Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Low molecular weight protein-tyrosine-phosphatase Ptp

Gene

ptp

Organism
Acinetobacter johnsonii
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates ptk. May be involved in the production and the transport of exopolysaccharides.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulationi

Inhibited by ammonium molybdate, sodium orthovanadate, N-ethylmaleimide and iodoacetic acid.

Pathwayi: exopolysaccharide biosynthesis

This protein is involved in the pathway exopolysaccharide biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway exopolysaccharide biosynthesis and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10NucleophileBy similarity1
Active sitei15By similarity1
Active sitei115Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processExopolysaccharide synthesis

Enzyme and pathway databases

UniPathwayiUPA00631.

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight protein-tyrosine-phosphatase Ptp (EC:3.1.3.48)
Gene namesi
Name:ptp
OrganismiAcinetobacter johnsonii
Taxonomic identifieri40214 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi10C → S: Loss of activity. 1 Publication1
Mutagenesisi16R → K: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465661 – 142Low molecular weight protein-tyrosine-phosphatase PtpAdd BLAST142

Structurei

3D structure databases

ProteinModelPortaliO52787.
SMRiO52787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR023485. Ptyr_pPase.
IPR036196. Ptyr_pPase_sf.
IPR017867. Tyr_phospatase_low_mol_wt.
PfamiView protein in Pfam
PF01451. LMWPc. 1 hit.
PRINTSiPR00719. LMWPTPASE.
SMARTiView protein in SMART
SM00226. LMWPc. 1 hit.
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

O52787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFKNILVVC IGNICRSPMA EYLLKQNYPQ LTIHSAGISG MIGYSADEKA
60 70 80 90 100
QLCMERIGID MSPHIAKKLN AELLKQADLI LVMSQNQQKH IEQTWPFAKG
110 120 130 140
KTFRLGHWQG KNIPDPYQHD QAFFDETSLL IQTCVADWTK HI
Length:142
Mass (Da):16,215
Last modified:June 1, 1998 - v1
Checksum:i62B53F3BDDBA5986
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15162 Genomic DNA. Translation: CAA75430.1.

Similar proteinsi

Entry informationi

Entry nameiPTP_ACIJO
AccessioniPrimary (citable) accession number: O52787
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 1, 1998
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families