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O52942 (O52942_PHOLP) Unreviewed, UniProtKB/TrEMBL

Last modified December 11, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine dehydrogenase PIRNR PIRNR000183

EC=1.4.1.1 PIRNR PIRNR000183
Gene names
Name:ald EMBL BAA24455.1
OrganismPhormidium lapideum EMBL BAA24455.1
Taxonomic identifier32060 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesPhormidium

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding177 – 1782NAD PDB 1PJC
Region93 – 953Pyruvate binding

Sites

Binding site151Pyruvate
Binding site741Pyruvate
Binding site1331NAD PDB 1PJC
Binding site1971NAD PDB 1PJC
Binding site2191NAD PDB 1PJC
Binding site2381NAD; via carbonyl oxygen PDB 1PJC
Binding site2661NAD; via carbonyl oxygen PDB 1PJC
Binding site2701NAD PDB 1PJC
Binding site3001NAD; via amide nitrogen PDB 1PJC
Site741Important for catalytic activity
Site951Important for catalytic activity
Site1171Important for catalytic activity
Site2691Important for catalytic activity

Sequences

Sequence LengthMass (Da)Tools
O52942 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 57CA14BB85DB4D08

FASTA36138,557
        10         20         30         40         50         60 
MEIGVPKEIK NQEFRVGLSP SSVRTLVEAG HTVFIETQAG IGAGFADQDY VQAGAQVVPS 

        70         80         90        100        110        120 
AKDAWSREMV VKVKEPLPAE YDLMQKDQLL FTYLHLAAAR ELTEQLMRVG LTAIAYETVE 

       130        140        150        160        170        180 
LPNRSLPLLT PMSIIAGRLS VQFGARFLER QQGGRGVLLG GVPGVKPGKV VILGGGVVGT 

       190        200        210        220        230        240 
EAAKMAVGLG AQVQIFDINV ERLSYLETLF GSRVELLYSN SAEIETAVAE ADLLIGAVLV 

       250        260        270        280        290        300 
PGRRAPILVP ASLVEQMRTG SVIVDVAVDQ GGCVETLHPT SHTQPTYEVF GVVHYGVPNM 

       310        320        330        340        350        360 
PGAVPWTATQ ALNNSTLPYV VKLANQGLKA LETDDALAKG LNVQAHRLVH PAVQQVFPDL 


A 

« Hide

References

[1]"Purification and characterization of alanine dehydrogenase from a cyanobacterium, Phormidium lapideum."
Sawa Y., Tani M., Murata K., Shibata H., Ochiai H.
J. Biochem. 116:995-1000(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]"Alanine Dehydrogenase from a Cyanobacterium, Phormidium lapideum: Cloning, Sequencing, Expression, and Sequence Comparisons to Amino Acid Dehydrogenases."
Sawa Y., Noshiro Y., Midorikawa Y., Sasai R., Murata K., Ashida H., Shibata H., Ochiai H.
Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase."
Baker P.J., Sawa Y., Shibata H., Sedelnikova S.E., Rice D.W.
Nat. Struct. Biol. 5:561-567(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH NAD AND PYRUVATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D37807 Genomic DNA. Translation: BAA24455.1.
PIRPX0078.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1PJBX-ray2.10A1-361[»]
1PJCX-ray2.00A1-361[»]
1SAYX-ray2.10A1-361[»]
ProteinModelPortalO52942.
SMRO52942. Positions 1-361.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-12816.
UniPathwayUPA00527; UER00585.

Family and domain databases

InterProIPR008143. Ala_DH/PNT_CS2.
IPR008141. Ala_DH/Pyr_transHydgase.
IPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
[Graphical view]
PANTHERPTHR10160:SF3. PTHR10160:SF3. 1 hit.
PfamPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
PIRSFPIRSF000183. Alanine_dh. 1 hit.
SMARTSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00518. alaDH. 1 hit.
PROSITEPS00837. ALADH_PNT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO52942.

Entry information

Entry nameO52942_PHOLP
AccessionPrimary (citable) accession number: O52942
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: December 11, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)