O53088 (ARCA_LACSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine deiminase
Short name=ADI
EC=3.5.3.6

Alternative name(s):
Arginine dihydrolase
Short name=AD

Gene names

Name:

arcA

Organism

Lactobacillus sakei

Taxonomic identifier

1599 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-arginine + H2O = L-citrulline + NH3. HAMAP-Rule MF_00242
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2. HAMAP-Rule MF_00242
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00242.
Sequence similarities	Belongs to the arginine deiminase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Hydrolase
Gene Ontology (GO)
Biological_process	arginine catabolic process to ornithine Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	arginine deiminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	Arginine deiminase HAMAP-Rule MF_00242		PRO_0000182215
Sites
	Active site	399	1	Amidino-cysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O53088 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: B2703702B3382DB5	FASTA	409	45,914
	10 20 30 40 50 60 MTSPIHVNSE IGKLKTVLLK RPGKEVENIT PDIMYRLLFD DIPYLPTIQK EHDQFAQTLR 70 80 90 100 110 120 DNGVEVLYLE NLAAEAIDAG DVKEAFLDKM LNESHIKSPQ VQAALKDYLI SMATLDMVEK 130 140 150 160 170 180 IMAGVRTNEI DIKSKALIDV SADDDYPFYM DPMPNLYFTR DPAASMGDGL TINKMTFEAR 190 200 210 220 230 240 QRESMFMEVI MQHHPRFANQ GAQVWRDRDH IDRMEGGDEL ILSDKVLAIG ISQRTSAQSI 250 260 270 280 290 300 EELAKVLFAN HSGFEKILAI KIPHKHAMMH LDTVFTMIDY DKFTIHPGIQ GAGGMVDTYI 310 320 330 340 350 360 LEPGNNDEIK ITHQTDLEKV LRDALEVPEL TLIPCGGGDA VVAPREQWND GSNTLAIAPG 370 380 390 400 VVVTYDRNYV SNENLRQYGI KVIEVPSSEL SRGRGGPRCM SMPLVRRKT

References

[1]

"Structural and functional analysis of the gene cluster encoding the enzymes of the arginine deiminase pathway of Lactobacillus sakei." Zuniga M., Champomier-Verges M.-C., Zagorec M., Perez-Martinez G. J. Bacteriol. 180:4154-4159(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ001330 Genomic DNA. Translation: CAA04682.1.
PIR	T46741.
3D structure databases
ProteinModelPortal	O53088.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00254; UER00364.
Family and domain databases
HAMAP	MF_00242. Arg_deiminase.
InterPro	IPR003198. Amidino_trans. IPR003876. Arg_deiminase. [Graphical view]
PANTHER	PTHR12737:SF9. PTHR12737:SF9. 1 hit.
Pfam	PF02274. Amidinotransf. 1 hit. [Graphical view]
PIRSF	PIRSF006356. Arg_deiminase. 1 hit.
PRINTS	PR01466. ARGDEIMINASE.
TIGRFAMs	TIGR01078. arcA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARCA_LACSK

Accession

Primary (citable) accession number: O53088

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program