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Protein
Submitted name:

Probable transcriptional regulatory protein (LuxR-family)

Gene

Rv2488c

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Enzyme and pathway databases

BioCyciMTBRV:RV2488C-MONOMER.
BRENDAi4.6.1.1. 3445.

Names & Taxonomyi

Protein namesi
Submitted name:
Probable transcriptional regulatory protein (LuxR-family)Imported
Gene namesi
Ordered Locus Names:Rv2488cImported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO53213.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2488c.

Structurei

3D structure databases

ProteinModelPortaliO53213.
SMRiO53213. Positions 1067-1129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 164107Guanylate cyclaseInterPro annotationAdd
BLAST
Domaini1063 – 112866HTH luxR-type DNA-bindingInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili586 – 61328Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains HTH luxR-type DNA-binding domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CQF. Bacteria.
COG2771. LUCA.
COG3903. LUCA.
HOGENOMiHOG000053696.
OMAiDDRISAC.
OrthoDBiEOG6HB9KM.
PhylomeDBiO53213.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 2 hits.
3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
IPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRRPRDFEQ SRRRCRCNAL RAGSMLASMS KIHPGVDVVP VDWSADGVSE
60 70 80 90 100
LVPTGTVTLL LADIEGATHL PGSQLDTTAI AKLDRTLTEL VREHRGVCPV
110 120 130 140 150
EQGEGDSFLV AFARASDAVA CALGLQRAPL APIRLRIGMH TGEVSSPDEG
160 170 180 190 200
NCVGPTIDRT ARLRELAHGG QTVLSGTTSD LVADLLPKDA WLNDLGTYRL
210 220 230 240 250
DDLPRPERVV QLCHPDLHNA FPPLRTRKVV GAHCLPAQLT RLVGRVDEVA
260 270 280 290 300
QVRGLLDVKR WVTLTGVGGV GKTRLATQVA SAVADGYPDG VWYVNLAPIT
310 320 330 340 350
DPALVPIAAA RVLGLPDQPG RSTVDTIVRR IGDRRMLVVL DNCEHLLDGC
360 370 380 390 400
AALIVALLGA CPALRVLATS REPIAVAGEQ IWRVPPLGHG EAIELFTDRA
410 420 430 440 450
REARPELEIT ADNLALVTEI CHRLDGIPLA IELAASRVRA LALTEIVDSL
460 470 480 490 500
HDRFRLLTGG SRIAVRRQQT MRASVDWSHA LLTGPEQVLF RRLAVFPSGF
510 520 530 540 550
DLDGAQAAAA GGDVQRYEVV DLLSLLADKS LVVTDDSDGR TRYRLLETVR
560 570 580 590 600
QYALEKLRES GDADAVRARH RDHYAAVAAG LDAPSVAGHE RRLNQAELEI
610 620 630 640 650
DNLRAAFAFS RENGDTGHAL LLASCLQPLW RARGRLQEGL AWFAAALADH
660 670 680 690 700
DAHPAGADPG LYARALADRA LIDAVAGITD RLDDAQKALA IARDIEDPAL
710 720 730 740 750
LARALTACGG VAAYNADLAR PWLAEAVGLA RAVGDKWRLA EVLAWQAYVG
760 770 780 790 800
FAGEGDPGAT RAAGEEARSL ADEIGDAFLS RSCRWALAAA NLWQGNLEAA
810 820 830 840 850
VGLSREVIGE SDAAHDMVSS CAGQACLAHA LAHRGDTEAA AAAQASIDTA
860 870 880 890 900
VGLSPVLSGS ACSALVFATL AAGDVAAAEH ARESATRFFG ASAAAIINDP
910 920 930 940 950
TSSAQISCAR GDLNAAHRLA DGAASITRGV HRARALTTRC RIEIAQGDRH
960 970 980 990 1000
RAERDAHDAL GVAASIGAYL WVPDILECLA SVMADAGSNR EAVRLFGAAD
1010 1020 1030 1040 1050
AARGRMGAVR FGIYQAGCNS SLATLRKSMG DSEFDDAWAE GTALSIDEAI
1060 1070 1080 1090 1100
AYAQRGRGAR KRPTSGWGAL TPTELEVALL VGEGLSNKEI GVRLFISPRT
1110 1120 1130
VHSHLTHVYT KLGLSSRLQL AQQAARRGES ERGPSRP
Length:1,137
Mass (Da):120,818
Last modified:June 1, 1998 - v1
Checksum:iF136E6444B7F4BF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45282.1.
RefSeqiNP_217004.1. NC_000962.3.
WP_003914906.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiCCP45282; CCP45282; Rv2488c.
GeneIDi887997.
KEGGimtu:Rv2488c.
mtv:RVBD_2488c.
PATRICi18154137. VBIMycTub87468_2789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45282.1.
RefSeqiNP_217004.1. NC_000962.3.
WP_003914906.1. NC_000962.3.

3D structure databases

ProteinModelPortaliO53213.
SMRiO53213. Positions 1067-1129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv2488c.

Proteomic databases

PaxDbiO53213.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP45282; CCP45282; Rv2488c.
GeneIDi887997.
KEGGimtu:Rv2488c.
mtv:RVBD_2488c.
PATRICi18154137. VBIMycTub87468_2789.

Phylogenomic databases

eggNOGiENOG4105CQF. Bacteria.
COG2771. LUCA.
COG3903. LUCA.
HOGENOMiHOG000053696.
OMAiDDRISAC.
OrthoDBiEOG6HB9KM.
PhylomeDBiO53213.

Enzyme and pathway databases

BioCyciMTBRV:RV2488C-MONOMER.
BRENDAi4.6.1.1. 3445.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 2 hits.
3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
IPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiO53213_MYCTU
AccessioniPrimary (citable) accession number: O53213
Secondary accession number(s): I6YDJ4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.