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Protein

Probable cation-transporting ATPase I

Gene

ctpI

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1053 – 105314-aspartylphosphate intermediateBy similarity
Metal bindingi1335 – 13351MagnesiumBy similarity
Metal bindingi1339 – 13391MagnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase I (EC:3.6.3.-)
Gene namesi
Name:ctpI
Ordered Locus Names:ML2671
ORF Names:MLCB1913.02
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2671.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence analysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence analysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence analysisAdd
BLAST
Transmembranei641 – 66121HelicalSequence analysisAdd
BLAST
Transmembranei673 – 69321HelicalSequence analysisAdd
BLAST
Transmembranei778 – 79821HelicalSequence analysisAdd
BLAST
Transmembranei921 – 94121HelicalSequence analysisAdd
BLAST
Transmembranei969 – 98921HelicalSequence analysisAdd
BLAST
Transmembranei997 – 101721HelicalSequence analysisAdd
BLAST
Transmembranei1396 – 141621HelicalSequence analysisAdd
BLAST
Transmembranei1426 – 144621HelicalSequence analysisAdd
BLAST
Transmembranei1542 – 156221HelicalSequence analysisAdd
BLAST
Transmembranei1573 – 159321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16091609Probable cation-transporting ATPase IPRO_0000046346Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2671.

Structurei

3D structure databases

ProteinModelPortaliO53114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C52. Bacteria.
COG0474. LUCA.
HOGENOMiHOG000053875.
KOiK12955.
OMAiQMVRRVV.
OrthoDBiEOG6HF5WH.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O53114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIPHVTDPV SNMVGGMAQV VRASTHAATG AVNTMQMLAS PVAEFAWPVV
60 70 80 90 100
QSVAKSTGRA LGTGHSPNFA NRVDPPVRWH NGQRVHLDLD PLLPFPRWHE
110 120 130 140 150
YAAVVEEPVR RIPGVAKGHV EGSLGRLVIE LDKNADSDVV LGKVRDVVIA
160 170 180 190 200
LAADLALTGA RSAPKVAPFA DPGNPLAILM PLTAAVMDLV ALSAAVTGWV
210 220 230 240 250
TRLPAVPQTI RAAAALVNHQ PRMVSLLESR LGRVGTDIAL SITTAAASGL
260 270 280 290 300
TQAVGTPLLD LACRGLQLSE AAAHQRVWRD REPQLASPKR PQAPVVPVIS
310 320 330 340 350
SAGEKSHAAG HNWTAAASNE ASHLVVGGSI DAAIDTAKGS MKGPVESYVD
360 370 380 390 400
SAANGSLIAA ASALLAGGGT EDAAGAILAG VPRAAHMGQQ AFAATLGRGL
410 420 430 440 450
ANAGQLVLDP GALRRLDQVK VVVIDGAALR GDHRAVLLAR GNTPGWDDDR
460 470 480 490 500
VYEVTDALLH GERAPEPDPD ESPATGARLR WVPLQGPSAT PVQGREHADL
510 520 530 540 550
VVNGECVGGV DVGWEVDPYA IPLLQTAHRT GARVVLRHVA GTEDLSASVG
560 570 580 590 600
ATHPPGTPLL KLVRELRTDR GPVLLITAVH RDFASTDTLA ALAIADVGVA
610 620 630 640 650
LDDPHAATPW TADIITGTDL AAAVRILSAL PVARSASESS VHLAQGGTTL
660 670 680 690 700
AGLLLITASA GSKSASPITL RRWFSPVNAA AATALVTGVV SASKVLRLPD
710 720 730 740 750
PTPQPLTAWH ALDPEIVYSR LAGVTQPLAV EPGTPDWRRR LDDLSYTRAL
760 770 780 790 800
SPLRKPVTKL ARLASATRQE FADPLTPILA VGAAASAIVG SNIDALLVAG
810 820 830 840 850
VMTVNAITGG VQRLRAEAAA AELFAEQDQL VRRVVVPAVA TTRRRLEAAQ
860 870 880 890 900
HATRTVTVSA KSLRAGDVID LAAPEVVPAD ARVLVAEDLE VDESLLTGES
910 920 930 940 950
LPVDKRVDPV AINDADRASM LFEGSAIVAG HARAIVVATG VGTAAHRAIS
960 970 980 990 1000
AVADVEVSAG VQARLRELTS KVLPLTLAGG AAVTGLALLR RASLRQAVAD
1010 1020 1030 1040 1050
GVAIAVAAVP EGLPLVATLS QLAAAQRLTA KGALVRSPRT IEALGRVDTI
1060 1070 1080 1090 1100
CFDKTGTLTE NRLRVVCAVP NTRMPHDPLP DITDPHSAAV LRDAARASTQ
1110 1120 1130 1140 1150
PHDGQGHTHA TDEAILTAAS SLNSHTDSTW SLIAEVPFES SRGYAAAIGI
1160 1170 1180 1190 1200
TGNGKAPMLM LKGAPEKILP RCRFADPEAD VAHAESLVRH LAEQGLRVLA
1210 1220 1230 1240 1250
VAQCSWGHDT TDDNDTDADA VDAAAHDLEL VGYIGLADTA RPSSRPLIEA
1260 1270 1280 1290 1300
LVTAGRNVVL ITGDHPITAR AIAQQLGLRS DARVVNGTEL IGLDEDACAE
1310 1320 1330 1340 1350
LAADVQVFAR VSPEQKVQIV AALQRCGQVT AMVGDGANDA AAIRMADVGI
1360 1370 1380 1390 1400
GVSGRGSSAA RGAADIVLTD DDLGVLLDAL VEGRSMWAGV RDAVTILVGG
1410 1420 1430 1440 1450
NVGEVVFTII GTVFGAGRAP VGTRQLLLVN LLTDMFPALS IAVTSQYEEP
1460 1470 1480 1490 1500
GEDEYQTDEE ADEARRTHQH EVLTGPTPSL DAPLMRQIVN RGVVTAAGAT
1510 1520 1530 1540 1550
TAWAIGRWTP GTERRTATMG LTALVTTQLA QTLLTRRHSP LVVATALGSA
1560 1570 1580 1590 1600
GVLIGIIQTP VISQFFGCTP LGPIAWSGVI TATAGATAVS VLAPQWLNKA

FGIAQLNQE
Length:1,609
Mass (Da):166,873
Last modified:June 1, 1998 - v1
Checksum:i58FA2079905E3995
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022118 Genomic DNA. Translation: CAA17934.1.
AL583926 Genomic DNA. Translation: CAC32203.1.
PIRiE87243.
RefSeqiNP_302704.1. NC_002677.1.
WP_010909023.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC32203; CAC32203; CAC32203.
GeneIDi910835.
KEGGimle:ML2671.
PATRICi18060463. VBIMycLep78757_5145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022118 Genomic DNA. Translation: CAA17934.1.
AL583926 Genomic DNA. Translation: CAC32203.1.
PIRiE87243.
RefSeqiNP_302704.1. NC_002677.1.
WP_010909023.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO53114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2671.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC32203; CAC32203; CAC32203.
GeneIDi910835.
KEGGimle:ML2671.
PATRICi18060463. VBIMycLep78757_5145.

Organism-specific databases

LepromaiML2671.

Phylogenomic databases

eggNOGiENOG4105C52. Bacteria.
COG0474. LUCA.
HOGENOMiHOG000053875.
KOiK12955.
OMAiQMVRRVV.
OrthoDBiEOG6HF5WH.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiCTPI_MYCLE
AccessioniPrimary (citable) accession number: O53114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 1998
Last modified: April 13, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.