O53223 (O53223_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Probable L,D-transpeptidase LdtB EMBL CCP45312.1

Gene names

Name:	ldtB EMBL CCP45312.1
Ordered Locus Names:	MT2594, Rv2518c EMBL CCP45312.1

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 4GSQ PDB 4GSR PDB 3TUR PDB 4HUC PDB 3U1P PDB 3TX4 PDB 3VAE PDB 4GSU PDB 4HU2 PDB 3U1Q Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidoglycan metabolic process Inferred from direct assay PubMed 20305661. Source: MTBBASE peptidoglycan-based cell wall biogenesis Inferred from direct assay PubMed 20305661. Source: MTBBASE
Cellular_component	cell wall Inferred from direct assay PubMed 20825248. Source: MTBBASE
Molecular_function	peptidoglycan L,D-transpeptidase activity Inferred from direct assay PubMed 20305661. Source: MTBBASE transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	354	1	Cysteine sulfenic acid (-SOH) PDB 3U1P PDB 3VAE

Sequences

	Sequence		Length	Mass (Da)
	O53223 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 8705AA9136A0D495	FASTA	408	43,366
	10 20 30 40 50 60 MPKVGIAAQA GRTRVRRAWL TALMMTAVMI GAVACGSGRG PAPIKVIADK GTPFADLLVP 70 80 90 100 110 120 KLTASVTDGA VGVTVDAPVS VTAADGVLAA VTMVNDNGRP VAGRLSPDGL RWSTTEQLGY 130 140 150 160 170 180 NRRYTLNATA LGLGGAATRQ LTFQTSSPAH LTMPYVMPGD GEVVGVGEPV AIRFDENIAD 190 200 210 220 230 240 RGAAEKAIKI TTNPPVEGAF YWLNNREVRW RPEHFWKPGT AVDVAVNTYG VDLGEGMFGE 250 260 270 280 290 300 DNVQTHFTIG DEVIATADDN TKILTVRVNG EVVKSMPTSM GKDSTPTANG IYIVGSRYKH 310 320 330 340 350 360 IIMDSSTYGV PVNSPNGYRT DVDWATQISY SGVFVHSAPW SVGAQGHTNT SHGCLNVSPS 370 380 390 400 NAQWFYDHVK RGDIVEVVNT VGGTLPGIDG LGDWNIPWDQ WRAGNAKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv and H37Rv EMBL CCP45312.1.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv." Camus J.C., Pryor M.J., Medigue C., Cole S.T. Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP45312.1.
[4]	"TubercuList--10 years after." Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. Tuberculosis 91:1-7(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP45312.1.
[5]	"The Structure of Mycobacterium tuberculosis L,D-transpeptidase 2 provides insights into targeting the cell wall of persisters." Erdemli S.B., Gupta R., Lamichhane G., Bishai W., Amzel L.M., Bianchet M.A. Submitted (SEP-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 122-408.
[6]	"Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2." Erdemli S.B., Gupta R., Bishai W.R., Lamichhane G., Amzel L.M., Bianchet M.A. Structure 20:2103-2115(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 122-408, CYSTEINE SULFENIC ACID (-SOH) AT CYS-354.
[7]	Lew J.M. Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP45312.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000516 Genomic DNA. Translation: AAK46901.1.
AL123456 Genomic DNA. Translation: CCP45312.1.

PIR

C70870.

RefSeq

NP_217034.1. NC_000962.3.
NP_337087.1. NC_002755.2.
YP_006515958.1. NC_018143.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3TUR	X-ray	1.72	A/B	122-408	[»]
3TX4	X-ray	2.32	A/B	122-408	[»]
3U1P	X-ray	2.80	A/B	122-408	[»]
3U1Q	X-ray	2.40	A/B	122-408	[»]
3VAE	X-ray	2.80	A/B	122-408	[»]
4GSQ	X-ray	1.80	A	131-408	[»]
4GSR	X-ray	1.79	A	131-408	[»]
4GSU	X-ray	2.00	A/B	131-408	[»]
4HU2	X-ray	1.46	A	55-250	[»]
4HUC	X-ray	1.86	A/B	149-408	[»]

SMR

O53223. Positions 57-407.

ModBase

Search...

Protein-protein interaction databases

STRING

83332.Rv2518c.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAK46901; AAK46901; MT2594.

GeneID

13319235.
888160.
925826.

KEGG

mtc:MT2594.
mtu:Rv2518c.
mtv:RVBD_2518c.

PATRIC

18127458. VBIMycTub22151_2833.

Organism-specific databases

TubercuList

Rv2518c.

Phylogenomic databases

HOGENOM

HOG000241380.

OMA

TERKLQN.

ProtClustDB

CLSK791900.

Family and domain databases

InterPro

IPR005490. LD_TPept_cat_dom.
[Graphical view]

Pfam

PF03734. YkuD. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

O53223_MYCTU

Accession

Primary (citable) accession number: O53223
Secondary accession number(s): F2GH40, Q7D6Z8

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)