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Protein

Catalase

Gene

katA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Enzyme regulationi

By peroxide and bfr-bound iron.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551PROSITE-ProRule annotation
Active sitei128 – 1281PROSITE-ProRule annotation
Metal bindingi338 – 3381Iron (heme axial ligand)By similarity

GO - Molecular functioni

  • catalase activity Source: PseudoCAP
  • heme binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:katA
Ordered Locus Names:PA4236
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4236.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482CatalasePRO_0000084994Add
BLAST

Proteomic databases

PaxDbiO52762.

Interactioni

Subunit structurei

Heteromultimer. Possibly an alpha2beta-heterotrimer where the alpha subunit is a 56 kDa protein and the beta subunit a 45 kDa protein.

Protein-protein interaction databases

STRINGi208964.PA4236.

Structurei

Secondary structure

1
482
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 254Combined sources
Helixi35 – 4410Combined sources
Beta strandi57 – 6711Combined sources
Turni72 – 743Combined sources
Helixi78 – 803Combined sources
Beta strandi86 – 949Combined sources
Beta strandi111 – 1188Combined sources
Beta strandi121 – 13111Combined sources
Helixi138 – 1403Combined sources
Helixi141 – 1488Combined sources
Turni152 – 1543Combined sources
Helixi159 – 1668Combined sources
Helixi170 – 1723Combined sources
Helixi173 – 1797Combined sources
Helixi182 – 1843Combined sources
Beta strandi185 – 1873Combined sources
Helixi189 – 1913Combined sources
Beta strandi200 – 2034Combined sources
Beta strandi209 – 21810Combined sources
Helixi227 – 23610Combined sources
Helixi240 – 25112Combined sources
Beta strandi256 – 26510Combined sources
Helixi266 – 2716Combined sources
Turni285 – 2873Combined sources
Beta strandi291 – 30010Combined sources
Helixi305 – 3084Combined sources
Turni309 – 3113Combined sources
Helixi329 – 34517Combined sources
Helixi350 – 3523Combined sources
Helixi354 – 3563Combined sources
Beta strandi384 – 3863Combined sources
Helixi396 – 3983Combined sources
Beta strandi409 – 4113Combined sources
Helixi414 – 4163Combined sources
Helixi422 – 4309Combined sources
Helixi433 – 44715Combined sources
Helixi452 – 46514Combined sources
Helixi467 – 47711Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E37X-ray2.53A/B/C/D3-482[»]
ProteinModelPortaliO52762.
SMRiO52762. Positions 3-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiENOG4105CH6. Bacteria.
COG0753. LUCA.
HOGENOMiHOG000087852.
InParanoidiO52762.
KOiK03781.
OMAiPNSYGRW.
PhylomeDBiO52762.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O52762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKTRLTTA AGAPVVDNQN VQTAGPRGPM LLQDVWFLEK LAHFDREVIP
60 70 80 90 100
ERRMHAKGSA AYGTFTVTHD ITPYTRAKIF SQVGKKTDMF LRFSTVAGER
110 120 130 140 150
GAADAERDIR GFSMRFYTEQ GNWDLVGNNT PVFYLRDPLK FPDLNHVVKR
160 170 180 190 200
DPRTNLRNAT FKWDFFSHLP ESLHQLTIDF SDRGLPKSYR HIHGFGSHTF
210 220 230 240 250
SFINANNERF WVKFHFKTQQ GIENLTNAEA AEVIAQDRES SQRDLYESIE
260 270 280 290 300
KGDFPRWKMY VQIMPEKEAA TYRYNPFDLT KVWPHGDYPL IEVGFFELNR
310 320 330 340 350
NPDNYFAEVE QAAFTPANVV PGIGFSPDKM LQGRLFSYGD AHRYRLGVNH
360 370 380 390 400
HQIPVNAARC PHQVYHRDGG MRVDGNNAHQ RVTYEPNSFN QWQEQPDFSE
410 420 430 440 450
PPLSLEGAAD HWNHRVDDDY YSQPAALFHL FTDEQKQRLF ANIAEDIRDV
460 470 480
PEQIQRRQIG LFLKVDPAYG KGVADALGLK LD
Length:482
Mass (Da):55,589
Last modified:June 1, 1998 - v1
Checksum:i84E5ABA647CAB414
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047025 Genomic DNA. Translation: AAC03118.1.
AE004091 Genomic DNA. Translation: AAG07624.1.
PIRiB83113.
RefSeqiNP_252926.1. NC_002516.2.
WP_003103909.1. NZ_ASJY01000704.1.

Genome annotation databases

EnsemblBacteriaiAAG07624; AAG07624; PA4236.
GeneIDi881831.
KEGGipae:PA4236.
PATRICi19843163. VBIPseAer58763_4437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047025 Genomic DNA. Translation: AAC03118.1.
AE004091 Genomic DNA. Translation: AAG07624.1.
PIRiB83113.
RefSeqiNP_252926.1. NC_002516.2.
WP_003103909.1. NZ_ASJY01000704.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E37X-ray2.53A/B/C/D3-482[»]
ProteinModelPortaliO52762.
SMRiO52762. Positions 3-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4236.

Proteomic databases

PaxDbiO52762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07624; AAG07624; PA4236.
GeneIDi881831.
KEGGipae:PA4236.
PATRICi19843163. VBIPseAer58763_4437.

Organism-specific databases

PseudoCAPiPA4236.

Phylogenomic databases

eggNOGiENOG4105CH6. Bacteria.
COG0753. LUCA.
HOGENOMiHOG000087852.
InParanoidiO52762.
KOiK03781.
OMAiPNSYGRW.
PhylomeDBiO52762.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATA_PSEAE
AccessioniPrimary (citable) accession number: O52762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.