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O53080

- CITXG_LEUMC

UniProt

O53080 - CITXG_LEUMC

Protein

Protein CitXG

Gene

citXG

Organism
Leuconostoc mesenteroides subsp. cremoris
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Bifunctional enzyme that catalyzes formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, and then the transfer of this prosthetic group precursor to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield the holo-acyl carrier protein.By similarity

    Catalytic activityi

    2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier-protein] = citrate lyase holo-[acyl-carrier-protein] + diphosphate.
    ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. holo-citrate lyase synthase activity Source: UniProtKB-EC
    3. triphosphoribosyl-dephospho-CoA synthase activity Source: InterPro

    GO - Biological processi

    1. phosphorylation Source: InterPro
    2. prosthetic group biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CitXG
    Including the following 2 domains:
    Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC:2.7.7.61)
    Alternative name(s):
    Apo-ACP nucleodityltransferase
    Holo-ACP synthase
    Holo-citrate lyase synthase
    2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (EC:2.4.2.52)
    Short name:
    2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase
    Gene namesi
    Name:citXG
    Synonyms:citG
    OrganismiLeuconostoc mesenteroides subsp. cremoris
    Taxonomic identifieri33965 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 467467Protein CitXGPRO_0000214683Add
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 178178Apo-citrate lyase phosphoribosyl-dephospho-CoA transferaseAdd
    BLAST
    Regioni179 – 4672892-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the CitX family.Curated
    In the C-terminal section; belongs to the CitG/MdcB family.Curated

    Family and domain databases

    HAMAPiMF_00397. CitG.
    MF_00398. CitX.
    InterProiIPR002736. CitG.
    IPR005551. CitX.
    IPR017551. TriPribosyl-deP-CoA_syn_CitG.
    [Graphical view]
    PfamiPF01874. CitG. 1 hit.
    PF03802. CitX. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03125. citrate_citG. 1 hit.
    TIGR03124. citrate_citX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O53080-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYFEGGERL NLMQVLDNRE WREKYQKQLM ASFPTAVITS VKLNLPGPIK    50
    TSPKLQSVFQ IIINDLNPVF KDLQIIKEAS FVDQITGPDI FFVTSGCLKL 100
    VKQIMITFEE SHLLGRLLDL DVMCQNADKQ LSREELGFAP RKCLLCGKDA 150
    KTCIKEGNHS LAEGYSQINK MLHNFEKSKM IVPQMTQSQV VNAALTGMLY 200
    EVSLAPKPGL VDPSSNGAHK DMTVFTFIDS SLALQPYLNE AYRIGNQFKG 250
    TDLPRMFSLL RNAGIRAEKD MFAATNGVNT HKGAVFSLGI MVTAVAYATQ 300
    KGITNLLTIQ KVISDMTQDL VKNDLGKNNL RHSQNQQTAG ERQFIKYKIP 350
    GVRGEAEKGF PIVMNLALPF LCEQQGNLNQ RLLNTLMKIA GNIDDTNLIK 400
    RAGNATISKD MQHWSVTFFQ IGGSYTPEGL KFLNDLDQMF IKRNLSMGGA 450
    ADNLILTIFL ARLVGSL 467
    Length:467
    Mass (Da):52,012
    Last modified:June 1, 1998 - v1
    Checksum:i0515A6063E4ACEA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10621 Genomic DNA. Translation: CAA71634.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10621 Genomic DNA. Translation: CAA71634.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    HAMAPi MF_00397. CitG.
    MF_00398. CitX.
    InterProi IPR002736. CitG.
    IPR005551. CitX.
    IPR017551. TriPribosyl-deP-CoA_syn_CitG.
    [Graphical view ]
    Pfami PF01874. CitG. 1 hit.
    PF03802. CitX. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03125. citrate_citG. 1 hit.
    TIGR03124. citrate_citX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Purification of Leuconostoc mesenteroides citrate lyase and cloning and characterization of the citCDEFG gene cluster."
      Bekal S., van Beeumen J., Samyn B., Garmyn D., Henini S., Divies C., Prevost H.
      J. Bacteriol. 180:647-654(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 195.

    Entry informationi

    Entry nameiCITXG_LEUMC
    AccessioniPrimary (citable) accession number: O53080
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Multifunctional enzyme

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3