O52787 (PTP_ACIJO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low molecular weight protein-tyrosine-phosphatase ptp
EC=3.1.3.48

Gene names

Name:

ptp

Organism

Acinetobacter johnsonii

Taxonomic identifier

40214 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Dephosphorylates ptk. May be involved in the production and the transport of exopolysaccharides.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Enzyme regulation	Inhibited by ammonium molybdate, sodium orthovanadate, N-ethylmaleimide and iodoacetic acid.
Pathway	Glycan metabolism; exopolysaccharide biosynthesis.
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
Biological process	Exopolysaccharide synthesis
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Low molecular weight protein-tyrosine-phosphatase ptp		PRO_0000046566
Sites
	Active site	10	1	Nucleophile By similarity
	Active site	15	1	By similarity
	Active site	115	1	Proton donor By similarity
Experimental info
	Mutagenesis	10	1	C → S: Loss of activity. Ref.2
	Mutagenesis	16	1	R → K: Loss of activity. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O52787 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 62B53F3BDDBA5986	FASTA	142	16,215
	10 20 30 40 50 60 MQFKNILVVC IGNICRSPMA EYLLKQNYPQ LTIHSAGISG MIGYSADEKA QLCMERIGID 70 80 90 100 110 120 MSPHIAKKLN AELLKQADLI LVMSQNQQKH IEQTWPFAKG KTFRLGHWQG KNIPDPYQHD 130 140 QAFFDETSLL IQTCVADWTK HI

References

[1]	"Characterization of a bacterial gene encoding an autophosphorylating protein tyrosine kinase." Grangeasse C., Doublet P., Vaganay E., Vincent C., Deleage G., Duclos B., Cozzone A.J. Gene 204:259-265(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Functional characterization of the low-molecular-mass phosphotyrosine-protein phosphatase of Acinetobacter johnsonii." Grangeasse C., Doublet P., Vincent C., Vaganay E., Riberty M., Duclos B., Cozzone A.J. J. Mol. Biol. 278:339-347(1998) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION, MUTAGENESIS OF CYS-10 AND ARG-16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y15162 Genomic DNA. Translation: CAA75430.1.
3D structure databases
ProteinModelPortal	O52787.
ModBase	Search...
Protein family/group databases
PptaseDB	P3D040495.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00631.
Family and domain databases
InterPro	IPR023485. Ptyr_pPase_SF. IPR000106. Tyr_phospatase/Ars_reductase. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. PTHR11717. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
PRINTS	PR00719. LMWPTPASE.
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTP_ACIJO

Accession

Primary (citable) accession number: O52787

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program