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O53223 (O53223_MYCTO) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Uncharacterized protein EMBL AAK46901.1
Gene names
Ordered Locus Names:MT2594 EMBL AAK46901.1
ORF Names:V735_02606 EMBL KBN13754.1
OrganismMycobacterium tuberculosis (strain CDC 1551 / Oshkosh) [Complete proteome] [HAMAP] EMBL AAK46901.1
Taxonomic identifier83331 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region95 – 995Sulfate 1 binding PDB 4HU2
Region209 – 2113Sulfate 2 binding PDB 4HU2
Region323 – 3242Acetate 6 binding
Region385 – 3873Acetate 7 binding

Sites

Metal binding2321Calcium PDB 4GSQ
Metal binding2341Calcium PDB 4GSQ
Metal binding2351Calcium; via amide nitrogen PDB 4GSQ
Metal binding2361Calcium; via amide nitrogen PDB 4GSQ
Metal binding3421Sodium; via carbonyl oxygen
Metal binding3431Sodium; via carbonyl oxygen
Metal binding3451Sodium; via carbonyl oxygen
Binding site1221Sulfate 1 PDB 4HU2
Binding site2011Sulfate 2 PDB 4HU2
Binding site2041Acetate 1
Binding site2151Acetate 2; via amide nitrogen
Binding site3191Acetate 5
Binding site3521Acetate 4
Binding site3761Acetate 3

Sequences

Sequence LengthMass (Da)Tools
O53223 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 8705AA9136A0D495

FASTA40843,366
        10         20         30         40         50         60 
MPKVGIAAQA GRTRVRRAWL TALMMTAVMI GAVACGSGRG PAPIKVIADK GTPFADLLVP 

        70         80         90        100        110        120 
KLTASVTDGA VGVTVDAPVS VTAADGVLAA VTMVNDNGRP VAGRLSPDGL RWSTTEQLGY 

       130        140        150        160        170        180 
NRRYTLNATA LGLGGAATRQ LTFQTSSPAH LTMPYVMPGD GEVVGVGEPV AIRFDENIAD 

       190        200        210        220        230        240 
RGAAEKAIKI TTNPPVEGAF YWLNNREVRW RPEHFWKPGT AVDVAVNTYG VDLGEGMFGE 

       250        260        270        280        290        300 
DNVQTHFTIG DEVIATADDN TKILTVRVNG EVVKSMPTSM GKDSTPTANG IYIVGSRYKH 

       310        320        330        340        350        360 
IIMDSSTYGV PVNSPNGYRT DVDWATQISY SGVFVHSAPW SVGAQGHTNT SHGCLNVSPS 

       370        380        390        400 
NAQWFYDHVK RGDIVEVVNT VGGTLPGIDG LGDWNIPWDQ WRAGNAKA 

« Hide

References

« Hide 'large scale' references
[1]"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains."
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J., DeBoy R., Dodson R., Gwinn M., Haft D., Hickey E., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M., Salzberg S.L., Delcher A., Utterback T. expand/collapse author list , Weidman J., Khouri H., Gill J., Mikula A., Bishai W., Jacobs Jr W.R.Jr., Venter J.C., Fraser C.M.
J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CDC 1551 / Oshkosh and CDC1551 EMBL AAK46901.1.
[2]Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J., DeBoy R.T., Dodson R., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. expand/collapse author list , Weidman J., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R.Jr., Venter J.C., Fraser C.M.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CDC1551.
[3]"The Structure of Mycobacterium tuberculosis L,D-transpeptidase 2 provides insights into targeting the cell wall of persisters."
Erdemli S.B., Gupta R., Lamichhane G., Bishai W., Amzel L.M., Bianchet M.A.
Submitted (SEP-2011) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 122-408.
[4]"Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2."
Erdemli S.B., Gupta R., Bishai W.R., Lamichhane G., Amzel L.M., Bianchet M.A.
Structure 20:2103-2115(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 122-408.
[5]"Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains."
Kim H.S., Kim J., Im H.N., Yoon J.Y., An D.R., Yoon H.J., Kim J.Y., Min H.K., Kim S.J., Lee J.Y., Han B.W., Suh S.W.
Acta Crystallogr. D 69:420-431(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 131-408 IN COMPLEX WITH CALCIUM.
[6]"Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis."
Both D., Steiner E.M., Stadler D., Lindqvist Y., Schnell R., Schneider G.
Acta Crystallogr. D 69:432-441(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) OF 55-250 IN COMPLEX WITH ACETATE; SODIUM AND SULFATE.
[7]"Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis."
Li W.J., Li D.F., Hu Y.L., Zhang X.E., Bi L.J., Wang D.C.
Cell Res. 23:728-731(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 140-408.
[8]"The Genome Sequence of Mycobacterium tuberculosis cdc1551."
The Broad Institute Genomics Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Earl A.M., Hung D., Gomez D., Hsueh P.R., Rozo J.C., Zambrano M.M., Desjardins C., Abeel T., Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S. expand/collapse author list , Hansen M., Howarth C., Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Cdc1551 EMBL KBN13754.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000516 Genomic DNA. Translation: AAK46901.1.
JLBH01000002 Genomic DNA. Translation: KBN13754.1.
PIRC70870.
RefSeqNP_337087.1. NC_002755.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3TURX-ray1.72A/B122-408[»]
3TX4X-ray2.32A/B122-408[»]
3U1PX-ray2.80A/B122-408[»]
3U1QX-ray2.40A/B122-408[»]
3VAEX-ray2.80A/B122-408[»]
3VYNX-ray2.50A/B55-408[»]
3VYOX-ray1.80A/B140-408[»]
3VYPX-ray1.40A/B140-408[»]
4GSQX-ray1.80A131-408[»]
4GSRX-ray1.79A131-408[»]
4GSUX-ray2.00A/B131-408[»]
4HU2X-ray1.46A55-250[»]
4HUCX-ray1.86A/B149-408[»]
ProteinModelPortalO53223.
SMRO53223. Positions 58-406.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING83332.Rv2518c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK46901; AAK46901; MT2594.
CCP45312; CCP45312; Rv2518c.
GeneID925826.
KEGGmtc:MT2594.
mtu:Rv2518c.
mtv:RVBD_2518c.
PATRIC18127458. VBIMycTub22151_2833.

Organism-specific databases

TubercuListRv2518c.
CMRSearch...

Phylogenomic databases

HOGENOMHOG000241380.
OMANAEWFYD.
OrthoDBEOG66QKTJ.

Enzyme and pathway databases

BioCycMTBRV:RV2518C-MONOMER.

Family and domain databases

InterProIPR005490. LD_TPept_cat_dom.
[Graphical view]
PfamPF03734. YkuD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameO53223_MYCTO
AccessionPrimary (citable) accession number: O53223
Secondary accession number(s): F2GH40, Q7D6Z8
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)