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O53080

- CITXG_LEUMC

UniProt

O53080 - CITXG_LEUMC

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Protein

Protein CitXG

Gene

citXG

Organism
Leuconostoc mesenteroides subsp. cremoris
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, and then the transfer of this prosthetic group precursor to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield the holo-acyl carrier protein.By similarity

Catalytic activityi

2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier protein] = citrate lyase holo-[acyl-carrier protein] + diphosphate.
ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. holo-citrate lyase synthase activity Source: UniProtKB-EC
  3. triphosphoribosyl-dephospho-CoA synthase activity Source: InterPro

GO - Biological processi

  1. phosphorylation Source: InterPro
  2. prosthetic group biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CitXG
Including the following 2 domains:
Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC:2.7.7.61)
Alternative name(s):
Apo-ACP nucleodityltransferase
Holo-ACP synthase
Holo-citrate lyase synthase
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (EC:2.4.2.52)
Short name:
2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase
Gene namesi
Name:citXG
Synonyms:citG
OrganismiLeuconostoc mesenteroides subsp. cremoris
Taxonomic identifieri33965 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Protein CitXGPRO_0000214683Add
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 178178Apo-citrate lyase phosphoribosyl-dephospho-CoA transferaseAdd
BLAST
Regioni179 – 4672892-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the CitX family.Curated
In the C-terminal section; belongs to the CitG/MdcB family.Curated

Family and domain databases

HAMAPiMF_00397. CitG.
MF_00398. CitX.
InterProiIPR002736. CitG.
IPR005551. CitX.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
PF03802. CitX. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03125. citrate_citG. 1 hit.
TIGR03124. citrate_citX. 1 hit.

Sequencei

Sequence statusi: Complete.

O53080-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYFEGGERL NLMQVLDNRE WREKYQKQLM ASFPTAVITS VKLNLPGPIK
60 70 80 90 100
TSPKLQSVFQ IIINDLNPVF KDLQIIKEAS FVDQITGPDI FFVTSGCLKL
110 120 130 140 150
VKQIMITFEE SHLLGRLLDL DVMCQNADKQ LSREELGFAP RKCLLCGKDA
160 170 180 190 200
KTCIKEGNHS LAEGYSQINK MLHNFEKSKM IVPQMTQSQV VNAALTGMLY
210 220 230 240 250
EVSLAPKPGL VDPSSNGAHK DMTVFTFIDS SLALQPYLNE AYRIGNQFKG
260 270 280 290 300
TDLPRMFSLL RNAGIRAEKD MFAATNGVNT HKGAVFSLGI MVTAVAYATQ
310 320 330 340 350
KGITNLLTIQ KVISDMTQDL VKNDLGKNNL RHSQNQQTAG ERQFIKYKIP
360 370 380 390 400
GVRGEAEKGF PIVMNLALPF LCEQQGNLNQ RLLNTLMKIA GNIDDTNLIK
410 420 430 440 450
RAGNATISKD MQHWSVTFFQ IGGSYTPEGL KFLNDLDQMF IKRNLSMGGA
460
ADNLILTIFL ARLVGSL
Length:467
Mass (Da):52,012
Last modified:June 1, 1998 - v1
Checksum:i0515A6063E4ACEA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10621 Genomic DNA. Translation: CAA71634.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10621 Genomic DNA. Translation: CAA71634.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

HAMAPi MF_00397. CitG.
MF_00398. CitX.
InterProi IPR002736. CitG.
IPR005551. CitX.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view ]
Pfami PF01874. CitG. 1 hit.
PF03802. CitX. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03125. citrate_citG. 1 hit.
TIGR03124. citrate_citX. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Purification of Leuconostoc mesenteroides citrate lyase and cloning and characterization of the citCDEFG gene cluster."
    Bekal S., van Beeumen J., Samyn B., Garmyn D., Henini S., Divies C., Prevost H.
    J. Bacteriol. 180:647-654(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 195.

Entry informationi

Entry nameiCITXG_LEUMC
AccessioniPrimary (citable) accession number: O53080
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3