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O52951

- KITH_BACNA

UniProt

O52951 - KITH_BACNA

Protein

Thymidine kinase

Gene

tdk

Organism
Bacillus subtilis subsp. natto
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei87 – 871Proton acceptorSequence Analysis
    Metal bindingi146 – 1461ZincBy similarity
    Metal bindingi151 – 1511ZincBy similarity
    Metal bindingi184 – 1841ZincBy similarity
    Metal bindingi187 – 1871ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 158ATPBy similarity
    Nucleotide bindingi86 – 894ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:tdk
    Encoded oniPlasmid pLS320 Publication
    OrganismiBacillus subtilis subsp. natto
    Taxonomic identifieri86029 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 195195Thymidine kinasePRO_0000175057Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO52951.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.Curated

    Family and domain databases

    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    [Graphical view]
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O52951-1 [UniParc]FASTAAdd to Basket

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    MDITFNTGLM GSGKSKKLID DYLIDPKEKV ALSVSLTEDT FSRGKIESRD    50
    GRSLRSINLN RDQFKQNISL LEIIIFMTNT QTIYIDESQF LPKETVEKFV 100
    SLSESYHVPI HFYGLDLTFT GELFDSSSHL LTILPSENIN RISRGCEASK 150
    CSKIAQYNAR IVDGKVSRSG ETFVEEKSYY LALCSDHYYN DEKII 195
    Length:195
    Mass (Da):22,221
    Last modified:June 1, 1998 - v1
    Checksum:i1ABFA791B1A56B23
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49467 Genomic DNA. Translation: BAA24875.1.
    RefSeqiWP_013603338.1. NC_015149.1.
    YP_004243650.1. NC_015149.1.

    Genome annotation databases

    GeneIDi10227784.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49467 Genomic DNA. Translation: BAA24875.1 .
    RefSeqi WP_013603338.1. NC_015149.1.
    YP_004243650.1. NC_015149.1.

    3D structure databases

    ProteinModelPortali O52951.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10227784.

    Family and domain databases

    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    [Graphical view ]
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel Bacillus natto plasmid pLS32 capable of replication in Bacillus subtilis."
      Tanaka T., Ogura M.
      FEBS Lett. 422:243-246(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: IAM 1163.

    Entry informationi

    Entry nameiKITH_BACNA
    AccessioniPrimary (citable) accession number: O52951
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3