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O52751

- RUVC_NOSS1

UniProt

O52751 - RUVC_NOSS1

Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi9 – 91MagnesiumBy similarity
    Metal bindingi76 – 761MagnesiumBy similarity
    Metal bindingi148 – 1481MagnesiumBy similarity
    Metal bindingi151 – 1511MagnesiumBy similarity

    GO - Molecular functioni

    1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-HAMAP
    2. DNA repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
    Alternative name(s):
    Holliday junction nuclease RuvC
    Holliday junction resolvase RuvC
    Gene namesi
    Name:ruvC
    Ordered Locus Names:all2297
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 163163Crossover junction endodeoxyribonuclease RuvCPRO_0000183075Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi103690.all2297.

    Structurei

    3D structure databases

    ProteinModelPortaliO52751.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvC family.Curated

    Phylogenomic databases

    eggNOGiCOG0817.
    HOGENOMiHOG000012182.
    KOiK01159.
    OMAiAIEMPFF.
    OrthoDBiEOG6RG044.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_00034. RuvC.
    InterProiIPR012337. RNaseH-like_dom.
    IPR020563. X-over_junc_endoDNase_Mg_BS.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view]
    PfamiPF02075. RuvC. 1 hit.
    [Graphical view]
    PRINTSiPR00696. RSOLVASERUVC.
    SUPFAMiSSF53098. SSF53098. 1 hit.
    TIGRFAMsiTIGR00228. ruvC. 1 hit.
    PROSITEiPS01321. RUVC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O52751-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKRILGLDP GLAILGFGAI TCTPGLTQLQ STKVNVLDFG VIKTSADIEI    50
    GQRLCTLFDD LHTVIDQLQP DVVAIEKLFF YRMSSTIVVA QARGVVMLAL 100
    AQHHLPYVEF TPAQIKLALT GYGNADKSEV QEAVARELDL AEIPRPDDAA 150
    DALAVALTAW YQM 163
    Length:163
    Mass (Da):17,741
    Last modified:June 1, 1998 - v1
    Checksum:i5024A6213E76CCD7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF046871 Genomic DNA. Translation: AAC03106.1.
    BA000019 Genomic DNA. Translation: BAB73996.1.
    PIRiAB2093.
    RefSeqiNP_486337.1. NC_003272.1.
    WP_010996454.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB73996; BAB73996; BAB73996.
    GeneIDi1105894.
    KEGGiana:all2297.
    PATRICi22774764. VBINosSp37423_2849.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF046871 Genomic DNA. Translation: AAC03106.1 .
    BA000019 Genomic DNA. Translation: BAB73996.1 .
    PIRi AB2093.
    RefSeqi NP_486337.1. NC_003272.1.
    WP_010996454.1. NC_003272.1.

    3D structure databases

    ProteinModelPortali O52751.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.all2297.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB73996 ; BAB73996 ; BAB73996 .
    GeneIDi 1105894.
    KEGGi ana:all2297.
    PATRICi 22774764. VBINosSp37423_2849.

    Phylogenomic databases

    eggNOGi COG0817.
    HOGENOMi HOG000012182.
    KOi K01159.
    OMAi AIEMPFF.
    OrthoDBi EOG6RG044.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_00034. RuvC.
    InterProi IPR012337. RNaseH-like_dom.
    IPR020563. X-over_junc_endoDNase_Mg_BS.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view ]
    Pfami PF02075. RuvC. 1 hit.
    [Graphical view ]
    PRINTSi PR00696. RSOLVASERUVC.
    SUPFAMi SSF53098. SSF53098. 1 hit.
    TIGRFAMsi TIGR00228. ruvC. 1 hit.
    PROSITEi PS01321. RUVC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Heterocyst pattern formation controlled by a diffusible peptide."
      Yoon H.-S., Golden J.W.
      Science 282:935-938(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576.

    Entry informationi

    Entry nameiRUVC_NOSS1
    AccessioniPrimary (citable) accession number: O52751
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3