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O52951

- KITH_BACNA

UniProt

O52951 - KITH_BACNA

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Protein

Thymidine kinase

Gene

tdk

Organism
Bacillus subtilis subsp. natto
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptorSequence Analysis
Metal bindingi146 – 1461ZincBy similarity
Metal bindingi151 – 1511ZincBy similarity
Metal bindingi184 – 1841ZincBy similarity
Metal bindingi187 – 1871ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPBy similarity
Nucleotide bindingi86 – 894ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Encoded oniPlasmid pLS320 Publication
OrganismiBacillus subtilis subsp. natto
Taxonomic identifieri86029 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 195195Thymidine kinasePRO_0000175057Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO52951.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.Curated

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O52951-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDITFNTGLM GSGKSKKLID DYLIDPKEKV ALSVSLTEDT FSRGKIESRD
60 70 80 90 100
GRSLRSINLN RDQFKQNISL LEIIIFMTNT QTIYIDESQF LPKETVEKFV
110 120 130 140 150
SLSESYHVPI HFYGLDLTFT GELFDSSSHL LTILPSENIN RISRGCEASK
160 170 180 190
CSKIAQYNAR IVDGKVSRSG ETFVEEKSYY LALCSDHYYN DEKII
Length:195
Mass (Da):22,221
Last modified:June 1, 1998 - v1
Checksum:i1ABFA791B1A56B23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49467 Genomic DNA. Translation: BAA24875.1.
RefSeqiWP_013603338.1. NC_015149.1.
YP_004243650.1. NC_015149.1.

Genome annotation databases

GeneIDi10227784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49467 Genomic DNA. Translation: BAA24875.1 .
RefSeqi WP_013603338.1. NC_015149.1.
YP_004243650.1. NC_015149.1.

3D structure databases

ProteinModelPortali O52951.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10227784.

Family and domain databases

InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view ]
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A novel Bacillus natto plasmid pLS32 capable of replication in Bacillus subtilis."
    Tanaka T., Ogura M.
    FEBS Lett. 422:243-246(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IAM 1163.

Entry informationi

Entry nameiKITH_BACNA
AccessioniPrimary (citable) accession number: O52951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3