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Protein
Submitted name:

Probable transcriptional regulatory protein (LuxR-family)

Gene

Rv2488c

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1087 – 1106H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

BRENDAi4.6.1.1 3445

Names & Taxonomyi

Protein namesi
Submitted name:
Probable transcriptional regulatory protein (LuxR-family)Imported
Gene namesi
Ordered Locus Names:Rv2488cImported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: MTBBASE
  • plasma membrane Source: MTBBASE

PTM / Processingi

Proteomic databases

PaxDbiO53213

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2488c

Structurei

3D structure databases

ProteinModelPortaliO53213
SMRiO53213
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 164Guanylate cyclaseInterPro annotationAdd BLAST107
Domaini1063 – 1128HTH luxR-typeInterPro annotationAdd BLAST66

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili586 – 613Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CQF Bacteria
COG2771 LUCA
COG3903 LUCA
HOGENOMiHOG000053696
OMAiTRLWERC
PhylomeDBiO53213

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
Gene3Di1.10.10.10, 1 hit
1.25.40.10, 1 hit
3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR029787 Nucleotide_cyclase
IPR027417 P-loop_NTPase
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR011990 TPR-like_helical_dom_sf
IPR000792 Tscrpt_reg_LuxR_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00196 GerE, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF48452 SSF48452, 1 hit
SSF52540 SSF52540, 1 hit
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS00622 HTH_LUXR_1, 1 hit
PS50043 HTH_LUXR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O53213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRRPRDFEQ SRRRCRCNAL RAGSMLASMS KIHPGVDVVP VDWSADGVSE
60 70 80 90 100
LVPTGTVTLL LADIEGATHL PGSQLDTTAI AKLDRTLTEL VREHRGVCPV
110 120 130 140 150
EQGEGDSFLV AFARASDAVA CALGLQRAPL APIRLRIGMH TGEVSSPDEG
160 170 180 190 200
NCVGPTIDRT ARLRELAHGG QTVLSGTTSD LVADLLPKDA WLNDLGTYRL
210 220 230 240 250
DDLPRPERVV QLCHPDLHNA FPPLRTRKVV GAHCLPAQLT RLVGRVDEVA
260 270 280 290 300
QVRGLLDVKR WVTLTGVGGV GKTRLATQVA SAVADGYPDG VWYVNLAPIT
310 320 330 340 350
DPALVPIAAA RVLGLPDQPG RSTVDTIVRR IGDRRMLVVL DNCEHLLDGC
360 370 380 390 400
AALIVALLGA CPALRVLATS REPIAVAGEQ IWRVPPLGHG EAIELFTDRA
410 420 430 440 450
REARPELEIT ADNLALVTEI CHRLDGIPLA IELAASRVRA LALTEIVDSL
460 470 480 490 500
HDRFRLLTGG SRIAVRRQQT MRASVDWSHA LLTGPEQVLF RRLAVFPSGF
510 520 530 540 550
DLDGAQAAAA GGDVQRYEVV DLLSLLADKS LVVTDDSDGR TRYRLLETVR
560 570 580 590 600
QYALEKLRES GDADAVRARH RDHYAAVAAG LDAPSVAGHE RRLNQAELEI
610 620 630 640 650
DNLRAAFAFS RENGDTGHAL LLASCLQPLW RARGRLQEGL AWFAAALADH
660 670 680 690 700
DAHPAGADPG LYARALADRA LIDAVAGITD RLDDAQKALA IARDIEDPAL
710 720 730 740 750
LARALTACGG VAAYNADLAR PWLAEAVGLA RAVGDKWRLA EVLAWQAYVG
760 770 780 790 800
FAGEGDPGAT RAAGEEARSL ADEIGDAFLS RSCRWALAAA NLWQGNLEAA
810 820 830 840 850
VGLSREVIGE SDAAHDMVSS CAGQACLAHA LAHRGDTEAA AAAQASIDTA
860 870 880 890 900
VGLSPVLSGS ACSALVFATL AAGDVAAAEH ARESATRFFG ASAAAIINDP
910 920 930 940 950
TSSAQISCAR GDLNAAHRLA DGAASITRGV HRARALTTRC RIEIAQGDRH
960 970 980 990 1000
RAERDAHDAL GVAASIGAYL WVPDILECLA SVMADAGSNR EAVRLFGAAD
1010 1020 1030 1040 1050
AARGRMGAVR FGIYQAGCNS SLATLRKSMG DSEFDDAWAE GTALSIDEAI
1060 1070 1080 1090 1100
AYAQRGRGAR KRPTSGWGAL TPTELEVALL VGEGLSNKEI GVRLFISPRT
1110 1120 1130
VHSHLTHVYT KLGLSSRLQL AQQAARRGES ERGPSRP
Length:1,137
Mass (Da):120,818
Last modified:June 1, 1998 - v1
Checksum:iF136E6444B7F4BF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP45282.1
RefSeqiNP_217004.1, NC_000962.3
WP_003914906.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP45282; CCP45282; Rv2488c
GeneIDi887997
KEGGimtu:Rv2488c
mtv:RVBD_2488c
PATRICifig|83332.111.peg.2785

Similar proteinsi

Entry informationi

Entry nameiO53213_MYCTU
AccessioniPrimary (citable) accession number: O53213
Secondary accession number(s): I6YDJ4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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