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Protein

Soluble epoxide hydrolase

Gene
N/A
Organism
Corynebacterium sp. (strain C12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in catabolic degradation of epoxides. Shows highest activity towards C6 and C7 carbocyclic epoxides. Also active towards linear 1,2-epoxyalkanes.

Catalytic activityi

An epoxide + H2O = a glycol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991NucleophileBy similarity
Active sitei209 – 2091Proton donorBy similarity
Active sitei264 – 2641Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-5099-MONOMER.

Protein family/group databases

ESTHERicorsp-cEH. CFTR-inhibitory-factor_Cif.

Names & Taxonomyi

Protein namesi
Recommended name:
Soluble epoxide hydrolase (EC:3.3.2.10)
Short name:
SEH
Alternative name(s):
Cytosolic epoxide hydrolase
Short name:
cEH
Epoxide hydratase
OrganismiCorynebacterium sp. (strain C12)
Taxonomic identifieri268954 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 286285Soluble epoxide hydrolasePRO_0000084110Add
BLAST

Expressioni

Inductioni

Expressed constitutively at a low level. Induced by cyclohexane oxide and (+/-)trans-1,2-dihydroxycyclohexane.

Interactioni

Subunit structurei

Homotetramer.Curated

Structurei

3D structure databases

ProteinModelPortaliO52866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O52866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEITHHQA MINGYRMHYV TAGSGYPLVL LHGWPQSWYE WRNVIPALAE
60 70 80 90 100
QFTVIAPDLR GLGDSEKPMT GFDKRTMATD VRELVSHLGY DKVGVIGHDW
110 120 130 140 150
GGSVAFYFAY DNRDLVERLF ILDMIPGLIK AGDSFPIPVA LMINHIFFHG
160 170 180 190 200
GNPDWATALI SKDVNLYLRR FLTTLDYNYS PNVFSEEDIA EYVRVNSLPG
210 220 230 240 250
SIRSGCQWYA TGLREDTENL AKATDKLTIP VIAWGGSHFL GDIRPAWQEV
260 270 280
AENVEGGAVE NCGHFVPEEK PQFVIDTALK FFAPLR
Length:286
Mass (Da):32,142
Last modified:January 23, 2007 - v3
Checksum:i520DE66D73DB0A8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224332 Genomic DNA. Translation: CAA11900.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224332 Genomic DNA. Translation: CAA11900.1.

3D structure databases

ProteinModelPortaliO52866.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERicorsp-cEH. CFTR-inhibitory-factor_Cif.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-5099-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-21 AND 127-134.

Entry informationi

Entry nameiHYES_CORS2
AccessioniPrimary (citable) accession number: O52866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 23, 2007
Last modified: September 16, 2015
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.