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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Aphanothece halophytica
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Synonyms:dnaK1
OrganismiAphanothece halophytica
Taxonomic identifieri72020 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesAphanothece

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 721721Chaperone protein DnaKPRO_0000078411Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei197 – 1971Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO52960.

Expressioni

Inductioni

By stress conditions e.g. heat shock and by hyperosmotic environments.

Structurei

3D structure databases

ProteinModelPortaliO52960.
SMRiO52960. Positions 1-537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52960-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVIGIDLG TTNSCFAVLE GGKPLVIENV EGGRTTPSIV AFTKEKERLV
60 70 80 90 100
GQLAKRQAVT NAENTIYSIK RFIGRRWEDT EQERNRVSYH CVPGRDKTVD
110 120 130 140 150
VKCWGKQYTP QELSAMILQT LKAGAEAYLN ETVTEAVITV PAYFTDAQRQ
160 170 180 190 200
ATKDAGTIAG LNVMRIINEP TAAALAFGLD KQEQREQVLV YDLGGGTLDV
210 220 230 240 250
SILQLGDGVF EVKATAGNNH LGGDDFDNVI VEWMLSEFQA QEGINLNEDK
260 270 280 290 300
MAMQRLREAA ERAKIELSTR PTTSINLPFI TAFSKGGGEV GPKHLKLNLS
310 320 330 340 350
RAKFNELSRP LVEKTIDPLK QAIEDSGLSV DQIDRILLVG GSTRIPEVQE
360 370 380 390 400
ALKKFFNGKE PDRSINPDEA VALGAAIQGG VLGQEQEVED LLLLVVIPLS
410 420 430 440 450
LGIETLGEVF TKVIERNTTI PTSKSQVFST ASDGQTSVEI HVLQGERAMA
460 470 480 490 500
NDNKTLGKFL LTGIPAAPRG VPQIEVSFDI DVNGILKVSA EDKGTGREQG
510 520 530 540 550
IVIKETGGLS QQEIERMQQE AEQYADEDRK RMQRIELSNQ ADSLFYSHEA
560 570 580 590 600
TLKDNQGLIP QKVKATANKK KEELMAILED PNVELGVIQT RLEDYRQAVL
610 620 630 640 650
SMGSEVYSQG SSKSSARDYE TVGEEEMTRE TGNSQESNAA FSTQPEGTVN
660 670 680 690 700
NDNLELEAVF STYNDHTQGS DVATSSHDEI DLGDASDNSQ TNFDLDDEDF
710 720
NPFEDFDEEE EASTDDYEAV E
Length:721
Mass (Da):79,117
Last modified:June 1, 1998 - v1
Checksum:i451D20C69963B2E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84421 Genomic DNA. Translation: BAA24445.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84421 Genomic DNA. Translation: BAA24445.1.

3D structure databases

ProteinModelPortaliO52960.
SMRiO52960. Positions 1-537.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO52960.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_APHHA
AccessioniPrimary (citable) accession number: O52960
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: October 14, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.