Reviewed, UniProtKB/Swiss-Prot O52748 (PATS_ANASP)

Names and origin

Protein names

Recommended name:
    Heterocyst inhibition-signaling peptide

Gene names

Name:	patS
Ordered Locus Names:	asl2301

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	17 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Inhibits heterocyst differentiation. Seems to control heterocyst pattern formation through intercellular signaling mechanisms. In Anabaena filaments every 10th vegetative cell terminally differentiates into a heterocyst specialized for nitrogen fixation. Seems to inhibit the formation of adjacent heterocysts. Inhibits the DNA-binding of hetR. Ref.1 Ref.3 Ref.4
Subcellular location	Periplasm Probable. Note: Seems to diffuse to adjacent cells.
Developmental stage	Expressed in proheterocysts.

Ontologies

Keywords
Cellular component	Periplasm
Developmental stage	Heterocyst
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heterocyst differentiation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 17	17	Heterocyst inhibition-signaling peptide		PRO_0000044184

Sequences

	Sequence		Length	Mass (Da)
	O52748-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 192BE168476867F3	FASTA	17	1,927
	10 MKAIMLVNFC DERGSGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Heterocyst pattern formation controlled by a diffusible peptide." Yoon H.-S., Golden J.W. Science 282:935-938(1998) [PubMed: 9794762] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]	"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"PatS and products of nitrogen fixation control heterocyst pattern." Yoon H.S., Golden J.W. J. Bacteriol. 183:2605-2613(2001) [PubMed: 11274121] [Abstract] Cited for: FUNCTION.
[4]	"HetR homodimer is a DNA-binding protein required for heterocyst differentiation, and the DNA-binding activity is inhibited by PatS." Huang X., Dong Y., Zhao J. Proc. Natl. Acad. Sci. U.S.A. 101:4848-4853(2004) [PubMed: 15051891] [Abstract] Cited for: FUNCTION IN INHIBITION OF DNA-BINDING OF HETR.

Web resources

Protein Spotlight

Heterocyst or not heterocyst? - Issue 23 of June 2002

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF046871 Genomic DNA. Translation: AAC03103.1. BA000019 Genomic DNA. Translation: BAB74000.1.
PIR	AF2093.
RefSeq	NP_486341.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1105898.
GenomeReviews	Gene locus asl2301 in contig BA000019_GR.
KEGG	ana:asl2301.
Organism-specific databases
CMR	Search...
Enzyme and pathway databases
BioCyc	NSP103690:ASL2301-MON.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PATS_ANASP

Accession

Primary (citable) accession number: O52748

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	June 1, 1998
Last modified:	July 28, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)