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Protein
Submitted name:

Probable transcriptional regulatory protein

Gene

Rv1474c

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Probable transcriptional regulatory proteinImported
Submitted name:
TetR family transcriptional regulatorImported
Gene namesi
Ordered Locus Names:Rv1474cImported
ORF Names:LH57_08085Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1474c.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: GO_Central
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1474c.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 7061HTH tetR-type DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Q5F. Bacteria.
ENOG410XSET. LUCA.
HOGENOMiHOG000248228.
OMAiLVQVMRN.
OrthoDBiEOG6ZKXQV.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKVSEDHLA ARRRQILDGA RRCFAEYGYD KATVRRLEQA IGMSRGAIFH
60 70 80 90 100
HFRDKDALFF ALAREDTERM AAVASREGLI GVMRDMLAAP DQFDWLATRL
110 120 130 140 150
EIARKLRNDP DFSRGWAERS AELAAATTDR LRRQKQANRV RDDVPSDVLR
160 170 180
CYLDLVLDGL LARLASGEDP QRLAAVLDLV ENSVRRS
Length:187
Mass (Da):21,269
Last modified:June 1, 1998 - v1
Checksum:iB0FEE0360661172F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14224.1.
AL123456 Genomic DNA. Translation: CCP44234.1.
RefSeqiNP_215990.1. NC_000962.3.
WP_003407514.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR14224; AIR14224; LH57_08085.
CCP44234; CCP44234; Rv1474c.
GeneIDi886543.
KEGGimtu:Rv1474c.
mtv:RVBD_1474c.
PATRICi18125110. VBIMycTub22151_1670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14224.1.
AL123456 Genomic DNA. Translation: CCP44234.1.
RefSeqiNP_215990.1. NC_000962.3.
WP_003407514.1. NZ_KK339370.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1474c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR14224; AIR14224; LH57_08085.
CCP44234; CCP44234; Rv1474c.
GeneIDi886543.
KEGGimtu:Rv1474c.
mtv:RVBD_1474c.
PATRICi18125110. VBIMycTub22151_1670.

Organism-specific databases

TubercuListiRv1474c.

Phylogenomic databases

eggNOGiENOG4108Q5F. Bacteria.
ENOG410XSET. LUCA.
HOGENOMiHOG000248228.
OMAiLVQVMRN.
OrthoDBiEOG6ZKXQV.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported and H37RvImported.
  2. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported and H37RvImported.

Entry informationi

Entry nameiO53165_MYCTU
AccessioniPrimary (citable) accession number: O53165
Secondary accession number(s): F2GES5, I6Y6M9, Q7D8D9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.