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O52847

- BGAL_BACMD

UniProt

O52847 - BGAL_BACMD

Protein

Beta-galactosidase

Gene

bgaM

Organism
Bacillus megaterium (strain DSM 319)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei481 – 4811Proton donorBy similarity
    Active sitei547 – 5471NucleophileBy similarity

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciBMEG592022:GIVX-2126-MONOMER.

    Protein family/group databases

    CAZyiGH2. Glycoside Hydrolase Family 2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidase (EC:3.2.1.23)
    Short name:
    Beta-gal
    Alternative name(s):
    Lactase
    Gene namesi
    Name:bgaM
    Ordered Locus Names:BMD_2126
    OrganismiBacillus megaterium (strain DSM 319)
    Taxonomic identifieri592022 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000002365: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. beta-galactosidase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10341034Beta-galactosidasePRO_0000057659Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO52847.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 2 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000252444.
    KOiK01190.
    OMAiRTIERDK.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.320. 2 hits.
    2.70.98.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR004199. B-gal_small/dom_5.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR008979. Galactose-bd-like.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF02929. Bgal_small_N. 1 hit.
    PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view]
    PRINTSiPR00132. GLHYDRLASE2.
    SMARTiSM01038. Bgal_small_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O52847-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKTGKKFHY TAPANGYPEW NNNPEIFQLN RSKAHALLMP YQTVEEALKN     50
    DRKSSVYYQS LNGSWYFHFA ENADGRVKNF FAPEFSYEKW DSISVPSHWQ 100
    LQGYDYPQYT NVTYPWVENE ELEPPFAPTK YNPVGQYVRT FTPKSEWKDQ 150
    PVYISFQGVE SAFYVWINGE FVGYSEDSFT PAEFDITSYL QEGENTIAVE 200
    VYRWSDASWL EDQDFWRMSG IFRDVYLYST PQVHIYDFSV RSSLDNNYED 250
    GELSVSADIL NYFEHDTQDL TFEVMLYDAN AQEVLQAPLQ TNLSVSDQRT 300
    VSLRTHIKSP AKWSAESPNL YTLVLSLKNA AGSIIETESC KVGFRTFEIK 350
    NGLMTINGKR IVLRGVNRHE FDSVKGRAGI TREDMIHDIL LMKQHNINAV 400
    RTSHYPNDSV WYELCNEYGL YVIDETNLET HGTWTYLQEG EQKAVPGSKP 450
    EWKENVLDRC RSMYERDKNH PSIIIWSLGN ESFGGENFQH MYTFFKEKDS 500
    TRLVHYEGIF HHRDYDASDI ESTMYVKPAD VERYALMNPK KPYILCEYSH 550
    AMGNSCGNLY KYWELFDQYP ILQGGFIWDW KDQALQATAE DGTSYLAYGG 600
    DFGDTPNDGN FCGNGLIFAD GTASPKIAEV KKCYQPVKWT AVDPAKGKFA 650
    VQNKHLFTNL NAYDFVWTVE KNGELVEKHA SLLNVAPDGT DELTLSYPLY 700
    EQENETDEFV LTLSLRLSKD TAWASAGYEV AYEQFVLPAK AAMPSVKAAH 750
    PALTVDQNEQ TLTVTGTNFT AIFDKRKGQF ISYNYERTEL LASGFRPNFW 800
    RAVTDNDLGN KLHERCQTWR QASLEQHVKK VTVQPQVDFV IISVELALDN 850
    SLASCYVTYT LYNDGEMKIE QSLAPSETMP EIPEIGMLFT MNAAFDSLTW 900
    YGRGPHENYW DRKTGAKLAL HKGSVKEQVT PYLRPQECGN KTDVRWATIT 950
    NDQGRGFLIK GLPTVELNAL PYSPFELEAY DHFYKLPASD SVTVRVNYKQ 1000
    MGVGGDDSWQ AKTHPNYTLY ANRSYTNTFT LKPL 1034
    Length:1,034
    Mass (Da):118,674
    Last modified:June 1, 1998 - v1
    Checksum:i38644C9A649415E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ000733 Genomic DNA. Translation: CAA04267.1.
    CP001982 Genomic DNA. Translation: ADF38979.1.
    PIRiT30574.
    RefSeqiWP_013082993.1. NC_014103.1.
    YP_003597329.1. NC_014103.1.

    Genome annotation databases

    EnsemblBacteriaiADF38979; ADF38979; BMD_2126.
    GeneIDi9117517.
    KEGGibmd:BMD_2126.
    PATRICi37254301. VBIBacMeg104484_2076.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ000733 Genomic DNA. Translation: CAA04267.1 .
    CP001982 Genomic DNA. Translation: ADF38979.1 .
    PIRi T30574.
    RefSeqi WP_013082993.1. NC_014103.1.
    YP_003597329.1. NC_014103.1.

    3D structure databases

    ProteinModelPortali O52847.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH2. Glycoside Hydrolase Family 2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADF38979 ; ADF38979 ; BMD_2126 .
    GeneIDi 9117517.
    KEGGi bmd:BMD_2126.
    PATRICi 37254301. VBIBacMeg104484_2076.

    Phylogenomic databases

    HOGENOMi HOG000252444.
    KOi K01190.
    OMAi RTIERDK.

    Enzyme and pathway databases

    BioCyci BMEG592022:GIVX-2126-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.320. 2 hits.
    2.70.98.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR004199. B-gal_small/dom_5.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR008979. Galactose-bd-like.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF02929. Bgal_small_N. 1 hit.
    PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00132. GLHYDRLASE2.
    SMARTi SM01038. Bgal_small_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Strey J.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Genome sequences of the industrial vitamin B12-producers B. megaterium QM B1551 and DSM319 reveal new insights into the Bacillus genome evolution and pan-genome structure."
      Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K., Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J., Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J., Vary P.S.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 319.

    Entry informationi

    Entry nameiBGAL_BACMD
    AccessioniPrimary (citable) accession number: O52847
    Secondary accession number(s): D5DFH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3