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O52980

- FKBP_METTL

UniProt

O52980 - FKBP_METTL

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Protein

FKBP-type peptidyl-prolyl cis-trans isomerase

Gene
N/A
Organism
Methanothermococcus thermolithotrophicus (Methanococcus thermolithotrophicus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by FK506.

Temperature dependencei

Thermostable.

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BRENDAi5.2.1.8. 3266.

Names & Taxonomyi

Protein namesi
Recommended name:
FKBP-type peptidyl-prolyl cis-trans isomerase (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
MtFK
Rotamase
OrganismiMethanothermococcus thermolithotrophicus (Methanococcus thermolithotrophicus)
Taxonomic identifieri2186 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanothermococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154FKBP-type peptidyl-prolyl cis-trans isomerasePRO_0000075378Add
BLAST

Structurei

Secondary structure

1
154
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 134
Beta strandi26 – 283
Helixi30 – 367
Beta strandi48 – 514
Turni52 – 554
Helixi59 – 668
Beta strandi75 – 784
Turni80 – 823
Helixi98 – 1014
Beta strandi111 – 1177
Beta strandi119 – 1268
Beta strandi129 – 1335
Beta strandi143 – 1464

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IX5NMR-A4-154[»]
ProteinModelPortaliO52980.
SMRiO52980. Positions 4-154.

Miscellaneous databases

EvolutionaryTraceiO52980.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 112102PPIase FKBP-typeAdd
BLAST

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52980-1 [UniParc]FASTAAdd to Basket

« Hide

MIFLVDKGVK IKVDYIGKLE SGDVFDTSIE EVAKEAGIYA PDREYEPLEF    50
VVGEGQLIQG FEEAVLDMEV GDEKTVKIPA EKAYGNRNEM LIQKIPRDAF 100
KEADFEPEEG MVILAEGIPA TITEVTDNEV TLDFNHELAG KDLVFTIKII 150
EVVE 154
Length:154
Mass (Da):17,184
Last modified:June 1, 1998 - v1
Checksum:i2CD3DDF8B26A006F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89881 Genomic DNA. Translation: BAA24446.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89881 Genomic DNA. Translation: BAA24446.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IX5 NMR - A 4-154 [» ]
ProteinModelPortali O52980.
SMRi O52980. Positions 4-154.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 5.2.1.8. 3266.

Miscellaneous databases

EvolutionaryTracei O52980.

Family and domain databases

InterProi IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Biochemical and genetic characterization of an FK506-sensitive peptidyl prolyl cis-trans isomerase from a thermophilic archaeon, Methanococcus thermolithotrophicus."
    Furutani M., Iida T., Yamano S., Kamino K., Maruyama T.
    J. Bacteriol. 180:388-394(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: ATCC 35097 / DSM 2095 / JCM 10549 / OCM 138 / SN-1.

Entry informationi

Entry nameiFKBP_METTL
AccessioniPrimary (citable) accession number: O52980
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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