMiHOG000161260.
OMAiREGYHAT.
PhylomeDBiO53323.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7438-MONOMER.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO53323_MYCTU
AccessioniPrimary (citable) accession number: O53323
Secondary accession number(s): F2GJN1, I6YFF6, Q7D602
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.