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O52980 (FKBP_METTL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FKBP-type peptidyl-prolyl cis-trans isomerase

Short name=PPIase
EC=5.2.1.8
Alternative name(s):
MtFK
Rotamase
OrganismMethanothermococcus thermolithotrophicus (Methanococcus thermolithotrophicus)
Taxonomic identifier2186 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanothermococcus

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by FK506.

Sequence similarities

Belongs to the FKBP-type PPIase family.

Contains 1 PPIase FKBP-type domain.

Biophysicochemical properties

Temperature dependence:

Thermostable.

Ontologies

Keywords
   Molecular functionIsomerase
Rotamase
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpeptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 154154FKBP-type peptidyl-prolyl cis-trans isomerase
PRO_0000075378

Regions

Domain11 – 112102PPIase FKBP-type

Secondary structure

.......................... 154
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O52980 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 2CD3DDF8B26A006F

FASTA15417,184
        10         20         30         40         50         60 
MIFLVDKGVK IKVDYIGKLE SGDVFDTSIE EVAKEAGIYA PDREYEPLEF VVGEGQLIQG 

        70         80         90        100        110        120 
FEEAVLDMEV GDEKTVKIPA EKAYGNRNEM LIQKIPRDAF KEADFEPEEG MVILAEGIPA 

       130        140        150 
TITEVTDNEV TLDFNHELAG KDLVFTIKII EVVE 

« Hide

References

[1]"Biochemical and genetic characterization of an FK506-sensitive peptidyl prolyl cis-trans isomerase from a thermophilic archaeon, Methanococcus thermolithotrophicus."
Furutani M., Iida T., Yamano S., Kamino K., Maruyama T.
J. Bacteriol. 180:388-394(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
Strain: ATCC 35097 / DSM 2095 / JCM 10549 / OCM 138 / SN-1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D89881 Genomic DNA. Translation: BAA24446.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1IX5NMR-A4-154[»]
ProteinModelPortalO52980.
SMRO52980. Positions 4-154.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA5.2.1.8. 3266.

Family and domain databases

InterProIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO52980.

Entry information

Entry nameFKBP_METTL
AccessionPrimary (citable) accession number: O52980
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references