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O52980

- FKBP_METTL

UniProt

O52980 - FKBP_METTL

Protein

FKBP-type peptidyl-prolyl cis-trans isomerase

Gene
N/A
Organism
Methanothermococcus thermolithotrophicus (Methanococcus thermolithotrophicus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Inhibited by FK506.

    Temperature dependencei

    Thermostable.

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Enzyme and pathway databases

    BRENDAi5.2.1.8. 3266.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FKBP-type peptidyl-prolyl cis-trans isomerase (EC:5.2.1.8)
    Short name:
    PPIase
    Alternative name(s):
    MtFK
    Rotamase
    OrganismiMethanothermococcus thermolithotrophicus (Methanococcus thermolithotrophicus)
    Taxonomic identifieri2186 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanothermococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 154154FKBP-type peptidyl-prolyl cis-trans isomerasePRO_0000075378Add
    BLAST

    Structurei

    Secondary structure

    1
    154
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi10 – 134
    Beta strandi26 – 283
    Helixi30 – 367
    Beta strandi48 – 514
    Turni52 – 554
    Helixi59 – 668
    Beta strandi75 – 784
    Turni80 – 823
    Helixi98 – 1014
    Beta strandi111 – 1177
    Beta strandi119 – 1268
    Beta strandi129 – 1335
    Beta strandi143 – 1464

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1IX5NMR-A4-154[»]
    ProteinModelPortaliO52980.
    SMRiO52980. Positions 4-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO52980.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 112102PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family.Curated
    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O52980-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIFLVDKGVK IKVDYIGKLE SGDVFDTSIE EVAKEAGIYA PDREYEPLEF    50
    VVGEGQLIQG FEEAVLDMEV GDEKTVKIPA EKAYGNRNEM LIQKIPRDAF 100
    KEADFEPEEG MVILAEGIPA TITEVTDNEV TLDFNHELAG KDLVFTIKII 150
    EVVE 154
    Length:154
    Mass (Da):17,184
    Last modified:June 1, 1998 - v1
    Checksum:i2CD3DDF8B26A006F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89881 Genomic DNA. Translation: BAA24446.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89881 Genomic DNA. Translation: BAA24446.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1IX5 NMR - A 4-154 [» ]
    ProteinModelPortali O52980.
    SMRi O52980. Positions 4-154.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 5.2.1.8. 3266.

    Miscellaneous databases

    EvolutionaryTracei O52980.

    Family and domain databases

    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Biochemical and genetic characterization of an FK506-sensitive peptidyl prolyl cis-trans isomerase from a thermophilic archaeon, Methanococcus thermolithotrophicus."
      Furutani M., Iida T., Yamano S., Kamino K., Maruyama T.
      J. Bacteriol. 180:388-394(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
      Strain: ATCC 35097 / DSM 2095 / JCM 10549 / OCM 138 / SN-1.

    Entry informationi

    Entry nameiFKBP_METTL
    AccessioniPrimary (citable) accession number: O52980
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3