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Protein
Submitted name:

Probable thioredoxin TrxA

Gene

trxA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein disulfide oxidoreductase activity Source: MTBBASE

GO - Biological processi

  • cell redox homeostasis Source: MTBBASE
  • glycerol ether metabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Probable thioredoxin TrxAImported
Submitted name:
ThioredoxinImported
Gene namesi
Name:trxAImported
Ordered Locus Names:Rv1470Imported
ORF Names:LH57_08060Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1470.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: MTBBASE
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1470.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 105105ThioredoxinInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiCOG0526. LUCA.
HOGENOMiHOG000292977.
OMAiYEGSSDK.
OrthoDBiEOG6QG8RK.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTRDLTAAY FQQTISANSN VLVYFWAPLC APCDLFTPTY EASSRKHFDV
60 70 80 90 100
VHGKVNIETE KDLASIAGVK LLPTLMAFKK GKLVFKQAGI ANPAIMDNLV
110 120
QQLRAYTFKS PAGEGIGPGT KTSS
Length:124
Mass (Da):13,472
Last modified:August 1, 1998 - v2
Checksum:i76E654E179BFC31C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14219.1.
AL123456 Genomic DNA. Translation: CCP44229.1.
RefSeqiNP_215986.1. NC_000962.3.
WP_003900345.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR14219; AIR14219; LH57_08060.
CCP44229; CCP44229; Rv1470.
GeneIDi886558.
KEGGimtu:Rv1470.
mtv:RVBD_1470.
PATRICi18125100. VBIMycTub22151_1665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14219.1.
AL123456 Genomic DNA. Translation: CCP44229.1.
RefSeqiNP_215986.1. NC_000962.3.
WP_003900345.1. NZ_KK339370.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1470.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR14219; AIR14219; LH57_08060.
CCP44229; CCP44229; Rv1470.
GeneIDi886558.
KEGGimtu:Rv1470.
mtv:RVBD_1470.
PATRICi18125100. VBIMycTub22151_1665.

Organism-specific databases

TubercuListiRv1470.

Phylogenomic databases

eggNOGiCOG0526. LUCA.
HOGENOMiHOG000292977.
OMAiYEGSSDK.
OrthoDBiEOG6QG8RK.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported and H37RvImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported and H37RvImported.

Entry informationi

Entry nameiO53161_MYCTU
AccessioniPrimary (citable) accession number: O53161
Secondary accession number(s): F2GET0, I6Y6M3, Q7D8E2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.