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O52787 (PTP_ACIJO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low molecular weight protein-tyrosine-phosphatase ptp

EC=3.1.3.48
Gene names
Name:ptp
OrganismAcinetobacter johnsonii
Taxonomic identifier40214 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Dephosphorylates ptk. May be involved in the production and the transport of exopolysaccharides.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulation

Inhibited by ammonium molybdate, sodium orthovanadate, N-ethylmaleimide and iodoacetic acid.

Pathway

Glycan metabolism; exopolysaccharide biosynthesis.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
   Biological processExopolysaccharide synthesis
   Molecular functionHydrolase
Protein phosphatase
Gene Ontology (GO)
   Biological_processpolysaccharide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 142142Low molecular weight protein-tyrosine-phosphatase ptp
PRO_0000046566

Sites

Active site101Nucleophile By similarity
Active site151 By similarity
Active site1151Proton donor By similarity

Experimental info

Mutagenesis101C → S: Loss of activity. Ref.2
Mutagenesis161R → K: Loss of activity. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O52787 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 62B53F3BDDBA5986

FASTA14216,215
        10         20         30         40         50         60 
MQFKNILVVC IGNICRSPMA EYLLKQNYPQ LTIHSAGISG MIGYSADEKA QLCMERIGID 

        70         80         90        100        110        120 
MSPHIAKKLN AELLKQADLI LVMSQNQQKH IEQTWPFAKG KTFRLGHWQG KNIPDPYQHD 

       130        140 
QAFFDETSLL IQTCVADWTK HI 

« Hide

References

[1]"Characterization of a bacterial gene encoding an autophosphorylating protein tyrosine kinase."
Grangeasse C., Doublet P., Vaganay E., Vincent C., Deleage G., Duclos B., Cozzone A.J.
Gene 204:259-265(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Functional characterization of the low-molecular-mass phosphotyrosine-protein phosphatase of Acinetobacter johnsonii."
Grangeasse C., Doublet P., Vincent C., Vaganay E., Riberty M., Duclos B., Cozzone A.J.
J. Mol. Biol. 278:339-347(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, MUTAGENESIS OF CYS-10 AND ARG-16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y15162 Genomic DNA. Translation: CAA75430.1.

3D structure databases

ProteinModelPortalO52787.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

PptaseDBP3D040495.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00631.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Entry information

Entry namePTP_ACIJO
AccessionPrimary (citable) accession number: O52787
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways